{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:13:13Z","timestamp":1789873993771,"version":"4.0.1"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.jtemb.2024.127520","type":"journal-article","created":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T17:34:33Z","timestamp":1725730473000},"page":"127520","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Serum trace elements and osteoarthritis: A meta-analysis and Mendelian randomization study"],"prefix":"10.1016","volume":"86","author":[{"given":"Haoyan","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haochen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbang","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingliang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtemb.2024.127520_bib1","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(20)32230-3","article-title":"Osteoarthritis in 2020 and beyond: A lancet commission","volume":"396","author":"Hunter","year":"2020","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/j.jtemb.2024.127520_bib2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.5792\/ksrr.16.061","article-title":"Hylan GF-20 viscosupplementation in the treatment of symptomatic osteoarthritis of the knee: Clinical effect survivorship at 5 years","volume":"29","author":"Boutefnouchet","year":"2017","journal-title":"Knee Surg. Relat. Res."},{"key":"10.1016\/j.jtemb.2024.127520_bib3","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.cell.2014.01.007","article-title":"Regulation of the catabolic cascade in osteoarthritis by the zinc-ZIP8-MTF1 axis","volume":"156","author":"Kim","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jtemb.2024.127520_bib4","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1002\/art.25002","article-title":"Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development","volume":"60","author":"Little","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jtemb.2024.127520_bib5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nrm2125","article-title":"Matrix metalloproteinases and the regulation of tissue remodelling","volume":"8","author":"Page-McCaw","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jtemb.2024.127520_bib6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.5694\/j.1326-5377.1980.tb76939.x","article-title":"Trace elements in nutrition","volume":"2","author":"Dreosti","year":"1980","journal-title":"Med. J. Aust."},{"key":"10.1016\/j.jtemb.2024.127520_bib7","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.cbi.2014.01.007","article-title":"Interplay of calcium and cadmium in mediating cadmium toxicity","volume":"211","author":"Choong","year":"2014","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jtemb.2024.127520_bib8","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/biof.5520280306","article-title":"Effects of boron and calcium supplementation on mechanical properties of bone in rats","volume":"28","author":"Naghii","year":"2006","journal-title":"BioFactors Oxf. Engl."},{"key":"10.1016\/j.jtemb.2024.127520_bib9","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1038\/s41598-020-58500-x","article-title":"Improved calcium homeostasis and force by selenium treatment and training in aged mouse skeletal muscle","volume":"10","author":"Fodor","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jtemb.2024.127520_bib10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1365-2796.1992.tb00518.x","article-title":"Calcium and peak bone mass","volume":"231","author":"Matkovic","year":"1992","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.jtemb.2024.127520_bib11","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1093\/ajcn\/60.6.831","article-title":"Calcium and osteoporosis","volume":"60","author":"Bronner","year":"1994","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jtemb.2024.127520_bib12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jare.2022.01.004","article-title":"Mechanical overloading induces GPX4-regulated chondrocyte ferroptosis in osteoarthritis via Piezo1 channel facilitated calcium influx","volume":"41","author":"Wang","year":"2022","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.jtemb.2024.127520_bib13","article-title":"The association of trace elements with arthritis in US adults: NHANES 2013-2016","volume":"76","author":"Guan","year":"2023","journal-title":"J. Trace Elem. Med. Biol. Organ Soc. Miner. Trace Elem. GMS"},{"key":"10.1016\/j.jtemb.2024.127520_bib14","doi-asserted-by":"crossref","first-page":"5586","DOI":"10.3390\/jcm11195586","article-title":"Relationship between selected micronutrient concentrations, total antioxidant status, pain severity, and the image of 1H MR spectroscopy in degenerative spine disease: a case-control study","volume":"11","author":"Jakoniuk","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.jtemb.2024.127520_bib15","first-page":"3917","article-title":"HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis","volume":"134","author":"Amarilio","year":"2007","journal-title":"Dev. Camb. Engl."},{"key":"10.1016\/j.jtemb.2024.127520_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.771297","article-title":"The impact of trace elements on osteoarthritis","volume":"8","author":"Li","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.jtemb.2024.127520_bib17","article-title":"Genotype and clinical course in 2 Chinese han siblings with wilson disease presenting with isolated disabling premature osteoarthritis: a case report","volume":"96","author":"Ye","year":"2017","journal-title":"Med. (Baltim. )"},{"key":"10.1016\/j.jtemb.2024.127520_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.144646","article-title":"Cadmium toxicity: A role in bone cell function and teeth development","volume":"769","author":"Ma","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jtemb.2024.127520_bib19","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1038\/s41598-017-02611-5","article-title":"Protective effect of low dose intra-articular cadmium on inflammation and joint destruction in arthritis","volume":"7","author":"Bonaventura","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jtemb.2024.127520_bib20","article-title":"Meta-analysis of the relationship between zinc and copper in patients with osteoarthritis","author":"Zhou","year":"2024","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jtemb.2024.127520_bib21","article-title":"The relationship between magnesium and osteoarthritis of knee: a MOOSE guided systematic review and meta-analysis","volume":"98","author":"Wu","year":"2019","journal-title":"Med. (Baltim.)"},{"key":"10.1016\/j.jtemb.2024.127520_bib22","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group","volume":"283","author":"Stroup","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.jtemb.2024.127520_bib23","doi-asserted-by":"crossref","first-page":"k601","DOI":"10.1136\/bmj.k601","article-title":"Reading mendelian randomisation studies: A guide, glossary, and checklist for clinicians","volume":"362","author":"Davies","year":"2018","journal-title":"BMJ"},{"key":"10.1016\/j.jtemb.2024.127520_bib24","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/jrsm.1346","article-title":"Meta-analysis and mendelian randomization: a review","volume":"10","author":"Bowden","year":"2019","journal-title":"Res. Synth. Methods"},{"key":"10.1016\/j.jtemb.2024.127520_bib25","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-2288-6-31","article-title":"Meta-DiSc: A software for meta-analysis of test accuracy data","volume":"6","author":"Zamora","year":"2006","journal-title":"BMC Med. Res. Methodol."},{"key":"10.1016\/j.jtemb.2024.127520_bib26","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.jtemb.2024.127520_bib27","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the newcastle-ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.jtemb.2024.127520_bib28","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1093\/hmg\/ddt239","article-title":"Genome-wide association study identifies loci affecting blood copper, selenium and zinc","volume":"22","author":"Evans","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jtemb.2024.127520_bib29","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/s41588-018-0079-y","article-title":"Genome-wide analyses using UK biobank data provide insights into the genetic architecture of osteoarthritis","volume":"50","author":"Zengini","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jtemb.2024.127520_bib30","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/s42003-022-03351-7","article-title":"Genome-wide association and mendelian randomization study of blood copper levels and 213 deep phenotypes in humans","volume":"5","author":"Yang","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.jtemb.2024.127520_bib31","doi-asserted-by":"crossref","first-page":"R89","DOI":"10.1093\/hmg\/ddu328","article-title":"Mendelian randomization: genetic anchors for causal inference in epidemiological studies","volume":"23","author":"Davey Smith","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jtemb.2024.127520_bib32","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1002\/sim.4197","article-title":"Bias in causal estimates from mendelian randomization studies with weak instruments","volume":"30","author":"Burgess","year":"2011","journal-title":"Stat. Med."},{"key":"10.1016\/j.jtemb.2024.127520_bib33","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1681\/ASN.2016010098","article-title":"Mendelian randomization as an approach to assess causality using observational data","volume":"27","author":"Sekula","year":"2016","journal-title":"J. Am. Soc. Nephrol. JASN"},{"key":"10.1016\/j.jtemb.2024.127520_bib34","article-title":"Orienting the causal relationship between imprecisely measured traits using GWAS summary data","volume":"13","author":"Hemani","year":"2017","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jtemb.2024.127520_bib35","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1002\/sim.7221","article-title":"A framework for the investigation of pleiotropy in two-sample summary data mendelian randomization","volume":"36","author":"Bowden","year":"2017","journal-title":"Stat. Med."},{"key":"10.1016\/j.jtemb.2024.127520_bib36","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","article-title":"Interpreting findings from mendelian randomization using the MR-egger method","volume":"32","author":"Burgess","year":"2017","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.jtemb.2024.127520_bib37","doi-asserted-by":"crossref","first-page":"5662","DOI":"10.1007\/s12011-023-03636-w","article-title":"The daily intake levels of copper, selenium, and zinc are associated with osteoarthritis but not with rheumatoid arthritis in a cross-sectional study","volume":"201","author":"Yang","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jtemb.2024.127520_bib38","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1385\/BTER:106:2:123","article-title":"Synovial fluid and plasma selenium, copper, zinc, and iron concentrations in patients with rheumatoid arthritis and osteoarthritis","volume":"106","author":"Yazar","year":"2005","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jtemb.2024.127520_bib39","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/BF01450895","article-title":"M. Magar\u00f3, Serum zinc and copper in active rheumatoid arthritis: correlation with interleukin 1 beta and tumour necrosis factor alpha","volume":"17","author":"Zoli","year":"1998","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.jtemb.2024.127520_bib40","first-page":"93","article-title":"Serum zinc and copper levels in patients with osteoartritis","volume":"23","author":"K\u0131l\u0131\u00e7","year":"2001","journal-title":"Erciyes T\u0131p Derg. Erciyes Med. J."},{"key":"10.1016\/j.jtemb.2024.127520_bib41","first-page":"171","article-title":"Serum metallomics study on patients with osteoarthritis based on ICP-MS technique","volume":"48","author":"Wang","year":"2016","journal-title":"Bulg. Chem. Commun."},{"key":"10.1016\/j.jtemb.2024.127520_bib42","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1136\/jcp.36.1.14","article-title":"Serum copper: a marker of disease activity in rheumatoid arthritis","volume":"36","author":"Youssef","year":"1983","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.jtemb.2024.127520_bib43","doi-asserted-by":"crossref","first-page":"11377","DOI":"10.3390\/ijerph191811377","article-title":"Concentration of selected macronutrients and toxic elements in the blood in relation to pain severity and hydrogen magnetic resonance spectroscopy in people with osteoarthritis of the spine","volume":"19","author":"Jakoniuk","year":"2022","journal-title":"Int. J. Environ. Res. Public. Health"},{"key":"10.1016\/j.jtemb.2024.127520_bib44","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/BF00317832","article-title":"Investigation of ischaemic necrosis of the femoral head with trace elements","volume":"12","author":"Milachowski","year":"1988","journal-title":"Int. Orthop."},{"key":"10.1016\/j.jtemb.2024.127520_bib45","doi-asserted-by":"crossref","first-page":"72","DOI":"10.2106\/JBJS.H.00502","article-title":"The effect of short tandem repeat loci and low selenium levels on endemic osteoarthritis in China","volume":"92","author":"Shi","year":"2010","journal-title":"J. Bone Jt. Surg. Am."},{"key":"10.1016\/j.jtemb.2024.127520_bib46","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3390\/nu13010053","article-title":"Zinc and cadmium in the aetiology and pathogenesis of osteoarthritis and rheumatoid arthritis","volume":"13","author":"Frangos","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jtemb.2024.127520_bib47","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.joca.2021.02.564","article-title":"Genetically predicted circulating levels of copper and zinc are associated with osteoarthritis but not with rheumatoid arthritis","volume":"29","author":"Zhou","year":"2021","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.jtemb.2024.127520_bib48","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: a disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jtemb.2024.127520_bib49","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.3390\/ijms22041742","article-title":"Overview of MMP-13 as a promising target for the treatment of osteoarthritis","volume":"22","author":"Hu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jtemb.2024.127520_bib50","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.abb.2007.03.019","article-title":"Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1)","volume":"463","author":"Laity","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jtemb.2024.127520_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2019.103307","article-title":"Impact of cadmium toxicity on cartilage loss in a 3D in vitro model","volume":"74","author":"Yessica Eduviges","year":"2020","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.jtemb.2024.127520_bib52","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.cbpc.2006.10.003","article-title":"Importance of metallothioneins in the cadmium detoxification process in Daphnia magna","volume":"144","author":"Fraysse","year":"2006","journal-title":"Comp. Biochem. Physiol. Toxicol. Pharmacol. CBP"},{"key":"10.1016\/j.jtemb.2024.127520_bib53","article-title":"Oxidative stress and inflammation in osteoarthritis pathogenesis: role of polyphenols","volume":"129","author":"Ansari","year":"2020","journal-title":"Biomed. Pharmacother. Biomed. Pharmacother."},{"key":"10.1016\/j.jtemb.2024.127520_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12013-009-9054-7","article-title":"Antioxidant activity of sulfur and selenium: a review of reactive oxygen species scavenging, glutathione peroxidase, and metal-binding antioxidant mechanisms","volume":"55","author":"Battin","year":"2009","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.jtemb.2024.127520_bib55","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1093\/rheumatology\/keaa622","article-title":"Causal relationship of serum nutritional factors with osteoarthritis: a mendelian randomization study","volume":"60","author":"Qu","year":"2021","journal-title":"Rheumatol. Oxf. Engl."}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X24001408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X24001408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T16:38:11Z","timestamp":1739896691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X24001408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":55,"alternative-id":["S0946672X24001408"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2024.127520","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum trace elements and osteoarthritis: A meta-analysis and Mendelian randomization study","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2024.127520","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"127520"}}