{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T02:15:41Z","timestamp":1773368141019,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002799","name":"Capital Medical University","doi-asserted-by":"publisher","award":["CXZH202406"],"award-info":[{"award-number":["CXZH202406"]}],"id":[{"id":"10.13039\/501100002799","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002799","name":"Capital Medical University","doi-asserted-by":"publisher","award":["CCMU2023ZKYXZ007"],"award-info":[{"award-number":["CCMU2023ZKYXZ007"]}],"id":[{"id":"10.13039\/501100002799","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016126","name":"Beijing Hospital Authority","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016126","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jtemb.2025.127795","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T17:08:47Z","timestamp":1761930527000},"page":"127795","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["TCF19 up-regulated in hypoxic lung cancer cells attenuates the anti-tumor effects of sodium selenite"],"prefix":"10.1016","volume":"92","author":[{"given":"Shengmin","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjia","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2873-7197","authenticated-orcid":false,"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kejian","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtemb.2025.127795_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101900","article-title":"Are trace element concentrations suitable biomarkers for the diagnosis of cancer?","volume":"42","author":"Lossow","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.jtemb.2025.127795_bib2","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/s41392-022-01229-y","article-title":"Copper homeostasis and cuproptosis in health and disease","volume":"7","author":"Chen","year":"2022","journal-title":"Signal Transduct. Target Ther."},{"issue":"3","key":"10.1016\/j.jtemb.2025.127795_bib3","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s12011-008-8240-6","article-title":"High-dose sodium selenite can induce apoptosis of lymphoma cells in adult patients with non-Hodgkin's lymphoma","volume":"127","author":"Asfour","year":"2009","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jtemb.2025.127795_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109651","article-title":"Selenite induced breast cancer MCF7 cells apoptosis through endoplasmic reticulum stress and oxidative stress pathway","volume":"349","author":"Cao","year":"2021","journal-title":"Chem. Biol. Inter."},{"issue":"3","key":"10.1016\/j.jtemb.2025.127795_bib5","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1002\/jcp.26783","article-title":"Sodium selenite induces apoptosis via ROS-mediated NF-\u03baB signaling and activation of the Bax-caspase-9-caspase-3 axis in 4T1 cells","volume":"234","author":"Zhang","year":"2019","journal-title":"J. Cell Physiol."},{"issue":"8","key":"10.1016\/j.jtemb.2025.127795_bib6","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.3390\/antiox13081004","article-title":"Sodium selenite induces autophagy and apoptosis in cervical cancer cells via mitochondrial ROS-activated AMPK\/mTOR\/FOXO3a pathway","volume":"13","author":"Lv","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.jtemb.2025.127795_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2023.127214","article-title":"Cytosolic JNK-dependent microtubule reassembly protects Jurkat leukemia cells from selenite-induced apoptosis","volume":"79","author":"Shi","year":"2023","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.jtemb.2025.127795_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.668424","article-title":"Selenite induces cell cycle arrest and apoptosis via reactive oxygen species-dependent inhibition of the AKT\/mTOR pathway in thyroid cancer","volume":"11","author":"Cheng","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jtemb.2025.127795_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110178","article-title":"ATM\/IKK alpha axis regulates the crosstalk between autophagy and apoptosis in selenite-treated Jurkat cells","volume":"367","author":"Shi","year":"2022","journal-title":"Chem. Biol. Inter."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127795_bib10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s12672-021-00427-4","article-title":"Selenite-induced ROS\/AMPK\/FoxO3a\/GABARAPL-1 signaling pathway modulates autophagy that antagonize apoptosis in colorectal cancer cells","volume":"12","author":"Yu","year":"2021","journal-title":"Discov. Oncol."},{"issue":"9","key":"10.1016\/j.jtemb.2025.127795_bib11","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.3390\/ph16091250","article-title":"Selenium in prostate cancer: prevention, progression, and treatment","volume":"16","author":"Jiang","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jtemb.2025.127795_bib12","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ejca.2021.07.013","article-title":"Selenium stimulates the antitumour immunity: insights to future research","volume":"155","author":"Razaghi","year":"2021","journal-title":"Eur. J. Cancer"},{"issue":"4","key":"10.1016\/j.jtemb.2025.127795_bib13","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3390\/nu5041149","article-title":"Is selenium a potential treatment for cancer metastasis?","volume":"5","author":"Chen","year":"2013","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.jtemb.2025.127795_bib14","doi-asserted-by":"crossref","DOI":"10.1080\/15384047.2024.2304161","article-title":"Hypoxia promotes non-small cell lung cancer cell stemness, migration, and invasion via promoting glycolysis by lactylation of SOX9","volume":"25","author":"Yan","year":"2024","journal-title":"Cancer Biol. Ther."},{"issue":"3","key":"10.1016\/j.jtemb.2025.127795_bib15","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41419-024-06587-9","article-title":"Hypoxia-induced miR-5100 promotes exosome-mediated activation of cancer-associated fibroblasts and metastasis of head and neck squamous cell carcinoma","volume":"15","author":"Duan","year":"2024","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127795_bib16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13046-024-02988-y","article-title":"Essential role of PLD2 in hypoxia-induced stemness and therapy resistance in ovarian tumors","volume":"43","author":"Mu\u00f1oz-Galv\u00e1n","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127795_bib17","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s12013-023-01205-5","article-title":"Hypoxia potentiated lung cancer cell migration and Invasion by up-regulating HIF1\u03b1\/JAK2\/STAT3 axis and activating MMP13 transcription","volume":"82","author":"Cheng","year":"2024","journal-title":"Cell Biochem Biophys."},{"key":"10.1016\/j.jtemb.2025.127795_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1227150","article-title":"An emerging research: the role of hepatocellular carcinoma-derived exosomal circRNAs in the immune microenvironment","volume":"14","author":"Xu","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtemb.2025.127795_bib19","doi-asserted-by":"crossref","DOI":"10.1111\/imm.13853","article-title":"Hypoxic tumour-derived exosomal miR-1290 exacerbates the suppression of CD8+ T cells by promoting M2 macrophage polarization","author":"Yang","year":"2024","journal-title":"Immunology"},{"issue":"3","key":"10.1016\/j.jtemb.2025.127795_bib20","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.semradonc.2010.01.003","article-title":"The tumor microenvironment in non-small-cell lung cancer","volume":"20","author":"Graves","year":"2010","journal-title":"Semin Radiat. Oncol."},{"issue":"71","key":"10.1016\/j.jtemb.2025.127795_bib21","doi-asserted-by":"crossref","first-page":"40984","DOI":"10.1039\/C8RA08142E","article-title":"Double-ratiometric fluorescence imaging of H2Se and O2\u02d9- under hypoxia for exploring Na2SeO3-induced HepG2 cells' apoptosis","volume":"8","author":"Gao","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.jtemb.2025.127795_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2024.101978","article-title":"TCF19 promotes cell proliferation and tumor formation in lung cancer by activating the Raf\/MEK\/ERK signaling pathway","volume":"45","author":"Tian","year":"2024","journal-title":"Transl. Oncol."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127795_bib23","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4149\/neo_2018_171227N845","article-title":"TCF19 enhances cell proliferation in hepatocellular carcinoma by activating the ATK\/FOXO1 signaling pathway","volume":"66","author":"Zeng","year":"2019","journal-title":"Neoplasma"},{"issue":"2","key":"10.1016\/j.jtemb.2025.127795_bib24","first-page":"655","article-title":"TCF19 aggravates the malignant progression of colorectal cancer by negatively regulating WWC1","volume":"24","author":"Du","year":"2020","journal-title":"Eur. Rev. Med Pharm. Sci."},{"issue":"3","key":"10.1016\/j.jtemb.2025.127795_bib25","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.toxlet.2012.06.007","article-title":"Induction of apoptosis and autophagy by sodium selenite in A549 human lung carcinoma cells through generation of reactive oxygen species","volume":"212","author":"Park","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.jtemb.2025.127795_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2023.127147","article-title":"Sodium selenite inhibits proliferation of lung cancer cells by inhibiting NF-\u03baB nuclear translocation and down-regulating PDK1 expression which is a key enzyme in energy metabolism expression","volume":"78","author":"Xu","year":"2023","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"8","key":"10.1016\/j.jtemb.2025.127795_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112944","article-title":"Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-\u03b2 axis","volume":"42","author":"Ma","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.jtemb.2025.127795_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216995","article-title":"Deciphering the TCF19\/miR-199a-5p\/SP1\/LOXL2 pathway: implications for breast cancer metastasis and epithelial-mesenchymal transition","volume":"597","author":"Li","year":"2024","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127795_bib29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0304-3835(84)80024-5","article-title":"Inhibition of human breast cancer cells by selenium","volume":"25","author":"Watrach","year":"1984","journal-title":"Cancer Lett."}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X25002081?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X25002081?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:28:12Z","timestamp":1773325692000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X25002081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":29,"alternative-id":["S0946672X25002081"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2025.127795","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TCF19 up-regulated in hypoxic lung cancer cells attenuates the anti-tumor effects of sodium selenite","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2025.127795","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"127795"}}