{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T20:21:37Z","timestamp":1787948497407,"version":"build-2784847793"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010743","name":"Nanjing Forestry University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010743","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["SP\/YO\/2021\/1734"],"award-info":[{"award-number":["SP\/YO\/2021\/1734"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jtemb.2025.127770","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T06:11:50Z","timestamp":1759212710000},"page":"127770","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Ferroptosis-targeting compounds modulate cancer cell cytotoxicity and migration: Insights from in vitro and in silico analyses"],"prefix":"10.1016","volume":"92","author":[{"given":"Kalimuthu","family":"Kalishwaralal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prajakta","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniket","family":"Mali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jtemb.2025.127770_bib1","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/jcb.30196","article-title":"The emerging role of selenium metabolic pathways in cancer: new therapeutic targets for cancer","volume":"123","author":"Kalimuthu","year":"2022","journal-title":"J. Cell. Biochem."},{"issue":"4","key":"10.1016\/j.jtemb.2025.127770_bib2","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"8","key":"10.1016\/j.jtemb.2025.127770_bib3","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.3390\/biom12081049","article-title":"Selenocysteine machinery primarily supports TXNRD1 and GPX4 functions and together they are functionally linked with SCD and PRDX6","volume":"12","author":"Santesmasses","year":"2022","journal-title":"Biomolecules"},{"issue":"23","key":"10.1016\/j.jtemb.2025.127770_bib4","doi-asserted-by":"crossref","first-page":"4645","DOI":"10.1016\/j.molcel.2024.10.027","article-title":"PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance","volume":"84","author":"Chen","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jtemb.2025.127770_bib5","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1016\/j.freeradbiomed.2025.05.219","article-title":"The discovery of a novel ferroptosis-inducing biochemical inhibitor of glutathione peroxidase 4 and thioredoxin reductase 1: PP I_F09","volume":"233","author":"Barrett","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jtemb.2025.127770_bib6","series-title":"Ferroptosis in Health and Disease","first-page":"369","article-title":"Selenium metabolic pathway in ferroptotic cell death","author":"Kalishwaralal","year":"2023"},{"key":"10.1016\/j.jtemb.2025.127770_bib7","article-title":"Selenoprotein k at the intersection of cellular pathways","author":"Odunsi","year":"2024","journal-title":"Arch. Biochem. Biophys."},{"issue":"3","key":"10.1016\/j.jtemb.2025.127770_bib8","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1152\/physrev.00039.2013","article-title":"Selenoproteins: molecular pathways and physiological roles","volume":"94","author":"Labunskyy","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jtemb.2025.127770_bib9","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01851-24","article-title":"HCMV infection downregulates GPX4 and stimulates lipid peroxidation but does not induce ferroptosis","author":"Martin","year":"2025","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.jtemb.2025.127770_bib10","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cmet.2008.07.005","article-title":"Glutathione peroxidase 4 senses and translates oxidative stress into 12\/15-lipoxygenase dependent-and AIF-mediated cell death","volume":"8","author":"Seiler","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.jtemb.2025.127770_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102703","article-title":"The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1","volume":"62","author":"Cheff","year":"2023","journal-title":"Redox Biol."},{"issue":"10","key":"10.1016\/j.jtemb.2025.127770_bib12","doi-asserted-by":"crossref","first-page":"6767","DOI":"10.1002\/jcp.29571","article-title":"Ferroptotic agent-induced endoplasmic reticulum stress response plays a pivotal role in the autophagic process outcome","volume":"235","author":"Lee","year":"2020","journal-title":"J. Cell. Physiol."},{"issue":"70","key":"10.1016\/j.jtemb.2025.127770_bib13","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.23046","article-title":"Molecular crosstalk between ferroptosis and apoptosis: emerging role of ER stress-induced p53-independent PUMA expression","volume":"8","author":"Hong","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jtemb.2025.127770_bib14","doi-asserted-by":"crossref","DOI":"10.1007\/s42514-021-00086-5","article-title":"Molecular docking-based computational platform for high-throughput virtual screening","author":"Zhang","year":"2022","journal-title":"CCF Trans. High. Perform. Comput."},{"key":"10.1016\/j.jtemb.2025.127770_bib15","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1006\/jmbi.1993.1626","article-title":"Comparative protein modelling by satisfaction of spatial restraints","volume":"234","author":"\u0160ali","year":"1993","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jtemb.2025.127770_bib16","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF chimera - a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"issue":"2","key":"10.1016\/j.jtemb.2025.127770_bib17","first-page":"237","article-title":"Crystal structures of the selenoprotein glutathione peroxidase 4 in its apo form and in complex with the covalently bound inhibitor ML162","volume":"77","author":"Moosmayer","year":"2021","journal-title":"Biol. Crystallogr."},{"issue":"7","key":"10.1016\/j.jtemb.2025.127770_bib18","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.jinorgbio.2009.05.006","article-title":"Terpyridine\u2013platinum (II) complexes are effective inhibitors of mammalian topoisomerases and human thioredoxin reductase 1","volume":"103","author":"Lo","year":"2009","journal-title":"J. Inorg. Biochem."},{"issue":"4","key":"10.1016\/j.jtemb.2025.127770_bib19","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.bbrc.2016.06.125","article-title":"Crystal structures of human peroxiredoxin 6 in different oxidation states","volume":"477","author":"Kim","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.jtemb.2025.127770_bib20","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1038\/s44321-024-00142-x","article-title":"Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis","volume":"16","author":"Ackermann","year":"2024","journal-title":"EMBO Mol. Med."},{"issue":"5","key":"10.1016\/j.jtemb.2025.127770_bib21","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1158\/0008-5472.CAN-23-2194","article-title":"Selenoprotein o promotes melanoma metastasis and regulates mitochondrial complex II activity","volume":"85","author":"Nascentes Melo","year":"2025","journal-title":"Cancer Res."},{"issue":"12","key":"10.1016\/j.jtemb.2025.127770_bib22","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1038\/s43018-024-00844-8","article-title":"Selenocysteine tRNA methylation promotes oxidative stress resistance in melanoma metastasis","volume":"5","author":"Nease","year":"2024","journal-title":"Nat. Cancer"},{"issue":"4","key":"10.1016\/j.jtemb.2025.127770_bib23","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jtemb.2025.127770_bib24","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.freeradbiomed.2024.08.042","article-title":"On the binding of auranofin to Prdx6 and its potential role in cancer cell sensitivity to treatment","volume":"224","author":"Inague","year":"2024","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127770_bib25","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3892\/ijo.2013.2182","article-title":"Selenium improves stem cell potency by stimulating the proliferation and active migration of 3T3-L1 preadipocytes","volume":"44","author":"Park","year":"2014","journal-title":"Int. J. Oncol."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127770_bib26","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/0026-2862(86)90047-6","article-title":"Selenium-induced cell migration and proliferation: relevance to angiogenesis and microangiopathy","volume":"32","author":"McAuslan","year":"1986","journal-title":"Microvasc. Res."}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X2500183X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X2500183X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:35:53Z","timestamp":1778776553000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X2500183X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":26,"alternative-id":["S0946672X2500183X"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2025.127770","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ferroptosis-targeting compounds modulate cancer cell cytotoxicity and migration: Insights from in vitro and in silico analyses","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2025.127770","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"127770"}}