{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:21:29Z","timestamp":1791321689675,"version":"4.3.1"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["202902\/Z\/16\/Z"],"award-info":[{"award-number":["202902\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.jtemb.2025.127699","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T15:24:41Z","timestamp":1752679481000},"page":"127699","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Biometal concentrations, distribution and re-distribution in the thymus of healthy mice and mice with inflammatory arthritis"],"prefix":"10.1016","volume":"91","author":[{"given":"Theoharris","family":"Frangos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Morrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1458-8231","authenticated-orcid":false,"given":"Wolfgang","family":"Maret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtemb.2025.127699_bib1","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.3389\/fimmu.2019.03099","article-title":"Thymic epithelial cells contribute to thymopoiesis and T cell development","volume":"10","author":"Wang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtemb.2025.127699_bib2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/nyas.13560","article-title":"Pathophysiological mechanisms of autoimmunity","volume":"1413","author":"Sudres","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jtemb.2025.127699_bib3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00281-021-00842-3","article-title":"Thymus and autoimmunity","volume":"43","author":"Marx","year":"2021","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.jtemb.2025.127699_bib4","doi-asserted-by":"crossref","first-page":"14096","DOI":"10.1038\/s41598-017-14375-z","article-title":"Association between AIRE gene polymorphism and rheumatoid arthritis: a systematic review and meta- analysis of case-control studies","volume":"7","author":"B\u00e9rczi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jtemb.2025.127699_bib5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/nyas.13529","article-title":"AIRE: a missing link to explain female susceptibility to autoimmune diseases","volume":"1412","author":"Berrih-Aknin","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jtemb.2025.127699_bib6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3390\/nu13010053","article-title":"Zinc and cadmium in the aetiology and pathogenesis of osteoarthritis and rheumatoid arthritis","volume":"13","author":"Frangos","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jtemb.2025.127699_bib7","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1146\/annurev-nutr-122019-120635","article-title":"Dietary and physiological effects of zinc on the immune system","volume":"41","author":"Wessels","year":"2021","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.jtemb.2025.127699_bib8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1146\/annurev.nutr.24.012003.132454","article-title":"Reprogramming of the immune system during zinc deficiency","volume":"24","author":"Fraker","year":"2004","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.jtemb.2025.127699_bib9","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/clin.1993.1016","article-title":"Restoration of the thymus in aging mice by in vivo zinc supplementation","volume":"66","author":"Dardenne","year":"1993","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.jtemb.2025.127699_bib10","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.autrev.2004.03.004","article-title":"Inflamm-aging: autoimmunity, and the immune-risk phenotype","volume":"3","author":"Boren","year":"2004","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jtemb.2025.127699_bib11","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/0192-0561(95)00059-B","article-title":"Reversibility of the thymic involution and of age-related peripheral immune dysfunctions by zinc supplementation in old mice","volume":"17","author":"Mocchegiani","year":"1995","journal-title":"Int. J. Immunopharmacol."},{"key":"10.1016\/j.jtemb.2025.127699_bib12","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/S0753-3322(99)80024-9","article-title":"Effect of dietary supplementation with zinc sulphate on the aging process: a study using high field intensity MRI and chemical shift imaging","volume":"52","author":"Sbarbati","year":"1998","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.jtemb.2025.127699_bib13","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.3389\/fimmu.2019.01299","article-title":"Ikaros zinc finger transcription factors: Regulators of cytokine signaling pathways and CD4+ T helper cell differentiation","volume":"10","author":"Powell","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtemb.2025.127699_bib14","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1136\/ard-2023-224479","article-title":"New biologic (Ab-IPL-IL-17) for IL-17-mediated diseases: identification of the bioactive sequence (nIL-17) for IL-17A\/F function","volume":"82","author":"Saviano","year":"2023","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jtemb.2025.127699_bib15","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/846348","article-title":"The Interplay between zinc, vitamin D, and IL-17 in patients with chronic hepatitis C liver disease","volume":"2015","author":"Reda","year":"2015","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.jtemb.2025.127699_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.687367","article-title":"Zap70 Regulates TCR-mediated Zip6 activation at the immunological synapse","volume":"12","author":"Kim","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtemb.2025.127699_bib17","doi-asserted-by":"crossref","first-page":"5607","DOI":"10.1128\/MCB.25.13.5607-5615.2005","article-title":"Generation and characterization of mice lacking the zinc uptake transporter ZIP3","volume":"25","author":"Dufner-Beattie","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jtemb.2025.127699_bib18","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s12276-021-00591-1","article-title":"ZIP8 exacerbates collagen-induced arthritis by increasing pathogenic T cell responses","volume":"53","author":"Kang","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jtemb.2025.127699_bib19","doi-asserted-by":"crossref","DOI":"10.1021\/acs.chemrev.1c00371","article-title":"The bioinorganic chemistry of mammalian metallothioneins","volume":"121","author":"Kr\u0119\u017cel","year":"2021","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jtemb.2025.127699_bib20","first-page":"348","article-title":"Functions of metallothionein generating interleukin-10-producing regulatory CD4+ T cells potentiate suppression of collagen-induced arthritis","volume":"17","author":"Huh","year":"2007","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.jtemb.2025.127699_bib21","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1002\/eji.201747151","article-title":"Metallothionein-1 suppresses rheumatoid arthritis pathogenesis by shifting the Th17\/Treg balance","volume":"48","author":"Sun","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jtemb.2025.127699_bib22","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1139\/o85-013","article-title":"Thymus metallothionein: regulation of zinc-thionein in the aging mouse","volume":"63","author":"Olafson","year":"1985","journal-title":"Can. J. Biochem. Cell Biol."},{"key":"10.1016\/j.jtemb.2025.127699_bib23","doi-asserted-by":"crossref","DOI":"10.1172\/JCI65624","article-title":"Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium","volume":"123","author":"Van Hauwermeiren","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jtemb.2025.127699_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/j.1460-2075.1991.tb04978.x","article-title":"Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis","volume":"10","author":"Keffer","year":"1991","journal-title":"EMBO J."},{"key":"10.1016\/j.jtemb.2025.127699_bib25","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S1074-7613(00)80038-2","article-title":"Impaired on\/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies","volume":"10","author":"Kontoyiannis","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.jtemb.2025.127699_bib26","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/BOR.0000000000000251","article-title":"The thymus and rheumatology: should we care?","volume":"28","author":"Cosway","year":"2016","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.jtemb.2025.127699_bib27","doi-asserted-by":"crossref","DOI":"10.1007\/s00216-016-0124-6","article-title":"A comparison of sample preparation strategies for biological tissues and subsequent trace element analysis using LA-ICP-MS","volume":"409","author":"Bonta","year":"2017","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jtemb.2025.127699_bib28","doi-asserted-by":"crossref","DOI":"10.1021\/acs.chemrev.0c01219","article-title":"Laser ablation\u2013inductively coupled plasma\u2013mass spectrometry imaging in biology","volume":"121","author":"Doble","year":"2021","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jtemb.2025.127699_bib29","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00216-021-03357-w","article-title":"Micro-droplet-based calibration for quantitative elemental bioimaging by LA-ICPMS","volume":"414","author":"Schweikert","year":"2022","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jtemb.2025.127699_bib30","article-title":"The copper\/zinc ratio correlates with markers of disease activity in patients with inflammatory bowel disease","volume":"2","author":"Schneider","year":"2020","journal-title":"Crohns Colitis 360."},{"key":"10.1016\/j.jtemb.2025.127699_bib31","series-title":"The elemental composition of human tissues and body fluids. A compilation of values","author":"Iyengar","year":"1978"},{"key":"10.1016\/j.jtemb.2025.127699_bib32","doi-asserted-by":"crossref","DOI":"10.1093\/rheumatology\/keab164","article-title":"Thymus variants on imaging in patients with rheumatoid arthritis\u2014clinical and immunological significance","volume":"60","author":"Murata","year":"2021","journal-title":"Rheumatology"},{"key":"10.1016\/j.jtemb.2025.127699_bib33","first-page":"5","article-title":"Mediastinal mass in a patient with rheumatoid arthritis: lymphoid cystic thymic hyperplasia","author":"Oral","year":"2021","journal-title":"Rheuma Adv. Pr."},{"key":"10.1016\/j.jtemb.2025.127699_bib34","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jbspin.2012.01.016","article-title":"Incomplete thymic involution in systemic sclerosis and rheumatoid arthritis","volume":"80","author":"Meunier","year":"2013","journal-title":"Jt. Bone Spine"},{"key":"10.1016\/j.jtemb.2025.127699_bib35","article-title":"Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA","volume":"275","author":"Lai","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jtemb.2025.127699_bib36","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.celrep.2013.01.009","article-title":"ZIP8 regulates host defense through zinc-mediated inhibition of NF-\u03baB","volume":"3","author":"Liu","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.jtemb.2025.127699_bib37","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s10534-013-9613-7","article-title":"Inhibitory zinc sites in enzymes","volume":"26","author":"Maret","year":"2013","journal-title":"Biometals"},{"key":"10.1016\/j.jtemb.2025.127699_bib38","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.C111.320796","article-title":"Picomolar concentrations of free zinc(II) ions regulate receptor protein-tyrosine phosphatase \u03b2 activity","volume":"287","author":"Wilson","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jtemb.2025.127699_bib39","doi-asserted-by":"crossref","first-page":"785","DOI":"10.3390\/biom12060785","article-title":"Zinc in regulating protein kinases and phosphatases in neurodegenerative diseases","volume":"12","author":"Zhang","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.jtemb.2025.127699_bib40","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1189\/jlb.1208759","article-title":"Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-\u03b3 expression in activated human T cells","volume":"86","author":"Aydemir","year":"2009","journal-title":"J. Leuk. Biol."},{"key":"10.1016\/j.jtemb.2025.127699_bib41","article-title":"Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans","volume":"272","author":"Beck","year":"1997","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.jtemb.2025.127699_bib42","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1079\/BJN19860010","article-title":"T-lymphocyte subsets and interleukin-2 production in zinc-deficient rats","volume":"55","author":"Dowd","year":"1986","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.jtemb.2025.127699_bib43","first-page":"68","article-title":"Zinc deficiency: changes in cytokine production and T-cell subpopulations in patients with head and neck cancer and in noncancer subjects","volume":"109","author":"Prasad","year":"1997","journal-title":"Proc. Assoc. Am. Physicians"},{"key":"10.1016\/j.jtemb.2025.127699_bib44","first-page":"312","article-title":"Copper levels in patients with rheumatoid arthritis","volume":"20","author":"Strecker","year":"2013","journal-title":"Ann. Agric. Environ. Med."},{"key":"10.1016\/j.jtemb.2025.127699_bib45","first-page":"BC09","article-title":"Serum copper as a marker of disease activity in rheumatoid arthritis","volume":"9","author":"Chakraborty","year":"2015","journal-title":"J. Clin. Diagn. Res."},{"key":"10.1016\/j.jtemb.2025.127699_bib46","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s12011-022-03148-z","article-title":"Circulating level of blood iron and copper associated with inflammation and disease activity of rheumatoid arthritis","volume":"201","author":"Wang","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jtemb.2025.127699_bib47","article-title":"The association of trace elements with arthritis in US adults: NHANES 2013-2016","volume":"76","author":"Guan","year":"2022","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.jtemb.2025.127699_bib48","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1093\/jn\/113.8.1583","article-title":"Chronic dietary copper deficiency alters biochemical and morphological properties of mouse lymphoid tissues","volume":"113","author":"Prohaska","year":"1983","journal-title":"J. Nutr."},{"key":"10.1016\/j.jtemb.2025.127699_bib49","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.jfma.2015.10.001","article-title":"Increased inflammation in rheumatoid arthritis patients living where farm soils contain high levels of copper","volume":"115","author":"Yang","year":"2016","journal-title":"J. Formos. Med. Assoc."},{"key":"10.1016\/j.jtemb.2025.127699_bib50","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jtemb.2009.10.002","article-title":"Iron absorption and distribution in TNF\u0394ARE\/+ mice, a model of chronic inflammation","volume":"24","author":"Sch\u0171mann","year":"2010","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.jtemb.2025.127699_bib51","doi-asserted-by":"crossref","DOI":"10.1093\/jn\/121.9.1418","article-title":"Lymphocyte subpopulations in the thymus, lymph nodes and spleen of iron-deficient and rehabilitated mice","volume":"121","author":"Dhur","year":"1991","journal-title":"J. Nutr."},{"key":"10.1016\/j.jtemb.2025.127699_bib52","first-page":"1","article-title":"Metallomics: The science of biometals and biometalloids, in: Metallomics","volume":"1055","author":"Maret","year":"2018"},{"key":"10.1016\/j.jtemb.2025.127699_bib53","article-title":"Analytical approaches for the characterization of nickel proteome","volume":"9","author":"Jim\u00e9nez-Lamanar","year":"2017","journal-title":"Metallomics"},{"key":"10.1016\/j.jtemb.2025.127699_bib54","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/advances\/nmaa154","article-title":"Nickel","volume":"12","author":"Nielsen","year":"2021","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.jtemb.2025.127699_bib55","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.tox.2017.10.006","article-title":"Molecular mechanisms of nickel induced neurotoxicity and chemoprevention","volume":"392","author":"Song","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.jtemb.2025.127699_bib56","doi-asserted-by":"crossref","first-page":"679","DOI":"10.3390\/ijerph17030679","article-title":"Nickel: Human Health and Environmental Toxicology","volume":"17","author":"Genchi","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.jtemb.2025.127699_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111006","article-title":"Immunotoxicity of nickel: Pathological and toxicological effects","volume":"203","author":"Guo","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jtemb.2025.127699_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jtemb.2012.01.002","article-title":"Nickel species: analysis and toxic effects","volume":"26","author":"Schauml\u00f6ffel","year":"2012","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.jtemb.2025.127699_bib59","first-page":"291","article-title":"Acute thymic involution and increased lipoperoxides in thymus of nickel chloride-treated rats","volume":"55","author":"Knight","year":"1987","journal-title":"Res. Commun. Chem. Pathol. Pharm."},{"key":"10.1016\/j.jtemb.2025.127699_bib60","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0021-9975(89)90062-5","article-title":"Histochemistry of the acutely involved thymus in nickel chloride-treated rats","volume":"101","author":"Mili\u0107evi\u0107","year":"1989","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.jtemb.2025.127699_bib61","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0013-9351(84)90039-2","article-title":"Immunologic effects of nickel: I. Suppression of cellular and humoral immunity","volume":"33","author":"Smialowicz","year":"1984","journal-title":"Environ. Res."},{"key":"10.1016\/j.jtemb.2025.127699_bib62","doi-asserted-by":"crossref","DOI":"10.4236\/health.2014.621326","article-title":"Effects of nickel chloride on histopathological lesions and oxidative damage in the thymus","volume":"6","author":"Tang","year":"2014","journal-title":"Health"},{"key":"10.1016\/j.jtemb.2025.127699_bib63","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0378-4274(97)00051-9","article-title":"Effect of dietary iron-deficiency on the disposition of nickel in rats","volume":"92","author":"Tallkvist","year":"1997","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.jtemb.2025.127699_bib64","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1177\/039463201202500223","article-title":"Effects of oral hyposensitization therapy with nickel on haemoglobin and haematocrit values in sensitized patients","volume":"25","author":"Tammaro","year":"2012","journal-title":"Int. J. Immunopathol. Pharm."}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X25001129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X25001129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:09:08Z","timestamp":1772755748000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X25001129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":64,"alternative-id":["S0946672X25001129"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2025.127699","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biometal concentrations, distribution and re-distribution in the thymus of healthy mice and mice with inflammatory arthritis","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2025.127699","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"127699"}}