{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:18:53Z","timestamp":1785284333000,"version":"3.55.0"},"reference-count":121,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.jtemb.2024.127542","type":"journal-article","created":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T13:50:24Z","timestamp":1728222624000},"page":"127542","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["The overlooked impact of cadmium on the progression of chronic hepatitis and the onset of renal failure in advanced cirrhosis"],"prefix":"10.1016","volume":"86","author":[{"given":"Ana","family":"Cirovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soisungwan","family":"Satarug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovan","family":"Jevtic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Ivanovski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orish E.","family":"Orisakwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasa","family":"Jankovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar","family":"Cirovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtemb.2024.127542_bib1","unstructured":"List SP (2020) ATSDR. In:"},{"key":"10.1016\/j.jtemb.2024.127542_bib2","unstructured":"Organization W.H. (2019) Preventing disease through healthy environments: exposure to cadmium: a major public health concern. In:World Health Organization."},{"key":"10.1016\/j.jtemb.2024.127542_bib3","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3390\/jmse11010100","article-title":"Environmental impact of cadmium in a volcanic archipelago: research challenges related to a natural pollution source","volume":"11","author":"Torres","year":"2023","journal-title":"J. Mar. Sci. Eng."},{"key":"10.1016\/j.jtemb.2024.127542_bib4","article-title":"Cd content in phosphate fertilizer: which potential risk for the environment and human health?","volume":"30","author":"Suciu","year":"2022","journal-title":"Curr. Opin. Environ. Sci. Health"},{"key":"10.1016\/j.jtemb.2024.127542_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170488","article-title":"Assessment of human exposure to cadmium and its nephrotoxicity in the Chinese population","volume":"918","author":"Zhu","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jtemb.2024.127542_bib6","doi-asserted-by":"crossref","unstructured":"Nordberg G., BA F. (2014) Nordberg M. Handbook on the Toxicity of Metals.","DOI":"10.1016\/B978-0-444-59453-2.00001-9"},{"key":"10.1016\/j.jtemb.2024.127542_bib7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.envpol.2004.12.006","article-title":"Lead and cadmium in indoor air and the urban environment","volume":"136","author":"Komarnicki","year":"2005","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jtemb.2024.127542_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123871","article-title":"Relationship between ambient PM2. 5 exposure and blood cadmium level in children under 14 years in Beijing, China","volume":"403","author":"Wu","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jtemb.2024.127542_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134309","article-title":"A comparative study of cadmium levels in blood from exposed populations in an industrial area of the Amazon, Brazil","volume":"698","author":"Naka","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jtemb.2024.127542_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.113873","article-title":"Dietary exposure to cadmium from six common foods in the United States","volume":"178","author":"Pokharel","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jtemb.2024.127542_bib11","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.envpol.2019.03.063","article-title":"Cadmium contamination in agricultural soils of China and the impact on food safety","volume":"249","author":"Wang","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jtemb.2024.127542_bib12","series-title":"Cadmium Toxicity: New Aspects in Human Disease, Rice Contamination, and Cytotoxicity","first-page":"103","article-title":"Regulations for cadmium in rice and soil in Japan and countermeasures to reduce the concentrations","author":"Makino","year":"2019"},{"key":"10.1016\/j.jtemb.2024.127542_bib13","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3109\/1354750X.2016.1153717","article-title":"A cross-sectional survey of cadmium biomarkers and cigarette smoking","volume":"21","author":"Hecht","year":"2016","journal-title":"Biomarkers"},{"key":"10.1016\/j.jtemb.2024.127542_bib14","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s11356-019-06840-1","article-title":"The influence of smoking habits on cadmium and lead blood levels in the Serbian adult people","volume":"27","author":"Repi\u0107","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.jtemb.2024.127542_bib15","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1177\/0748233710362375","article-title":"Cadmium transport in blood serum","volume":"26","author":"Saljooghi","year":"2010","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.jtemb.2024.127542_bib16","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1039\/C9MT00178F","article-title":"Chemical imaging and assessment of cadmium distribution in the human body","volume":"11","author":"Egger","year":"2019","journal-title":"Metallomics"},{"key":"10.1016\/j.jtemb.2024.127542_bib17","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s10534-005-5619-0","article-title":"Tissue cadmium (Cd) concentrations of people living in a Cd polluted area, Japan","volume":"19","author":"Uetani","year":"2006","journal-title":"Biometals"},{"key":"10.1016\/j.jtemb.2024.127542_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153355","article-title":"A hypoxia-driven occurrence of chronic kidney disease and osteoporosis in COPD individuals: new insights into environmental cadmium exposure","volume":"482","author":"Cirovic","year":"2022","journal-title":"Toxicology"},{"key":"10.1016\/j.jtemb.2024.127542_bib19","first-page":"1559","article-title":"Relationship between blood levels of heavy metals and lung function based on the Korean National Health and Nutrition Examination Survey IV\u2013V.","author":"Leem","year":"2015","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"10.1016\/j.jtemb.2024.127542_bib20","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s12011-014-9982-y","article-title":"Iron deficiency increases blood cadmium levels in adolescents surveyed in KNHANES 2010-2011","volume":"159","author":"Lee","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jtemb.2024.127542_bib21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.toxlet.2007.10.011","article-title":"Involvement of intestinal calcium transporter 1 and metallothionein in cadmium accumulation in the liver and kidney of mice fed a low-calcium diet","volume":"176","author":"Min","year":"2008","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.jtemb.2024.127542_bib22","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.envres.2011.10.013","article-title":"Iron deficiency is associated with increased levels of blood cadmium in the Korean general population: analysis of 2008-2009 Korean National Health and Nutrition Examination Survey data","volume":"112","author":"Lee","year":"2012","journal-title":"Environ. Res."},{"key":"10.1016\/j.jtemb.2024.127542_bib23","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1248\/bpb.b15-00341","article-title":"Dietary deficiency of calcium and\/or iron, an age-related risk factor for renal accumulation of cadmium in mice","volume":"38","author":"Min","year":"2015","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jtemb.2024.127542_bib24","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s12011-023-03689-x","article-title":"The association between environmental cadmium exposure and parathyroid hormone levels","volume":"202","author":"Tang","year":"2024","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jtemb.2024.127542_bib25","unstructured":"Organization W.H. (2017) Global hepatitis report 2017. World Health Organization."},{"key":"10.1016\/j.jtemb.2024.127542_bib26","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1016\/j.cgh.2019.07.060","article-title":"Contemporary epidemiology of chronic liver disease and cirrhosis","volume":"18","author":"Moon","year":"2020","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jtemb.2024.127542_bib27","article-title":"Mortality due to cirrhosis and liver cancer in the United States, 1999-2016: observational study","volume":"362","author":"Tapper","year":"2018","journal-title":"bmj"},{"key":"10.1016\/j.jtemb.2024.127542_bib28","unstructured":"Heidelbauch J., Bruderly M. (2006) Cirrhosis and chronic liver failure: part II complications and treatment."},{"key":"10.1016\/j.jtemb.2024.127542_bib29","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.jhep.2011.10.016","article-title":"Renal failure and cirrhosis: a systematic review of mortality and prognosis","volume":"56","author":"Fede","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jtemb.2024.127542_bib30","doi-asserted-by":"crossref","first-page":"3984","DOI":"10.3748\/wjg.v27.i26.3984","article-title":"Acute kidney injury and hepatorenal syndrome in cirrhosis","volume":"27","author":"Gupta","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jtemb.2024.127542_bib31","doi-asserted-by":"crossref","first-page":"774","DOI":"10.2215\/CJN.12451018","article-title":"Hepatorenal syndrome","volume":"14","author":"Francoz","year":"2019","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jtemb.2024.127542_bib32","doi-asserted-by":"crossref","DOI":"10.1097\/MOG.0000000000000261","article-title":"Cause and management of muscle wasting in chronic liver disease","author":"Dasarathy","year":"2016","journal-title":"Curr. Opin. Gastroenterol. 32:159-165"},{"key":"10.1016\/j.jtemb.2024.127542_bib33","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1136\/gut.52.1.126","article-title":"Impact of smoking on histological liver lesions in chronic hepatitis C","volume":"52","author":"Hezode","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.jtemb.2024.127542_bib34","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1158\/1055-9965.EPI-09-1297","article-title":"Interaction between cigarette smoking and hepatitis B and C virus infection on the risk of liver cancer: a meta-analysis","volume":"19","author":"Chuang","year":"2010","journal-title":"Cancer Epidemiol., Biomark. Prev."},{"key":"10.1016\/j.jtemb.2024.127542_bib35","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.cgh.2006.03.019","article-title":"Relationship of smoking and fibrosis in patients with chronic hepatitis C","volume":"4","author":"Dev","year":"2006","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jtemb.2024.127542_bib36","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1053\/jhep.2001.25385","article-title":"Cigarette smoking and hepatic lesions in patients with chronic hepatitis C","volume":"34","author":"Pessione","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.jtemb.2024.127542_bib37","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.amjmed.2018.01.011","article-title":"Cigarette smoking in persons living with hepatitis C: the National health and nutrition examination survey (NHANES), 1999-2014","volume":"131","author":"Kim","year":"2018","journal-title":"Am. J. Med."},{"key":"10.1016\/j.jtemb.2024.127542_bib38","doi-asserted-by":"crossref","DOI":"10.1100\/2012\/729430","article-title":"Levels of heavy metals in popular cigarette brands and exposure to these metals via smoking","volume":"2012","author":"Ashraf","year":"2012","journal-title":"Sci. World J."},{"key":"10.1016\/j.jtemb.2024.127542_bib39","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.3945\/jn.109.120659","article-title":"Blood cadmium concentrations of male cigarette smokers are inversely associated with fruit consumption12","volume":"140","author":"Kim","year":"2010","journal-title":"J. Nutr."},{"key":"10.1016\/j.jtemb.2024.127542_bib40","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1161\/01.ATV.0000205616.70614.e5","article-title":"Increased serum cadmium and strontium levels in young smokers: effects on arterial endothelial cell gene transcription","volume":"26","author":"Bernhard","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jtemb.2024.127542_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.140372","article-title":"Co-exposure to cadmium and microplastics promotes liver fibrosis through the hemichannels -ATP-P2X7 pathway","volume":"344","author":"Sun","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.jtemb.2024.127542_bib42","article-title":"Serum cadmium is associated with hepatic steatosis and fibrosis: Korean national health and nutrition examination survey data IV-VII","volume":"101","author":"Han","year":"2022","journal-title":"Med. (Baltim. )"},{"key":"10.1016\/j.jtemb.2024.127542_bib43","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/tox.23731","article-title":"Cadmium modulates steatosis, fibrosis, and oncogenic signaling in liver cancer cells by activating notch and AKT\/mTOR pathways","volume":"38","author":"Niture","year":"2023","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.jtemb.2024.127542_bib44","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/s11605-013-2210-9","article-title":"Cadmium exposure and liver disease among US adults","volume":"17","author":"Hyder","year":"2013","journal-title":"J. Gastrointest. Surg."},{"key":"10.1016\/j.jtemb.2024.127542_bib45","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3961\/jpmph.21.435","article-title":"Association between cadmium exposure and liver function in adults in the united states: a cross-sectional study","volume":"54","author":"Hong","year":"2021","journal-title":"J. Prev. Med. Public Health"},{"key":"10.1016\/j.jtemb.2024.127542_bib46","doi-asserted-by":"crossref","first-page":"39768","DOI":"10.1007\/s11356-022-18950-4","article-title":"Association between urinary cadmium concentrations and liver function in adolescents","volume":"29","author":"Xu","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.jtemb.2024.127542_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.146958","article-title":"Chronic cadmium exposure at environmental-relevant level accelerates the development of hepatotoxicity to hepatocarcinogenesis","volume":"783","author":"Xu","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jtemb.2024.127542_bib48","article-title":"Liver and cadmium toxicity","volume":"5","author":"Arroyo","year":"2012","journal-title":"J. Drug Metab. Toxicol. S"},{"key":"10.1016\/j.jtemb.2024.127542_bib49","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.etp.2009.03.010","article-title":"Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin","volume":"62","author":"Renugadevi","year":"2010","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.jtemb.2024.127542_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117770","article-title":"Hepatoprotective effect of atorvastatin on Cadmium chloride induced hepatotoxicity in rats","volume":"254","author":"Goodarzi","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.jtemb.2024.127542_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17010138","article-title":"Cadmium induces acute liver injury by inhibiting Nrf2 and the role of NF-\u03baB, NLRP3, and MAPKs signaling pathway","volume":"17","author":"Liu","year":"2019","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.jtemb.2024.127542_bib52","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1039\/C8TX00194D","article-title":"Chronic low-level cadmium exposure in rats affects cytokine production by activated T cells","volume":"8","author":"Turley","year":"2019","journal-title":"Toxicol. Res (Camb. )"},{"key":"10.1016\/j.jtemb.2024.127542_bib53","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1515\/BC.2009.111","article-title":"Mechanisms of liver disease: cross-talk between the NF-kappaB and JNK pathways","volume":"390","author":"Papa","year":"2009","journal-title":"Biol. Chem."},{"key":"10.1016\/j.jtemb.2024.127542_bib54","doi-asserted-by":"crossref","first-page":"6800","DOI":"10.1038\/sj.onc.1209938","article-title":"Current insights into the regulation of programmed cell death by NF-kappaB.","volume":"25","author":"Dutta","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.jtemb.2024.127542_bib55","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1210\/er.2006-0031","article-title":"Hepatic tumor necrosis factor signaling and nuclear factor-kappaB: effects on liver homeostasis and beyond","volume":"28","author":"Wullaert","year":"2007","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jtemb.2024.127542_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120971","article-title":"The role of inflammation in cadmium nephrotoxicity: NF-\u03baB comes into view","volume":"308","author":"Hassanein","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.jtemb.2024.127542_bib57","first-page":"1","article-title":"TGF-\u03b2\/SMAD pathway mediates cadmium poisoning-induced chicken liver fibrosis and epithelial-mesenchymal transition","author":"Zhang","year":"2024","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jtemb.2024.127542_bib58","article-title":"Molecular mechanisms and potential new therapeutic drugs for liver fibrosis","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jtemb.2024.127542_bib59","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","article-title":"The JAK\/STAT signaling pathway: from bench to clinic","volume":"6","author":"Hu","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jtemb.2024.127542_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.aohep.2020.06.010","article-title":"STAT3: a key regulator in liver fibrosis","volume":"21","author":"Zhao","year":"2021","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.jtemb.2024.127542_bib61","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s00775-011-0799-2","article-title":"Chemistry and biology of mammalian metallothioneins","volume":"16","author":"Va\u0161\u00e1k","year":"2011","journal-title":"JBIC J. Biol. Inorg. Chem."},{"key":"10.1016\/j.jtemb.2024.127542_bib62","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/toxsci\/kfn004","article-title":"Cadmium, vectorial active transport, and MT-3-dependent regulation of cadherin expression in human proximal tubular cells","volume":"102","author":"Bathula","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.jtemb.2024.127542_bib63","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120132","article-title":"Cadherin expression, vectorial active transport, and metallothionein isoform 3 mediated EMT\/MET responses in cultured primary and immortalized human proximal tubule cells","volume":"10","author":"Slusser","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jtemb.2024.127542_bib64","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jtemb.2017.11.011","article-title":"Expression and immunolocalization of metallothioneins MT1, MT2 and MT3 in rat nephron","volume":"46","author":"Saboli\u0107","year":"2018","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.jtemb.2024.127542_bib65","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1093\/jn\/114.9.1683","article-title":"Measurement of plasma metallothionein-I in the assessment of the zinc status of zinc-deficient and stressed rats","volume":"114","author":"Sato","year":"1984","journal-title":"J. Nutr."},{"key":"10.1016\/j.jtemb.2024.127542_bib66","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/jn\/128.4.707","article-title":"Metallothionein expression is increased in monocytes and erythrocytes of young men during zinc supplementation","volume":"128","author":"Sullivan","year":"1998","journal-title":"J. Nutr."},{"key":"10.1016\/j.jtemb.2024.127542_bib67","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1006\/bbrc.1995.1167","article-title":"Differential control of the metal-mediated activation of the human heme oxygenase-1 and metallothionein IIA genes","volume":"207","author":"Takeda","year":"1995","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.jtemb.2024.127542_bib68","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0378-4274(00)00301-5","article-title":"Nitric oxide induces metallothionein (MT) gene expression apparently by displacing zinc bound to MT","volume":"119","author":"Katakai","year":"2001","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.jtemb.2024.127542_bib69","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.etap.2012.08.002","article-title":"Expression of metallothionein isoforms in peripheral blood leukocytes from Thai population residing in cadmium-contaminated areas","volume":"34","author":"Boonprasert","year":"2012","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.jtemb.2024.127542_bib70","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.toxlet.2016.02.016","article-title":"The stress response of human proximal tubule cells to cadmium involves up-regulation of haemoxygenase 1 and metallothionein but not cytochrome P450 enzymes","volume":"249","author":"Boonprasert","year":"2016","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.jtemb.2024.127542_bib71","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2131\/jts.45.539","article-title":"Involvement of metal transporters in the intestinal uptake of cadmium","volume":"45","author":"Ohta","year":"2020","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.jtemb.2024.127542_bib72","doi-asserted-by":"crossref","first-page":"559","DOI":"10.2131\/jts.42.559","article-title":"Concentration-dependent roles of DMT1 and ZIP14 in cadmium absorption in Caco-2 cells","volume":"42","author":"Fujishiro","year":"2017","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.jtemb.2024.127542_bib73","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s10787-017-0309-4","article-title":"Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-\u03baB signaling","volume":"25","author":"Jarosz","year":"2017","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jtemb.2024.127542_bib74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15287394.2012.722185","article-title":"Increased risk of cancer mortality associated with cadmium exposures in older Americans with low zinc intake","volume":"76","author":"Lin","year":"2013","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.jtemb.2024.127542_bib75","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.envres.2014.06.013","article-title":"Low serum zinc is associated with elevated risk of cadmium nephrotoxicity","volume":"134","author":"Lin","year":"2014","journal-title":"Environ. Res."},{"key":"10.1016\/j.jtemb.2024.127542_bib76","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1465-9921-11-53","article-title":"Cigarette smoking, cadmium exposure, and zinc intake on obstructive lung disorder","volume":"11","author":"Lin","year":"2010","journal-title":"Respir. Res."},{"key":"10.1016\/j.jtemb.2024.127542_bib77","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.taap.2009.03.026","article-title":"Metallothionein protection of cadmium toxicity","volume":"238","author":"Klaassen","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jtemb.2024.127542_bib78","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s12011-017-1119-7","article-title":"Zinc metabolism and metallothioneins","volume":"183","author":"Baltaci","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jtemb.2024.127542_bib79","doi-asserted-by":"crossref","DOI":"10.1155\/2009\/101659","article-title":"Metallothionein as an anti-inflammatory mediator","author":"Inoue","year":"2009","journal-title":"Mediat. Inflamm. 2009"},{"key":"10.1016\/j.jtemb.2024.127542_bib80","doi-asserted-by":"crossref","first-page":"22413","DOI":"10.1074\/jbc.M114.548677","article-title":"Heavy metal-induced metallothionein expression is regulated by specific protein phosphatase 2A complexes","volume":"289","author":"Chen","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jtemb.2024.127542_bib81","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3109\/10715761003692511","article-title":"Protective effect of metallothionein on oxidative stress-induced DNA damage","volume":"44","author":"Chiaverini","year":"2010","journal-title":"Free Radic. Res"},{"key":"10.1016\/j.jtemb.2024.127542_bib82","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1006\/taap.1997.8334","article-title":"Cadmium-induced apoptosis in mouse liver","volume":"149","author":"Habeebu","year":"1998","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.jtemb.2024.127542_bib83","doi-asserted-by":"crossref","first-page":"13992","DOI":"10.1021\/acs.est.9b05131","article-title":"Inhibition of mitochondrial fatty acid oxidation contributes to development of nonalcoholic fatty liver disease induced by environmental cadmium exposure","volume":"53","author":"He","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jtemb.2024.127542_bib84","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/modpathol.2013.62","article-title":"The liver in itai-itai disease (chronic cadmium poisoning): pathological features and metallothionein expression","volume":"26","author":"Baba","year":"2013","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.jtemb.2024.127542_bib85","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph13060582","article-title":"Serum concentrations of selected heavy metals in patients with alcoholic liver cirrhosis from the lublin region in Eastern Poland","volume":"13","author":"Prystupa","year":"2016","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.jtemb.2024.127542_bib86","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s12011-014-0105-6","article-title":"Oxidative stress and Ca 2+ signals involved on cadmium-induced apoptosis in rat hepatocyte","volume":"161","author":"Wang","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jtemb.2024.127542_bib87","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jtemb.2009.03.010","article-title":"Induction of necrosis in cadmium-induced hepatic oxidative stress and its prevention by the prophylactic properties of taurine","volume":"23","author":"Sinha","year":"2009","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.jtemb.2024.127542_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114123","article-title":"Cadmium induces liver dysfunction and ferroptosis through the endoplasmic stress-ferritinophagy axis","volume":"245","author":"He","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jtemb.2024.127542_bib89","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1074\/jbc.M111.308296","article-title":"Lipocalin-2 (24p3\/neutrophil gelatinase-associated lipocalin (NGAL)) receptor is expressed in distal nephron and mediates protein endocytosis","volume":"287","author":"Langelueddecke","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jtemb.2024.127542_bib90","doi-asserted-by":"crossref","first-page":"7262","DOI":"10.3390\/ijms22147262","article-title":"Increased endocytosis of cadmium-metallothionein through the 24p3 receptor in an in vivo model with reduced proximal tubular activity","volume":"22","author":"Zavala-Guevara","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jtemb.2024.127542_bib91","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s10534-019-00183-7","article-title":"Iron uptake by ZIP8 and ZIP14 in human proximal tubular epithelial cells","volume":"32","author":"van Raaij","year":"2019","journal-title":"Biometals"},{"key":"10.1016\/j.jtemb.2024.127542_bib92","doi-asserted-by":"crossref","first-page":"7025","DOI":"10.1074\/jbc.RA118.006390","article-title":"Proximal tubule transferrin uptake is modulated by cellular iron and mediated by apical membrane megalin-cubilin complex and transferrin receptor 1","volume":"294","author":"Smith","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jtemb.2024.127542_bib93","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20102379","article-title":"Cadmium complexed with \u03b22-microglubulin, albumin and lipocalin-2 rather than metallothionein cause megalin:cubilin dependent toxicity of the renal proximal tubule","volume":"20","author":"Fels","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jtemb.2024.127542_bib94","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1136\/oem.52.12.818","article-title":"Decreased glomerular filtration rate in solderers exposed to cadmium","volume":"52","author":"J\u00e4rup","year":"1995","journal-title":"Occup. Environ. Med"},{"key":"10.1016\/j.jtemb.2024.127542_bib95","doi-asserted-by":"crossref","first-page":"766","DOI":"10.2215\/CJN.06780619","article-title":"Environment-wide association study of CKD","volume":"15","author":"Lee","year":"2020","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jtemb.2024.127542_bib96","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.kint.2020.08.027","article-title":"Plasma cadmium is associated with increased risk of long-term kidney graft failure","volume":"99","author":"Sotomayor","year":"2021","journal-title":"Kidney Int"},{"key":"10.1016\/j.jtemb.2024.127542_bib97","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24109050","article-title":"Chronic kidney disease induced by cadmium and diabetes: a quantitative case-control study","volume":"24","author":"Yimthiang","year":"2023","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.jtemb.2024.127542_bib98","doi-asserted-by":"crossref","first-page":"12337","DOI":"10.3390\/ijerph182312337","article-title":"The risk factors of blood cadmium elevation in chronic kidney disease","volume":"18","author":"Tsai","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.jtemb.2024.127542_bib99","doi-asserted-by":"crossref","DOI":"10.3390\/toxics11090755","article-title":"Estimation of the cadmium nephrotoxicity threshold from loss of glomerular filtration rate and albuminuria","author":"Satarug","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.jtemb.2024.127542_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.crtox.2023.100140","article-title":"The pathogenesis of albuminuria in cadmium nephropathy","volume":"6","author":"Satarug","year":"2024","journal-title":"Curr. Res Toxicol."},{"key":"10.1016\/j.jtemb.2024.127542_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116403","article-title":"Cadmium and molybdenum co-induce pyroptosis via ROS\/PTEN\/PI3K\/AKT axis in duck renal tubular epithelial cells","volume":"272","author":"Zhang","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jtemb.2024.127542_bib102","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114149","article-title":"Role of poly (ADP-ribose) polymerase-1 in cadmium-induced cellular DNA damage and cell cycle arrest in rat renal tubular epithelial cell line NRK-52E","volume":"261","author":"Luo","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jtemb.2024.127542_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.113601","article-title":"Hyperoside attenuates Cd-induced kidney injury via inhibiting NLRP3 inflammasome activation and ROS\/MAPK\/NF-\u03baB signaling pathway in vivo and in vitro","volume":"172","author":"Li","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jtemb.2024.127542_bib104","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.fct.2016.07.030","article-title":"Epigallocatechin-3-gallate attenuates cadmium-induced chronic renal injury and fibrosis","volume":"96","author":"Chen","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jtemb.2024.127542_bib105","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.toxlet.2010.05.007","article-title":"Chronic cadmium exposure induces transcriptional activation of the Wnt pathway and upregulation of epithelial-to-mesenchymal transition markers in mouse kidney","volume":"198","author":"Chakraborty","year":"2010","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.jtemb.2024.127542_bib106","doi-asserted-by":"crossref","first-page":"177","DOI":"10.21037\/atm.2019.03.66","article-title":"Effects of sub-chronic, low-dose cadmium exposure on kidney damage and potential mechanisms","volume":"7","author":"Liu","year":"2019","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.jtemb.2024.127542_bib107","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/tox.22884","article-title":"Effect of cadmium on osteoclast differentiation during bone injury in female mice","volume":"35","author":"He","year":"2020","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.jtemb.2024.127542_bib108","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111152","article-title":"HO-1 activation contributes to cadmium-induced ferroptosis in renal tubular epithelial cells via increasing the labile iron pool and promoting mitochondrial ROS generation","volume":"399","author":"Lv","year":"2024","journal-title":"Chem. -Biol. Interact."},{"key":"10.1016\/j.jtemb.2024.127542_bib109","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/taap.1993.1225","article-title":"Nephrotoxicity in rats following liver transplantation from cadmium-exposed rats","volume":"123","author":"Chan","year":"1993","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jtemb.2024.127542_bib110","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1007\/s10157-020-02018-z","article-title":"Non-invasive fibrosis assessments of non-alcoholic fatty liver disease associated with low estimated glomerular filtration rate among CKD patients: the Fukuoka Kidney disease Registry Study","volume":"25","author":"Hara","year":"2021","journal-title":"Clin. Exp. Nephrol."},{"key":"10.1016\/j.jtemb.2024.127542_bib111","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-22636-9","article-title":"Prediction of decreased estimated glomerular filtration rate using liver fibrosis markers: a renal biopsy-based study","volume":"12","author":"Mima","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jtemb.2024.127542_bib112","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/s11605-013-2210-9","article-title":"Cadmium exposure and liver disease among US adults","volume":"17","author":"Hyder","year":"2013","journal-title":"J. Gastrointest. Surg."},{"key":"10.1016\/j.jtemb.2024.127542_bib113","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3961\/jpmph.21.435","article-title":"Association between cadmium exposure and liver function in adults in the United States: a cross-sectional study","volume":"54","author":"Hong","year":"2021","journal-title":"J. Prev. Med. Public Health"},{"key":"10.1016\/j.jtemb.2024.127542_bib114","doi-asserted-by":"crossref","first-page":"39768","DOI":"10.1007\/s11356-022-18950-4","article-title":"Association between urinary cadmium concentrations and liver function in adolescents","volume":"29","author":"Xu","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.jtemb.2024.127542_bib115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12940-016-0113-4","article-title":"Elevated blood lead and cadmium levels associated with chronic infections among non-smokers in a cross-sectional analysis of NHANES data","volume":"15","author":"Krueger","year":"2016","journal-title":"Environ. Health"},{"key":"10.1016\/j.jtemb.2024.127542_bib116","article-title":"Environmental exposures are important risk factors for advanced liver fibrosis in African American adults","volume":"5","author":"Ma","year":"2023","journal-title":"JHEP Rep."},{"key":"10.1016\/j.jtemb.2024.127542_bib117","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0288190","article-title":"Exposure to low levels of heavy metals and chronic kidney disease in the US population: a cross sectional study","volume":"19","author":"Akinleye","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.jtemb.2024.127542_bib118","doi-asserted-by":"crossref","first-page":"6783","DOI":"10.3390\/ijerph18136783","article-title":"Association between Pb, Cd, and Hg exposure and liver injury among Korean adults","volume":"18","author":"Kim","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.jtemb.2024.127542_bib119","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1136\/oemed-2012-101063","article-title":"Effects of environmental cadmium exposure on liver function in adults","volume":"70","author":"Kang","year":"2013","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.jtemb.2024.127542_bib120","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128947","article-title":"Association between environmental exposure to cadmium and risk of suspected non-alcoholic fatty liver disease","volume":"266","author":"Park","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.jtemb.2024.127542_bib121","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0299507","article-title":"Increased risk of chronic kidney disease and mortality in a cohort of people diagnosed with metabolic dysfunction associated steatotic liver disease with hepatic fibrosis","volume":"19","author":"Gurun","year":"2024","journal-title":"PLoS One"}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X24001627?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X24001627?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T21:40:31Z","timestamp":1739914831000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X24001627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":121,"alternative-id":["S0946672X24001627"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2024.127542","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The overlooked impact of cadmium on the progression of chronic hepatitis and the onset of renal failure in advanced cirrhosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2024.127542","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"127542"}}