{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T09:58:47Z","timestamp":1793699927715,"version":"4.5.1"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021856","name":"Ministero dell&apos;Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009104","name":"University of Modena and Reggio Emilia","doi-asserted-by":"publisher","award":["2022MHMRPR"],"award-info":[{"award-number":["2022MHMRPR"]}],"id":[{"id":"10.13039\/100009104","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009104","name":"University of Modena and Reggio Emilia","doi-asserted-by":"publisher","award":["UNIMORE FAR 2023"],"award-info":[{"award-number":["UNIMORE FAR 2023"]}],"id":[{"id":"10.13039\/100009104","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jtemb.2025.127765","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T03:53:53Z","timestamp":1758772433000},"page":"127765","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Biomarkers of total selenium and selenium species in paired serum and cerebrospinal fluid samples"],"prefix":"10.1016","volume":"92","author":[{"given":"Teresa","family":"Urbano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Filippini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara R.","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren A.","family":"Wise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Zamboni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Chiari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Vinceti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Tondelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Marti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella","family":"Malavolti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0551-2473","authenticated-orcid":false,"given":"Marco","family":"Vinceti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Michalke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jtemb.2025.127765_bib1","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s40572-018-0213-0","article-title":"Environmental selenium and human health: an update","volume":"5","author":"Vinceti","year":"2018","journal-title":"Curr. Environ. Health Rep."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127765_bib2","doi-asserted-by":"crossref","DOI":"10.2903\/j.efsa.2026.9858","article-title":"Scientific opinion on the tolerable upper intake level for selenium","volume":"21","author":"EFSA Panel on Nutrition Novel Foods Food Allergens","year":"2023","journal-title":"EFSA J."},{"issue":"5","key":"10.1016\/j.jtemb.2025.127765_bib3","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.3892\/mmr.2017.6377","article-title":"Health risk assessment of environmental selenium: emerging evidence and challenges","volume":"15","author":"Vinceti","year":"2017","journal-title":"Mol. Med Rep."},{"key":"10.1016\/j.jtemb.2025.127765_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.113092","article-title":"Safety of selenium exposure and limitations of selenoprotein maximization: molecular and epidemiologic perspectives","volume":"211","author":"Vinceti","year":"2022","journal-title":"Environ. Res"},{"key":"10.1016\/j.jtemb.2025.127765_bib5","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2164-12-26","article-title":"Selenium toxicity but not deficient or super-nutritional selenium status vastly alters the transcriptome in rodents","volume":"12","author":"Raines","year":"2011","journal-title":"BMC Genom."},{"issue":"2","key":"10.1016\/j.jtemb.2025.127765_bib6","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3945\/an.110.000240","article-title":"Selenium regulation of the selenoprotein and nonselenoprotein transcriptomes in rodents","volume":"2","author":"Sunde","year":"2011","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.jtemb.2025.127765_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.111210","article-title":"A systematic review and dose-response meta-analysis of exposure to environmental selenium and the risk of type 2 diabetes in nonexperimental studies","volume":"197","author":"Vinceti","year":"2021","journal-title":"Environ. Res"},{"key":"10.1016\/j.jtemb.2025.127765_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuro.2025.06.006","article-title":"Iron species in cerebrospinal fluid and dementia risk in subjects with mild cognitive impairment: a cohort study","volume":"110","author":"Urbano","year":"2025","journal-title":"Neurotoxicology"},{"issue":"1-2","key":"10.1016\/j.jtemb.2025.127765_bib9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.aca.2010.09.054","article-title":"Review on metal speciation analysis in cerebrospinal fluid-current methods and results: a review","volume":"682","author":"Michalke","year":"2010","journal-title":"Anal. Chim. Acta"},{"issue":"1","key":"10.1016\/j.jtemb.2025.127765_bib10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s42000-019-00125-5","article-title":"Selenium intake, status, and health: a complex relationship","volume":"19","author":"Rayman","year":"2020","journal-title":"Horm. (Athens)"},{"issue":"4","key":"10.1016\/j.jtemb.2025.127765_bib11","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1515\/REVEH.2001.16.4.233","article-title":"Adverse health effects of selenium in humans","volume":"16","author":"Vinceti","year":"2001","journal-title":"Rev. Environ. Health"},{"key":"10.1016\/j.jtemb.2025.127765_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2025.127693","article-title":"Selenium exposure and risk of skin cancer: a systematic review and dose-response meta-analysis of epidemiologic evidence","volume":"90","author":"Filippini","year":"2025","journal-title":"J. Trace Elem. Med Biol."},{"issue":"5","key":"10.1016\/j.jtemb.2025.127765_bib13","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1093\/ajcn\/37.5.872","article-title":"Endemic selenium intoxication of humans in China","volume":"37","author":"Yang","year":"1983","journal-title":"Am. J. Clin. Nutr."},{"issue":"4","key":"10.1016\/j.jtemb.2025.127765_bib14","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.3390\/nu5041024","article-title":"Selenium toxicity from a misformulated dietary supplement, adverse health effects, and the temporal response in the nail biologic monitor","volume":"5","author":"Morris","year":"2013","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.jtemb.2025.127765_bib15","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.toxlet.2013.11.016","article-title":"Selenium neurotoxicity in humans: bridging laboratory and epidemiologic studies","volume":"230","author":"Vinceti","year":"2014","journal-title":"Toxicol. Lett."},{"issue":"10","key":"10.1016\/j.jtemb.2025.127765_bib16","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1001\/jamaneurol.2018.1669","article-title":"Selenium toxicity associated with reversible leukoencephalopathy and cortical blindness","volume":"75","author":"Rae","year":"2018","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.jtemb.2025.127765_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108742","article-title":"Amyotrophic lateral sclerosis incidence following exposure to inorganic selenium in drinking water: a long-term follow-up","volume":"179","author":"Vinceti","year":"2019","journal-title":"Environ. Res"},{"key":"10.1016\/j.jtemb.2025.127765_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.144329","article-title":"A comprehensive review on the neuropathophysiology of selenium","volume":"767","author":"Naderi","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"11","key":"10.1016\/j.jtemb.2025.127765_bib19","doi-asserted-by":"crossref","DOI":"10.1289\/EHP11445","article-title":"Selenium species in cerebrospinal fluid and hippocampal volume among individuals with mild cognitive impairment","volume":"130","author":"Vinceti","year":"2022","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127765_bib20","doi-asserted-by":"crossref","first-page":"8792","DOI":"10.1038\/s41598-023-36084-6","article-title":"Selenoprotein p concentrations and risk of progression from mild cognitive impairment to dementia","volume":"13","author":"Vinceti","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jtemb.2025.127765_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2025.120913","article-title":"Urinary selenium, cranial MRI, and cognitive function in American Indians: the strong heart study","volume":"269","author":"Williams","year":"2025","journal-title":"Environ. Res"},{"key":"10.1016\/j.jtemb.2025.127765_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2021.108831","article-title":"Differential protein expression due to se deficiency and se toxicity in rat liver","volume":"98","author":"Cardoso","year":"2021","journal-title":"J. Nutr. Biochem"},{"key":"10.1016\/j.jtemb.2025.127765_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.630016","article-title":"Selenium at the neural barriers: a review","volume":"15","author":"Solovyev","year":"2021","journal-title":"Front Neurosci."},{"issue":"4","key":"10.1016\/j.jtemb.2025.127765_bib24","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jtemb.2009.06.001","article-title":"A method for low volume and low se concentration samples and application to paired cerebrospinal fluid and serum samples","volume":"23","author":"Michalke","year":"2009","journal-title":"J. Trace Elem. Med Biol."},{"issue":"6","key":"10.1016\/j.jtemb.2025.127765_bib25","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1007\/s00216-012-6294-y","article-title":"Selenium speciation in paired serum and cerebrospinal fluid samples","volume":"405","author":"Solovyev","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127765_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1471-4159.2003.01854.x","article-title":"Selenium and selenoproteins in the brain and brain diseases","volume":"86","author":"Chen","year":"2003","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.jtemb.2025.127765_bib27","doi-asserted-by":"crossref","DOI":"10.1136\/jnnp-2024-334339","article-title":"Attendees of the workshop on guidance for clinical care of people living with a pathogenic variant At-Risk for ALS and FTD, guidance for clinical management of pathogenic variant carriers at elevated genetic risk for ALS\/FTD","volume":"96","author":"Benatar","year":"2025","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jtemb.2025.127765_bib28","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.freeradbiomed.2022.07.022","article-title":"Selenoproteins in brain development and function","volume":"190","author":"Schweizer","year":"2022","journal-title":"Free Radic. Biol. Med"},{"issue":"2","key":"10.1016\/j.jtemb.2025.127765_bib29","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.abb.2013.02.021","article-title":"Selenium homeostasis and antioxidant selenoproteins in brain: implications for disorders in the central nervous system","volume":"536","author":"Steinbrenner","year":"2013","journal-title":"Arch. Biochem Biophys."},{"issue":"5","key":"10.1016\/j.jtemb.2025.127765_bib30","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1001\/jama.2015.19451","article-title":"Association of seafood consumption, brain Mercury level, and APOE epsilon4 status with brain neuropathology in older adults","volume":"315","author":"Morris","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.jtemb.2025.127765_bib31","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.trac.2017.08.008","article-title":"The importance of speciation analysis in neurodegeneration research","volume":"104","author":"Michalke","year":"2018","journal-title":"Trends Anal. Chem."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127765_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000502357","article-title":"Selenium and other trace elements in the etiology of parkinson's disease: a systematic review and meta-analysis of case-control studies","volume":"54","author":"Adani","year":"2020","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.jtemb.2025.127765_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2025.127692","article-title":"The close relationship between trace elements (Cu, Fe, Zn, Se, Rb, Si, Cr, and V) and alzheimer's disease: research progress and insights","volume":"90","author":"Mao","year":"2025","journal-title":"J. Trace Elem. Med Biol."},{"issue":"6","key":"10.1016\/j.jtemb.2025.127765_bib34","doi-asserted-by":"crossref","first-page":"2025S","DOI":"10.3945\/ajcn.2009.27230F","article-title":"Methods of assessment of selenium status in humans: a systematic review","volume":"89","author":"Ashton","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jtemb.2025.127765_bib35","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neuro.2013.05.016","article-title":"Cerebrospinal fluid of newly diagnosed amyotrophic lateral sclerosis patients exhibits abnormal levels of selenium species including elevated selenite","volume":"38","author":"Vinceti","year":"2013","journal-title":"Neurotoxicology"},{"issue":"1","key":"10.1016\/j.jtemb.2025.127765_bib36","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3233\/JAD-160622","article-title":"A.r. Group, selenium levels in serum, red blood bells, and cerebrospinal fluid of alzheimer's disease patients: a report from The Australian imaging, biomarker & lifestyle flagship study of ageing (AIBL)","volume":"57","author":"Cardoso","year":"2017","journal-title":"J. Alzheimers Dis."},{"issue":"8","key":"10.1016\/j.jtemb.2025.127765_bib37","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.4103\/1673-5374.235239","article-title":"Bioelemental patterns in the cerebrospinal fluid as potential biomarkers for neurodegenerative disorders","volume":"13","author":"Maass","year":"2018","journal-title":"Neural Regen. Res"},{"issue":"3","key":"10.1016\/j.jtemb.2025.127765_bib38","doi-asserted-by":"crossref","first-page":"676","DOI":"10.3390\/nu12030676","article-title":"Functional biomarkers for the selenium status in a human nutritional intervention study","volume":"12","author":"M\u00fcller","year":"2020","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.jtemb.2025.127765_bib39","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1177\/02601060241296004","article-title":"Association between selenium biomarkers and insulin resistance in women with obesity: a case-control study","volume":"31","author":"Soares","year":"2025","journal-title":"Nutr. Health"},{"key":"10.1016\/j.jtemb.2025.127765_bib40","series-title":"Selenium: Its Molecular Biology and Role in Human Health","first-page":"137","article-title":"Selenoproteins: hierarchy, requirements, and biomarkers","author":"Sunde","year":"2011"},{"key":"10.1016\/j.jtemb.2025.127765_bib41","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1007\/s12011-024-04311-4","article-title":"Changes in cerebrospinal fluid concentrations of selenium species induced by tofersen administration in subjects with amyotrophic lateral sclerosis carrying SOD1 gene mutations","volume":"203","author":"Vinceti","year":"2025","journal-title":"Biol. Trace Elem. Res"},{"issue":"12","key":"10.1016\/j.jtemb.2025.127765_bib42","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3390\/toxics12120933","article-title":"Exposure to cadmium and other trace elements among individuals with mild cognitive impairment","volume":"12","author":"Urbano","year":"2024","journal-title":"Toxics"},{"issue":"3","key":"10.1016\/j.jtemb.2025.127765_bib43","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/joim.12190","article-title":"Mild cognitive impairment: a concept in evolution","volume":"275","author":"Petersen","year":"2014","journal-title":"J. Intern Med"},{"issue":"3","key":"10.1016\/j.jtemb.2025.127765_bib44","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S1474-4422(19)30368-0","article-title":"The characterisation of subjective cognitive decline","volume":"19","author":"Jessen","year":"2020","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jtemb.2025.127765_bib45","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1039\/b701206c","article-title":"Determination of selenoprotein p in submicrolitre samples of human plasma using micro-affinity chromatography coupled with low flow ICP-MS","volume":"22","author":"Shigeta","year":"2007","journal-title":"J. Anal. Spectrom."},{"issue":"3","key":"10.1016\/j.jtemb.2025.127765_bib46","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1039\/B712693J","article-title":"Speciation analysis of selenoproteins in human serum by solid-phase extraction and affinity HPLC hyphenated to ICP-quadrupole MS","volume":"23","author":"Jitaru","year":"2008","journal-title":"J. Anal. Spectrom."},{"issue":"11","key":"10.1016\/j.jtemb.2025.127765_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142444","article-title":"Hypothetical outcome plots outperform error bars and violin plots for inferences about reliability of variable ordering","volume":"10","author":"Hullman","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jtemb.2025.127765_bib48","series-title":"Methods of dealing with values below the limit of detection using SAS, US-EPA","author":"Croghan","year":"2003"},{"key":"10.1016\/j.jtemb.2025.127765_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.685517","article-title":"Selenium transport mechanism via selenoprotein P-Its physiological role and related diseases","volume":"8","author":"Saito","year":"2021","journal-title":"Front Nutr."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127765_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3164\/jcbn.19-31","article-title":"Selenoprotein p as an in vivo redox regulator: disorders related to its deficiency and excess","volume":"66","author":"Saito","year":"2020","journal-title":"J. Clin. Biochem Nutr."},{"issue":"17","key":"10.1016\/j.jtemb.2025.127765_bib51","doi-asserted-by":"crossref","first-page":"9865","DOI":"10.3390\/ijms23179865","article-title":"Selenoprotein p concentrations in the cerebrospinal fluid and serum of individuals affected by amyotrophic lateral sclerosis, mild cognitive impairment and alzheimer's dementia","volume":"23","author":"Urbano","year":"2022","journal-title":"Int J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.jtemb.2025.127765_bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140353","article-title":"Regulation of selenocysteine content of human selenoprotein p by dietary selenium and insertion of cysteine in place of selenocysteine","volume":"10","author":"Turanov","year":"2015","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.jtemb.2025.127765_bib53","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1089\/ars.2009.2533","article-title":"Relative abundance of selenoprotein p isoforms in human plasma depends on genotype, se intake, and cancer status","volume":"11","author":"Meplan","year":"2009","journal-title":"Antioxid. Redox Signal"},{"issue":"12","key":"10.1016\/j.jtemb.2025.127765_bib54","doi-asserted-by":"crossref","first-page":"6283","DOI":"10.3390\/ijms22126283","article-title":"Characterization and quantification of selenoprotein P: challenges to mass spectrometry","volume":"22","author":"Lamarche","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.jtemb.2025.127765_bib55","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1146\/annurev.nutr.24.012003.132120","article-title":"Selenoprotein P: an extracellular protein with unique physical characteristics and a role in selenium homeostasis","volume":"25","author":"Burk","year":"2005","journal-title":"Annu Rev. Nutr."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127765_bib56","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1471-4159.2009.06109.x","article-title":"The brain selenoproteome: priorities in the hierarchy and different levels of selenium homeostasis in the brain of selenium-deficient rats","volume":"110","author":"Kuhbacher","year":"2009","journal-title":"J. Neurochem."},{"issue":"4","key":"10.1016\/j.jtemb.2025.127765_bib57","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jtemb.2014.08.009","article-title":"Selenium status in elderly: relation to cognitive decline","volume":"28","author":"Cardoso","year":"2014","journal-title":"J. Trace Elem. Med Biol."},{"key":"10.1016\/j.jtemb.2025.127765_bib58","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jtemb.2019.03.002","article-title":"Selenium and selenium species in the etiology of alzheimer's dementia: the potential for bias of the case-control study design","volume":"53","author":"Vinceti","year":"2019","journal-title":"J. Trace Elem. Med Biol."},{"key":"10.1016\/j.jtemb.2025.127765_bib59","series-title":"Expert consultation on human vitamin and mineral requirements, vitamin and mineral requirements in human nutrition. Second edition","author":"Joint FAO\/WHO","year":"2004"},{"issue":"1","key":"10.1016\/j.jtemb.2025.127765_bib60","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0946-672X(96)80006-X","article-title":"Determination of selenium in the serum of healthy Swiss adults and correlation to dietary intake","volume":"10","author":"Haldimann","year":"1996","journal-title":"J. Trace Elem. Med Biol."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127765_bib61","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13195-017-0323-1","article-title":"A selenium species in cerebrospinal fluid predicts conversion to alzheimer's dementia in persons with mild cognitive impairment","volume":"9","author":"Vinceti","year":"2017","journal-title":"Alzheimers Res Ther."},{"issue":"8","key":"10.1016\/j.jtemb.2025.127765_bib62","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1096\/fj.14-252874","article-title":"Selenoprotein p and apolipoprotein e receptor-2 interact at the blood-brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration","volume":"28","author":"Burk","year":"2014","journal-title":"FASEB J."},{"issue":"7","key":"10.1016\/j.jtemb.2025.127765_bib63","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1021\/acschemneuro.7b00014","article-title":"The APOE epsilon4 allele is associated with lower selenium levels in the brain: implications for alzheimer's disease","volume":"8","author":"R. Cardoso","year":"2017","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.jtemb.2025.127765_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2023.127266","article-title":"Human serum albumin-bound selenium (Se-HSA) in serum and its correlation with other selenium species","volume":"79","author":"Filippini","year":"2023","journal-title":"J. Trace Elem. Med Biol."},{"issue":"13","key":"10.1016\/j.jtemb.2025.127765_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110566","article-title":"Selenoprotein P-mediated reductive stress impairs cold-induced thermogenesis in brown fat","volume":"38","author":"Oo","year":"2022","journal-title":"Cell Rep."},{"issue":"12","key":"10.1016\/j.jtemb.2025.127765_bib66","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.015719","article-title":"Potassium intake and blood pressure: a dose-response meta-analysis of randomized controlled trials","volume":"9","author":"Filippini","year":"2020","journal-title":"J. Am. Heart Assoc."},{"issue":"7","key":"10.1016\/j.jtemb.2025.127765_bib67","first-page":"1899","article-title":"Dose-response relationships in health risk assessment of nutritional and toxicological factors in foods: development and application of novel biostatistical methods","volume":"17","author":"Vinceti","year":"2020","journal-title":"EFSA Support Publ."},{"key":"10.1016\/j.jtemb.2025.127765_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.115239","article-title":"Fluoride exposure and cognitive neurodevelopment: systematic review and dose-response meta-analysis","volume":"221","author":"Veneri","year":"2023","journal-title":"Environ. Res"},{"key":"10.1016\/j.jtemb.2025.127765_bib69","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1291010","article-title":"Gut microbiome predicts selenium supplementation efficiency across different Chinese adult cohorts using hybrid modeling and feature refining","volume":"14","author":"Jiang","year":"2023","journal-title":"Front Microbiol"},{"issue":"5","key":"10.1016\/j.jtemb.2025.127765_bib70","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1001\/jamaneurol.2016.5778","article-title":"Association of antioxidant supplement use and dementia in the prevention of alzheimer's disease by vitamin e and selenium trial (PREADViSE)","volume":"74","author":"Kryscio","year":"2017","journal-title":"JAMA Neurol."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127765_bib71","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s13311-018-0662-z","article-title":"Supranutritional sodium selenate supplementation delivers selenium to the central nervous system: results from a randomized controlled pilot trial in alzheimer's disease","author":"Cardoso","year":"2019","journal-title":"Neurotherapeutics 6"},{"issue":"2","key":"10.1016\/j.jtemb.2025.127765_bib72","first-page":"115","article-title":"Changes in selenoprotein p in substantia nigra and putamen in parkinson's disease","volume":"2","author":"Bellinger","year":"2012","journal-title":"J. Park. Dis."},{"issue":"2","key":"10.1016\/j.jtemb.2025.127765_bib73","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3233\/JAD-141755","article-title":"Increased selenoprotein p in choroid plexus and cerebrospinal fluid in alzheimer's disease brain","volume":"44","author":"Rueli","year":"2015","journal-title":"J. Alzheimers Dis."}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X25001786?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X25001786?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T08:22:27Z","timestamp":1773130947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X25001786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":73,"alternative-id":["S0946672X25001786"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2025.127765","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomarkers of total selenium and selenium species in paired serum and cerebrospinal fluid samples","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2025.127765","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"127765"}}