{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:13:43Z","timestamp":1783462423921,"version":"3.55.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"publisher","award":["APQ-03336-18"],"award-info":[{"award-number":["APQ-03336-18"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["case 408295\/2017-1"],"award-info":[{"award-number":["case 408295\/2017-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.jtemb.2023.127275","type":"journal-article","created":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T02:12:15Z","timestamp":1690596735000},"page":"127275","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Effects of iodine supplementation on thyroid function parameter: Systematic review and meta-analysis"],"prefix":"10.1016","volume":"80","author":[{"given":"Aline Carare","family":"Candido","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francilene Maria","family":"Azevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora Let\u00edcia Frizzi","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Aparecida Vieira","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia do Carmo","family":"Castro Franceschini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jtemb.2023.127275_bib1","first-page":"107","article-title":"Iodine supplementation in pregnancy: is it important?","volume":"33","author":"Jacob","year":"2015","journal-title":"Rev. Port. Saude Publica"},{"issue":"4","key":"10.1016\/j.jtemb.2023.127275_bib2","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1590\/1413-81232021264.13482019","article-title":"Factors associated with the nutritional status of iodine in the maternal-infant group: a systematic review","volume":"26","author":"Candido","year":"2021","journal-title":"Cienc. e Saude Coletiva"},{"issue":"11","key":"10.1016\/j.jtemb.2023.127275_bib3","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S2213-8587(17)30332-7","article-title":"Effect of iodine supplementation in pregnant women on child neurodevelopment: a randomised, double-blind, placebo-controlled trial","volume":"5","author":"Gowachirapant","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.jtemb.2023.127275_bib4","unstructured":"WHO, 2007. Assessment of the iodine deficiency disorders and monitoring their elimination. World Heal Organ (WHO), Geneva [Internet]. 2007;3:1\u2013107. Available from: http:\/\/apps.who.int\/iris\/bitstream\/10665\/43781\/1\/9789241595827_eng.pdf."},{"issue":"3","key":"10.1016\/j.jtemb.2023.127275_bib5","article-title":"Iodine supplementation for women during the preconception, pregnancy and postpartum period","volume":"2017","author":"Harding","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jtemb.2023.127275_bib6","unstructured":"Food Standards Australia New Zealand, 2015. Australia New Zealand Food Standards Code \u2013 Standard 2.1.1 \u2013 Cereal and cereal products [Internet]. 2015. p. 1\u20133. Available from: \u3008https:\/\/www.legislation.gov.au\/Details\/F2015L00420\u3009."},{"issue":"4","key":"10.1016\/j.jtemb.2023.127275_bib7","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1136\/jech.51.4.391","article-title":"Iodine, milk, and the elimination of endemic goitre in Britain: the story of an accidental public health triumph","volume":"51","author":"Phillips","year":"1997","journal-title":"J. Epidemiol. Community Health"},{"issue":"4","key":"10.1016\/j.jtemb.2023.127275_bib8","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/cen.14368","article-title":"Iodine status in UK\u2013An accidental public health triumph gone sour","volume":"94","author":"Woodside","year":"2021","journal-title":"Clin. Endocrinol. (Oxf. )"},{"key":"10.1016\/j.jtemb.2023.127275_bib9","first-page":"60","article-title":"Iodine status in the Nordic countries past and present","author":"Nystr\u00f6m","year":"2016","journal-title":"Food Nutr. Res."},{"key":"10.1016\/j.jtemb.2023.127275_bib10","unstructured":"Iodine Global Network, 2021. Global Scorecard of iodine nutrition in 2021. 2021;(24):1\u201315."},{"issue":"2","key":"10.1016\/j.jtemb.2023.127275_bib11","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s12011-019-02020-x","article-title":"Maternal urinary iodine concentration and pregnancy outcomes in euthyroid pregnant women: a systematic review and meta-analysis","volume":"197","author":"Nazarpour","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"issue":"2","key":"10.1016\/j.jtemb.2023.127275_bib12","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/ajcn\/nqaa071","article-title":"Systematic review and meta-analysis of the effects of iodine supplementation on thyroid function and child neurodevelopment in mildly-to-moderately iodine-deficient pregnant women","volume":"112","author":"Dineva","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"issue":"2","key":"10.1016\/j.jtemb.2023.127275_bib13","first-page":"89","article-title":"TNH and MRC. Iodine supplementation for pregnant and breastfeeding women","volume":"22","author":"(NHMRC)","year":"2010","journal-title":"NHMRC PubliC StateMeNt"},{"issue":"2","key":"10.1016\/j.jtemb.2023.127275_bib14","first-page":"76","article-title":"European thyroid association guidelines for the management of subclinical hypothyroidism in pregnancy and in children","volume":"3","author":"Lazarus","year":"2014","journal-title":"Eur. Thyroid J. 2014"},{"issue":"10","key":"10.1016\/j.jtemb.2023.127275_bib15","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1089\/thy.2011.0087","article-title":"Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum","volume":"21","author":"Stagnaro-Green","year":"2011","journal-title":"Thyroid"},{"issue":"7","key":"10.1016\/j.jtemb.2023.127275_bib16","first-page":"9","article-title":"Iodine deficiency in Danish pregnant women","volume":"60","author":"Andersen","year":"2013","journal-title":"Dan. Med J."},{"key":"10.1016\/j.jtemb.2023.127275_bib17","first-page":"372","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","author":"Page","year":"2021","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.jtemb.2023.127275_bib18","first-page":"1","article-title":"Rayyan-a web and mobile app for systematic reviews","volume":"5","author":"Ouzzani","year":"2016","journal-title":"Syst. Rev. [Internet]"},{"key":"10.1016\/j.jtemb.2023.127275_bib19","unstructured":"Joanna Briggs Institute. Critical Appraisal Checklist for Cohort Studies. JbiGlobal [Internet]. 2020;1\u20135. Available from: https:\/\/joannabriggs.org\/critical_appraisal_tools."},{"key":"10.1016\/j.jtemb.2023.127275_bib20","unstructured":"Joanna Briggs Institute. Checklist for randomized controlled trials - Critical Appraisal tools for use in JBI Systematic Reviews. Jbi Glob [Internet]. 2020;1\u20135. Available from: https:\/\/joannabriggs.org\/critical_appraisal_tools."},{"key":"10.1016\/j.jtemb.2023.127275_bib21","unstructured":"Joanna Briggs Institute. Critical Appraisal Checklist for Analytical Cross Sectional Studies. Jbi Glob [Internet]. 2020;1\u20135. Available from: https:\/\/joannabriggs.org\/critical_appraisal_tools."},{"issue":"8","key":"10.1016\/j.jtemb.2023.127275_bib22","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1590\/1413-81232015208.10762014","article-title":"Constru\u00e7\u00e3o de uma escala para avaliar a qualidade metodol\u00f3gica de revis\u00f5es sistem\u00e1ticas","volume":"20","author":"Costa","year":"2015","journal-title":"Cienc. e Saude Coletiva"},{"issue":"9","key":"10.1016\/j.jtemb.2023.127275_bib23","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1210\/jc.2008-2652","article-title":"Effect of iodine prophylaxis during pregnancy on neurocognitive development of children during the first two years of life","volume":"94","author":"Velasco","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"7","key":"10.1016\/j.jtemb.2023.127275_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu14071393","article-title":"Iodine supplementation in pregnancy in an iodine-deficient region: a cross-sectional survey","volume":"14","author":"Lopes","year":"2022","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.jtemb.2023.127275_bib25","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1017\/S0007114512005880","article-title":"Infant neurocognitive development is independent of the use of iodised salt or iodine supplements given during pregnancy","volume":"110","author":"Santiago","year":"2013","journal-title":"Br. J. Nutr."},{"issue":"1","key":"10.1016\/j.jtemb.2023.127275_bib26","first-page":"1","article-title":"The effect of iodine supplementation in pregnancy on early childhood neurodevelopment and clinical outcomes: Results of an aborted randomised placebo-controlled trial","volume":"16","author":"Zhou","year":"2015","journal-title":"Trials [Internet]"},{"issue":"11","key":"10.1016\/j.jtemb.2023.127275_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/nu11112639","article-title":"The effects of iodine supplementation in pregnancy on iodine status, thyroglobulin levels and thyroid function parameters: results from a randomized controlled clinical trial in a mild-to-moderate iodine deficiency area","volume":"11","author":"Censi","year":"2019","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.jtemb.2023.127275_bib28","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1159\/000506800","article-title":"Comparison of the effectiveness of universal and targeted iodine supplementation in pregnant women: a randomized controlled trial","volume":"85","author":"Tinna","year":"2020","journal-title":"Gynecol. Obstet. Invest"},{"issue":"4","key":"10.1016\/j.jtemb.2023.127275_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/mcn.13204","article-title":"Improved first trimester maternal iodine status with preconception supplementation: the women first trial","volume":"17","author":"Young","year":"2021","journal-title":"Matern Child Nutr."},{"issue":"6","key":"10.1016\/j.jtemb.2023.127275_bib30","first-page":"3411","article-title":"A randomized, double-blind study of iodine supplementation during pregnancy in Sweden: pilot evaluation of maternal iodine status and thyroid function","volume":"60","author":"Manousou","year":"2021","journal-title":"Eur. J. Nutr. [Internet]"},{"issue":"8","key":"10.1016\/j.jtemb.2023.127275_bib31","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/jp.2014.62","article-title":"Effects of maternal iodine supplementation during pregnancy and lactation on iodine status and neonatal thyroid-stimulating hormone","volume":"34","author":"Sukkhojaiwaratkul","year":"2014","journal-title":"J. Perinatol. [Internet]"},{"issue":"1","key":"10.1016\/j.jtemb.2023.127275_bib32","first-page":"1","article-title":"Thyroglobulin level at week 16 of pregnancy is superior to urinary iodine concentration in revealing preconceptual and first trimester iodine supply","volume":"14","author":"Katko","year":"2017","journal-title":"Matern Child Nutr."},{"issue":"5","key":"10.1016\/j.jtemb.2023.127275_bib33","first-page":"507","article-title":"Implications of iodine deficiency by gestational trimester: a systematic review","volume":"64","author":"Candido","year":"2020","journal-title":"Arch. Endocrinol. Metab."},{"key":"10.1016\/j.jtemb.2023.127275_bib34","first-page":"1","article-title":"Mild-to-moderate gestational iodine deficiency processing disorder","volume":"11","author":"Ian","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.jtemb.2023.127275_bib35","unstructured":"American Thyroid Association. Iodine Supplementation for Pregnancy and Lactation\u2014 United States and Canada: Recommendations of the American Thyroid Association [Internet]. 2006 [cited 2021 Jul 15]. Available from: \u3008https:\/\/www.thyroid.org\/iodine-supplementation-for-pregnancy-and-lactation-united-states-and-canada-recommendations-of-the-american-thyroid-association\/\u3009."},{"key":"10.1016\/j.jtemb.2023.127275_bib36","unstructured":"American Academy of Pediatrics, 2014. Iodine deficiency: Pregnant, breastfeeding women need supplementation. 2014; Available from: \u3008https:\/\/www.aappublications.org\/content\/35\/6\/11.1\u3009."},{"issue":"8","key":"10.1016\/j.jtemb.2023.127275_bib37","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1210\/jc.2011-2803","article-title":"Management of thyroid dysfunction during pregnancy and postpartum: an endocrine society clinical practice guideline","volume":"97","author":"De Groot","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jtemb.2023.127275_bib38","doi-asserted-by":"crossref","unstructured":"Poppe K., Bisschop P., Fugazzola L., Mintziori G., Unuane D., Weghofer A.Erratum: 2021 European Thyroid Association Guideline on Thyroid Disorders prior to and during Assisted Reproduction (European Thyroid Journal (2020) 9 (281\u2013295) DOI: 10.1159\/000512790). Eur Thyroid J. 2021;10(3):268.","DOI":"10.1159\/000512790"},{"key":"10.1016\/j.jtemb.2023.127275_bib39","doi-asserted-by":"crossref","unstructured":"Skeaff S., A. S. Iodine Deficiency in Pregnancy: The Effect on Neurodevelopment in the Child. Nutrients [Internet]. 2011 Feb 18 [cited 2018 Jan 9];3(12):265\u201373. Available from: \u3008http:\/\/www.mdpi.com\/2072\u20136643\/3\/2\/265\/\u3009.","DOI":"10.3390\/nu3020265"},{"key":"10.1016\/j.jtemb.2023.127275_bib40","unstructured":"Portugal. Minist\u00e9rio da Sa\u00fade. DGS. Aporte de iodo em mulheres na pr\u00e9conce\u00e7\u00e3o, gravidez e amamenta\u00e7\u00e3o [Internet]. Lisboa: Dire\u00e7\u00e3o Geral de Sa\u00fade. 2013. Available from: \u3008http:www.dgs.ptdirectrizesdadgsorientacoesecircularesinf\u3009."},{"issue":"1","key":"10.1016\/j.jtemb.2023.127275_bib41","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1365-3016.2012.01275.x","article-title":"The effects of iodine deficiency in pregnancy and infancy","volume":"26","author":"Zimmermann","year":"2012","journal-title":"Paediatr. Perinat. Epidemiol."},{"issue":"4","key":"10.1016\/j.jtemb.2023.127275_bib42","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.3390\/nu5041384","article-title":"Iodine and mental development of children 5 years old and under: a systematic review and meta-analysis","volume":"5","author":"Bougma","year":"2013","journal-title":"Nutrients"}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X23001517?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X23001517?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:50:03Z","timestamp":1777593003000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X23001517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":42,"alternative-id":["S0946672X23001517"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2023.127275","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of iodine supplementation on thyroid function parameter: Systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2023.127275","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"127275"}}