{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T17:14:02Z","timestamp":1778778842206,"version":"3.51.4"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007316","name":"Klaus Tschira Stiftung","doi-asserted-by":"publisher","award":["GSO\/KT-49"],"award-info":[{"award-number":["GSO\/KT-49"]}],"id":[{"id":"10.13039\/501100007316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jtemb.2025.127788","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T19:26:47Z","timestamp":1761593207000},"page":"127788","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Selective impact of zinc on human circulating CD56dim NK cells"],"prefix":"10.1016","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0477-2748","authenticated-orcid":false,"given":"Sabrina B.","family":"Bennstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronja","family":"St\u00f6cker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Heenen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Jakobs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Ohl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lothar","family":"Rink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtemb.2025.127788_bib1","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.dib.2017.04.019","article-title":"Reference values for T, B and NK human lymphocyte subpopulations in adults","volume":"12","author":"Apoil","year":"2017","journal-title":"Data Brief."},{"issue":"7","key":"10.1016\/j.jtemb.2025.127788_bib2","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.4049\/jimmunol.1502570","article-title":"Human CD56 bright NK cells: an update","volume":"196","author":"Michel","year":"2016","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.jtemb.2025.127788_bib3","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.immuni.2017.10.008","article-title":"The broad spectrum of human natural killer cell diversity","volume":"47","author":"Freud","year":"2017","journal-title":"Immunity"},{"issue":"19","key":"10.1016\/j.jtemb.2025.127788_bib4","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1182\/blood-2010-04-281675","article-title":"Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education","volume":"116","author":"Bj\u00f6rkstr\u00f6m","year":"2010","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.jtemb.2025.127788_bib5","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-002899","article-title":"Deregulation of HLA-I in cancer and its central importance for immunotherapy","volume":"9","author":"Hazini","year":"2021","journal-title":"J. Immunother. Cancer"},{"issue":"6","key":"10.1016\/j.jtemb.2025.127788_bib6","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S1074-7613(00)80065-5","article-title":"The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells","volume":"10","author":"Cohen","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.jtemb.2025.127788_bib7","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0167-5699(90)90097-S","article-title":"In search of the \u2018missing self\u2019: MHC molecules and NK cell recognition","volume":"11","author":"Ljunggren","year":"1990","journal-title":"Immunol. Today"},{"key":"10.1016\/j.jtemb.2025.127788_bib8","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev-immunol-020711-075005","article-title":"Controlling natural killer cell responses: integration of signals for activation and inhibition","volume":"31","author":"Long","year":"2013","journal-title":"Annu Rev. Immunol."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127788_bib9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1046\/j.1365-2567.1999.00738.x","article-title":"CD69 is a stimulatory receptor for natural killer cell and its cytotoxic effect is blocked by CD94 inhibitory receptor","volume":"97","author":"Borrego","year":"1999","journal-title":"Immunology"},{"issue":"7","key":"10.1016\/j.jtemb.2025.127788_bib10","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.it.2018.04.009","article-title":"NK cells mediate a crucial graft-versus-leukemia effect in haploidentical-HSCT to cure high-risk acute leukemia","volume":"39","author":"Locatelli","year":"2018","journal-title":"Trends Immunol."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127788_bib11","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s40164-025-00633-8","article-title":"The clinical landscape of CAR NK cells","volume":"14","author":"J\u00f8rgensen","year":"2025","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.jtemb.2025.127788_bib12","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1146\/annurev-nutr-122019-120635","article-title":"Dietary and physiological effects of zinc on the immune system","volume":"41","author":"Wessels","year":"2021","journal-title":"Annu Rev. Nutr."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127788_bib13","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12979-022-00295-8","article-title":"Short-term zinc supplementation of zinc-deficient seniors counteracts CREM\u03b1 - mediated IL-2 suppression","volume":"19","author":"Baarz","year":"2022","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.jtemb.2025.127788_bib14","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jtemb.2018.02.020","article-title":"A short 18 items food frequency questionnaire biochemically validated to estimate zinc status in humans","volume":"49","author":"Trame","year":"2018","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.jtemb.2025.127788_bib15","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jff.2018.07.027","article-title":"Influence of zinc deficiency and supplementation on NK cell cytotoxicity","volume":"48","author":"Rolles","year":"2018","journal-title":"J. Funct. Foods"},{"issue":"1","key":"10.1016\/j.jtemb.2025.127788_bib16","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1186\/s12967-025-06259-y","article-title":"Short-term oral zinc supplementation enhances Natural Killer cell functionality and decreases circulating Innate Lymphoid Cell counts and frequencies in healthy young adults","volume":"23","author":"Amling","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jtemb.2025.127788_bib17","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.clnu.2025.06.010","article-title":"Zinc supplementation among zinc-deficient vegetarians and vegans restores antiviral interferon-\u03b1 response by upregulating interferon regulatory factor 3","volume":"51","author":"Vallboehmer","year":"2025","journal-title":"Clin. Nutr."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127788_bib18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1046\/j.1365-2567.1999.00738.x","article-title":"CD69 is a stimulatory receptor for natural killer cell and its cytotoxic effect is blocked by CD94 inhibitory receptor","volume":"97","author":"Borrego","year":"1999","journal-title":"Immunology"},{"key":"10.1016\/j.jtemb.2025.127788_bib19","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.55232","article-title":"Umbilical cord blood-derived ILC1-like cells constitute a novel precursor for mature KIR+NKG2A- NK cells","volume":"9","author":"Bennstein","year":"2020","journal-title":"eLife"},{"issue":"1","key":"10.1016\/j.jtemb.2025.127788_bib20","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/imr.12316","article-title":"Human KIR repertoires: shaped by genetic diversity and evolution","volume":"267","author":"Manser","year":"2015","journal-title":"Immunol. Rev."},{"issue":"4","key":"10.1016\/j.jtemb.2025.127788_bib21","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1002\/eji.200323582","article-title":"KIR enrichment at the effector-target cell interface is more sensitive than signaling to the strength of ligand binding","volume":"33","author":"Borszcz","year":"2003","journal-title":"Eur. J. Immunol."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127788_bib22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.molcel.2016.03.009","article-title":"Zinc-induced polymerization of killer-cell Ig-like receptor into filaments promotes its inhibitory function at cytotoxic immunological synapses","volume":"62","author":"Kumar","year":"2016","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.jtemb.2025.127788_bib23","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.4049\/jimmunol.161.3.1299","article-title":"Zinc bound to the killer cell-inhibitory receptor modulates the negative signal in human NK cells","volume":"161","author":"Rajagopalan","year":"1998","journal-title":"J. Immunol."},{"issue":"9","key":"10.1016\/j.jtemb.2025.127788_bib24","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.4049\/jimmunol.155.9.4143","article-title":"The Ig-related killer cell inhibitory receptor binds zinc and requires zinc for recognition of HLA-C on target cells","volume":"155","author":"Rajagopalan","year":"1995","journal-title":"J. Immunol."},{"issue":"23","key":"10.1016\/j.jtemb.2025.127788_bib25","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1016\/j.febslet.2007.08.030","article-title":"Zinc up-regulates NF-\u03baB activation via phosphorylation of I\u03baB in HUT-78 (Th0) cells","volume":"581","author":"Bao","year":"2007","journal-title":"FEBS Lett."},{"issue":"2","key":"10.1016\/j.jtemb.2025.127788_bib26","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0041-008X(03)00167-4","article-title":"Zinc-induced NF-kappaB inhibition can be modulated by changes in the intracellular metallothionein level","volume":"190","author":"Kim","year":"2003","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.jtemb.2025.127788_bib27","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jtemb.2019.08.007","article-title":"Selection of an inadequate housekeeping gene leads to misinterpretation of target gene expression in zinc deficiency and zinc supplementation models","volume":"56","author":"Kloubert","year":"2019","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.jtemb.2025.127788_bib28","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.3389\/fnmol.2024.1408949","article-title":"Multi-faceted regulation of CREB family transcription factors","volume":"17","author":"Chowdhury","year":"2024","journal-title":"Front. Mol. Neurosci."},{"issue":"6","key":"10.1016\/j.jtemb.2025.127788_bib29","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/eji.201646837","article-title":"CD69: from activation marker to metabolic gatekeeper","volume":"47","author":"Cibri\u00e1n","year":"2017","journal-title":"Eur. J. Immunol."},{"issue":"5","key":"10.1016\/j.jtemb.2025.127788_bib30","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/eji.1830230509","article-title":"Regulation of CD69 expression on human natural killer cells: differential involvement of protein kinase C and protein tyrosine kinases","volume":"23","author":"Borrego","year":"1993","journal-title":"Eur. J. Immunol."},{"issue":"6","key":"10.1016\/j.jtemb.2025.127788_bib31","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1002\/sctm.20-0300","article-title":"Transcriptional and functional characterization of neonatal circulating ILCs","volume":"10","author":"Bennstein","year":"2021","journal-title":"STEM CELLS Transl. Med."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127788_bib32","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/s41420-024-02104-1","article-title":"Ca(2+) signals are essential for T-cell proliferation, while Zn(2+) signals are necessary for T helper cell 1 differentiation","volume":"10","author":"Jakobs","year":"2024","journal-title":"Cell Death Discov."},{"issue":"10","key":"10.1016\/j.jtemb.2025.127788_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18102222","article-title":"Zinc Signals and Immunity","volume":"18","author":"Maywald","year":"2017","journal-title":"Int J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.jtemb.2025.127788_bib34","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1189\/jlb.0307148","article-title":"Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9","volume":"83","author":"Overbeck","year":"2007","journal-title":"J. Leukoc. Biol."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127788_bib35","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3390\/s90100386","article-title":"Human NK cell up-regulation of CD69, HLA-DR, interferon \u03b3 secretion and cytotoxic activity by plasmacytoid dendritic cells is regulated through overlapping but different pathways","volume":"9","author":"Benlahrech","year":"2009","journal-title":"Sensors"},{"issue":"12","key":"10.1016\/j.jtemb.2025.127788_bib36","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1002\/eji.202149608","article-title":"Tissue-resident CD69+CXCR6+ Natural Killer cells with exhausted phenotype accumulate in human non-small cell lung cancer","volume":"52","author":"Chen","year":"2022","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jtemb.2025.127788_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2024.127556","article-title":"Zinc deficiency impairs the development of human regulatory B cells from purified B cells","volume":"86","author":"Puppa","year":"2024","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"8","key":"10.1016\/j.jtemb.2025.127788_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25084302","article-title":"Zinc ionophore pyrithione mimics CD28 costimulatory signal in CD3 activated T cells","volume":"25","author":"Jakobs","year":"2024","journal-title":"Int J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.jtemb.2025.127788_bib39","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/mnfr.201500524","article-title":"Zinc supplementation induces regulatory T cells by inhibition of Sirt-1 deacetylase in mixed lymphocyte cultures","volume":"60","author":"Rosenkranz","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"issue":"12","key":"10.1016\/j.jtemb.2025.127788_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/nu9121286","article-title":"Zinc as a gatekeeper of immune function","volume":"9","author":"Wessels","year":"2017","journal-title":"Nutrients"},{"issue":"7","key":"10.1016\/j.jtemb.2025.127788_bib41","doi-asserted-by":"crossref","first-page":"841","DOI":"10.3390\/antiox13070841","article-title":"Antioxidant properties of zinc and copper\u2014blood zinc-to copper-ratio as a marker of cancer risk BRCA1 mutation carriers","volume":"13","author":"Matuszczak","year":"2024","journal-title":"Antioxidants"},{"issue":"5S","key":"10.1016\/j.jtemb.2025.127788_bib42","doi-asserted-by":"crossref","first-page":"1447s","DOI":"10.1093\/jn\/130.5.1447S","article-title":"The antioxidant properties of zinc","volume":"130","author":"Powell","year":"2000","journal-title":"J. Nutr."},{"issue":"2021","key":"10.1016\/j.jtemb.2025.127788_bib43","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1146\/annurev-nutr-122019-120635","article-title":"Dietary and physiological effects of zinc on the immune system","volume":"41","author":"Wessels","year":"2021","journal-title":"Annu. Rev. Nutr."},{"issue":"4","key":"10.1016\/j.jtemb.2025.127788_bib44","first-page":"323","article-title":"Zinc and its transporters in epigenetics","volume":"43","author":"Brito","year":"2020","journal-title":"Mol. Cells"},{"issue":"6","key":"10.1016\/j.jtemb.2025.127788_bib45","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1111\/j.1582-4934.2011.01391.x","article-title":"Mesenchymal stem cells promote the sustained expression of CD69 on activated T lymphocytes: roles of canonical and non-canonical NF-\u03baB signalling","volume":"16","author":"Saldanha-Araujo","year":"2012","journal-title":"J. Cell Mol. Med"},{"issue":"1","key":"10.1016\/j.jtemb.2025.127788_bib46","doi-asserted-by":"crossref","first-page":"7920","DOI":"10.1038\/s41467-023-43763-5","article-title":"Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38\u03b1","volume":"14","author":"Pous","year":"2023","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.jtemb.2025.127788_bib47","doi-asserted-by":"crossref","first-page":"7101","DOI":"10.4049\/jimmunol.179.10.7101","article-title":"MAPK p38 regulates transcriptional activity of NF-kappaB in primary human astrocytes via acetylation of p65","volume":"179","author":"Saha","year":"2007","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.jtemb.2025.127788_bib48","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0047-6374(03)00023-X","article-title":"Metallothioneins\/PARP-1\/IL-6 interplay on natural killer cell activity in elderly: parallelism with nonagenarians and old infected humans. Effect of zinc supply","volume":"124","author":"Mocchegiani","year":"2003","journal-title":"Mech. Ageing Dev."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127788_bib49","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12979-025-00511-1","article-title":"Zinc deficiency as possible link between immunosenescence and age-related diseases","volume":"22","author":"Schulz","year":"2025","journal-title":"Immun. Ageing"},{"issue":"25","key":"10.1016\/j.jtemb.2025.127788_bib50","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1182\/blood.2021013950","article-title":"Activation of the zinc-sensing receptor GPR39 promotes T-cell reconstitution after hematopoietic cell transplant in mice","volume":"139","author":"Iovino","year":"2022","journal-title":"Blood"},{"issue":"ement 1","key":"10.1016\/j.jtemb.2025.127788_bib51","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1182\/blood-2023-182370","article-title":"Zinc status affects T cell reconstitution in patients receiving na\u00efve T cell depleted allogeneic HSCT","volume":"142","author":"Iovino","year":"2023","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.jtemb.2025.127788_bib52","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.jaci.2024.06.016","article-title":"Circulating innate lymphoid cells (cILCs): Unconventional lymphocytes with hidden talents","volume":"154","author":"Bennstein","year":"2024","journal-title":"J. Allergy Clin. Immunol."},{"issue":"32","key":"10.1016\/j.jtemb.2025.127788_bib53","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adv9650","article-title":"A human NK cell progenitor that originates in the thymus and generates KIR+NKG2A-NK cells","volume":"11","author":"Rei\u00df","year":"2025","journal-title":"Sci. Adv."},{"issue":"2","key":"10.1016\/j.jtemb.2025.127788_bib54","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1365-2567.2007.02573.x","article-title":"In vivo kinetics of human natural killer cells: the effects of ageing and acute and chronic viral infection","volume":"121","author":"Zhang","year":"2007","journal-title":"Immunology"},{"issue":"1","key":"10.1016\/j.jtemb.2025.127788_bib55","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/imr.13332","article-title":"Tissue-resident memory NK cells: homing in on local effectors and regulators","volume":"323","author":"Schuster","year":"2024","journal-title":"Immunol. Rev."},{"issue":"2","key":"10.1016\/j.jtemb.2025.127788_bib56","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s10238-020-00677-6","article-title":"Zinc as a complementary treatment for cancer patients: a systematic review","volume":"21","author":"Hoppe","year":"2021","journal-title":"Clin. Exp. Med"},{"issue":"10","key":"10.1016\/j.jtemb.2025.127788_bib57","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/ejcn.2013.146","article-title":"Zinc supplementation in children and adolescents with acute leukemia","volume":"67","author":"Consolo","year":"2013","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.jtemb.2025.127788_bib58","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ejon.2018.01.007","article-title":"The effect of zinc sulfate on prevention, incidence, and severity of mucositis in leukemia patients undergoing chemotherapy","volume":"33","author":"Rambod","year":"2018","journal-title":"Eur. J. Oncol. Nurs."},{"key":"10.1016\/j.jtemb.2025.127788_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.117918","article-title":"Impact of zinc on hepatocellular carcinoma cell behavior and metallothionein expression: insights from preclinical models","volume":"185","author":"Higuera","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jtemb.2025.127788_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2023.109482","article-title":"Leukemia cells accumulate zinc for oncofusion protein stabilization","volume":"123","author":"G\u00f6rg","year":"2024","journal-title":"J. Nutr. Biochem."},{"issue":"12","key":"10.1016\/j.jtemb.2025.127788_bib61","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1038\/s41418-024-01369-4","article-title":"Intracellular zinc protects tumours from T cell-mediated cytotoxicity","volume":"31","author":"Lelliott","year":"2024","journal-title":"Cell Death Differ."},{"issue":"11","key":"10.1016\/j.jtemb.2025.127788_bib62","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/intimm\/dxac024","article-title":"The cellular and molecular basis of CD69 function in anti-tumor immunity","volume":"34","author":"Koyama-Nasu","year":"2022","journal-title":"Int Immunol."},{"issue":"11","key":"10.1016\/j.jtemb.2025.127788_bib63","doi-asserted-by":"crossref","first-page":"4399","DOI":"10.1182\/blood-2004-10-3854","article-title":"Induction of tumor NK-cell immunity by anti-CD69 antibody therapy","volume":"105","author":"Esplugues","year":"2005","journal-title":"Blood"},{"issue":"8000","key":"10.1016\/j.jtemb.2025.127788_bib64","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/s41586-023-06945-1","article-title":"Natural killer cell therapies","volume":"626","author":"Vivier","year":"2024","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.jtemb.2025.127788_bib65","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.biocel.2007.01.011","article-title":"Zinc improves the development of human CD34+ cell progenitors towards Natural Killer cells and induces the expression of GATA-3 transcription factor","volume":"39","author":"Muzzioli","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"5","key":"10.1016\/j.jtemb.2025.127788_bib66","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s10522-008-9201-3","article-title":"Zinc improves the development of human CD34+ cell progenitors towards NK cells and increases the expression of GATA-3 transcription factor in young and old ages","volume":"10","author":"Muzzioli","year":"2009","journal-title":"Biogerontology"},{"issue":"7230","key":"10.1016\/j.jtemb.2025.127788_bib67","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nature07537","article-title":"A human NK cell subset provides an innate source of IL-22 for mucosal immunity","volume":"457","author":"Cella","year":"2009","journal-title":"Nature"},{"issue":"24","key":"10.1016\/j.jtemb.2025.127788_bib68","doi-asserted-by":"crossref","first-page":"10961","DOI":"10.1073\/pnas.1005641107","article-title":"Expansion of human NK-22 cells with IL-7, IL-2, and IL-1\u03b2 reveals intrinsic functional plasticity","volume":"107","author":"Cella","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"5545","key":"10.1016\/j.jtemb.2025.127788_bib69","article-title":"Efficient in vitro generation of IL-22-secreting ILC3 from CD34+ hematopoietic progenitors in a human mesenchymal stem cell niche","volume":"12","author":"Bennstein","year":"2021","journal-title":"Front. Immunol."},{"issue":"5406","key":"10.1016\/j.jtemb.2025.127788_bib70","article-title":"CD33 delineates two functionally distinct NK cell populations divergent in cytokine production and antibody-mediated cellular cytotoxicity","volume":"12","author":"Hejazi","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127788_bib71","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3390\/jcm9010010","article-title":"HCMV infection in a mesenchymal stem cell niche: differential impact on the development of NK cells versus ILC3","volume":"9","author":"Ising","year":"2019","journal-title":"J. Clin. Med."},{"issue":"19","key":"10.1016\/j.jtemb.2025.127788_bib72","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1182\/bloodadvances.2018019059","article-title":"NK cell development in a human stem cell niche: KIR expression occurs independently of the presence of HLA class I ligands","volume":"2","author":"Zhao","year":"2018","journal-title":"Blood Adv."},{"key":"10.1016\/j.jtemb.2025.127788_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2023.127132","article-title":"Calculating zinc uptake by zinc-APP","volume":"77","author":"Trame","year":"2023","journal-title":"J. Trace Elem. Med Biol."},{"issue":"7","key":"10.1016\/j.jtemb.2025.127788_bib74","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1039\/c4mt00051j","article-title":"Differential impact of zinc deficiency on phagocytosis, oxidative burst, and production of pro-inflammatory cytokines by human monocytes","volume":"6","author":"Mayer","year":"2014","journal-title":"Metallomics"},{"issue":"1","key":"10.1016\/j.jtemb.2025.127788_bib75","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26010254","article-title":"Zinc deficiency exacerbates lead-induced interleukin-2 suppression by regulating CREM expression","volume":"26","author":"Trojan","year":"2024","journal-title":"Int. J. Mol. Sci."}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X25002019?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X25002019?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:36:09Z","timestamp":1778776569000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X25002019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":75,"alternative-id":["S0946672X25002019"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2025.127788","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selective impact of zinc on human circulating CD56dim NK cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2025.127788","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"127788"}}