{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T17:56:17Z","timestamp":1770141377085,"version":"3.49.0"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.jtemb.2022.127034","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T12:20:24Z","timestamp":1657282824000},"page":"127034","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Evaluation of trace elements in essential thrombocytosis and reactive thrombocytosis"],"prefix":"10.1016","volume":"73","author":[{"given":"Tuba Ozkan","family":"Tekin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denizhan","family":"Karis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Ates Alkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guven","family":"Cetin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alev Meltem","family":"Ercan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtemb.2022.127034_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2020.126509","article-title":"Alkan, Level of trace elements in serum and toenail samples of patients with onychocryptosis (ingrown toenail) and onychomycosis","volume":"61","author":"Kilinc","year":"2020","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.jtemb.2022.127034_bib2","unstructured":"A. Lau, L.N. Chan, Electrolytes, other minerals and trace elements, in: M. Lee (Ed.), Basic Skills in Interpreting Laboratory Data, 5 th Ed, American Society of Health-System Pharmacists, Bethesda, 2013, pp. 119\u2013160. ISBN: 978\u20131-58528\u2013343-9."},{"issue":"1","key":"10.1016\/j.jtemb.2022.127034_bib3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s12011-018-1352-8","article-title":"Analysis of the relationship between hemorheologic parameters, aluminum, manganese, and selenium in smokers","volume":"187","author":"Ates Alkan","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jtemb.2022.127034_bib4","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jinorgbio.2013.07.003","article-title":"Aluminium, carbonyls and cytokines in human nipple aspirate fluids: Possible relationship between inflammation, oxidative stress and breast cancer microenvironment","volume":"128","author":"Mannello","year":"2013","journal-title":"J. Inorg. Biochem"},{"issue":"5","key":"10.1016\/j.jtemb.2022.127034_bib5","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1590\/S0100-879X1997000500005","article-title":"Aluminum induces lipid peroxidation and aggregation of human blood platelets","volume":"30","author":"Neiva","year":"1997","journal-title":"Braz. J. Med. Biol. Res"},{"issue":"4","key":"10.1016\/j.jtemb.2022.127034_bib6","first-page":"401","article-title":"Evaluation of eelenium levels and mean platelet volume in patients with simple febrile convulsion","volume":"24","author":"Abuhandan","year":"2014","journal-title":"Iran. J. Pediatr."},{"issue":"1","key":"10.1016\/j.jtemb.2022.127034_bib7","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1182\/blood.V66.1.213.213","article-title":"Zinc-induced platelet aggregation is mediated by the fibrinogen receptor and is not accompanied by release or by thromboxane synthesis","volume":"66","author":"Eldor","year":"1985","journal-title":"Blood"},{"issue":"02","key":"10.1016\/j.jtemb.2022.127034_bib8","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1079\/BJN19920109","article-title":"Erythrocytes, erythrocyte membranes, neutrophils and platelets as biopsy materials for the assessment of zinc status in humans","volume":"68","author":"Ruz M","year":"1992","journal-title":"Br. J. Nutr."},{"issue":"8","key":"10.1016\/j.jtemb.2022.127034_bib9","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1093\/jn\/124.8.1258","article-title":"Platelet thrombus formation and hemostasis are delayed in the microcirculation of copper-deficient rats","volume":"124","author":"Schuschke","year":"1994","journal-title":"J. Nutr."},{"issue":"5","key":"10.1016\/j.jtemb.2022.127034_bib10","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/clinchem\/25.5.699","article-title":"Elemental composition of platelets. Part I. Sampling and sample preparation of platelets for trace-element analysis","volume":"25","author":"Iyengar G","year":"1979","journal-title":"Clin. Chem."},{"issue":"5","key":"10.1016\/j.jtemb.2022.127034_bib11","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1093\/clinchem\/25.5.705","article-title":"Elemental composition of platelets. Part II. Water content of normal human platelets and measurements of their concentrations of Cu, Fe, K, And Zn by neutron activation analysis","volume":"25","author":"Kiem","year":"1979","journal-title":"Clin. Chem."},{"issue":"1","key":"10.1016\/j.jtemb.2022.127034_bib12","first-page":"7","article-title":"Trace elements and cancer risk: A review of the epidemiologic evidence","volume":"18","author":"Silvera","year":"2007","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.jtemb.2022.127034_bib13","unstructured":"M.K. Schwartz, Role of trace elements in cancer, Cancer Res. 35(11 Part 2) (1975) 3481\u20133487."},{"issue":"2","key":"10.1016\/j.jtemb.2022.127034_bib14","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/01616412.2020.1833147","article-title":"Determination of cerebral blood flow velocity and microembolic signals in essential thrombocytosis by transcranial doppler ultrasonography","volume":"43","author":"Cinar","year":"2020","journal-title":"Neurol. Res."},{"key":"10.1016\/j.jtemb.2022.127034_bib15","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0008-6363(96)00146-0","article-title":"Mechanisms and consequences of cell activation in the microcirculation","volume":"32","author":"Mazzoni","year":"1996","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.jtemb.2022.127034_bib16","first-page":"15","article-title":"Essential thrombocythemia: Update on pathogenesis, diagnosis, and management","volume":"77","author":"Y\u00f6nal","year":"2014","journal-title":"J. Ist. Fac. Med"},{"issue":"12","key":"10.1016\/j.jtemb.2022.127034_bib17","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.3109\/02713683.2014.906624","article-title":"Peripapillary retinal nerve fiber layer changes in asymptomatic essential thrombocythemia patients","volume":"39","author":"Ayintap","year":"2014","journal-title":"Curr. Eye Res."},{"issue":"17","key":"10.1016\/j.jtemb.2022.127034_bib18","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.1002\/cncr.24440","article-title":"The 2008 World Health Organization classification system for myeloproliferative neoplasms","volume":"115","author":"Tefferi","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.jtemb.2022.127034_bib19","unstructured":"A. Lal, Essential thrombocytosis, Ed. E.C. Besa. http:\/\/emedicine.medscape.com\/article\/206697-overview (accessed 19 May 2021)."},{"issue":"6","key":"10.1016\/j.jtemb.2022.127034_bib20","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1177\/000992289403300605","volume":"33","author":"Yohannan","year":"1994","journal-title":"Clin. Pediatr."},{"key":"10.1016\/j.jtemb.2022.127034_bib21","doi-asserted-by":"crossref","unstructured":"C.N. Harrison, D. Bareford, N. Butt, P. Campbell, E. Conneally, M. Drummond, W. Erber, T. Everington, A.R. Green, G.W. Hall, B.J. Hunt, C.A. Ludlam CA, R. Murrin, C. Nelson-Piercy, D.H. Radia, J.T. Reilly, J. Van der Walt, B. Wilkins, M.F. McMullin, British Committee for Standards in Haematology, Guideline for investigation and management of adults and children presenting with a thrombocytosis, Br. J. Haematol. 149(3) (2010) 352\u2013375. https: doi.org\/10.1111\/j.1365\u20132141.2010.08122.x.","DOI":"10.1111\/j.1365-2141.2010.08122.x"},{"key":"10.1016\/j.jtemb.2022.127034_bib22","doi-asserted-by":"crossref","unstructured":"A.F. Goddard, M.W. James, A.S. McIntyre, B.B. Scott, Guidelines for the management of iron de\ufb01ciency anaemia, British Society of Gastroenterology. Guidelines for the management of iron deficiency anaemia, Gut. 46(3) (2000) 1309\u20131316. https:\/\/doi.org\/10.1136\/gut.2010.228874.","DOI":"10.1136\/gut.2010.228874"},{"issue":"02","key":"10.1016\/j.jtemb.2022.127034_bib23","doi-asserted-by":"crossref","first-page":"106","DOI":"10.5482\/HAMO-16-12-0046","article-title":"Acute transmural myocardial infarction by coronary embolism in a patient with JAK2 V617F-positive essential thrombocythemia","volume":"38","author":"detto Loria","year":"2018","journal-title":"H\u00e4mostaseologie"},{"issue":"2","key":"10.1016\/j.jtemb.2022.127034_bib24","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/10428190802688152","article-title":"JAK2V617F mutation in essential thrombocythemia: correlation with clinical characteristics, response to therapy and long-term outcome in a cohort of 275 patients","volume":"50","author":"Palandri","year":"2009","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.jtemb.2022.127034_bib25","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1056\/NEJMra035363","article-title":"Thrombocytosis","volume":"350","author":"Schafer","year":"2004","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.jtemb.2022.127034_bib26","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1100\/tsw.2011.108","article-title":"Defining the trombotic risk in patients with myeloproliferative neoplasms","volume":"11","author":"Vianello","year":"2011","journal-title":"Sci. World J."},{"issue":"12","key":"10.1016\/j.jtemb.2022.127034_bib27","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.4065\/73.12.1177","article-title":"The Philadelphia chromosome negative chronic myeloproliferative disorders: A practical overview","volume":"73","author":"Tefferi","year":"1998","journal-title":"Mayo Clin. Proc."},{"issue":"2","key":"10.1016\/j.jtemb.2022.127034_bib28","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/sj.leu.2404500","article-title":"Risk stratification for survival and leukemic transformation in essential thrombocythemia: a single institutional study of 605 patients","volume":"21","author":"Gangat","year":"2007","journal-title":"Leukemia"},{"key":"10.1016\/j.jtemb.2022.127034_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00277-001-0409-4","article-title":"Iron deficiency anemia increases nitric oxide production in healthy adolescents","volume":"81","author":"Choi","year":"2002","journal-title":"Ann. Hematol."},{"issue":"4","key":"10.1016\/j.jtemb.2022.127034_bib30","first-page":"305","article-title":"Does serum lipid profile differ in anemia and non-anemic older subjects?","volume":"8","author":"Shirvani","year":"2017","journal-title":"Casp. J. Intern. Med"},{"issue":"8","key":"10.1016\/j.jtemb.2022.127034_bib31","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1097\/MIB.0b013e318281f4db","article-title":"Iron deficiency generates secondary thrombocytosis and platelet activation in IBD: the randomized, controlled thromboVIT trial","volume":"19","author":"Kulnigg-Dabsch","year":"2013","journal-title":"Inflamm. Bowel Dis."},{"issue":"4","key":"10.1016\/j.jtemb.2022.127034_bib32","first-page":"71","article-title":"Assessment of some selected trace metals in chronic myeloid leukemia patients in a tertiary health facility in South West Nigeria. Asian","volume":"5","author":"Akanni","year":"2013","journal-title":"J. Med. Sci."},{"issue":"5","key":"10.1016\/j.jtemb.2022.127034_bib33","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/ajh.23409","article-title":"The expression of lysyl-oxidase gene family members in myeloproliferative neoplasms","volume":"88","author":"Tadmor","year":"2013","journal-title":"Am. J. Hematol."},{"issue":"2","key":"10.1016\/j.jtemb.2022.127034_bib34","doi-asserted-by":"crossref","first-page":"344","DOI":"10.5505\/ejm.2021.58751","article-title":"Evaluation of serum levels of trace elements in myeloproliferative neoplasms: a case-control study","volume":"26","author":"Yetisgin","year":"2021","journal-title":"East. J. Med."},{"key":"10.1016\/j.jtemb.2022.127034_bib35","doi-asserted-by":"crossref","DOI":"10.1007\/s12011-020-02538-5","article-title":"The association between trace elements and osmolality in plasma and aqueous humor fluid in diabetic rabbits","author":"Ergun","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"issue":"10","key":"10.1016\/j.jtemb.2022.127034_bib36","doi-asserted-by":"crossref","first-page":"6737","DOI":"10.1007\/s11033-014-3559-x","article-title":"Evaluation of clinical and laboratory findings with JAK2 V617F mutation as an independent variable in essential thrombocytosis","volume":"41","author":"Cetin","year":"2014","journal-title":"Mol. Biol. Rep."},{"issue":"4","key":"10.1016\/j.jtemb.2022.127034_bib37","doi-asserted-by":"crossref","first-page":"620","DOI":"10.3324\/haematol.2013.092684","article-title":"Primary thrombocytosis in children","volume":"99","author":"Kucine","year":"2014","journal-title":"Haematologica"},{"key":"10.1016\/j.jtemb.2022.127034_bib38","doi-asserted-by":"crossref","unstructured":"R.L. Levine, A. Pardanani, A. Tefferi, D.G. Gilliland, Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders, Nat. Rev. Cancer. 7(9) (2007) 673\u2013683. https\/\/doi.org\/10.1038\/nrc2210. PMID: 17721432.","DOI":"10.1038\/nrc2210"},{"issue":"10","key":"10.1016\/j.jtemb.2022.127034_bib39","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1182\/blood.V96.10.3310","article-title":"Hypersensitivity of circulating progenitor cells to megakaryocyte growth and development factor (PEG-rHu MGDF) in essential thrombocythemia","volume":"96","author":"Axelrad","year":"2000","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.jtemb.2022.127034_bib40","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/leu.2008.72","article-title":"Life expectancy and prognostic factors in the classic Bcr\/Abl-negative myeloproliferative disorders","volume":"22","author":"Cervantes","year":"2008","journal-title":"Leukemia"},{"issue":"3","key":"10.1016\/j.jtemb.2022.127034_bib41","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/jso.2930520311","article-title":"Serum and tissue trace elements in colorectal cancer","volume":"52","author":"Gupta","year":"1993","journal-title":"J. Surg. Oncol."},{"issue":"1","key":"10.1016\/j.jtemb.2022.127034_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1385\/BTER:89:1:1","article-title":"Serum and tissue trace elements in patients with breast cancer in Taiwan","volume":"89","author":"Kuo","year":"2002","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jtemb.2022.127034_bib43","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jtemb.2014.04.006","article-title":"Global perspectives on trace element requirements","volume":"31","author":"Freeland-Graves","year":"2015","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"5","key":"10.1016\/j.jtemb.2022.127034_bib44","doi-asserted-by":"crossref","first-page":"1041S","DOI":"10.1093\/ajcn\/67.5.1041S","article-title":"Copper intake and assessment of copper status","volume":"67","author":"Milne","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"issue":"2","key":"10.1016\/j.jtemb.2022.127034_bib45","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1385\/BTER:79:2:107","article-title":"Serum levels of selenium, manganese, copper and iron in colorectal cancer patients","volume":"79","author":"Milde","year":"2001","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jtemb.2022.127034_bib46","first-page":"537","article-title":"Correlation of serum trace elements with other biological parameters in hemoproliferative disorders","volume":"4","author":"Beguin","year":"1986","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"8","key":"10.1016\/j.jtemb.2022.127034_bib47","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1002\/1097-0142(19800415)45:8<2156::AID-CNCR2820450824>3.0.CO;2-C","article-title":"Serum copper levels in Non\u2010Hodgkin's lymphoma","volume":"45","author":"Shah\u2010Reddy","year":"1980","journal-title":"cancer"},{"key":"10.1016\/j.jtemb.2022.127034_bib48","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ctrv.2008.07.004","article-title":"Elevated copper and oxidative stress in cancer cells as a target for cancer treatment","volume":"35","author":"Gupte","year":"2009","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.jtemb.2022.127034_bib49","first-page":"3471","article-title":"Altered serum levels of elements in acute leukemia cases in Turkey, Asian Pac","volume":"12","author":"Demir","year":"2011","journal-title":"J. Cancer"},{"issue":"3","key":"10.1016\/j.jtemb.2022.127034_bib50","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/ajh.25008","article-title":"The role of extracellular matrix stiffness in megakaryocyte and platelet development and function","volume":"93","author":"Leiva","year":"2018","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.jtemb.2022.127034_bib51","unstructured":"S. Pazirandeh, D.L. Burns, I.J. Griffin, T.O. Lipman, A.G. Hoppin, Overview of dietary trace minerals. UpToDate. https:\/\/somepomed.org\/articulos\/contents\/mobipreview.htm?19\/26\/19872?source=see_link (accessed 19 May 2021)."},{"issue":"10","key":"10.1016\/j.jtemb.2022.127034_bib52","first-page":"627","article-title":"Iron deprivation results in an increase in P53 expression","volume":"376","author":"Fukuchi","year":"1995","journal-title":"Biol. Chem. Hoppe-Seyler"},{"issue":"8","key":"10.1016\/j.jtemb.2022.127034_bib53","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.3390\/nu5082836","article-title":"Iron deprivation in cancer-potential therapeutic implications","volume":"5","author":"Health","year":"2013","journal-title":"Nutrients"},{"key":"10.1016\/j.jtemb.2022.127034_bib54","doi-asserted-by":"crossref","unstructured":"J. Koprivnikar, C.M. Kessler, Thrombocytosis: Essential thrombocythemia and reactive causes, consultative hemostasis and thrombosis (Third Edition) Expert Consult - Online and Print, (2013) 298\u2013323. https:\/\/doi.org\/10.1016\/B978\u20131-4557\u20132296-9.00019\u20131.","DOI":"10.1016\/B978-1-4557-2296-9.00019-1"},{"issue":"3","key":"10.1016\/j.jtemb.2022.127034_bib55","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/ejh.12150","article-title":"Serum hepcidin and growth differentiation factor-15 (GDF-15) levels in polycythemia vera and essential thrombocythemia","volume":"91","author":"Tarkun","year":"2013","journal-title":"Eur. J. Hematol."},{"issue":"6","key":"10.1016\/j.jtemb.2022.127034_bib56","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/09537100903137306","article-title":"Platelet counts in adults with iron de\ufb01ciency anemia","volume":"20","author":"Kuku","year":"2009","journal-title":"Platelets"},{"issue":"3","key":"10.1016\/j.jtemb.2022.127034_bib57","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000041038","article-title":"Thrombopoietic cytokines in patients with iron deficiency anemia with or without thrombocytosis","volume":"103","author":"Akan","year":"2000","journal-title":"Acta Haematol."},{"issue":"5","key":"10.1016\/j.jtemb.2022.127034_bib58","doi-asserted-by":"crossref","first-page":"348","DOI":"10.3109\/09537104.2012.699641","article-title":"The relationship between iron parameters and platelet parameters in women with iron deficiency anemia and thrombocytosis","volume":"24","author":"Park","year":"2013","journal-title":"Platelets"},{"issue":"3","key":"10.1016\/j.jtemb.2022.127034_bib59","doi-asserted-by":"crossref","first-page":"782","DOI":"10.3324\/haematol.2019.245092","article-title":"Iron deficiency-induced thrombocytosis increases thrombotic tendency in rats","volume":"106","author":"Jimenez","year":"2021","journal-title":"Haematologica"},{"issue":"3","key":"10.1016\/j.jtemb.2022.127034_bib60","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1160\/TH12-07-0465","article-title":"Zinc: an important cofactor in haemostasis and thrombosis","volume":"109","author":"Vu","year":"2013","journal-title":"Thromb. Haemost."},{"issue":"2","key":"10.1016\/j.jtemb.2022.127034_bib61","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/ajh.2830190207","article-title":"The procoagulant effect of zinc on fibrin clot formation","volume":"19","author":"Marx","year":"1985","journal-title":"Am. J. Hematol."},{"issue":"10","key":"10.1016\/j.jtemb.2022.127034_bib62","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1182\/blood-2014-01-547596","article-title":"Two faces of ET: CALR and JAK","volume":"123","author":"Chao","year":"2014","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.jtemb.2022.127034_bib63","first-page":"227","article-title":"Diagnostic and prognostic significance of serum and tissue trace elements in breast malignancy","volume":"48","author":"Sharma","year":"1994","journal-title":"INJMAO"},{"issue":"1","key":"10.1016\/j.jtemb.2022.127034_bib64","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/0168-583X(90)90243-N","article-title":"Use of PIXE to measure serum copper, zinc, selenium, and bromine in patients with hematologic malignancies","volume":"49","author":"Beguin","year":"1990","journal-title":"Nucl. Instrum. Meth. B"},{"key":"10.1016\/j.jtemb.2022.127034_bib65","first-page":"734","article-title":"Significance of the serum level of Cu, Zn, Mn, Cr and Ni in acute leukemia","volume":"28","author":"Wen","year":"1989","journal-title":"Zhonghua nei ke za zhi"},{"key":"10.1016\/j.jtemb.2022.127034_bib66","first-page":"80","article-title":"The chemical element content of the erythrocytes in polycythemia vera","volume":"10","author":"Vydyborets","year":"1989","journal-title":"Vrach. Delo."},{"issue":"5","key":"10.1016\/j.jtemb.2022.127034_bib67","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1600-0609.1987.tb01440.x","article-title":"Zinc status in polycythaemia","volume":"38","author":"Simmer","year":"1987","journal-title":"Eur. J. Hematol."},{"issue":"4","key":"10.1016\/j.jtemb.2022.127034_bib68","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00277-010-1089-8","article-title":"The role of zinc protoporphyrin measurement in the differentiation between primary myelofibrosis and essential thrombocythaemia","volume":"90","author":"Metzgeroth","year":"2011","journal-title":"Ann. Hematol."},{"issue":"9225","key":"10.1016\/j.jtemb.2022.127034_bib69","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0140-6736(00)02490-9","article-title":"The importance of selenium to human health","volume":"356","author":"Rayman","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jtemb.2022.127034_bib70","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.jtemb.2018.04.008","article-title":"Selenium supplementation ameliorates electromagnetic field-induced oxidative stress in the HEK2","volume":"50","author":"Pastac\u0131 \u00d6zsobac\u0131","year":"2018","journal-title":"93 Cells, J. Trace Elem. Med. Biol."},{"issue":"2","key":"10.1016\/j.jtemb.2022.127034_bib71","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s12011-009-8415-9","article-title":"Environmental manganese and cancer mortality rates by county in North Carolina: an ecological study","volume":"133","author":"Spangler","year":"2010","journal-title":"Biol. Trace Elem. Res."},{"issue":"1","key":"10.1016\/j.jtemb.2022.127034_bib72","first-page":"92","article-title":"Inhibitory effects of manganese upon muscle \u0131mmunogenesis by nickel sulfide","volume":"34","author":"Sunderman","year":"1974","journal-title":"Cancer Res"},{"issue":"5","key":"10.1016\/j.jtemb.2022.127034_bib73","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0020-711X(78)90101-5","article-title":"Purification and characterization of a manganese containing superoxide dismutase from bovine heart mitochondria","volume":"9","author":"Marklund","year":"1978","journal-title":"Int. J. Biochem"},{"key":"10.1016\/j.jtemb.2022.127034_bib74","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.3109\/10428194.2013.825904","article-title":"Mimic of manganese superoxide dismutase induces apoptosis in human acute myeloid leukemia cells","volume":"55","author":"Wang","year":"2014","journal-title":"Leuk. Lymphoma"},{"issue":"4","key":"10.1016\/j.jtemb.2022.127034_bib75","first-page":"887","article-title":"Dietary boron \u0131ntake and prostate cancer risk","volume":"11","author":"Cui","year":"2004","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.jtemb.2022.127034_bib76","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jtemb.2017.10.008","article-title":"The importance of boron in biological systems","volume":"45","author":"Uluisik","year":"2018","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"4","key":"10.1016\/j.jtemb.2022.127034_bib77","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1046\/j.1365-2141.2002.03967.x","article-title":"Mechanisms involved in the antiplatelet activity of magnesium in human platelets","volume":"119","author":"Sheu","year":"2002","journal-title":"Br. J. Haematol."},{"issue":"10","key":"10.1016\/j.jtemb.2022.127034_bib78","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1093\/ajh\/5.10.700","article-title":"Effect of extracellular magnesium on platelet activation and intracellular calcium mobilization","volume":"5","author":"Hwang","year":"1992","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.jtemb.2022.127034_bib79","article-title":"Magnesium for the prevention and treatment of cardiovascular disease","volume":"5","author":"Di Nicolantonio","year":"2018","journal-title":"Open Heart"},{"issue":"3","key":"10.1016\/j.jtemb.2022.127034_bib80","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.biocel.2008.07.012","article-title":"Cobalt \u0131nduces oxidative stress in \u0131solated liver mitochondria responsible for permeability transition and \u0131ntrinsic apoptosis in hepatocyte primary cultures","volume":"41","author":"Battaglia","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"2","key":"10.1016\/j.jtemb.2022.127034_bib81","first-page":"236","article-title":"Selected aspects of the action of cobalt ions in the human body, Centr","volume":"40","author":"Czarnek","year":"2015","journal-title":"Eur. J. Immunol."},{"issue":"5","key":"10.1016\/j.jtemb.2022.127034_bib82","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1289\/ehp.9451","article-title":"Temporal variability of tungsten and cobalt in Fallon, Nevada","volume":"115","author":"Sheppard","year":"2007","journal-title":"Environ. Health Perspect."},{"issue":"12","key":"10.1016\/j.jtemb.2022.127034_bib83","first-page":"3471","article-title":"Altered serum levels of elements in acute leukemia cases in Turkey","volume":"12","author":"Demir","year":"2011","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"2","key":"10.1016\/j.jtemb.2022.127034_bib84","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0021-9681(70)90071-8","article-title":"Chromium deficiency as a factor in atherosclerosis","volume":"23","author":"Schroeder","year":"1970","journal-title":"J. Chronic Dis."},{"issue":"2","key":"10.1016\/j.jtemb.2022.127034_bib85","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1515\/intox-2016-0007","article-title":"Adverse hematological effects of hexavalent chromium: an overview","volume":"9","author":"Ray","year":"2016","journal-title":"Interdiscip. Toxicol."},{"issue":"2","key":"10.1016\/j.jtemb.2022.127034_bib86","first-page":"154","article-title":"M.P. Vaquero, Silicon, aluminium, arsenic and lithium: essentiality and human health implications","volume":"6","author":"P\u00e9rez-Granados","year":"2002","journal-title":"J. Nutr. Health Aging"},{"issue":"8383","key":"10.1016\/j.jtemb.2022.127034_bib87","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S0140-6736(84)92399-7","article-title":"Bladder cancer in the aluminium industry","volume":"323","author":"Th\u00e9riault","year":"1984","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.jtemb.2022.127034_bib88","first-page":"375","article-title":"Analysis of serum nickel, silicium, arsenic and boron in smoking individuals","volume":"43","author":"Ate\u015f Alkan","year":"2021","journal-title":"OMJ"},{"issue":"5","key":"10.1016\/j.jtemb.2022.127034_bib89","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.acthis.2012.10.002","article-title":"Silicic acid in drinking water prevents age-related alterations in the endothelium-dependent vascular relaxation modulating eNOS and AQP1 expression in experimental mice: an immunohistochemical study","volume":"115","author":"Buffoli","year":"2013","journal-title":"Acta Histochem"},{"issue":"8","key":"10.1016\/j.jtemb.2022.127034_bib90","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1164\/rccm.200409-1202OC","article-title":"Silica particles enhance peripheral thrombosis: key role of lung macrophage-neutrophil cross - talk","volume":"171","author":"Nemmar","year":"2005","journal-title":"Am. J. Respir. Crit. Care. Med."},{"key":"10.1016\/j.jtemb.2022.127034_bib91","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.nut.2015.03.014","article-title":"Dietary silicon-enriched spirulina improves early atherosclerosis markers in hamsters on a high-fat diet","volume":"31","author":"Vid\u00e9","year":"2015","journal-title":"Nutrition"},{"key":"10.1016\/j.jtemb.2022.127034_bib92","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.3390\/nu11112574","article-title":"Dietary supplementation with silicon-enriched spirulina \u0131mproves arterial remodeling and function in hypertensive rats","volume":"11","author":"Arthur-Ataam","year":"2019","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.jtemb.2022.127034_bib93","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1040-8428(01)00214-1","article-title":"Nickel essentiality, toxicity, and carcinogenicity","volume":"42","author":"Denkhaus","year":"2002","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"4","key":"10.1016\/j.jtemb.2022.127034_bib94","first-page":"412","article-title":"Dhundasi, Nickel, its adverse health effects & oxidative stress","volume":"128","author":"Das","year":"2008","journal-title":"IMIREV"},{"issue":"9","key":"10.1016\/j.jtemb.2022.127034_bib95","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1177\/0748233708100091","article-title":"Urinary level of nickel and acute leukaemia in Chinese children","volume":"24","author":"Yang","year":"2008","journal-title":"Toxicol. Ind. Health"}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X22001146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X22001146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:18:20Z","timestamp":1760555900000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X22001146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":95,"alternative-id":["S0946672X22001146"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2022.127034","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of trace elements in essential thrombocytosis and reactive thrombocytosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2022.127034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"127034"}}