{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:26:43Z","timestamp":1785389203305,"version":"3.55.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.jtemb.2023.127239","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T19:45:12Z","timestamp":1686167112000},"page":"127239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Oligoelements in serum and intestinal tissue of pediatric IBD patients"],"prefix":"10.1016","volume":"79","author":[{"given":"Vedrana","family":"Makevic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan D.","family":"Milovanovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevena","family":"Popovac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa\u0161a","family":"Jankovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna","family":"Jankovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srdjan","family":"Stefanovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoran","family":"Bukumiric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio R.","family":"de Luka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jtemb.2023.127239_bib1","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1096\/fj.201902396R","article-title":"Impact of dietary manganese on experimental colitis in mice","volume":"34","author":"Choi","year":"2020","journal-title":"Faseb J."},{"issue":"3","key":"10.1016\/j.jtemb.2023.127239_bib2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.pcl.2017.01.005","article-title":"Pediatric inflammatory bowel disease","volume":"64","author":"Conrad","year":"2017","journal-title":"Pedia Clin. North Am."},{"key":"10.1016\/j.jtemb.2023.127239_bib3","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jinorgbio.2019.03.013","article-title":"The essential metals for humans: a brief overview","volume":"195","author":"Zoroddu","year":"2019","journal-title":"J. Inorg. Biochem"},{"key":"10.1016\/j.jtemb.2023.127239_bib4","unstructured":"WHO Expert Committee on Trace Elements in Human Nutrition & World Health Organization. (\u200e1973)\u200e. Trace elements in human nutrition : report of a WHO expert committee [\u200emeeting held in Geneva from 9 to 17 April 1973]\u200e. World Health Organization."},{"key":"10.1016\/j.jtemb.2023.127239_bib5","first-page":"151","article-title":"Arsenic induction of metallothionein and metallothionein induction against arsenic cytotoxicity","volume":"240","author":"Rahman","year":"2017","journal-title":"Rev. Environ. Contam. Toxicol."},{"issue":"2","key":"10.1016\/j.jtemb.2023.127239_bib6","first-page":"45","article-title":"Aluminium toxicosis: a review of toxic actions and effects","volume":"12","author":"Igbokwe","year":"2019","journal-title":"Inter. Toxicol."},{"issue":"2","key":"10.1016\/j.jtemb.2023.127239_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/nu12020372","article-title":"Nutritional aspects in inflammatory bowel diseases","volume":"12","author":"Balestrieri","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jtemb.2023.127239_bib8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jtemb.2019.06.016","article-title":"Serum trace elements profile in the pediatric inflammatory bowel disease progress evaluation","volume":"55","author":"Stochel-Gaudyn","year":"2019","journal-title":"J. Trace Elem. Med Biol."},{"key":"10.1016\/j.jtemb.2023.127239_bib9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jtemb.2014.04.006","article-title":"Global perspectives on trace element requirements","volume":"31","author":"Freeland-Graves","year":"2015","journal-title":"J. Trace Elem. Med Biol."},{"issue":"10114","key":"10.1016\/j.jtemb.2023.127239_bib10","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.jtemb.2023.127239_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00204-015-1579-5","article-title":"Redox- and non-redox-metal-induced formation of free radicals and their role in human disease","volume":"90","author":"Valko","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.jtemb.2023.127239_bib12","article-title":"Pb toxicity on gut physiology and microbiota","volume":"12","author":"Liu","year":"2021","journal-title":"Front Physiol."},{"issue":"2","key":"10.1016\/j.jtemb.2023.127239_bib13","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/ncp.10373","article-title":"Micronutrient deficiencies in children with inflammatory bowel diseases","volume":"35","author":"Ehrlich","year":"2020","journal-title":"Nutr. Clin. Pr."},{"issue":"5","key":"10.1016\/j.jtemb.2023.127239_bib14","doi-asserted-by":"crossref","first-page":"500","DOI":"10.5009\/gnl13183","article-title":"Nutritional status and growth in Korean children with Crohn's disease: a single-center study","volume":"8","author":"Song","year":"2014","journal-title":"Gut Liver"},{"issue":"2","key":"10.1016\/j.jtemb.2023.127239_bib15","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00210-018-1578-1","article-title":"Arsenic trioxide ameliorates murine colon inflammation through inflammatory cell enzymatic modulation","volume":"392","author":"Moulahoum","year":"2019","journal-title":"Naunyn Schmiede Arch. Pharm."},{"key":"10.1016\/j.jtemb.2023.127239_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.158017","article-title":"Gene\/environment interaction in the susceptibility of Crohn's disease patients to aluminum","volume":"850","author":"Djouina","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"6","key":"10.1016\/j.jtemb.2023.127239_bib17","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1097\/MPG.0000000000000239","article-title":"ESPGHAN revised porto criteria for the diagnosis of inflammatory bowel disease in children and adolescents","volume":"58","author":"Levine","year":"2014","journal-title":"J. Pedia Gastroenterol. Nutr."},{"issue":"1","key":"10.1016\/j.jtemb.2023.127239_bib18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.advms.2018.08.001","article-title":"The combination of fecal calprotectin with ESR, CRP and albumin discriminates more accurately children with Crohn's disease","volume":"64","author":"Daniluk","year":"2019","journal-title":"Adv. Med Sci."},{"issue":"1","key":"10.1016\/j.jtemb.2023.127239_bib19","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s12011-017-1225-6","article-title":"Hair mineral and trace element contents as reliable markers of nutritional status compared to serum levels of these elements in children newly diagnosed with inflammatory bowel disease","volume":"185","author":"Cho","year":"2018","journal-title":"Biol. Trace Elem. Res"},{"issue":"6","key":"10.1016\/j.jtemb.2023.127239_bib20","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1080\/00365529850171936","article-title":"Altered plasma and mucosal concentrations of trace elements and antioxidants in active ulcerative colitis","volume":"33","author":"Sturniolo","year":"1998","journal-title":"Scand. J. Gastroenterol."},{"issue":"10","key":"10.1016\/j.jtemb.2023.127239_bib21","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1007\/BF02093613","article-title":"Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease","volume":"41","author":"Lih-Brody","year":"1996","journal-title":"Dig. Dis. Sci."},{"issue":"2","key":"10.1016\/j.jtemb.2023.127239_bib22","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s12640-009-9130-1","article-title":"Manganese (Mn) and iron (Fe): interdependency of transport and regulation","volume":"18","author":"Fitsanakis","year":"2010","journal-title":"Neurotox. Res"},{"issue":"1","key":"10.1016\/j.jtemb.2023.127239_bib23","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jtemb.2012.07.002","article-title":"Increased whole blood manganese concentrations observed in children with iron deficiency anaemia","volume":"27","author":"Smith","year":"2013","journal-title":"J. Trace Elem. Med Biol."},{"issue":"46","key":"10.1016\/j.jtemb.2023.127239_bib24","doi-asserted-by":"crossref","first-page":"28930","DOI":"10.1073\/pnas.2014742117","article-title":"A missense variant in SLC39A8 confers risk for Crohn\u2019s disease by disrupting manganese homeostasis and intestinal barrier integrity","volume":"117","author":"Nakata","year":"2020","journal-title":"PNAS"},{"issue":"9\u201310","key":"10.1016\/j.jtemb.2023.127239_bib25","first-page":"116","article-title":"The serum concentrations of zinc, copper and selenium in children with inflammatory bowel disease","volume":"48","author":"Ojuawo","year":"2002","journal-title":"Cent. Afr. J. Med"},{"key":"10.1016\/j.jtemb.2023.127239_bib26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.mad.2015.01.004","article-title":"Serum copper to zinc ratio: relationship with aging and health status","volume":"151","author":"Malavolta","year":"2015","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.jtemb.2023.127239_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2022.127064","article-title":"Serum copper concentration reflect inflammatory activation in the complex coronary artery disease - a pilot study","volume":"74","author":"Urbanowicz","year":"2022","journal-title":"J. Trace Elem. Med Biol."},{"issue":"7","key":"10.1016\/j.jtemb.2023.127239_bib28","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3109\/00365529309096096","article-title":"Serum selenium, copper, and zinc concentrations in Crohn's disease and ulcerative colitis","volume":"28","author":"Ringstad","year":"1993","journal-title":"Scand. J. Gastroenterol."},{"issue":"2","key":"10.1016\/j.jtemb.2023.127239_bib29","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s12011-016-0891-0","article-title":"Evaluation of serum trace element levels and superoxide dismutase activity in patients with inflammatory bowel disease: translating basic research into clinical application","volume":"177","author":"Mohammadi","year":"2017","journal-title":"Biol. Trace Elem. Res"},{"issue":"3","key":"10.1016\/j.jtemb.2023.127239_bib30","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1753-4887.2010.00271.x","article-title":"Metabolic crossroads of iron and copper","volume":"68","author":"Collins","year":"2010","journal-title":"Nutr. Rev."},{"issue":"6","key":"10.1016\/j.jtemb.2023.127239_bib31","first-page":"576","article-title":"Micronutrient deficiencies in inflammatory bowel disease","volume":"18","author":"Weisshof","year":"2015","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"issue":"6","key":"10.1016\/j.jtemb.2023.127239_bib32","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1177\/0009922810397041","article-title":"Trace elements and vitamins at diagnosis in pediatric-onset inflammatory bowel disease","volume":"50","author":"Sikora","year":"2011","journal-title":"Clin. Pedia (Philos. )"},{"issue":"2","key":"10.1016\/j.jtemb.2023.127239_bib33","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1203\/01.PDR.0000132851.50841.D7","article-title":"Zinc metabolism in adolescents with Crohn's disease","volume":"56","author":"Griffin","year":"2004","journal-title":"Pedia Res"},{"key":"10.1016\/j.jtemb.2023.127239_bib34","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.semcdb.2020.11.002","article-title":"Magnesium and inflammation: advances and perspectives","volume":"115","author":"Maier","year":"2021","journal-title":"Semin Cell Dev. Biol."},{"key":"10.1016\/j.jtemb.2023.127239_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7247238","article-title":"Review and update on the pathogenesis of inflammatory bowel disease","volume":"2019","author":"Guan","year":"2019","journal-title":"J. Immunol. Res"},{"key":"10.1016\/j.jtemb.2023.127239_bib36","article-title":"Blood chromium exposure, immune inflammation and genetic damage: exploring associations and mediation effects in chromate exposed population","author":"Hu","year":"2022","journal-title":"J. Hazard Mater425"},{"key":"10.1016\/j.jtemb.2023.127239_bib37","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6665697","article-title":"Metallothioneins in inflammatory bowel diseases: importance in pathogenesis and potential therapy target","volume":"2021","author":"Socha-Banasiak","year":"2021","journal-title":"Can. J. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.jtemb.2023.127239_bib38","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1177\/0961203311430090","article-title":"Aluminum as an adjuvant in Crohn\u2019s disease induction","volume":"21","author":"Lerner","year":"2012","journal-title":"Lupus"},{"issue":"3","key":"10.1016\/j.jtemb.2023.127239_bib39","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/mi.2013.78","article-title":"Aluminum enhances inflammation and decreases mucosal healing in experimental colitis in mice","volume":"7","author":"Pineton de Chambrun","year":"2014","journal-title":"Mucosal Immunol."},{"issue":"329","key":"10.1016\/j.jtemb.2023.127239_bib40","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.morpho.2016.01.003","article-title":"Gut: an underestimated target organ for Aluminum","volume":"100","author":"Vignal","year":"2016","journal-title":"Morphologie"},{"issue":"Pt 2","key":"10.1016\/j.jtemb.2023.127239_bib41","article-title":"Aluminum induced intestinal dysfunction via mechanical, immune, chemical and biological barriers","volume":"288","author":"Hao","year":"2022","journal-title":"Chemosphere"}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X23001153?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X23001153?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:22:16Z","timestamp":1760556136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X23001153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":41,"alternative-id":["S0946672X23001153"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2023.127239","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oligoelements in serum and intestinal tissue of pediatric IBD patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2023.127239","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"127239"}}