{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T13:22:41Z","timestamp":1774012961632,"version":"3.50.1"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013795","name":"Fujian Medical University","doi-asserted-by":"publisher","award":["2024XH017"],"award-info":[{"award-number":["2024XH017"]}],"id":[{"id":"10.13039\/501100013795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jtemb.2026.127831","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T19:01:12Z","timestamp":1769713272000},"page":"127831","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Association between systemic inflammation and serum cobalt level in patients with metallic implants: Evidence from NHANES 2015\u20132020"],"prefix":"10.1016","volume":"94","author":[{"given":"Dingxiang","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.jtemb.2026.127831_bib1","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1007\/s00402-021-04297-x","article-title":"Prevalence of osteoporosis and osteopenia in elderly patients scheduled for total knee arthroplasty","volume":"142","author":"Delsmann","year":"2022","journal-title":"Arch. Orthop. Trauma Surg."},{"issue":"9","key":"10.1016\/j.jtemb.2026.127831_bib2","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.3899\/jrheum.170990","article-title":"Rates of total joint replacement in the United States: Future projections to 2020-2040 using the National Inpatient sample","volume":"46","author":"Singh","year":"2019","journal-title":"J. Rheumatol."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127831_bib3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11914-022-00720-3","article-title":"Macrophage polarization and the osteoimmunology of periprosthetic osteolysis","volume":"20","author":"Goodman","year":"2022","journal-title":"Curr. Osteoporos. Rep."},{"issue":"8","key":"10.1016\/j.jtemb.2026.127831_bib4","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1002\/jbm.a.37599","article-title":"Friend or foe? Inflammation and the foreign body response to orthopedic biomaterials","volume":"112","author":"Gibon","year":"2024","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"10.1016\/j.jtemb.2026.127831_bib5","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3389\/fbioe.2019.00176","article-title":"Mechanisms of adverse local tissue reactions to hip implants","volume":"7","author":"Eltit","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.jtemb.2026.127831_bib6","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.actbio.2021.10.002","article-title":"Corrosion of titanium under simulated inflammation conditions: clinical context and in vitro investigations","volume":"136","author":"Prestat","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jtemb.2026.127831_bib7","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.2147\/IJN.S459255","article-title":"Prosthetic metals: release, metabolism and toxicity","volume":"19","author":"Zhong","year":"2024","journal-title":"Int. J. Nanomed."},{"issue":"3","key":"10.1016\/j.jtemb.2026.127831_bib8","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1039\/C2CP42968C","article-title":"CoCrMo metal-on-metal hip replacements","volume":"15","author":"Liao","year":"2013","journal-title":"Phys. Chem. Chem. Phys."},{"issue":"3","key":"10.1016\/j.jtemb.2026.127831_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ma12030407","article-title":"Corrosion of metallic biomaterials: a review","volume":"12","author":"Eliaz","year":"2019","journal-title":"Materials"},{"key":"10.1016\/j.jtemb.2026.127831_bib10","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.actbio.2021.06.039","article-title":"Cobalt ions induce metabolic stress in synovial fibroblasts and secretion of cytokines\/chemokines that may be diagnostic markers for adverse local tissue reactions to hip implants","volume":"131","author":"Eltit","year":"2021","journal-title":"Acta Biomater."},{"issue":"5","key":"10.1016\/j.jtemb.2026.127831_bib11","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.jaip.2015.07.011","article-title":"Allergy to surgical implants","volume":"3","author":"Pacheco","year":"2015","journal-title":"J. Allergy Clin. Immunol. Pract."},{"issue":"4","key":"10.1016\/j.jtemb.2026.127831_bib12","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3109\/10408444.2013.779633","article-title":"A review of the health hazards posed by cobalt","volume":"43","author":"Paustenbach","year":"2013","journal-title":"Crit. Rev. Toxicol."},{"issue":"8","key":"10.1016\/j.jtemb.2026.127831_bib13","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00204-008-0313-y","article-title":"Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms","volume":"82","author":"Beyersmann","year":"2008","journal-title":"Arch. Toxicol."},{"issue":"7","key":"10.1016\/j.jtemb.2026.127831_bib14","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/jor.20826","article-title":"Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: a novel mechanism for implant debris reactivity","volume":"27","author":"Caicedo","year":"2009","journal-title":"J. Orthop. Res. Off. Publ. Orthop. Res. Soc."},{"key":"10.1016\/j.jtemb.2026.127831_bib15","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.actbio.2015.03.008","article-title":"In vivo electrochemical corrosion study of a CoCrMo biomedical alloy in human synovial fluids","volume":"21","author":"Igual Munoz","year":"2015","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jtemb.2026.127831_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2024.1485428","article-title":"Association between oxidative balance score and serum cobalt level in population with metal implants: a cross-sectional study from NHANES 2015-2020","volume":"11","author":"Yuan","year":"2024","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jtemb.2026.127831_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jnutbio.2015.12.007","article-title":"The relation of saturated fatty acids with low-grade inflammation and cardiovascular disease","volume":"36","author":"Ruiz-N\u00fa\u00f1ez","year":"2016","journal-title":"J. Nutr. Biochem."},{"issue":"2","key":"10.1016\/j.jtemb.2026.127831_bib18","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/cvr\/cvaa211","article-title":"Inflammation and cardiovascular diseases: lessons from seminal clinical trials","volume":"117","author":"Liberale","year":"2021","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127831_bib19","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1186\/s12877-022-03094-4","article-title":"Associations between albumin, globulin, albumin to globulin ratio and muscle mass in adults: results from the national health and nutrition examination survey 2011-2014","volume":"22","author":"Chen","year":"2022","journal-title":"BMC Geriatr."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127831_bib20","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.numecd.2023.10.006","article-title":"Association between inflammatory burden index and all-cause mortality in the general population aged over 45 years: data from NHANES 2005-2017","volume":"34","author":"He","year":"2024","journal-title":"Nutr. Metab. Cardiovasc. Dis. NMCD"},{"issue":"Pt 2","key":"10.1016\/j.jtemb.2026.127831_bib21","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1258\/acb.2011.011141","article-title":"Clinical usefulness of blood metal measurements to assess the failure of metal-on-metal hip implants","volume":"49","author":"Sampson","year":"2012","journal-title":"Ann. Clin. Biochem."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127831_bib22","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12877-022-03710-3","article-title":"Accumulation of blood chromium and cobalt in the participants with metal objects: findings from the 2015 to 2018 National Health and Nutrition Examination Survey (NHANES)","volume":"23","author":"He","year":"2023","journal-title":"BMC Geriatr."},{"issue":"6","key":"10.1016\/j.jtemb.2026.127831_bib23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1080\/15287390802647336","article-title":"Age-related impairments of mobility associated with cobalt and other heavy metals: data from NHANES 1999-2004","volume":"72","author":"Lang","year":"2009","journal-title":"J. Toxicol. Environ. Health Part A"},{"issue":"4","key":"10.1016\/j.jtemb.2026.127831_bib24","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3904\/kjim.2016.015","article-title":"Differences among skeletal muscle mass indices derived from height-, weight-, and body mass index-adjusted models in assessing sarcopenia","volume":"31","author":"Kim","year":"2016","journal-title":"Korean J. Intern. Med."},{"issue":"4","key":"10.1016\/j.jtemb.2026.127831_bib25","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.jand.2018.09.007","article-title":"Association between body iron status and leukocyte telomere length, a biomarker of biological aging, in a nationally representative sample of US Adults","volume":"119","author":"Liu","year":"2019","journal-title":"J. Acad. Nutr. Diet."},{"key":"10.1016\/j.jtemb.2026.127831_bib26","article-title":"Association between the oxidative balance score and telomere length from the National Health and Nutrition Examination Survey 1999-2002","volume":"2022","author":"Zhang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127831_bib27","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1186\/s12885-024-13279-2","article-title":"The potential carcinogenicity of orthopaedic implants - a scoping review","volume":"24","author":"Sun","year":"2024","journal-title":"BMC Cancer"},{"issue":"6","key":"10.1016\/j.jtemb.2026.127831_bib28","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.arth.2011.12.016","article-title":"Cobalt and chromium ion release after large-diameter metal-on-metal total hip arthroplasty","volume":"27","author":"Hasegawa","year":"2012","journal-title":"J. Arthroplast."},{"key":"10.1016\/j.jtemb.2026.127831_bib29","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tox.2017.05.015","article-title":"Cobalt toxicity in humans-a review of the potential sources and systemic health effects","volume":"387","author":"Leyssens","year":"2017","journal-title":"Toxicology"},{"issue":"8","key":"10.1016\/j.jtemb.2026.127831_bib30","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1002\/jbm.a.34122","article-title":"Orthopedic implant cobalt-alloy particles produce greater toxicity and inflammatory cytokines than titanium alloy and zirconium alloy-based particles in vitro, in human osteoblasts, fibroblasts, and macrophages","volume":"100","author":"Dalal","year":"2012","journal-title":"J. Biomed. Mater. Res. Part A"},{"issue":"12","key":"10.1016\/j.jtemb.2026.127831_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics12122958","article-title":"Role of biomarkers in periprosthetic joint infections","volume":"12","author":"Akcaalan","year":"2022","journal-title":"Diagnostics"},{"issue":"3","key":"10.1016\/j.jtemb.2026.127831_bib32","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41563-018-0271-6","article-title":"Sterile particle-induced inflammation is mediated by macrophages releasing IL-33 through a Bruton's tyrosine kinase-dependent pathway","volume":"18","author":"Mishra","year":"2019","journal-title":"Nat. Mater."},{"issue":"2","key":"10.1016\/j.jtemb.2026.127831_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/biology8020026","article-title":"Mitochondrial dysfunction and the aging immune system","volume":"8","author":"McGuire","year":"2019","journal-title":"Biology"},{"key":"10.1016\/j.jtemb.2026.127831_bib34","doi-asserted-by":"crossref","DOI":"10.4178\/epih.e2023051","article-title":"Association of the dietary inflammatory index with phenotypic age in the United States adults","volume":"45","author":"Sun","year":"2023","journal-title":"Epidemiol. Health"},{"key":"10.1016\/j.jtemb.2026.127831_bib35","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.actbio.2019.10.039","article-title":"Wear particles induce a new macrophage phenotype with the potential to accelerate material corrosion within total hip replacement interfaces","volume":"101","author":"Bijukumar","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jtemb.2026.127831_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111610","article-title":"Osteoclast-mediated biocorrosion of pure titanium in an inflammatory microenvironment","volume":"119","author":"Yu","year":"2021","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.jtemb.2026.127831_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2020.103488","article-title":"Luteolin supplementation ameliorates cobalt-induced oxidative stress and inflammation by suppressing NF-\u043aB\/Kim-1 signaling in the heart and kidney of rats","volume":"80","author":"Oyagbemi","year":"2020","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.jtemb.2026.127831_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112725","article-title":"NOX2 activation contributes to cobalt nanoparticles-induced inflammatory responses and Tau phosphorylation in mice and microglia","volume":"225","author":"Li","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127831_bib39","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12989-017-0219-z","article-title":"Cobalt nanoparticles induce lung injury, DNA damage and mutations in mice","volume":"14","author":"Wan","year":"2017","journal-title":"Part. Fibre Toxicol."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127831_bib40","article-title":"The mediation effect of systemic immunity inflammation index between urinary metals and TOFAT among adults in the NHANES dataset","volume":"14","author":"Zhang","year":"2024","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.jtemb.2026.127831_bib41","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.jbspin.2020.05.014","article-title":"Cobalt hip prosthesis intoxication mimicking an autoimmune disease","volume":"87","author":"Biglia","year":"2020","journal-title":"Jt. Bone Spine"},{"issue":"3","key":"10.1016\/j.jtemb.2026.127831_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/jfb8030033","article-title":"Immunological responses to total hip arthroplasty","volume":"8","author":"Man","year":"2017","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.jtemb.2026.127831_bib43","first-page":"355","article-title":"Interaction pathways of implant metal localized corrosion and macrophage inflammatory reactions","volume":"31","author":"Li","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jtemb.2026.127831_bib44","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/125705","article-title":"The role of inflammatory cytokines, the RANKL\/OPG axis, and the immunoskeletal interface in physiological bone turnover and osteoporosis","volume":"2013","author":"Weitzmann","year":"2013","journal-title":"Scientifica"},{"issue":"12","key":"10.1016\/j.jtemb.2026.127831_bib45","doi-asserted-by":"crossref","first-page":"21913","DOI":"10.3390\/ijms151221913","article-title":"The inhibition of RANKL-induced osteoclastogenesis through the suppression of p38 signaling pathway by naringenin and attenuation of titanium-particle-induced osteolysis","volume":"15","author":"Wang","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jtemb.2026.127831_bib46","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1479-5876-12-74","article-title":"On the inflammatory response in metal-on-metal implants","volume":"12","author":"Dapunt","year":"2014","journal-title":"J. Transl. Med."},{"issue":"13","key":"10.1016\/j.jtemb.2026.127831_bib47","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/j.electacta.2003.12.043","article-title":"Passive and transpassive behaviour of CoCrMo in simulated biological solutions","volume":"49","author":"Hodgson","year":"2004","journal-title":"Electrochim. Acta"},{"issue":"3","key":"10.1016\/j.jtemb.2026.127831_bib48","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s10856-010-4224-0","article-title":"Effect of the environment on wear ranking and corrosion of biomedical CoCrMo alloys","volume":"22","author":"Mu\u00f1oz","year":"2011","journal-title":"J. Mater. Sci. Mater. Med."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127831_bib49","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.biomaterials.2004.02.005","article-title":"Comparison of metal release from various metallic biomaterials in vitro","volume":"26","author":"Okazaki","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.jtemb.2026.127831_bib50","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.wear.2014.12.030","article-title":"A metal ion release study of CoCrMo exposed to corrosion and tribocorrosion conditions in simulated body fluids","volume":"332-333","author":"Espallargas","year":"2015","journal-title":"Wear"},{"key":"10.1016\/j.jtemb.2026.127831_bib51","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.3389\/fimmu.2018.01332","article-title":"Glucocorticoids, sex hormones, and immunity","volume":"9","author":"Bereshchenko","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtemb.2026.127831_bib52","article-title":"Associations between dietary inflammatory index and sex hormones among 6- to 19-year-old children and adolescents in NHANES 2015-2016","volume":"12","author":"Ma","year":"2021","journal-title":"Front. Endocrinol."},{"issue":"8","key":"10.1016\/j.jtemb.2026.127831_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/jfb14080392","article-title":"Corrosion products from metallic implants induce ROS and cell death in human motoneurons in vitro","volume":"14","author":"Gla\u00df","year":"2023","journal-title":"J. Funct. Biomater."},{"issue":"12","key":"10.1016\/j.jtemb.2026.127831_bib54","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1161\/CIRCRESAHA.111.258723","article-title":"2nd: mitochondrial fusion is essential for organelle function and cardiac homeostasis","volume":"109","author":"Chen","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.jtemb.2026.127831_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101482","article-title":"Sex differences in inflammation, redox biology, mitochondria and autoimmunity","volume":"31","author":"Di Florio","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.jtemb.2026.127831_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2024.1374719","article-title":"Association between oxidative balance score in adults with and without chronic kidney disease: 2011-2028 NHANES","volume":"11","author":"Cao","year":"2024","journal-title":"Front. Nutr."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127831_bib57","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/eurjpc\/zwad342","article-title":"Oxidative stress-related genetic variation and antioxidant vitamin intake in intact and ruptured abdominal aortic aneurysm: does sex matter?","volume":"31","author":"Basnet","year":"2024","journal-title":"Eur. J. Prev. Cardiol."},{"issue":"11","key":"10.1016\/j.jtemb.2026.127831_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/cells10112974","article-title":"The role of immune cells in oxi-inflamm-aging","volume":"10","author":"Mart\u00ednez de Toda","year":"2021","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.jtemb.2026.127831_bib59","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/s12964-025-02308-7","article-title":"Mitochondrial dysfunction in the regulation of aging and aging-related diseases","volume":"23","author":"Zhang","year":"2025","journal-title":"Cell Commun. Signal. CCS"},{"issue":"1","key":"10.1016\/j.jtemb.2026.127831_bib60","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1186\/s12889-024-18638-z","article-title":"Association between multiple-heavy-metal exposures and systemic immune inflammation in a middle-aged and elderly Chinese general population","volume":"24","author":"Zhao","year":"2024","journal-title":"BMC Public Health"},{"key":"10.1016\/j.jtemb.2026.127831_bib61","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1138488","article-title":"The association between oxidative balance score and periodontitis in adults: a population-based study","volume":"10","author":"Qu","year":"2023","journal-title":"Front Nutr."},{"key":"10.1016\/j.jtemb.2026.127831_bib62","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/bs.ircmb.2018.05.006","article-title":"Mitochondria and reactive oxygen species in aging and age-related diseases","volume":"340","author":"Giorgi","year":"2018","journal-title":"Int. Rev. Cell Mol. Biol."},{"issue":"4","key":"10.1016\/j.jtemb.2026.127831_bib63","doi-asserted-by":"crossref","DOI":"10.3390\/antiox13040394","article-title":"Progress in understanding oxidative stress, aging, and aging-related diseases","volume":"13","author":"Yang","year":"2024","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.jtemb.2026.127831_bib64","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.devcel.2023.11.017","article-title":"D-Mannose reduces cellular senescence and NLRP3\/GasderminD\/IL-1\u03b2-driven pyroptotic uroepithelial cell shedding in the murine bladder","volume":"59","author":"Joshi","year":"2024","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jtemb.2026.127831_bib65","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.2147\/IJN.S188193","article-title":"Anti-inflammatory drug-eluting implant model system to prevent wear particle-induced periprosthetic osteolysis","volume":"14","author":"Rivera","year":"2019","journal-title":"Int. J. Nanomed."}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X26000179?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X26000179?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T10:52:25Z","timestamp":1774003945000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X26000179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":65,"alternative-id":["S0946672X26000179"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2026.127831","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between systemic inflammation and serum cobalt level in patients with metallic implants: Evidence from NHANES 2015\u20132020","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2026.127831","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"127831"}}