{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:29:00Z","timestamp":1792499340334,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T00:00:00Z","timestamp":1695427200000},"content-version":"am","delay-in-days":296,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000125","name":"National Institute for Occupational Safety and Health","doi-asserted-by":"publisher","award":["1K01 OH011648"],"award-info":[{"award-number":["1K01 OH011648"]}],"id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["NIEHS-1R21 ES024700"],"award-info":[{"award-number":["NIEHS-1R21 ES024700"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.jtemb.2022.127077","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T12:44:43Z","timestamp":1663073083000},"page":"127077","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["In vivo quantification of strontium in bone among adults using portable x-ray fluorescence"],"prefix":"10.1016","volume":"74","author":[{"given":"Xinxin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen M.","family":"Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron J.","family":"Specht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc G.","family":"Weisskopf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Weuve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda H.","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jtemb.2022.127077_bib1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1359\/jbmr.1999.14.5.661","article-title":"Strontium and bone","volume":"14","author":"Cabrera","year":"1999","journal-title":"J. Bone Min. Res"},{"key":"10.1016\/j.jtemb.2022.127077_bib2","unstructured":"Agency for Toxic Substances and Disease Registry: Toxicological profile for Strontium. In. Edited by U.S. Department of Health and Human Services PHS. Atlanta, GA; 2004."},{"issue":"3","key":"10.1016\/j.jtemb.2022.127077_bib3","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.bone.2004.04.026","article-title":"The biological role of strontium","volume":"35","author":"Pors Nielsen","year":"2004","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.jtemb.2022.127077_bib4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0021-5198(19)35850-0","article-title":"Effects of strontium on calcium metabolism in rats. I. A distinction between the pharmacological and toxic doses","volume":"64","author":"Morohashi","year":"1994","journal-title":"Jpn J. Pharm."},{"issue":"4","key":"10.1016\/j.jtemb.2022.127077_bib5","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/8756-3282(94)90820-6","article-title":"Strontium alters the complexed acidic phospholipid content of mineralizing tissues","volume":"15","author":"Neufeld","year":"1994","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.jtemb.2022.127077_bib6","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1136\/adc.75.6.524","article-title":"Rickets and soil strontium","volume":"75","author":"Ozgur","year":"1996","journal-title":"Arch. Dis. Child"},{"issue":"17","key":"10.1016\/j.jtemb.2022.127077_bib7","doi-asserted-by":"crossref","first-page":"5520","DOI":"10.1016\/S0021-9258(20)81136-3","article-title":"Rachitogenic activity of dietary strontium. I. Inhibition of intestinal calcium absorption and 1,25-dihydroxycholecalciferol synthesis","volume":"247","author":"Omdahl","year":"1972","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.jtemb.2022.127077_bib8","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/8756-3282(96)00080-4","article-title":"The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro","volume":"18","author":"Canalis","year":"1996","journal-title":"Bone"},{"key":"10.1016\/j.jtemb.2022.127077_bib9","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.micron.2015.10.006","article-title":"The effects of strontium on bone mineral: A review on current knowledge and microanalytical approaches","volume":"80","author":"Querido","year":"2016","journal-title":"Micron"},{"issue":"9","key":"10.1016\/j.jtemb.2022.127077_bib10","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1359\/JBMR.050405","article-title":"Long-term strontium ranelate administration in monkeys preserves characteristics of bone mineral crystals and degree of mineralization of bone","volume":"20","author":"Farlay","year":"2005","journal-title":"J. Bone Min. Res"},{"issue":"6","key":"10.1016\/j.jtemb.2022.127077_bib11","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1007\/s00198-010-1369-0","article-title":"How strontium ranelate, via opposite effects on bone resorption and formation, prevents osteoporosis","volume":"22","author":"Marie","year":"2011","journal-title":"Osteoporos. Int"},{"issue":"5","key":"10.1016\/j.jtemb.2022.127077_bib12","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1056\/NEJMoa022436","article-title":"The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis","volume":"350","author":"Meunier","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.jtemb.2022.127077_bib13","first-page":"2060","article-title":"Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis--a 2-year randomized placebo controlled trial","volume":"87","author":"Meunier","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"21","key":"10.1016\/j.jtemb.2022.127077_bib14","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.2174\/1381612023393639","article-title":"Strontium ranelate in osteoporosis","volume":"8","author":"Reginster","year":"2002","journal-title":"Curr. Pharm. Des."},{"issue":"9","key":"10.1016\/j.jtemb.2022.127077_bib15","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1517\/14740338.2014.939169","article-title":"Cardiac concerns associated with strontium ranelate","volume":"13","author":"Reginster","year":"2014","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.jtemb.2022.127077_bib16","first-page":"913","article-title":"History of cardiovascular events and cardiovascular risk factors among patients initiating strontium ranelate for treatment of osteoporosis","volume":"7","author":"Yu","year":"2015","journal-title":"Int J. Women\u2019s. Health"},{"issue":"6","key":"10.1016\/j.jtemb.2022.127077_bib17","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1007\/s00198-015-3109-y","article-title":"The position of strontium ranelate in today's management of osteoporosis","volume":"26","author":"Reginster","year":"2015","journal-title":"Osteoporos. Int"},{"key":"10.1016\/j.jtemb.2022.127077_bib18","unstructured":"Assessment report\u2014periodic safety update report (EPAR - Protelos-H-C-560-PSU31) [\u3008http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_-_Assessment_Report_-_Variation\/human\/000560\/WC500147168.pdf\u3009]."},{"issue":"18","key":"10.1016\/j.jtemb.2022.127077_bib19","doi-asserted-by":"crossref","first-page":"23048","DOI":"10.1007\/s11356-021-12378-y","article-title":"Strontium in public drinking water and associated public health risks in Chinese cities","volume":"28","author":"Peng","year":"2021","journal-title":"Environ. Sci. Pollut. Res Int"},{"issue":"3","key":"10.1016\/j.jtemb.2022.127077_bib20","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s11596-021-2366-6","article-title":"Association of urinary strontium levels with pregnancy-induced hypertension","volume":"41","author":"Tang","year":"2021","journal-title":"Curr. Med Sci."},{"key":"10.1016\/j.jtemb.2022.127077_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111694","article-title":"Urinary biomarker of strontium exposure is positively associated with semen quality among men from an infertility clinic","volume":"208","author":"Miao","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jtemb.2022.127077_bib22","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.envres.2011.11.005","article-title":"Urinary strontium and the risk of breast cancer: a case-control study in Guangzhou, China","volume":"112","author":"Chen","year":"2012","journal-title":"Environ. Res"},{"key":"10.1016\/j.jtemb.2022.127077_bib23","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bone.2014.01.002","article-title":"Monitoring bone strontium intake in osteoporotic females self-supplementing with strontium citrate with a novel in-vivo X-ray fluorescence based diagnostic tool","volume":"61","author":"Moise","year":"2014","journal-title":"Bone"},{"issue":"11","key":"10.1016\/j.jtemb.2022.127077_bib24","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1359\/JBMR.050810","article-title":"Long-term effect of strontium ranelate treatment on BMD","volume":"20","author":"Blake","year":"2005","journal-title":"J. Bone Min. Res"},{"key":"10.1016\/j.jtemb.2022.127077_bib25","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/398032","article-title":"Portable XRF technology to quantify Pb in bone in vivo","volume":"2014","author":"Specht","year":"2014","journal-title":"J. Biomark."},{"issue":"8","key":"10.1016\/j.jtemb.2022.127077_bib26","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1177\/0003702817694383","article-title":"Measurements of Strontium Levels in Human Bone In Vivo Using Portable X-ray Fluorescence (XRF)","volume":"71","author":"Specht","year":"2017","journal-title":"Appl. Spectrosc."},{"issue":"2","key":"10.1016\/j.jtemb.2022.127077_bib27","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1080\/1354750X.2017.1380082","article-title":"Quantification of manganese and mercury in toenail in vivo using portable X-ray fluorescence (XRF)","volume":"23","author":"Zhang","year":"2018","journal-title":"Biomark.: Biochem. Indic. Expo., Response, susceptibility Chem."},{"key":"10.1016\/j.jtemb.2022.127077_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142351","article-title":"Evaluation of a portable XRF device for in vivo quantification of lead in bone among a US population","volume":"753","author":"Zhang","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jtemb.2022.127077_bib29","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.scitotenv.2018.01.091","article-title":"Bone lead levels in an environmentally exposed elderly population in shanghai, China","volume":"626","author":"Specht","year":"2018","journal-title":"Sci. Total Environ."},{"issue":"5","key":"10.1016\/j.jtemb.2022.127077_bib30","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1097\/HP.0000000000000971","article-title":"Study of Portable X-ray Fluorescence in Vivo Metal Measurements","volume":"116","author":"Specht","year":"2019","journal-title":"Health Phys."},{"key":"10.1016\/j.jtemb.2022.127077_bib31","doi-asserted-by":"crossref","unstructured":"Cohen-Tannoudji C.D.-R.J., Grynberg G.: Atom-photon Interactions: Basic Processes and Applications: John Wiley & Sons Inc.; 1997.","DOI":"10.1002\/9783527617197"},{"issue":"5","key":"10.1016\/j.jtemb.2022.127077_bib32","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1088\/0967-3334\/34\/5\/503","article-title":"Design of a phantom equivalent to measure bone-fluorine in a human's hand via delayed neutron activation analysis","volume":"34","author":"Mostafaei","year":"2013","journal-title":"Physiol. Meas."},{"key":"10.1016\/j.jtemb.2022.127077_bib33","first-page":"116","article-title":"Evaluation of portable X-ray fluorescence spectrometers for in vivo quantification of bone strontium and lead on the bases of the minimum detection limit: A phantom study","volume":"61","author":"Da Silva","year":"2018","journal-title":"Adv. X-ray Anal."}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X22001572?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X22001572?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:35:13Z","timestamp":1778776513000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X22001572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":33,"alternative-id":["S0946672X22001572"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2022.127077","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vivo quantification of strontium in bone among adults using portable x-ray fluorescence","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2022.127077","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"127077"}}