{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T20:12:11Z","timestamp":1776888731618,"version":"3.51.2"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.jtemb.2024.127521","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T15:07:05Z","timestamp":1725635225000},"page":"127521","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Salidroside prevents cadmium chloride-induced DNA damage in human fetal lung fibroblasts"],"prefix":"10.1016","volume":"86","author":[{"given":"Yufei","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtemb.2024.127521_bib1","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.scitotenv.2019.04.395","article-title":"Cadmium exposure in living organisms: a short review","volume":"678","author":"Zhang","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"3","key":"10.1016\/j.jtemb.2024.127521_bib2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.taap.2009.04.020","article-title":"Current status of cadmium as an environmental health problem","volume":"238","author":"Jarup","year":"2009","journal-title":"Toxicol. Appl. Pharm."},{"issue":"5","key":"10.1016\/j.jtemb.2024.127521_bib3","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s10534-010-9343-z","article-title":"Cadmium exposure in the population: from health risks to strategies of prevention","volume":"23","author":"Nawrot","year":"2010","journal-title":"Biometals"},{"key":"10.1016\/j.jtemb.2024.127521_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115161","article-title":"Implications for prenatal cadmium exposure and adverse health outcomes in adulthood","volume":"403","author":"Young","year":"2020","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.jtemb.2024.127521_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2023.127377","article-title":"A review on heavy metal-induced toxicity in fishes: bioaccumulation, antioxidant defense system, histopathological manifestations, and transcriptional profiling of genes","volume":"83","author":"Kumar","year":"2024","journal-title":"J. Trace Elem. Med Biol."},{"key":"10.1016\/j.jtemb.2024.127521_bib6","doi-asserted-by":"crossref","first-page":"5407159","DOI":"10.1155\/2020\/5407159","article-title":"Exploration of cadmium dioxide nanoparticles on bioaccumulation, oxidative stress, and carcinogenic potential in oreochromis mossambicus L","volume":"2020","author":"Al-Abdan","year":"2020","journal-title":"Oxid. Med Cell Longev."},{"issue":"1","key":"10.1016\/j.jtemb.2024.127521_bib7","doi-asserted-by":"crossref","first-page":"9130005","DOI":"10.26599\/NTM.2022.9130005","article-title":"Advances in porous inorganic nanomaterials for bone regeneration","volume":"1","author":"Dai","year":"2022","journal-title":"Nano TransMed"},{"key":"10.1016\/j.jtemb.2024.127521_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.109851","article-title":"Isoorientin plays an important role in alleviating Cadmium-induced DNA damage and G0\/G1 cell cycle arrest","volume":"187","author":"Chen","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"10","key":"10.1016\/j.jtemb.2024.127521_bib9","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1080\/10408444.2023.2173557","article-title":"Cadmium exposure and DNA damage (genotoxicity): a systematic review and meta-analysis","volume":"52","author":"Nagaraju","year":"2022","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.jtemb.2024.127521_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.172812","article-title":"Nitric oxide alleviates programmed cell death induced by cadmium in Solanum lycopersicum seedlings through protein S-nitrosylation","volume":"931","author":"Huang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jtemb.2024.127521_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112091","article-title":"MAPK, AKT\/FoxO3a and mTOR pathways are involved in cadmium regulating the cell cycle, proliferation and apoptosis of chicken follicular granulosa cells","volume":"214","author":"Zhu","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jtemb.2024.127521_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.142138","article-title":"NBR1-dependent autophagy activation protects against environmental cadmium-evoked placental trophoblast senescence","volume":"358","author":"Ling","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.jtemb.2024.127521_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114098","article-title":"Sirtuin-1 attenuates cadmium-induced renal cell senescence through p53 deacetylation","volume":"245","author":"Chou","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jtemb.2024.127521_bib14","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.toxlet.2022.03.003","article-title":"Cadmium and breast cancer - Current state and research gaps in the underlying mechanisms","volume":"361","author":"Tarhonska","year":"2022","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.jtemb.2024.127521_bib15","first-page":"491","article-title":"Cadmium and cancer","volume":"11","author":"Hartwig","year":"2013","journal-title":"Met Ions Life Sci."},{"key":"10.1016\/j.jtemb.2024.127521_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2024.153787","article-title":"Reproductive toxicity of cadmium stress in male animals","volume":"504","author":"Zhang","year":"2024","journal-title":"Toxicology"},{"key":"10.1016\/j.jtemb.2024.127521_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123462","article-title":"Cadmium exposure and cardiovascular disease risk: a systematic review and dose-response meta-analysis","volume":"345","author":"Verzelloni","year":"2024","journal-title":"Environ. Pollut."},{"issue":"1-2","key":"10.1016\/j.jtemb.2024.127521_bib18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.mrfmmm.2011.09.002","article-title":"Mechanisms of cadmium induced genomic instability","volume":"733","author":"Filipic","year":"2012","journal-title":"Mutat. Res"},{"key":"10.1016\/j.jtemb.2024.127521_bib19","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.bone.2014.12.059","article-title":"Gastrodin: an ancient Chinese herbal medicine as a source for anti-osteoporosis agents via reducing reactive oxygen species","volume":"73","author":"Huang","year":"2015","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.jtemb.2024.127521_bib20","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1142\/S0192415X17500252","article-title":"Chinese herbal medicine for the optimal management of polycystic ovary syndrome","volume":"45","author":"Ong","year":"2017","journal-title":"Am. J. Chin. Med"},{"key":"10.1016\/j.jtemb.2024.127521_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2020.109268","article-title":"Salidroside: a review of its recent advances in synthetic pathways and pharmacological properties","volume":"339","author":"Zhang","year":"2021","journal-title":"Chem. Biol. Inter."},{"issue":"2","key":"10.1016\/j.jtemb.2024.127521_bib22","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1007\/s11357-023-00921-3","article-title":"Salidroside promotes healthy longevity by interfering with HSP90 activity","volume":"46","author":"Zhang","year":"2024","journal-title":"Geroscience"},{"issue":"17","key":"10.1016\/j.jtemb.2024.127521_bib23","first-page":"5349","article-title":"Multiple mechanisms of salidroside on anti-tumor effects","volume":"25","author":"Wang","year":"2021","journal-title":"Eur. Rev. Med Pharm. Sci."},{"key":"10.1016\/j.jtemb.2024.127521_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109975","article-title":"Salidroside attenuates lipopolysaccharide-induced neuroinflammation and cognitive impairment in septic encephalopathy mice","volume":"117","author":"Xiao","year":"2023","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.jtemb.2024.127521_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155376","article-title":"Salidroside protects pulmonary artery endothelial cells against hypoxia-induced apoptosis via the AhR\/NF-\u03baB and Nrf2\/HO-1 pathways","volume":"128","author":"Lei","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jtemb.2024.127521_bib26","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jpba.2014.11.036","article-title":"An UPLC-MS-based metabolomics investigation on the anti-fatigue effect of salidroside in mice","volume":"105","author":"Ma","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jtemb.2024.127521_bib27","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.intimp.2016.05.008","article-title":"Rhodioloside ameliorates depressive behavior via up-regulation of monoaminergic system activity and anti-inflammatory effect in olfactory bulbectomized rats","volume":"36","author":"Zhang","year":"2016","journal-title":"Int Immunopharmacol."},{"issue":"7","key":"10.1016\/j.jtemb.2024.127521_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0306926","article-title":"Therapeutic potential of salidroside in type I diabetic erectile dysfunction: attenuation of oxidative stress and apoptosis via the Nrf2\/HO-1 pathway","volume":"19","author":"Li","year":"2024","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jtemb.2024.127521_bib29","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s12011-014-0201-7","article-title":"Salidroside ameliorates Cd-induced calcium overload and gap junction dysfunction in BRL 3A rat liver cells","volume":"164","author":"Zou","year":"2015","journal-title":"Biol. Trace Elem. Res"},{"issue":"6","key":"10.1016\/j.jtemb.2024.127521_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0129788","article-title":"Salidroside Protects against Cadmium-Induced Hepatotoxicity in Rats via GJIC and MAPK pathways","volume":"10","author":"Zou","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jtemb.2024.127521_bib31","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/bcpt.12906","article-title":"Salidroside, a Chemopreventive Glycoside, Diminishes Cytotoxic Effect of Cisplatin in Vitro","volume":"122","author":"Zduriencikova","year":"2018","journal-title":"Basic Clin. Pharm. Toxicol."},{"issue":"11-12","key":"10.1016\/j.jtemb.2024.127521_bib32","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.mad.2010.10.003","article-title":"Salidroside protects human fibroblast cells from premature senescence induced by H(2)O(2) partly through modulating oxidative status","volume":"131","author":"Mao","year":"2010","journal-title":"Mech. Ageing Dev."},{"issue":"5","key":"10.1016\/j.jtemb.2024.127521_bib33","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.3892\/or.2017.5940","article-title":"Salidroside, a scavenger of ROS, enhances the radioprotective effect of Ex-RAD(R) via a p53-dependent apoptotic pathway","volume":"38","author":"Feng","year":"2017","journal-title":"Oncol. Rep."},{"issue":"18","key":"10.1016\/j.jtemb.2024.127521_bib34","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1182\/blood-2011-10-387332","article-title":"Salidroside stimulates DNA repair enzyme Parp-1 activity in mouse HSC maintenance","volume":"119","author":"Li","year":"2012","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.jtemb.2024.127521_bib35","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1002\/jcb.20838","article-title":"p21Waf1\/Cip1 plays a critical role in modulating senescence through changes of DNA methylation","volume":"98","author":"Zheng","year":"2006","journal-title":"J. Cell Biochem"},{"key":"10.1016\/j.jtemb.2024.127521_bib36","doi-asserted-by":"crossref","unstructured":"G.X. Mao, L.D. Zheng, Y.B. Cao, Z.M. Chen, Y.D. Lv, Y.Z. Wang, X.L. Hu, G.F. Wang, J. Yan, Antiaging effect of pine pollen in human diploid fibroblasts and in a mouse model induced by D-galactose, Oxid. Med Cell Longev. 2012 (2012) 750963.","DOI":"10.1155\/2012\/750963"},{"issue":"1","key":"10.1016\/j.jtemb.2024.127521_bib37","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0047-6374(94)01557-3","article-title":"The proliferative response and anti-oncogene expression in old 2BS cells after growth factor stimulation","volume":"80","author":"Li","year":"1995","journal-title":"Mech. Ageing Dev."},{"issue":"8","key":"10.1016\/j.jtemb.2024.127521_bib38","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1007\/s00204-019-02511-9","article-title":"Validation of the gammaH2AX biomarker for genotoxicity assessment: a review","volume":"93","author":"Kopp","year":"2019","journal-title":"Arch. Toxicol."},{"issue":"4","key":"10.1016\/j.jtemb.2024.127521_bib39","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1080\/09603123.2013.835032","article-title":"Cellular mechanisms of cadmium-induced toxicity: a review","volume":"24","author":"Rani","year":"2014","journal-title":"Int J. Environ. Health Res"},{"issue":"35","key":"10.1016\/j.jtemb.2024.127521_bib40","doi-asserted-by":"crossref","first-page":"43582","DOI":"10.1007\/s11356-020-10783-3","article-title":"Metal toxicity and natural antidotes: prevention is better than cure","volume":"27","author":"Rajak","year":"2020","journal-title":"Environ. Sci. Pollut. Res Int"},{"issue":"7267","key":"10.1016\/j.jtemb.2024.127521_bib41","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08467","article-title":"The DNA-damage response in human biology and disease","volume":"461","author":"Jackson","year":"2009","journal-title":"Nature"},{"issue":"147","key":"10.1016\/j.jtemb.2024.127521_bib42","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0122-2017","article-title":"Cadmium in tobacco smokers: a neglected link to lung disease?","volume":"27","author":"Ganguly","year":"2018","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.jtemb.2024.127521_bib43","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.etap.2018.01.001","article-title":"Salidroside influences the cellular cross-talk of human fetal lung diploid fibroblasts: a proteomic approach","volume":"58","author":"Xing","year":"2018","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.jtemb.2024.127521_bib44","doi-asserted-by":"crossref","first-page":"5276096","DOI":"10.1155\/2019\/5276096","article-title":"Salidroside Delays Cellular Senescence by Stimulating Mitochondrial Biogenesis Partly through a miR-22\/SIRT-1 Pathway","volume":"2019","author":"Mao","year":"2019","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.jtemb.2024.127521_bib45","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s40360-016-0059-8","article-title":"Salidroside alleviates oxidative stress in the liver with non- alcoholic steatohepatitis in rats","volume":"17","author":"Yang","year":"2016","journal-title":"BMC Pharm. Toxicol."},{"issue":"1","key":"10.1016\/j.jtemb.2024.127521_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2024.114034","article-title":"Salidroside induces mitochondrial dysfunction and ferroptosis to inhibit melanoma progression through reactive oxygen species production","volume":"438","author":"Zhang","year":"2024","journal-title":"Exp. Cell Res."},{"issue":"4","key":"10.1016\/j.jtemb.2024.127521_bib47","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1159\/000481971","article-title":"Inhibiting ROS-TFEB-dependent autophagy enhances salidroside-induced apoptosis in human chondrosarcoma cells","volume":"43","author":"Zeng","year":"2017","journal-title":"Cell Physiol. Biochem"},{"key":"10.1016\/j.jtemb.2024.127521_bib48","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.freeradbiomed.2024.04.234","article-title":"Mitochondrial redox state, bioenergetics, and calcium transport in caloric restriction: a metabolic nexus","volume":"219","author":"Vilas-Boas","year":"2024","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.jtemb.2024.127521_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2023.127230","article-title":"Interaction between mitophagy, cadmium and zinc","volume":"79","author":"Isaev","year":"2023","journal-title":"J. Trace Elem. Med. Biol."}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X2400141X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X2400141X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T21:38:20Z","timestamp":1739914700000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X2400141X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":49,"alternative-id":["S0946672X2400141X"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2024.127521","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Salidroside prevents cadmium chloride-induced DNA damage in human fetal lung fibroblasts","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2024.127521","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"127521"}}