{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T14:26:29Z","timestamp":1783088789473,"version":"3.54.6"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.jtemb.2023.127221","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T21:05:57Z","timestamp":1684875957000},"page":"127221","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Vitamin D and calcium co-therapy mitigates pre-established cadmium nephropathy by regulating renal calcium homeostatic molecules and improving anti-oxidative and anti-inflammatory activities in rat"],"prefix":"10.1016","volume":"79","author":[{"given":"Ahmad A.","family":"Obaid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussain","family":"Almasmoum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riyad A.","family":"Almaimani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"El-Boshy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhmed","family":"Aslam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakir","family":"Idris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazen M.","family":"Ghaith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud Z.","family":"El-Readi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jawwad","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesam F.","family":"Farrash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman","family":"Mujalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safaa Y.","family":"Eid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed E.","family":"Elzubier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4267-1016","authenticated-orcid":false,"given":"Bassem","family":"Refaat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.jtemb.2023.127221_bib1","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/modpathol.2013.62","article-title":"The liver in itai-itai disease (chronic cadmium poisoning): pathological features and metallothionein expression","volume":"26","author":"Baba","year":"2013","journal-title":"Mod. Pathol.: Off. J. U. S. Can. Acad. Pathol., Inc."},{"issue":"3","key":"10.1016\/j.jtemb.2023.127221_bib2","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2174\/138920012799320446","article-title":"Long-term exposure to cadmium in food and cigarette smoke, liver effects and hepatocellular carcinoma","volume":"13","author":"Satarug","year":"2012","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.jtemb.2023.127221_bib3","doi-asserted-by":"crossref","unstructured":"S.E. Orr , C.C.J.Ijoms Bridges , Chronic kidney disease and exposure to nephrotoxic metals, 18(5) (2017) 1039.","DOI":"10.3390\/ijms18051039"},{"key":"10.1016\/j.jtemb.2023.127221_bib4","doi-asserted-by":"crossref","unstructured":"C. Chen, X. Han, G. Wang, D. Liu, L. Bao, C. Jiao, J. Luan, Y. Hou, Y. Xu, H.J.Ao.T. Wang, Nrf2 deficiency aggravates the kidney injury induced by subacute cadmium exposure in mice, 95(3) , 2021. pp. 883\u2013893.","DOI":"10.1007\/s00204-020-02964-3"},{"issue":"8","key":"10.1016\/j.jtemb.2023.127221_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/toxics10080472","article-title":"Multiple targets of toxicity in environmental exposure to low-dose cadmium","volume":"10","author":"Satarug","year":"2022","journal-title":"Toxics"},{"issue":"4","key":"10.1016\/j.jtemb.2023.127221_bib6","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.3390\/ijerph19042259","article-title":"Effects of Environmental Exposure to Cadmium and Lead on the Risks of Diabetes and Kidney Dysfunction","volume":"19","author":"Yimthiang","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"4","key":"10.1016\/j.jtemb.2023.127221_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/toxics8040086","article-title":"Cadmium and lead exposure, nephrotoxicity, and mortality","volume":"8","author":"Satarug","year":"2020","journal-title":"Toxics"},{"issue":"4","key":"10.1016\/j.jtemb.2023.127221_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/nu11040758","article-title":"Extract from aronia melanocarpa L. berries protects against cadmium-induced lipid peroxidation and oxidative damage to proteins and DNA in the liver: a study using a rat model of environmental human exposure to this xenobiotic","volume":"11","author":"Mezynska","year":"2019","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.jtemb.2023.127221_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22440","article-title":"Vitamin D(3) and calcium cosupplementation alleviates cadmium hepatotoxicity in the rat: enhanced antioxidative and anti-inflammatory actions by remodeling cellular calcium pathways","volume":"34","author":"El-Boshy","year":"2020","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"11","key":"10.1016\/j.jtemb.2023.127221_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/biom11111575","article-title":"Cadmium-induced kidney injury: oxidative damage as a unifying mechanism","volume":"11","author":"Yan","year":"2021","journal-title":"Biomolecules"},{"issue":"13","key":"10.1016\/j.jtemb.2023.127221_bib11","doi-asserted-by":"crossref","first-page":"12372","DOI":"10.1007\/s11356-017-8876-x","article-title":"Studies on the protective effect of the artichoke (Cynara scolymus) leaf extract against cadmium toxicity-induced oxidative stress, hepatorenal damage, and immunosuppressive and hematological disorders in rats","volume":"24","author":"El-Boshy","year":"2017","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"22","key":"10.1016\/j.jtemb.2023.127221_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24224176","article-title":"Carnosic acid attenuates cadmium induced nephrotoxicity by inhibiting oxidative stress, promoting Nrf2\/HO-1 signalling and impairing TGF-\u03b21\/Smad\/collagen IV signalling","volume":"24","author":"Das","year":"2019","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.jtemb.2023.127221_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26051252","article-title":"Protective effect of thymus serrulatus essential oil on cadmium-induced nephrotoxicity in rats, through suppression of oxidative stress and downregulation of NF-\u03baB, iNOS, and Smad2 mRNA expression","volume":"26","author":"Ansari","year":"2021","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.jtemb.2023.127221_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11010156","article-title":"Association between enzyme-linked immunosorbent assay-measured kidney injury markers and urinary cadmium levels in chronic kidney disease","volume":"11","author":"Tsai","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.jtemb.2023.127221_bib15","first-page":"1","article-title":"Synthesized gold nanoparticles mediated by Crassocephalum rubens extract down-regulate KIM-1\/NGAL genes and inhibit oxidative stress in cadmium-induced kidney damage in rats","author":"Adewale","year":"2022","journal-title":"Drug Chem. Toxicol."},{"issue":"3","key":"10.1016\/j.jtemb.2023.127221_bib16","doi-asserted-by":"crossref","first-page":"369","DOI":"10.18388\/abp.2013_1994","article-title":"The toxic Doppelganger: on the ionic and molecular mimicry of cadmium","volume":"60","author":"Chmielowska-B\u0105k","year":"2013","journal-title":"Acta Biochim. Pol."},{"issue":"6","key":"10.1016\/j.jtemb.2023.127221_bib17","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1159\/000431032","article-title":"Calcium homeostasis disruption \u2013 a bridge connecting cadmium-induced apoptosis, autophagy and tumorigenesis","volume":"38","author":"Zhou","year":"2015","journal-title":"Oncol. Res. Treat."},{"key":"10.1016\/j.jtemb.2023.127221_bib18","doi-asserted-by":"crossref","first-page":"848","DOI":"10.3389\/fcell.2020.00848","article-title":"Iron and cadmium entry into renal mitochondria: physiological and toxicological implications","volume":"8","author":"Th\u00e9venod","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.jtemb.2023.127221_bib19","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1177\/0960327116646840","article-title":"Functional involvement of L-type calcium channels and cyclic nucleotide-dependent pathways in cadmium-induced myometrial relaxation in rats","volume":"36","author":"Saroj","year":"2017","journal-title":"Hum. Exp. Toxicol."},{"issue":"2","key":"10.1016\/j.jtemb.2023.127221_bib20","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s12011-017-1040-0","article-title":"Dose-dependent differential effects of in vivo exposure of cadmium on myometrial activity in rats: involvement of VDCC and Ca(2+)-mimicking pathways","volume":"181","author":"Saroj","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"issue":"3","key":"10.1016\/j.jtemb.2023.127221_bib21","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s10534-019-00176-6","article-title":"Channels, transporters and receptors for cadmium and cadmium complexes in eukaryotic cells: myths and facts","volume":"32","author":"Th\u00e9venod","year":"2019","journal-title":"Biometals"},{"key":"10.1016\/j.jtemb.2023.127221_bib22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.tox.2017.03.016","article-title":"Cadmium disrupts autophagic flux by inhibiting cytosolic Ca(2+)-dependent autophagosome-lysosome fusion in primary rat proximal tubular cells","volume":"383","author":"Liu","year":"2017","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.jtemb.2023.127221_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2013.10.009","article-title":"Calcium-calmodulin signaling elicits mitochondrial dysfunction and the release of cytochrome c during cadmium-induced apoptosis in primary osteoblasts","volume":"224","author":"Liu","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.jtemb.2023.127221_bib24","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.tox.2018.06.002","article-title":"CaMK mediates cadmium induced apoptosis in rat primary osteoblasts through MAPK activation and endoplasmic reticulum stress","volume":"406\u2013407","author":"Liu","year":"2018","journal-title":"Toxicology"},{"issue":"3","key":"10.1016\/j.jtemb.2023.127221_bib25","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1167\/iovs.06-0738","article-title":"RAGE ligand upregulation of VEGF secretion in ARPE-19 cells","volume":"48","author":"Ma","year":"2007","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"30","key":"10.1016\/j.jtemb.2023.127221_bib26","doi-asserted-by":"crossref","first-page":"15896","DOI":"10.1074\/jbc.M115.713107","article-title":"S100A1 protein does not compete with calmodulin for ryanodine receptor binding but structurally alters the ryanodine receptor.calmodulin complex","volume":"291","author":"Rebbeck","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.jtemb.2023.127221_bib27","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s13181-013-0343-6","article-title":"The role of chelation in the treatment of other metal poisonings","volume":"9","author":"Smith","year":"2013","journal-title":"J. Med. Toxicol.: Off. J. Am. Coll. Med. Toxicol."},{"key":"10.1016\/j.jtemb.2023.127221_bib28","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jtemb.2019.05.003","article-title":"Heavy metal toxicity: An update of chelating therapeutic strategies","volume":"54","author":"Kim","year":"2019","journal-title":"J. Trace Elem. Med. Biol.: Organ Soc. Miner. Trace Elem. (GMS)"},{"issue":"1","key":"10.1016\/j.jtemb.2023.127221_bib29","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/s12967-016-1040-4","article-title":"The fibrolytic potentials of vitamin D and thymoquinone remedial therapies: insights from liver fibrosis established by CCl4 in rats","volume":"14","author":"Abdelghany","year":"2016","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jtemb.2023.127221_bib30","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.freeradbiomed.2019.06.030","article-title":"Vitamin D protects against oxidative stress, inflammation and hepatorenal damage induced by acute paracetamol toxicity in rat","volume":"141","author":"El-Boshy","year":"2019","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.jtemb.2023.127221_bib31","doi-asserted-by":"crossref","first-page":"4853","DOI":"10.1038\/s41598-018-23258-w","article-title":"Vitamin D alleviates lead induced renal and testicular injuries by immunomodulatory and antioxidant mechanisms in rats","volume":"8","author":"BaSalamah","year":"2018","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.jtemb.2023.127221_bib32","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.bbadis.2018.11.023","article-title":"Enhanced remedial effects for vitamin D(3) and calcium co-supplementation against pre-existing lead nephrotoxicity in mice: The roles of renal calcium homeostatic molecules","volume":"1865","author":"Almaimani","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"7","key":"10.1016\/j.jtemb.2023.127221_bib33","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1136\/oem.55.7.446","article-title":"Measurement of vitamin D3 metabolites in smelter workers exposed to lead and cadmium","volume":"55","author":"Chalkley","year":"1998","journal-title":"Occup. Environ. Med."},{"issue":"1","key":"10.1016\/j.jtemb.2023.127221_bib34","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/CM9.0000000000001068","article-title":"Association between blood cadmium and vitamin D levels in the Yangtze Plain of China in the context of rapid urbanization","volume":"134","author":"Chen","year":"2020","journal-title":"Chin. Med J."},{"key":"10.1016\/j.jtemb.2023.127221_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.113034","article-title":"Blood metals and vitamin D status in a pregnancy cohort: a bidirectional biomarker analysis","volume":"211","author":"Fisher","year":"2022","journal-title":"Environ. Res."},{"issue":"11","key":"10.1016\/j.jtemb.2023.127221_bib36","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1007\/s00204-005-0680-6","article-title":"Effect of low-level lifetime exposure to cadmium on calciotropic hormones in aged female rats","volume":"79","author":"Brzoska","year":"2005","journal-title":"Arch. Toxicol."},{"issue":"10","key":"10.1016\/j.jtemb.2023.127221_bib37","first-page":"2469","article-title":"[Prokaryotic expression of human vitamin D receptor (hVDR) and its binding activities to Cd and Pb]","volume":"31","author":"Jiao","year":"2010","journal-title":"Huan jing ke xue= Huanjing kexue"},{"issue":"5","key":"10.1016\/j.jtemb.2023.127221_bib38","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1177\/0192623310374328","article-title":"The effects of a vitamin D-deficient diet on chronic cadmium exposure in rats","volume":"38","author":"Uchida","year":"2010","journal-title":"Toxicol. Pathol."},{"issue":"10","key":"10.1016\/j.jtemb.2023.127221_bib39","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1248\/bpb.b15-00341","article-title":"Dietary deficiency of calcium and\/or iron, an age-related risk factor for renal accumulation of cadmium in mice","volume":"38","author":"Min","year":"2015","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jtemb.2023.127221_bib40","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.chemosphere.2016.08.023","article-title":"Maternal and fetal exposure to cadmium, lead, manganese and mercury: The MIREC study","volume":"163","author":"Arbuckle","year":"2016","journal-title":"Chemosphere"},{"issue":"4","key":"10.1016\/j.jtemb.2023.127221_bib41","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1177\/0960327117705425","article-title":"Changes in blood and urinary cadmium levels and bone mineral density according to osteoporosis medication in individuals with an increased cadmium body burden","volume":"37","author":"Eom","year":"2018","journal-title":"Hum. Exp. Toxicol."},{"issue":"4","key":"10.1016\/j.jtemb.2023.127221_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/nu11040849","article-title":"Protective effects of moderate Ca supplementation against Cd-induced bone damage under different population-relevant doses in young female rats","volume":"11","author":"Huang","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.jtemb.2023.127221_bib43","article-title":"Protecting effects of n-acetyl cysteine supplementation against lead and cadmium-induced brain toxicity in rat models","author":"Jaafarzadeh","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"issue":"3","key":"10.1016\/j.jtemb.2023.127221_bib44","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1080\/10520295.2021.1925965","article-title":"Partial protective effects of melatonin on cadmium-induced changes in hematological characteristics in rats","volume":"97","author":"K\u0131sadere","year":"2022","journal-title":"Biotech. Histochem.: Off. Publ. Biol. Stain Comm."},{"key":"10.1016\/j.jtemb.2023.127221_bib45","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.toxrep.2016.07.005","article-title":"Calcium, zinc and vitamin E ameliorate cadmium-induced renal oxidative damage in albino Wistar rats","volume":"3","author":"Adi","year":"2016","journal-title":"Toxicol. Rep."},{"issue":"2","key":"10.1016\/j.jtemb.2023.127221_bib46","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"key":"10.1016\/j.jtemb.2023.127221_bib47","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jare.2021.08.010","article-title":"Enhanced renoprotective actions of Paricalcitol and omega-3 fatty acids co-therapy against diabetic nephropathy in rat","volume":"38","author":"El-Boshy","year":"2022","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.jtemb.2023.127221_bib48","doi-asserted-by":"crossref","DOI":"10.1369\/0022155418782696","article-title":"Acute and chronic iron overloading differentially modulates the expression of cellular iron-homeostatic molecules in normal rat kidney","author":"Refaat","year":"2018","journal-title":"J. Histochem. Cytochem.: Off. J. Histochem. Soc."},{"key":"10.1016\/j.jtemb.2023.127221_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/pore.2021.1610032","article-title":"Profiling activins and follistatin in colorectal cancer according to clinical stage, tumour sidedness and Smad4 status","volume":"27","author":"Refaat","year":"2021","journal-title":"Pathol. Oncol. Res."},{"issue":"2","key":"10.1016\/j.jtemb.2023.127221_bib50","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/biof.1804","article-title":"Vitamin D(3) enhances the effects of omega-3 oils against metabolic dysfunction-associated fatty liver disease in rat","volume":"48","author":"Refaat","year":"2022","journal-title":"Biofactors"},{"key":"10.1016\/j.jtemb.2023.127221_bib51","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1476-069X-12-22","article-title":"Kidney cadmium levels and associations with urinary calcium and bone mineral density: a cross-sectional study in Sweden","volume":"12","author":"Wallin","year":"2013","journal-title":"Environ. Health"},{"key":"10.1016\/j.jtemb.2023.127221_bib52","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.toxrep.2022.01.002","article-title":"The preferential accumulation of cadmium ions among various tissues in mice","volume":"9","author":"Tai","year":"2022","journal-title":"Toxicol. Rep."},{"issue":"10","key":"10.1016\/j.jtemb.2023.127221_bib53","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/j.bbamcr.2012.06.023","article-title":"1alpha,25-dihydroxyvitamin D(3) mechanism of action: modulation of L-type calcium channels leading to calcium uptake and intermediate filament phosphorylation in cerebral cortex of young rats","volume":"1823","author":"Zanatta","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"8","key":"10.1016\/j.jtemb.2023.127221_bib54","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1017\/S0007114511006830","article-title":"Effect of vitamin D3 in reducing metabolic and oxidative stress in the liver of streptozotocin-induced diabetic rats","volume":"108","author":"George","year":"2012","journal-title":"Br. J. Nutr."},{"issue":"8","key":"10.1016\/j.jtemb.2023.127221_bib55","doi-asserted-by":"crossref","first-page":"747","DOI":"10.2174\/1566524016666160920111407","article-title":"Calcitriol reduces hepatic triglyceride accumulation and glucose output through Ca2+\/CaMKK\u03b2\/AMPK activation under insulin-resistant conditions in type 2 diabetes mellitus","volume":"16","author":"Cheng","year":"2016","journal-title":"Curr. Mol. Med."},{"issue":"12","key":"10.1016\/j.jtemb.2023.127221_bib56","doi-asserted-by":"crossref","first-page":"E2485","DOI":"10.1210\/jc.2014-1977","article-title":"Calcium-vitamin D cosupplementation influences circulating inflammatory biomarkers and adipocytokines in vitamin D-insufficient diabetics: a randomized controlled clinical trial, The","volume":"99","author":"Tabesh","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"9","key":"10.1016\/j.jtemb.2023.127221_bib57","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1007\/s00125-014-3293-x","article-title":"Effects of calcium\u2013vitamin D co-supplementation on glycaemic control, inflammation and oxidative stress in gestational diabetes: a randomised placebo-controlled trial","volume":"57","author":"Asemi","year":"2014","journal-title":"Diabetologia"},{"issue":"4","key":"10.1016\/j.jtemb.2023.127221_bib58","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/jhn.12339","article-title":"The effects of vitamin D plus calcium supplementation on metabolic profiles, biomarkers of inflammation, oxidative stress and pregnancy outcomes in pregnant women at risk for pre-eclampsia","volume":"29","author":"Samimi","year":"2016","journal-title":"J. Hum. Nutr. Diet.: Off. J. Br. Diet. Assoc."},{"issue":"1","key":"10.1016\/j.jtemb.2023.127221_bib59","first-page":"496","article-title":"Reduction of some atherogenic indices in patients with non-alcoholic fatty liver by vitamin D and calcium co-supplementation: a double blind randomized controlled clinical trial","volume":"18","author":"Shidfar","year":"2019","journal-title":"Iran. J. Pharm. Res."},{"issue":"8","key":"10.1016\/j.jtemb.2023.127221_bib60","first-page":"1208","article-title":"Effect of treatment with vitamin D plus calcium on oxidative stress in streptozotocin-induced diabetic rats","volume":"26","author":"Alatawi","year":"2018","journal-title":"Saudi Pharm. J.: SPJ: Off. Publ. Saudi Pharm. Soc."}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X23000974?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X23000974?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:19:45Z","timestamp":1760555985000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X23000974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":60,"alternative-id":["S0946672X23000974"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2023.127221","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin D and calcium co-therapy mitigates pre-established cadmium nephropathy by regulating renal calcium homeostatic molecules and improving anti-oxidative and anti-inflammatory activities in rat","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2023.127221","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"127221"}}