{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:50:25Z","timestamp":1787619025818,"version":"build-2736575974"},"reference-count":112,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jtemb.2025.127806","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T16:46:37Z","timestamp":1765471597000},"page":"127806","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Fluoride-induced gut dysbiosis in metabolic disorders: Mechanisms and public health implications"],"prefix":"10.1016","volume":"93","author":[{"given":"Sarasa","family":"Meenakshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TV","family":"Amrutha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md","family":"Abubakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ved","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9865-7454","authenticated-orcid":false,"given":"Krishna","family":"Murti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtemb.2025.127806_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.113006","article-title":"Preventive effects of Lactobacillus johnsonii on the renal injury of mice induced by high fluoride exposure: Insights from colonic microbiota and co-occurrence network analysis","volume":"228","author":"Xin","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jtemb.2025.127806_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119241","article-title":"Challenges of fluoride pollution in environment: Mechanisms and pathological significance of toxicity - A review","volume":"304","author":"Wu","year":"2022","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127806_bib3","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s12967-022-03296-9","article-title":"Microbiota medicine: towards clinical revolution","volume":"20","author":"Gebrayel","year":"2022","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jtemb.2025.127806_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.999001","article-title":"Human gut microbiota in health and disease: Unveiling the relationship","volume":"13","author":"Afzaal","year":"2022","journal-title":"Front. Microbiol."},{"issue":"10","key":"10.1016\/j.jtemb.2025.127806_bib5","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.3390\/cells9102162","article-title":"At the forefront of the mucosal barrier: the role of macrophages in the intestine","volume":"9","author":"Ruder","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jtemb.2025.127806_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2025.108907","article-title":"Impact of fluoride exposure on reproductive health: insights into molecular mechanisms and health implications","volume":"135","author":"Chhabra","year":"2025","journal-title":"Reprod. Toxicol."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127806_bib7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41574-022-00746-8","article-title":"The multiple roles of life stress in metabolic disorders","volume":"19","author":"Kivimaki","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"issue":"4","key":"10.1016\/j.jtemb.2025.127806_bib8","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.3390\/ijms25042251","article-title":"The metabolic syndrome, a human disease","volume":"25","author":"Alemany","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jtemb.2025.127806_bib9","doi-asserted-by":"crossref","unstructured":"H. Huang, Y. Lin, J. Xin, N. Sun, Z. Zhao, H. Wang, L. Duan, Y. Zhou, X. Liu, J.J.E. Fang, E. Safety, Fluoride exposure-induced gut microbiota alteration mediates colonic ferroptosis through N6-methyladenosine (m6A) mediated silencing of SLC7A11, 283 (2024) 116816.","DOI":"10.1016\/j.ecoenv.2024.116816"},{"issue":"24","key":"10.1016\/j.jtemb.2025.127806_bib10","doi-asserted-by":"crossref","first-page":"12884","DOI":"10.3390\/ijerph182412884","article-title":"Impacts of fluoride neurotoxicity and mitochondrial dysfunction on cognition and mental health: a literature review","volume":"18","author":"Adkins","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"5","key":"10.1016\/j.jtemb.2025.127806_bib11","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1039\/D1VA00039J","article-title":"Fluoride contamination, consequences and removal techniques in water: a review","volume":"1","author":"Ahmad","year":"2022","journal-title":"Environ. Sci. Adv."},{"issue":"4","key":"10.1016\/j.jtemb.2025.127806_bib12","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s00204-020-02687-5","article-title":"Principles of fluoride toxicity and the cellular response: a review","volume":"94","author":"Johnston","year":"2020","journal-title":"Arch. Toxicol."},{"issue":"2","key":"10.1016\/j.jtemb.2025.127806_bib13","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s13105-021-00837-6","article-title":"Effects of gut microbiota-derived extracellular vesicles on obesity and diabetes and their potential modulation through diet","volume":"78","author":"Diez-Sainz","year":"2022","journal-title":"J. Physiol. Biochem"},{"key":"10.1016\/j.jtemb.2025.127806_bib14","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.toxlet.2023.03.001","article-title":"Does fluoride exposure impact on the human microbiome?","volume":"379","author":"Moran","year":"2023","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127806_bib15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s13237-023-00460-4","article-title":"Individual and combined effects of fluoride and arsenic on gut bacteria: a recent update","volume":"68","author":"Mukherjee","year":"2023","journal-title":"Nucleus"},{"issue":"8","key":"10.1016\/j.jtemb.2025.127806_bib16","doi-asserted-by":"crossref","first-page":"985","DOI":"10.3390\/antiox13080985","article-title":"Gut microbiota dysbiosis, oxidative stress, inflammation, and epigenetic alterations in metabolic diseases","volume":"13","author":"Mostafavi Abdolmaleky","year":"2024","journal-title":"Antioxidants"},{"issue":"2","key":"10.1016\/j.jtemb.2025.127806_bib17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3390\/ani10020179","article-title":"Dietary high sodium fluoride impairs digestion and absorption ability, mucosal immunity, and alters cecum microbial community of laying hens","volume":"10","author":"Miao","year":"2020","journal-title":"Animals"},{"key":"10.1016\/j.jtemb.2025.127806_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125617","article-title":"Intestinal fungal dysbiosis in mice induced by fluoride","volume":"245","author":"Cao","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.jtemb.2025.127806_bib19","doi-asserted-by":"crossref","first-page":"1394161","DOI":"10.3389\/fimmu.2024.1394161","article-title":"Progress in research on the role of fluoride in immune damage","volume":"15","author":"Zhu","year":"2024","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.jtemb.2025.127806_bib20","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.3390\/metabo13111159","article-title":"The dose-response effect of fluoride exposure on the gut microbiome and its functional pathways in rats","volume":"13","author":"Mo","year":"2023","journal-title":"Metabolites"},{"issue":"27","key":"10.1016\/j.jtemb.2025.127806_bib21","doi-asserted-by":"crossref","first-page":"69913","DOI":"10.1007\/s11356-023-27051-9","article-title":"Aberrant gut microbiota and fecal metabolites in patients with coal-burning endemic fluorosis in Guizhou, China","volume":"30","author":"Wang","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"11","key":"10.1016\/j.jtemb.2025.127806_bib22","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1021\/acs.jafc.8b00296","article-title":"Fuzhuan brick tea polysaccharides attenuate metabolic syndrome in high-fat diet induced mice in association with modulation in the gut microbiota","volume":"66","author":"Chen","year":"2018","journal-title":"J. Agric. Food Chem."},{"issue":"7","key":"10.1016\/j.jtemb.2025.127806_bib23","doi-asserted-by":"crossref","first-page":"7596","DOI":"10.1007\/s11356-019-07201-8","article-title":"Fluoride-induced rectal barrier damage and microflora disorder in mice","volume":"27","author":"Wang","year":"2020","journal-title":"Environ. Sci. Pollut. Res Int"},{"key":"10.1016\/j.jtemb.2025.127806_bib24","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.chemosphere.2019.06.080","article-title":"Intestinal barrier damage involved in intestinal microflora changes in fluoride-induced mice","volume":"234","author":"Liu","year":"2019","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.jtemb.2025.127806_bib25","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s12011-021-02617-1","article-title":"Effect of fluoride in drinking water on fecal microbial community in rats","volume":"200","author":"Zhong","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"issue":"10","key":"10.1016\/j.jtemb.2025.127806_bib26","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3390\/microorganisms7100399","article-title":"Characteristics of gut microbiota in patients with hypertension and\/or hyperlipidemia: a cross-sectional study on rural residents in Xinxiang County, Henan Province","volume":"7","author":"Li","year":"2019","journal-title":"Microorganisms"},{"issue":"1","key":"10.1016\/j.jtemb.2025.127806_bib27","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3390\/nu14010166","article-title":"Gut microbiota and complications of type-2 diabetes","volume":"14","author":"Iatcu","year":"2021","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.jtemb.2025.127806_bib28","doi-asserted-by":"crossref","first-page":"65","DOI":"10.4239\/wjd.v13.i1.65","article-title":"Gut microbiota-derived metabolites are novel targets for improving insulin resistance","volume":"13","author":"Bastos","year":"2022","journal-title":"World J. Diabetes"},{"issue":"6","key":"10.1016\/j.jtemb.2025.127806_bib29","doi-asserted-by":"crossref","first-page":"730","DOI":"10.4239\/wjd.v12.i6.730","article-title":"Mechanisms linking gut microbial metabolites to insulin resistance","volume":"12","author":"Jang","year":"2021","journal-title":"World J. Diabetes"},{"issue":"5","key":"10.1016\/j.jtemb.2025.127806_bib30","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s13238-020-00814-7","article-title":"The role of the gut microbiome and its metabolites in metabolic diseases","volume":"12","author":"Wu","year":"2021","journal-title":"Protein Cell"},{"key":"10.1016\/j.jtemb.2025.127806_bib31","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.aninu.2021.11.005","article-title":"Gut microbiota-derived short chain fatty acids are potential mediators in gut inflammation","volume":"8","author":"Akhtar","year":"2022","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.jtemb.2025.127806_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111732","article-title":"The beneficial or detrimental fluoride to gut microbiota depends on its dosages","volume":"209","author":"Chen","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"11","key":"10.1016\/j.jtemb.2025.127806_bib33","article-title":"Type-2 diabetes mellitus and the gut microbiota: systematic review","volume":"15","author":"Slouha","year":"2023","journal-title":"Cureus"},{"issue":"1","key":"10.1016\/j.jtemb.2025.127806_bib34","doi-asserted-by":"crossref","DOI":"10.2174\/0115733998281910231231051814","article-title":"Gut microbiota and insulin resistance: understanding the mechanism of better treatment of type 2 diabetes mellitus","volume":"21","author":"Al-Busaidi","year":"2024","journal-title":"Curr. Diabetes Rev."},{"issue":"8","key":"10.1016\/j.jtemb.2025.127806_bib35","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1136\/gutjnl-2019-318427","article-title":"Leaky gut: mechanisms, measurement and clinical implications in humans","volume":"68","author":"Camilleri","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.jtemb.2025.127806_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.571731","article-title":"Gut microbiota as a trigger for metabolic inflammation in obesity and type 2 diabetes","volume":"11","author":"Scheithauer","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtemb.2025.127806_bib37","doi-asserted-by":"crossref","DOI":"10.2174\/011570159X384737250626094315","article-title":"Diabetes, alzheimer's disease risk factors, and the cafeteria diet: a comprehensive review","author":"Abubakar","year":"2025","journal-title":"Curr. Neuropharmacol."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127806_bib38","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12964-023-01219-9","article-title":"Short-chain fatty acids in diseases","volume":"21","author":"Zhang","year":"2023","journal-title":"Cell Commun. Signal"},{"issue":"19","key":"10.1016\/j.jtemb.2025.127806_bib39","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.2174\/0115680266293416240515075450","article-title":"GLP-1\/GIP agonist as an intriguing and ultimate remedy for combating alzheimer's disease through its supporting DPP4 inhibitors: a review","volume":"24","author":"Abubakar","year":"2024","journal-title":"Curr. Top. Med Chem."},{"key":"10.1016\/j.jtemb.2025.127806_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106355","article-title":"Gut microbiota induces DNA methylation via SCFAs predisposing obesity-prone individuals to diabetes","volume":"182","author":"Guo","year":"2022","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jtemb.2025.127806_bib41","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3389\/fimmu.2019.00277","article-title":"Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases","volume":"10","author":"Venegas","year":"2019","journal-title":"Front Immunol."},{"key":"10.1016\/j.jtemb.2025.127806_bib42","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jare.2022.10.010","article-title":"Fluoride induced leaky gut and bloom of Erysipelatoclostridium ramosum mediate the exacerbation of obesity in high-fat-diet fed mice","volume":"50","author":"Chen","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.jtemb.2025.127806_bib43","article-title":"Role of metabolic endotoxemia in systemic inflammation and potential interventions","volume":"11","author":"Mohammad","year":"2020","journal-title":"Front Immunol."},{"issue":"11","key":"10.1016\/j.jtemb.2025.127806_bib44","doi-asserted-by":"crossref","first-page":"5925","DOI":"10.1039\/D1FO04428A","article-title":"The impact of prebiotic fructooligosaccharides on gut dysbiosis and inflammation in obesity and diabetes related kidney disease","volume":"13","author":"Pengrattanachot","year":"2022","journal-title":"Food Funct."},{"issue":"3","key":"10.1016\/j.jtemb.2025.127806_bib45","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41575-023-00867-z","article-title":"Gut microbiota in overweight and obesity: crosstalk with adipose tissue","volume":"21","author":"Cani","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"10","key":"10.1016\/j.jtemb.2025.127806_bib46","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1017\/S0007114520000380","article-title":"Microbial dysbiosis-induced obesity: role of gut microbiota in homoeostasis of energy metabolism","volume":"123","author":"Amabebe","year":"2020","journal-title":"Br. J. Nutr."},{"issue":"8","key":"10.1016\/j.jtemb.2025.127806_bib47","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3390\/metabo11080531","article-title":"The Role of Gut Microbiota and Its Produced Metabolites in Obesity, Dyslipidemia, Adipocyte Dysfunction, and Its Interventions","volume":"11","author":"Zwartjes","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.jtemb.2025.127806_bib48","doi-asserted-by":"crossref","first-page":"1031498","DOI":"10.3389\/fmicb.2022.1031498","article-title":"Modulation of adipose tissue metabolism by microbial-derived metabolites","volume":"13","author":"Liu","year":"2022","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jtemb.2025.127806_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112839","article-title":"Gut microbiota-derived metabolites as key actors in type 2 diabetes mellitus","volume":"149","author":"Du","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jtemb.2025.127806_bib50","article-title":"A multi-strain probiotic blend reshaped obesity-related gut dysbiosis and improved lipid metabolism in obese children","volume":"9","author":"Chen","year":"2022","journal-title":"Front Nutr."},{"key":"10.1016\/j.jtemb.2025.127806_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134858","article-title":"Alleviation of fluoride-induced colitis by tea polysaccharides: insights into the role of Limosilactobacillus vaginalis and butyric acid","volume":"476","author":"Zhao","year":"2024","journal-title":"J. Hazard Mater."},{"issue":"4","key":"10.1016\/j.jtemb.2025.127806_bib52","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s10096-017-3143-0","article-title":"Gut microbiome production of short-chain fatty acids and obesity in children","volume":"37","author":"Murugesan","year":"2018","journal-title":"Eur. J. Clin. Microbiol Infect. Dis."},{"key":"10.1016\/j.jtemb.2025.127806_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.571731","article-title":"Gut microbiota as a trigger for metabolic inflammation in obesity and type 2 diabetes","volume":"11","author":"Scheithauer","year":"2020","journal-title":"Front Immunol."},{"key":"10.1016\/j.jtemb.2025.127806_bib54","doi-asserted-by":"crossref","unstructured":"C.-I. Craciun, M.-A. Neag, A. Catinean, A.-O. Mitre, A. Rusu, C. Bala, G. Roman, A.-D. Buzoianu, D.-M. Muntean, A.-E. Craciun, The Relationships between Gut Microbiota and Diabetes Mellitus, and Treatments for Diabetes Mellitus, 10(2) (2022) 308.","DOI":"10.3390\/biomedicines10020308"},{"issue":"1","key":"10.1016\/j.jtemb.2025.127806_bib55","doi-asserted-by":"crossref","first-page":"480","DOI":"10.3390\/ijms23010480","article-title":"The role of the gut microbiota in the pathogenesis of diabetes","volume":"23","author":"Bielka","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.jtemb.2025.127806_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112839","article-title":"Gut microbiota-derived metabolites as key actors in type 2 diabetes mellitus","volume":"149","author":"Du","year":"2022","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.jtemb.2025.127806_bib57","article-title":"Gut microbiota: A new target for T2DM prevention and treatment","volume":"13","author":"Liu","year":"2022","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.jtemb.2025.127806_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116816","article-title":"Fluoride exposure-induced gut microbiota alteration mediates colonic ferroptosis through N(6)-methyladenosine (m(6)A) mediated silencing of SLC7A11","volume":"283","author":"Huang","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jtemb.2025.127806_bib59","first-page":"1","article-title":"Naringin alleviates fluoride-induced neurodevelopmental disorders by modulation of SIRT1, autophagy, mitochondrial fission, and ROS generation","author":"Chhabra","year":"2025","journal-title":"Naunyn Schmiede Arch. Pharm."},{"issue":"7","key":"10.1016\/j.jtemb.2025.127806_bib60","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1007\/s12011-021-03003-7","article-title":"Metagenomic Analysis of Intestinal Microbiota in Florated Rats","volume":"200","author":"Komuroglu","year":"2022","journal-title":"Biol. Trace Elem. Res"},{"key":"10.1016\/j.jtemb.2025.127806_bib61","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2022.834598","article-title":"Porcine models of the intestinal microbiota: the translational key to understanding how gut commensals contribute to gastrointestinal disease","volume":"9","author":"Rose","year":"2022","journal-title":"Front. Vet. Sci."},{"issue":"2","key":"10.1016\/j.jtemb.2025.127806_bib62","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3390\/ani10020179","article-title":"Dietary high sodium fluoride impairs digestion and absorption ability, mucosal immunity, and alters cecum microbial community of laying hens","volume":"10","author":"Miao","year":"2020","journal-title":"Animals"},{"issue":"15","key":"10.1016\/j.jtemb.2025.127806_bib63","doi-asserted-by":"crossref","first-page":"6715","DOI":"10.1007\/s00253-016-7480-1","article-title":"Intestinal microecology associated with fluoride resistance capability of the silkworm (Bombyx mori L.)","volume":"100","author":"Li","year":"2016","journal-title":"Appl. Microbiol Biotechnol."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127806_bib64","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/s41598-017-00796-3","article-title":"Sodium fluoride induces nephrotoxicity via oxidative stress-regulated mitochondrial SIRT3 signaling pathway","volume":"7","author":"Song","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jtemb.2025.127806_bib65","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2022.850771","article-title":"Effect of fluoride on cytotoxicity involved in mitochondrial dysfunction: a review of mechanism","volume":"9","author":"Wei","year":"2022","journal-title":"Front Vet. Sci."},{"key":"10.1016\/j.jtemb.2025.127806_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116959","article-title":"Gut microbiome and function are altered for individuals living in high fluoride concentration areas in Pakistan","volume":"284","author":"Bibi","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jtemb.2025.127806_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108569","article-title":"Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity","volume":"186","author":"Sen","year":"2024","journal-title":"Environ. Int"},{"issue":"1","key":"10.1016\/j.jtemb.2025.127806_bib68","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s12011-021-02617-1","article-title":"Effect of fluoride in drinking water on fecal microbial community in rats","volume":"200","author":"Zhong","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127806_bib69","doi-asserted-by":"crossref","first-page":"480","DOI":"10.3390\/ijms23010480","article-title":"The role of the gut microbiota in the pathogenesis of diabetes","volume":"23","author":"Bielka","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jtemb.2025.127806_bib70","article-title":"Gut microbiota: A new target for T2DM prevention and treatment","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jtemb.2025.127806_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.159482","article-title":"Assessing impacts of global climate change on water and food security in the black soil region of Northeast China using an improved SWAT-CO2 model","volume":"857","author":"Zhang","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jtemb.2025.127806_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108569","article-title":"Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity","volume":"186","author":"Sen","year":"2024","journal-title":"Environ. Int."},{"issue":"2","key":"10.1016\/j.jtemb.2025.127806_bib73","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3390\/metabo14020108","article-title":"Deciphering the role of the gut microbiota in exposure to emerging contaminants and diabetes: a review","volume":"14","author":"Li","year":"2024","journal-title":"Metabolites"},{"key":"10.1016\/j.jtemb.2025.127806_bib74","doi-asserted-by":"crossref","first-page":"1394161","DOI":"10.3389\/fimmu.2024.1394161","article-title":"Progress in research on the role of fluoride in immune damage","volume":"15","author":"Zhu","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtemb.2025.127806_bib75","series-title":"Guidelines for drinking-water quality","author":"Organization","year":"2004"},{"issue":"2","key":"10.1016\/j.jtemb.2025.127806_bib76","article-title":"Fluorosis Mitigation Programmes and its Impact on Health-The Indian Scenario","volume":"13","author":"Avisek","year":"2021","journal-title":"RGUHS J. Dent. Sci."},{"issue":"4","key":"10.1016\/j.jtemb.2025.127806_bib77","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/heapol\/czad008","article-title":"The utilization of systematic review evidence in formulating India\u2019s National Health Programme guidelines between 2007 and 2021","volume":"38","author":"Rajwar","year":"2023","journal-title":"Health Policy Plan."},{"key":"10.1016\/j.jtemb.2025.127806_bib78","first-page":"1","article-title":"Review on health impacts from domestic coal burning: emphasis on endemic fluorosis in Guizhou Province, Southwest China","volume":"258","author":"Guo","year":"2021","journal-title":"Rev. Environ. Contam. Toxicol."},{"key":"10.1016\/j.jtemb.2025.127806_bib79","article-title":"Measures designed to prevent endemic fluorosis caused by burning coal improve the health of most residents in the area of Guizhou, China, but not of the elderly","volume":"53","author":"Zhao","year":"2020","journal-title":"Fluoride"},{"issue":"8","key":"10.1016\/j.jtemb.2025.127806_bib80","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1177\/0748233717706802","article-title":"Arsenic and fluoride co-contamination in shallow aquifers from agricultural suburbs and an industrial area of Punjab, Pakistan: spatial trends, sources and human health implications","volume":"33","author":"Qurat-ul-Ain","year":"2017","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.jtemb.2025.127806_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.156058","article-title":"Monitoring and prediction of high fluoride concentrations in groundwater in Pakistan","volume":"839","author":"Ling","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.jtemb.2025.127806_bib82","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1007\/s12011-024-04334-x","article-title":"Development and Psychometric Validation of Population-Based Knowledge Attitudes and Practices-Questionnaire on Fluoride (PBKAP-QF)","volume":"203","author":"Bahekar","year":"2025","journal-title":"Biol. Trace Elem. Res"},{"issue":"2","key":"10.1016\/j.jtemb.2025.127806_bib83","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1080\/15376516.2023.2268722","article-title":"The fluorosis conundrum: bridging the gap between science and public health","volume":"34","author":"Kumar","year":"2024","journal-title":"Toxicol. Mech. Methods"},{"issue":"13","key":"10.1016\/j.jtemb.2025.127806_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e33744","article-title":"Fluoride in groundwater sources in Ghana: A multifaceted and country-wide review","volume":"10","author":"Kazapoe","year":"2024","journal-title":"Heliyon"},{"issue":"1","key":"10.1016\/j.jtemb.2025.127806_bib85","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2038856","article-title":"The potential utility of fecal (or intestinal) microbiota transplantation in controlling infectious diseases","volume":"14","author":"Ghani","year":"2022","journal-title":"Gut Microbes"},{"issue":"1","key":"10.1016\/j.jtemb.2025.127806_bib86","doi-asserted-by":"crossref","first-page":"2423026","DOI":"10.1080\/19490976.2024.2423026","article-title":"Faecal (or intestinal) microbiota transplant: a tool for repairing the gut microbiome","volume":"16","author":"Ghani","year":"2024","journal-title":"Gut Microbes"},{"issue":"1","key":"10.1016\/j.jtemb.2025.127806_bib87","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s12088-019-00808-y","article-title":"Recent Advancements in the Development of Modern Probiotics for Restoring Human Gut Microbiome Dysbiosis","volume":"60","author":"Kumar","year":"2020","journal-title":"Indian J. Microbiol"},{"issue":"1","key":"10.1016\/j.jtemb.2025.127806_bib88","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.01300-22","article-title":"Adjunctive probio-X Treatment enhances the therapeutic effect of a conventional drug in managing type 2 diabetes mellitus by promoting short-chain fatty acid-producing bacteria and bile acid pathways","volume":"8","author":"Chen","year":"2023","journal-title":"mSystems"},{"issue":"5","key":"10.1016\/j.jtemb.2025.127806_bib89","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1007\/s00394-021-02520-4","article-title":"Manipulation of intestinal microbiome as potential treatment for insulin resistance and type 2 diabetes","volume":"60","author":"Ghorbani","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.jtemb.2025.127806_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113148","article-title":"Modulation of gut microbiota by bioactive compounds for prevention and management of type 2 diabetes","volume":"152","author":"Sharma","year":"2022","journal-title":"Biomed. Pharm."},{"issue":"23","key":"10.1016\/j.jtemb.2025.127806_bib91","doi-asserted-by":"crossref","first-page":"5139","DOI":"10.3390\/nu14235139","article-title":"The effect of prebiotics and oral anti-diabetic agents on gut microbiome in patients with type 2 diabetes: a systematic review and network meta-analysis of randomised controlled trials","volume":"14","author":"Ojo","year":"2022","journal-title":"Nutrients"},{"issue":"11","key":"10.1016\/j.jtemb.2025.127806_bib92","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.3390\/ijms23116097","article-title":"Prebiotics as a tool for the prevention and treatment of obesity and diabetes: classification and ability to modulate the gut microbiota","volume":"23","author":"Megur","year":"2022","journal-title":"Int J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jtemb.2025.127806_bib93","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12967-019-02169-y","article-title":"The potential therapeutic effects of the gut microbiome manipulation by synbiotic containing-Lactobacillus plantarum on neuropsychological performance of diabetic rats","volume":"18","author":"Morshedi","year":"2020","journal-title":"J. Transl. Med"},{"issue":"16","key":"10.1016\/j.jtemb.2025.127806_bib94","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.3390\/foods11162438","article-title":"Synbiotics and gut microbiota: new perspectives in the treatment of type 2 diabetes mellitus","volume":"11","author":"Jiang","year":"2022","journal-title":"Foods"},{"issue":"8","key":"10.1016\/j.jtemb.2025.127806_bib95","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1080\/10408398.2021.1958744","article-title":"Role of prebiotics in enhancing the function of next-generation probiotics in gut microbiota","volume":"63","author":"Fei","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"8","key":"10.1016\/j.jtemb.2025.127806_bib96","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.3390\/biomedicines12081871","article-title":"The role of fecal microbiota transplantation (FMT) in the management of metabolic diseases in humans: a narrative review","volume":"12","author":"Zikou","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.jtemb.2025.127806_bib97","series-title":"Therapeutic Strategies of Targeting Gut Microbiota in Colorectal Cancer Management, Role of Gut Microbiota and Postbiotics for Colorectal Cancer","first-page":"323","author":"Sen","year":"2025"},{"issue":"10","key":"10.1016\/j.jtemb.2025.127806_bib98","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.3855\/jidc.12780","article-title":"Benefits of fecal microbiota transplantation: A comprehensive review","volume":"14","author":"Ademe","year":"2020","journal-title":"J. Infect. Dev. Ctries"},{"issue":"3","key":"10.1016\/j.jtemb.2025.127806_bib99","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2022-003282","article-title":"Fecal microbiota transplantation ameliorates type 2 diabetes via metabolic remodeling of the gut microbiota in db\/db mice","volume":"11","author":"Chen","year":"2023","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"10.1016\/j.jtemb.2025.127806_bib100","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3389\/fcimb.2019.00455","article-title":"Promising treatment for Type 2 diabetes: fecal microbiota transplantation reverses insulin resistance and impaired islets","volume":"9","author":"Wang","year":"2019","journal-title":"Front Cell Infect. Microbiol"},{"key":"10.1016\/j.jtemb.2025.127806_bib101","doi-asserted-by":"crossref","unstructured":"C. Almeida, R. Oliveira, P. Baylina, R. Fernandes, F.G. Teixeira, P. Barata, Current Trends and Challenges of Fecal Microbiota Transplantation\u2014An Easy Method That Works for All?, 10(11) (2022) 2742.","DOI":"10.3390\/biomedicines10112742"},{"key":"10.1016\/j.jtemb.2025.127806_bib102","article-title":"Fecal microbiota transplantation reverses insulin resistance in type 2 diabetes: a randomized, controlled, prospective study","volume":"12","author":"Wu","year":"2022","journal-title":"Front. Cell Infect. Microbiol."},{"issue":"2","key":"10.1016\/j.jtemb.2025.127806_bib103","doi-asserted-by":"crossref","DOI":"10.1128\/cmr.00060-22","article-title":"Fecal microbiota transplantation: current challenges and future landscapes","volume":"37","author":"Yadegar","year":"2024","journal-title":"Clin. Microbiol Rev."},{"key":"10.1016\/j.jtemb.2025.127806_bib104","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1439176","article-title":"Safety and efficacy of fecal microbiota transplantation (FMT) as a modern adjuvant therapy in various diseases and disorders: a comprehensive literature review","volume":"15","author":"Karimi","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtemb.2025.127806_bib105","article-title":"Gut Microbiota and Anti-diabetic Drugs: Perspectives of Personalized Treatment in Type 2 Diabetes Mellitus","volume":"12","author":"Liu","year":"2022","journal-title":"Front Cell Infect. Microbiol"},{"issue":"9","key":"10.1016\/j.jtemb.2025.127806_bib106","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3390\/life10090195","article-title":"The Effects of metformin on the gut microbiota of patients with type 2 diabetes: a two-center, quasi-experimental study","volume":"10","author":"Nakajima","year":"2020","journal-title":"Life"},{"issue":"1","key":"10.1016\/j.jtemb.2025.127806_bib107","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cmet.2017.09.019","article-title":"Metformin alters upper small intestinal microbiota that impact a glucose-SGLT1-sensing glucoregulatory pathway","volume":"27","author":"Bauer","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.jtemb.2025.127806_bib108","doi-asserted-by":"crossref","unstructured":"Q. Zhang, X. Xiao, J. Zheng, M. Li, M. Yu, F. Ping, T. Wang, X. Wang, Featured article: Structure moderation of gut microbiota in liraglutide-treated diabetic male rats, Experimental biology and medicine (Maywood, N.J.) 243(1) (2018) 34-44.","DOI":"10.1177\/1535370217743765"},{"issue":"3","key":"10.1016\/j.jtemb.2025.127806_bib109","doi-asserted-by":"crossref","first-page":"154","DOI":"10.4239\/wjd.v10.i3.154","article-title":"Crosstalk between gut microbiota and anti-diabetic drug action","volume":"10","author":"Kyriachenko","year":"2019","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.jtemb.2025.127806_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119069","article-title":"A comparative study of acarbose, vildagliptin and saxagliptin intended for better efficacy and safety on type 2 diabetes mellitus treatment","volume":"274","author":"Wang","year":"2021","journal-title":"Life Sci."},{"issue":"11","key":"10.1016\/j.jtemb.2025.127806_bib111","doi-asserted-by":"crossref","first-page":"5744","DOI":"10.3390\/ijms25115744","article-title":"Comparative binding study of gliptins to bacterial DPP4-like enzymes for the treatment of type 2 diabetes mellitus (T2DM)","volume":"25","author":"Carpio","year":"2024","journal-title":"Int J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.jtemb.2025.127806_bib112","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jcjd.2019.05.008","article-title":"Metformin and Dipeptidyl Peptidase-4 Inhibitor Differentially Modulate the Intestinal Microbiota and Plasma Metabolome of Metabolically Dysfunctional Mice","volume":"44","author":"Ryan","year":"2020","journal-title":"Can. J. Diabetes"}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X25002196?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X25002196?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T07:17:17Z","timestamp":1769584637000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X25002196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":112,"alternative-id":["S0946672X25002196"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2025.127806","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fluoride-induced gut dysbiosis in metabolic disorders: Mechanisms and public health implications","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2025.127806","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"127806"}}