{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T03:17:17Z","timestamp":1771039037198,"version":"3.50.1"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.jtemb.2024.127407","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T01:07:45Z","timestamp":1706836065000},"page":"127407","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Zinc as a potential regulator of the BCR-ABL oncogene in chronic myelocytic leukemia cells"],"prefix":"10.1016","volume":"83","author":[{"given":"Bo","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longshuo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhonghua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengyou","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zichun","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.jtemb.2024.127407_bib1","first-page":"2167","article-title":"Treatment of philadelphia chromosome-positive, accelerated-phase chronic myelogenous leukemia with imatinib mesylate","volume":"8","author":"Kantarjian","year":"2002","journal-title":"Clin. Cancer Res"},{"issue":"4","key":"10.1016\/j.jtemb.2024.127407_bib2","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.ccell.2020.03.006","article-title":"Response and resistance to BCR-ABL1-targeted therapies","volume":"37","author":"Braun","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jtemb.2024.127407_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106156","article-title":"Targeting BCR-Abl in the treatment of Philadelphia-chromosome positive chronic myelogenous leukemia","volume":"178","author":"Roskoski","year":"2022","journal-title":"Pharm. Res."},{"issue":"19","key":"10.1016\/j.jtemb.2024.127407_bib4","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1007\/s00018-019-03397-7","article-title":"Elucidation of protein interactions necessary for the maintenance of the BCR-ABL signaling complex","volume":"77","author":"Gregor","year":"2020","journal-title":"Cell Mol. Life Sci."},{"issue":"6","key":"10.1016\/j.jtemb.2024.127407_bib5","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/ajh.25792","article-title":"Chronic myeloid leukemia: 2020 update on diagnosis, therapy and monitoring","volume":"95","author":"Jabbour","year":"2020","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.jtemb.2024.127407_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.blre.2021.100825","article-title":"Chronic myeloid leukemia: modern therapies, current challenges and future directions","volume":"49","author":"Osman","year":"2021","journal-title":"Blood Rev."},{"issue":"9","key":"10.1016\/j.jtemb.2024.127407_bib7","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1002\/ajh.26642","article-title":"Chronic myeloid leukemia: 2022 update on diagnosis, therapy, and monitoring","volume":"97","author":"Jabbour","year":"2022","journal-title":"Am. J. Hematol."},{"issue":"Suppl 1","key":"10.1016\/j.jtemb.2024.127407_bib8","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1365-2141.1991.tb08116.x","article-title":"The molecular pathology of chronic myelogenous leukaemia","volume":"79","author":"Kurzrock","year":"1991","journal-title":"Br. J. Haematol."},{"issue":"8","key":"10.1016\/j.jtemb.2024.127407_bib9","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1023\/A:1008349405763","article-title":"Analysis of Philadelphia chromosome-negative BCR-ABL-positive chronic myelogenous leukemia by hypermetaphase fluorescence in situ hybridization","volume":"10","author":"Seong","year":"1999","journal-title":"Ann. Oncol."},{"issue":"1","key":"10.1016\/j.jtemb.2024.127407_bib10","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1182\/blood-2006-01-0092","article-title":"Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results","volume":"108","author":"Hughes","year":"2006","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.jtemb.2024.127407_bib11","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1182\/blood-2015-10-674242","article-title":"Impact of BCR-ABL transcript type on outcome in patients with chronic-phase CML treated with tyrosine kinase inhibitors","volume":"127","author":"Jain","year":"2016","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.jtemb.2024.127407_bib12","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0145-2126(01)00197-7","article-title":"Bcr-Abl variants: biological and clinical aspects","volume":"26","author":"Advani","year":"2002","journal-title":"Leuk. Res."},{"issue":"8","key":"10.1016\/j.jtemb.2024.127407_bib13","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1182\/blood-2011-06-361691","article-title":"Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis","volume":"119","author":"Yuan","year":"2012","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.jtemb.2024.127407_bib14","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1002\/ajh.26650","article-title":"BRD4 degradation blocks expression of MYC and multiple forms of stem cell resistance in Ph(+) chronic myeloid leukemia","volume":"97","author":"Peter","year":"2022","journal-title":"Am. J. Hematol."},{"issue":"5","key":"10.1016\/j.jtemb.2024.127407_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-021-03732-6","article-title":"Suppression of USP7 induces BCR-ABL degradation and chronic myelogenous leukemia cell apoptosis","volume":"12","author":"Jiang","year":"2021","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.jtemb.2024.127407_bib16","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1186\/s13287-021-02659-1","article-title":"Chronic myeloid leukemia stem cells: targeting therapeutic implications","volume":"12","author":"Mojtahedi","year":"2021","journal-title":"Stem Cell Res. Ther."},{"issue":"8","key":"10.1016\/j.jtemb.2024.127407_bib17","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/leu.2010.101","article-title":"BCR and BCR-ABL regulation during myeloid differentiation in healthy donors and in chronic phase\/blast crisis CML patients","volume":"24","author":"Marega","year":"2010","journal-title":"Leukemia"},{"issue":"5","key":"10.1016\/j.jtemb.2024.127407_bib18","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nm0596-561","article-title":"Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells","volume":"2","author":"Druker","year":"1996","journal-title":"Nat. Med."},{"issue":"18","key":"10.1016\/j.jtemb.2024.127407_bib19","doi-asserted-by":"crossref","first-page":"8120","DOI":"10.1021\/acs.jmedchem.8b01040","article-title":"Discovery of Asciminib (ABL001), an allosteric inhibitor of the Tyrosine Kinase Activity of BCR-ABL1","volume":"61","author":"Schoepfer","year":"2018","journal-title":"J. Med Chem."},{"issue":"5 Suppl 17","key":"10.1016\/j.jtemb.2024.127407_bib20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1053\/sonc.2001.29184","article-title":"Imatinib mesylate: clinical results in Philadelphia chromosome-positive leukemias","volume":"28","author":"Kantarjian","year":"2001","journal-title":"Semin Oncol."},{"issue":"14","key":"10.1016\/j.jtemb.2024.127407_bib21","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1056\/NEJM200104053441401","article-title":"Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia","volume":"344","author":"Druker","year":"2001","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.jtemb.2024.127407_bib22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.abb.2016.03.035","article-title":"Activation of zinc-requiring ectoenzymes by ZnT transporters during the secretory process: biochemical and molecular aspects","volume":"611","author":"Kambe","year":"2016","journal-title":"Arch. Biochem Biophys."},{"issue":"16","key":"10.1016\/j.jtemb.2024.127407_bib23","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1007\/s00018-020-03473-3","article-title":"Why and how to investigate the role of protein phosphorylation in ZIP and ZnT zinc transporter activity and regulation","volume":"77","author":"Thingholm","year":"2020","journal-title":"Cell Mol. Life Sci."},{"issue":"12","key":"10.1016\/j.jtemb.2024.127407_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/nu9121286","article-title":"Zinc as a gatekeeper of immune function","volume":"9","author":"Wessels","year":"2017","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.jtemb.2024.127407_bib25","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1007\/s00204-020-02702-9","article-title":"Recent aspects of the effects of zinc on human health","volume":"94","author":"Chasapis","year":"2020","journal-title":"Arch. Toxicol."},{"issue":"10","key":"10.1016\/j.jtemb.2024.127407_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/nu11102273","article-title":"Role of zinc in immune system and anti-cancer defense mechanisms","volume":"11","author":"Skrajnowska","year":"2019","journal-title":"Nutrients"},{"issue":"7","key":"10.1016\/j.jtemb.2024.127407_bib27","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1001\/archoto.2010.111","article-title":"The Bradford Hill criteria and zinc-induced anosmia: a causality analysis","volume":"136","author":"Davidson","year":"2010","journal-title":"Arch. Otolaryngol. Head. Neck Surg."},{"key":"10.1016\/j.jtemb.2024.127407_bib28","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1146\/annurev-nutr-122019-120635","article-title":"Dietary and physiological effects of zinc on the immune system","volume":"41","author":"Wessels","year":"2021","journal-title":"Annu Rev. Nutr."},{"issue":"3","key":"10.1016\/j.jtemb.2024.127407_bib29","doi-asserted-by":"crossref","first-page":"612","DOI":"10.20892\/j.issn.2095-3941.2020.0106","article-title":"Zinc dysregulation in cancers and its potential as a therapeutic target","volume":"17","author":"Wang","year":"2020","journal-title":"Cancer Biol. Med"},{"issue":"8","key":"10.1016\/j.jtemb.2024.127407_bib30","doi-asserted-by":"crossref","first-page":"875","DOI":"10.3390\/nu4080875","article-title":"Cellular mechanisms of zinc dysregulation: a perspective on zinc homeostasis as an etiological factor in the development and progression of breast cancer","volume":"4","author":"Alam","year":"2012","journal-title":"Nutrients"},{"issue":"7","key":"10.1016\/j.jtemb.2024.127407_bib31","doi-asserted-by":"crossref","first-page":"648","DOI":"10.3390\/nu4070648","article-title":"Zinc and cancer: implications for LIV-1 in breast cancer","volume":"4","author":"Grattan","year":"2012","journal-title":"Nutrients"},{"key":"10.1016\/j.jtemb.2024.127407_bib32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1385\/BTER:114:1:41","article-title":"Levels of selenium, zinc, copper, and antioxidant enzyme activity in patients with leukemia","volume":"114","author":"Zuo","year":"2006","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jtemb.2024.127407_bib33","first-page":"812","article-title":"Determination the levels of zinc and copper in patients with leukemia","volume":"4","author":"Alkufi","year":"2015","journal-title":"Int J Curr Microbiol. Appl. Sci."},{"issue":"2","key":"10.1016\/j.jtemb.2024.127407_bib34","first-page":"344","article-title":"Evaluation of serum levels of trace elements in myeloproliferative neoplasms: A case-control study, Eastern","volume":"26","author":"Yetisgin","year":"2021","journal-title":"J. Med."},{"issue":"7","key":"10.1016\/j.jtemb.2024.127407_bib35","first-page":"723","article-title":"Serum levels of zinc and copper in patients with newly diagnosed chronic myeloid leukemia","volume":"16","author":"Ahmadi-Faghih","year":"2013","journal-title":"KAUMS J. (FEYZ)"},{"issue":"3","key":"10.1016\/j.jtemb.2024.127407_bib36","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00775-018-1545-9","article-title":"The role of zinc and its compounds in leukemia","volume":"23","author":"Orlov","year":"2018","journal-title":"J. Biol. Inorg. Chem."},{"key":"10.1016\/j.jtemb.2024.127407_bib37","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jinorgbio.2017.07.007","article-title":"PML-RARalpha stabilized by zinc in human acute promyelocytic leukemia NB4 cells","volume":"175","author":"Zhu","year":"2017","journal-title":"J. Inorg. Biochem"},{"issue":"5","key":"10.1016\/j.jtemb.2024.127407_bib38","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1159\/000479539","article-title":"Zinc depletion by TPEN Induces apoptosis in human acute promyelocytic NB4 cells","volume":"42","author":"Zhu","year":"2017","journal-title":"Cell Physiol. Biochem."},{"issue":"3","key":"10.1016\/j.jtemb.2024.127407_bib39","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s10534-017-0015-0","article-title":"Metal chelator TPEN selectively induces apoptosis in K562 cells through reactive oxygen species signaling mechanism: implications for chronic myeloid leukemia","volume":"30","author":"Rojas-Valencia","year":"2017","journal-title":"Biometals"},{"issue":"7","key":"10.1016\/j.jtemb.2024.127407_bib40","doi-asserted-by":"crossref","DOI":"10.1007\/s12032-022-01697-w","article-title":"Combinational treatment of TPEN and TPGS induces apoptosis in acute lymphoblastic and chronic myeloid leukemia cells in vitro and ex vivo","volume":"39","author":"Mendivil-Perez","year":"2022","journal-title":"Med. Oncol."},{"issue":"3","key":"10.1016\/j.jtemb.2024.127407_bib41","first-page":"401","article-title":"Gene profile identifies zinc transporters differentially expressed in normal human organs and human pancreatic cancer","volume":"13","author":"Yang","year":"2013","journal-title":"Curr. Mol. Med."},{"issue":"2","key":"10.1016\/j.jtemb.2024.127407_bib42","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3892\/br.2014.219","article-title":"Expression analysis of zinc transporters in resting and stimulated human peripheral blood mononuclear cells","volume":"2","author":"Wex","year":"2014","journal-title":"Biomed. Rep."},{"issue":"1","key":"10.1016\/j.jtemb.2024.127407_bib43","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0378-4274(96)03632-6","article-title":"Isoform-specific expression of metallothionein mRNA in the developing and adult human kidney","volume":"85","author":"Mididoddi","year":"1996","journal-title":"Toxicol. Lett."},{"issue":"5","key":"10.1016\/j.jtemb.2024.127407_bib44","doi-asserted-by":"crossref","DOI":"10.1093\/mtomcs\/mfad022","article-title":"Expression pattern and prognostic implication of zinc homeostasis-related genes in acute myeloid leukemia","volume":"15","author":"Zhu","year":"2023","journal-title":"Metallomics"},{"key":"10.1016\/j.jtemb.2024.127407_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2023.127264","article-title":"Zinc depletion induces JNK\/p38 phosphorylation and suppresses Akt\/mTOR expression in acute promyelocytic NB4 cells","volume":"79","author":"Zhu","year":"2023","journal-title":"J. Trace Elem. Med Biol."},{"key":"10.1016\/j.jtemb.2024.127407_bib46","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jare.2020.04.016","article-title":"Transcriptome profiling reveals the high incidence of hnRNPA1 exon 8 inclusion in chronic myeloid leukemia","volume":"24","author":"Li","year":"2020","journal-title":"J. Adv. Res"},{"issue":"2","key":"10.1016\/j.jtemb.2024.127407_bib47","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41388-022-02536-y","article-title":"Intracellular angiopoietin-1 promotes TKI-resistance via activation of JAK\/STAT5 pathway in chronic myeloid leukemia","volume":"42","author":"Ma","year":"2023","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.jtemb.2024.127407_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0229104","article-title":"Adaptive phenotypic modulations lead to therapy resistance in chronic myeloid leukemia cells","volume":"15","author":"Baykal-K\u00f6se","year":"2020","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.jtemb.2024.127407_bib49","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.jtemb.2024.127407_bib50","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1248\/cpb.c18-00703","article-title":"Development of a potent protein degrader against oncogenic BCR-ABL protein","volume":"67","author":"Shibata","year":"2019","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"issue":"1","key":"10.1016\/j.jtemb.2024.127407_bib51","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s12291-018-0779-1","article-title":"A prognostic and predictive Study of BCR-ABL expression based on characterization of fusion transcripts","volume":"35","author":"Upadhyay","year":"2020","journal-title":"Indian J. Clin. Biochem"},{"issue":"7","key":"10.1016\/j.jtemb.2024.127407_bib52","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1038\/sj.leu.2404224","article-title":"Hypoxia suppresses BCR\/Abl and selects imatinib-insensitive progenitors within clonal CML populations","volume":"20","author":"Giuntoli","year":"2006","journal-title":"Leukemia"},{"issue":"2","key":"10.1016\/j.jtemb.2024.127407_bib53","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3324\/haematol.2010.029082","article-title":"Glucose availability in hypoxia regulates the selection of chronic myeloid leukemia progenitor subsets with different resistance to imatinib-mesylate","volume":"96","author":"Giuntoli","year":"2011","journal-title":"Haematologica"},{"issue":"17","key":"10.1016\/j.jtemb.2024.127407_bib54","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13174372","article-title":"Glutamine availability controls BCR\/Abl protein expression and functional phenotype of chronic myeloid leukemia cells endowed with stem\/progenitor cell potential","volume":"13","author":"Poteti","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"3","key":"10.1016\/j.jtemb.2024.127407_bib55","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1152\/physrev.00035.2014","article-title":"The physiological, biochemical, and molecular roles of zinc transporters in zinc homeostasis and metabolism","volume":"95","author":"Kambe","year":"2015","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.jtemb.2024.127407_bib56","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s10534-020-00262-0","article-title":"TPEN exerts selective anti-leukemic efficacy in ex vivo drug-resistant childhood acute leukemia","volume":"34","author":"Mendivil-Perez","year":"2021","journal-title":"Biometals"},{"issue":"1","key":"10.1016\/j.jtemb.2024.127407_bib57","doi-asserted-by":"crossref","DOI":"10.1007\/s12032-022-01873-y","article-title":"TPEN\/TPGS (T2) combo dramatically reduces Philadelphia chromosome-positive pro-lymphoblastic B leukemia in BALB\/c mice","volume":"40","author":"Mendivil-Perez","year":"2022","journal-title":"Med Oncol."},{"issue":"12","key":"10.1016\/j.jtemb.2024.127407_bib58","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1161\/CIRCRESAHA.108.171264","article-title":"Nitric-oxide-mediated zinc release contributes to hypoxic regulation of pulmonary vascular tone","volume":"102","author":"Bernal","year":"2008","journal-title":"Circ. Res"},{"issue":"2","key":"10.1016\/j.jtemb.2024.127407_bib59","doi-asserted-by":"crossref","first-page":"L185","DOI":"10.1152\/ajplung.00267.2001","article-title":"Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein\/thionein","volume":"282","author":"St Croix","year":"2002","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"12","key":"10.1016\/j.jtemb.2024.127407_bib60","doi-asserted-by":"crossref","first-page":"4636","DOI":"10.1021\/bi0474463","article-title":"S-Nitrosation and regulation of inducible nitric oxide synthase","volume":"44","author":"Mitchell","year":"2005","journal-title":"Biochemistry"},{"issue":"Pt 1","key":"10.1016\/j.jtemb.2024.127407_bib61","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1042\/bj3440253","article-title":"Nitric oxide induces Zn2+ release from metallothionein by destroying zinc-sulphur clusters without concomitant formation of S-nitrosothiol","volume":"344","author":"Aravindakumar","year":"1999","journal-title":"Biochem J."},{"issue":"10","key":"10.1016\/j.jtemb.2024.127407_bib62","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23105488","article-title":"Nitric oxide mobilizes intracellular Zn(2+) via the GC\/cGMP\/PKG signaling pathway and stimulates adipocyte differentiation","volume":"23","author":"Chen","year":"2022","journal-title":"Int J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jtemb.2024.127407_bib63","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1586\/14737159.8.1.73","article-title":"Stat5 as a diagnostic marker for leukemia","volume":"8","author":"Lewis","year":"2008","journal-title":"Expert Rev. Mol. Diagn."},{"issue":"3","key":"10.1016\/j.jtemb.2024.127407_bib64","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nchembio.775","article-title":"BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia","volume":"8","author":"Hantschel","year":"2012","journal-title":"Nat. Chem. Biol."},{"issue":"20","key":"10.1016\/j.jtemb.2024.127407_bib65","doi-asserted-by":"crossref","first-page":"9564","DOI":"10.18632\/oncotarget.2465","article-title":"Inhibition of STAT5: a therapeutic option in BCR-ABL1-driven leukemia","volume":"5","author":"Berger","year":"2014","journal-title":"Oncotarget"},{"issue":"17","key":"10.1016\/j.jtemb.2024.127407_bib66","doi-asserted-by":"crossref","first-page":"10052","DOI":"10.1111\/jcmm.15612","article-title":"Acriflavine targets oncogenic STAT5 signaling in myeloid leukemia cells","volume":"24","author":"Hallal","year":"2020","journal-title":"J. Cell Mol. Med"},{"key":"10.1016\/j.jtemb.2024.127407_bib67","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jtemb.2019.04.018","article-title":"Alterations in membrane fluidity are involved in inhibition of GM-CSF-induced signaling in myeloid cells by zinc","volume":"54","author":"Aster","year":"2019","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"2","key":"10.1016\/j.jtemb.2024.127407_bib68","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1021\/cb500043a","article-title":"Measuring picomolar intracellular exchangeable zinc in PC-12 cells using a ratiometric fluorescence biosensor","volume":"1","author":"Bozym","year":"2006","journal-title":"ACS Chem. Biol."}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X24000270?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X24000270?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:25:26Z","timestamp":1760556326000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X24000270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":68,"alternative-id":["S0946672X24000270"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2024.127407","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zinc as a potential regulator of the BCR-ABL oncogene in chronic myelocytic leukemia cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2024.127407","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"127407"}}