{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:28:04Z","timestamp":1777879684268,"version":"3.51.4"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007446","name":"King Khalid University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023674","name":"King Khalid University Deanship of Scientific Research","doi-asserted-by":"publisher","award":["RGP2\/373\/46"],"award-info":[{"award-number":["RGP2\/373\/46"]}],"id":[{"id":"10.13039\/501100023674","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jtemb.2026.127836","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:40:12Z","timestamp":1770136812000},"page":"127836","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Ayanin combats against barium sulphate nanoparticles induced hepatotoxicity via modulating SIRT1\/FOXO3a and HO-1\/ferritin pathways: A biochemical, histopathological and computational approaches"],"prefix":"10.1016","volume":"94","author":[{"given":"Di","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanzhi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salim","family":"Jamil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafsa","family":"Ashfaq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Al-Emam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hesham M.","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtemb.2026.127836_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-018-0343-4","article-title":"Cerium oxide and barium sulfate nanoparticle inhalation affects gene expression in alveolar epithelial cells type II","volume":"16","author":"Schwotzer","year":"2018","journal-title":"J. Nanobiotech"},{"key":"10.1016\/j.jtemb.2026.127836_bib2","first-page":"30","article-title":"Recent advances in the preparation of barium sulfate nanoparticles: a mini-review","volume":"6","author":"Ketegenov","year":"2022","journal-title":"Chem. Eng."},{"key":"10.1016\/j.jtemb.2026.127836_bib3","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1007\/s10876-020-01878-5","article-title":"Metal-doped barium sulphate nanoparticles decorated with gelatin as antibacterial agents","volume":"32","author":"Sooch","year":"2021","journal-title":"J. Clust. Sci."},{"key":"10.1016\/j.jtemb.2026.127836_bib4","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/open.202000126","article-title":"Sub-10 nm radiolabeled barium sulfate nanoparticles as carriers for theranostic applications and targeted alpha therapy","volume":"9","author":"Reissig","year":"2020","journal-title":"ChemistryOpen"},{"key":"10.1016\/j.jtemb.2026.127836_bib5","doi-asserted-by":"crossref","first-page":"8163","DOI":"10.1038\/s41598-019-44551-2","article-title":"Fate of barium sulfate nanoparticles deposited in the lungs of rats","volume":"9","author":"Molina","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jtemb.2026.127836_bib6","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1080\/17435390.2016.1235740","article-title":"Barium sulfate micro-and nanoparticles as bioinert reference material in particle toxicology","volume":"10","author":"Loza","year":"2016","journal-title":"Nanotoxicol"},{"key":"10.1016\/j.jtemb.2026.127836_bib7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12989-014-0055-3","article-title":"Biokinetics and effects of barium sulfate nanoparticles","volume":"11","author":"Konduru","year":"2014","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.jtemb.2026.127836_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2025.127650","article-title":"Uptake, localization and dissolution of barium sulfate nanoparticles in human lung cells explored by the combination of ICP-MS, TEM and NanoSIMS","volume":"89","author":"Subirana","year":"2025","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.jtemb.2026.127836_bib9","first-page":"237","article-title":"SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress","volume":"16","author":"Kobayashi","year":"2005","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jtemb.2026.127836_bib10","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1126\/science.1094637","article-title":"Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase","volume":"303","author":"Brunet","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.jtemb.2026.127836_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174644","article-title":"Syringaresinol attenuates sepsis-induced cardiac dysfunction by inhibiting inflammation and pyroptosis in mice","volume":"913","author":"Wei","year":"2021","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.jtemb.2026.127836_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2024.106859","article-title":"Pesticide avermectin-induced hepatotoxicity and growth inhibition in carp: Ameliorative capacity and potential mechanisms of quercetin as a dietary additive","volume":"268","author":"Xin","year":"2024","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.jtemb.2026.127836_bib13","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3390\/ddc3010011","article-title":"Plant-derived natural products: a source for drug discovery and development","volume":"3","author":"Chaachouay","year":"2024","journal-title":"Drugs Drug. Candidates"},{"key":"10.1016\/j.jtemb.2026.127836_bib14","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.3390\/molecules28041845","article-title":"Therapeutic potential of phenolic compounds in medicinal plants\u2014Natural health products for human health","volume":"28","author":"Sun","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.jtemb.2026.127836_bib15","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1055\/s-2006-960776","article-title":"Relaxant effects of quercetin methyl ether derivatives in isolated guinea pig trachea and their structure-activity relationships","volume":"65","author":"Ko","year":"1999","journal-title":"Planta Med."},{"key":"10.1016\/j.jtemb.2026.127836_bib16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2332\/allergolint.R-06-135","article-title":"Flavonoids and related compounds as anti-allergic substances","volume":"56","author":"Kawai","year":"2007","journal-title":"Allergol. Int."},{"key":"10.1016\/j.jtemb.2026.127836_bib17","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1016\/j.bmc.2010.12.043","article-title":"Structure\u2013activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP)","volume":"19","author":"Pick","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jtemb.2026.127836_bib18","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1055\/s-2002-26755","article-title":"Inhibitory effect of N (G)-nitro-L-arginine methyl ester on the anti-adrenergic response elicited by ayanin in the pithed rat","volume":"68","author":"Guerrero","year":"2002","journal-title":"Planta Med."},{"key":"10.1016\/j.jtemb.2026.127836_bib19","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jtemb.2026.127836_bib20","first-page":"27","article-title":"Glutathione peroxidase activities from rat liver","volume":"523","author":"Pierce","year":"1978","journal-title":"BBA Enzymology"},{"key":"10.1016\/j.jtemb.2026.127836_bib21","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/BF02712155","article-title":"Assay of superoxide dismutase activity in animal tissues","volume":"13","author":"Nandi","year":"1988","journal-title":"J. Biosci."},{"key":"10.1016\/j.jtemb.2026.127836_bib22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ab.2017.11.013","article-title":"New spectrophotometric assay for assessments of catalase activity in biological samples","volume":"542","author":"Hadwan","year":"2018","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jtemb.2026.127836_bib23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0304-4165(79)90289-7","article-title":"Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver","volume":"582","author":"Moron","year":"1979","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.jtemb.2026.127836_bib24","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000136485","article-title":"Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3, 4-bromobenzene oxide as the hepatotoxic metabolite","volume":"11","author":"Jollow","year":"1974","journal-title":"Pharmacol"},{"key":"10.1016\/j.jtemb.2026.127836_bib25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.mrgentox.2007.04.006","article-title":"High-throughput spectrophotometric assay of reactive oxygen species in serum","volume":"631","author":"Hayashi","year":"2007","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"key":"10.1016\/j.jtemb.2026.127836_bib26","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ab.2016.10.021","article-title":"Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: analytical and biological challenges","volume":"524","author":"Tsikas","year":"2017","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jtemb.2026.127836_bib27","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.3390\/nu15092209","article-title":"Guided metabolic detoxification program supports phase II detoxification enzymes and antioxidant balance in healthy participants","volume":"15","author":"Panda","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.jtemb.2026.127836_bib28","doi-asserted-by":"crossref","first-page":"733","DOI":"10.3390\/nu15030733","article-title":"Mechanistic understanding of D-glucaric acid to support liver detoxification essential to muscle health using a computational systems biology approach","volume":"15","author":"Ayyadurai","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.jtemb.2026.127836_bib29","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3390\/coatings11050501","article-title":"Antioxidant, antigenotoxic, and hepatic ameliorative effects of quercetin\/zinc complex on cadmium-induced hepatotoxicity and alterations in hepatic tissue structure","volume":"11","author":"Refat","year":"2021","journal-title":"Coatings"},{"key":"10.1016\/j.jtemb.2026.127836_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9564297","article-title":"Role of autophagy in cadmium-induced hepatotoxicity and liver diseases","volume":"2021","author":"Niture","year":"2021","journal-title":"J. Toxicol."},{"key":"10.1016\/j.jtemb.2026.127836_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134855","article-title":"Selenium restored mitophagic flux to alleviate cadmium-induced hepatotoxicity by inhibiting excessive GPER1-mediated mitophagy activation","volume":"475","author":"Zhang","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jtemb.2026.127836_bib32","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/4139117","article-title":"A comprehensive review of the pharmacological importance of dietary flavonoids as hepatoprotective agents","volume":"2023","author":"Gajender","year":"2023","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.jtemb.2026.127836_bib33","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2174\/1389557522666220602141142","article-title":"An insight into the hepatoprotective activity and structure-activity relationships of flavonoids","volume":"23","author":"Majee","year":"2023","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.jtemb.2026.127836_bib34","doi-asserted-by":"crossref","first-page":"17475","DOI":"10.18632\/oncotarget.15728","article-title":"Spermidine coupled with exercise rescues skeletal muscle atrophy from D-gal-induced aging rats through enhanced autophagy and reduced apoptosis via AMPK-FOXO3a signal pathway","volume":"8","author":"Fan","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jtemb.2026.127836_bib35","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.molcel.2004.08.031","article-title":"Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin","volume":"16","author":"Vaquero","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jtemb.2026.127836_bib36","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/hep.26412","article-title":"The degree of liver injury determines the role of p21 in liver regeneration and hepatocarcinogenesis in mice","volume":"58","author":"Buitrago-Molina","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jtemb.2026.127836_bib37","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1126\/scitranslmed.aan1230","article-title":"TGF\u03b2 inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence","volume":"10","author":"Bird","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jtemb.2026.127836_bib38","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.biopha.2017.12.083","volume":"98","author":"Tomiotto-Pellissier","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jtemb.2026.127836_bib39","doi-asserted-by":"crossref","first-page":"9583","DOI":"10.1039\/D1FO01036K","article-title":"Toward improved human health: Nrf2 plays a critical role in regulating ferroptosis","volume":"12","author":"Lu","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.jtemb.2026.127836_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.freeradbiomed.2025.04.047","article-title":"Mechanistic insights into cadmium-induced nephrotoxicity: NRF2-Driven HO-1 activation promotes ferroptosis via iron overload and oxidative stress in vitro","author":"Luo","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jtemb.2026.127836_bib41","series-title":"Homeostasis-an integrated vision","article-title":"Reactive oxygen species, cellular redox homeostasis and cancer","author":"Mydin","year":"2018"},{"key":"10.1016\/j.jtemb.2026.127836_bib42","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.redox.2016.01.010","article-title":"Redox homeostasis: The Golden Mean of healthy living","volume":"8","author":"Ursini","year":"2016","journal-title":"Redox Biol."},{"key":"10.1016\/j.jtemb.2026.127836_bib43","series-title":"Free Radic. Biol. Med","author":"Halliwell","year":"2015"},{"key":"10.1016\/j.jtemb.2026.127836_bib44","doi-asserted-by":"crossref","first-page":"4642","DOI":"10.3390\/ijms22094642","article-title":"The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies","volume":"22","author":"Juan","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jtemb.2026.127836_bib45","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00204-023-03476-6","article-title":"ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis","volume":"97","author":"Wang","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.jtemb.2026.127836_bib46","series-title":"Liver function tests","author":"Lala","year":"2023"},{"key":"10.1016\/j.jtemb.2026.127836_bib47","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2147\/CEG.S160537","article-title":"Liver function tests in identifying patients with liver disease","author":"Ahmed","year":"2018","journal-title":"Clin. Exp. Gastroenterol."},{"key":"10.1016\/j.jtemb.2026.127836_bib48","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1152\/physrev.00008.2013","article-title":"Systemic iron homeostasis","volume":"93","author":"Ganz","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jtemb.2026.127836_bib49","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s42003-022-03108-2","article-title":"Hemojuvelin deficiency promotes liver mitochondrial dysfunction and predisposes mice to hepatocellular carcinoma","volume":"5","author":"Allameh","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.jtemb.2026.127836_bib50","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1002\/hep.31836","article-title":"Albumin in advanced liver diseases: the good and bad of a drug!","volume":"74","author":"Jagdish","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jtemb.2026.127836_bib51","first-page":"164","article-title":"Serum total protein concentration and liver enzymes activities in albino rats model administered with ethanolic leaf extract of Ficus capensis","volume":"20","author":"Chukwudoruo","year":"2021","journal-title":"Afr. J. Biotechnol."},{"key":"10.1016\/j.jtemb.2026.127836_bib52","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1590\/1519-6984.228437","article-title":"Apoptosis (programmed cell death) and its signals-a review","volume":"81","author":"Obeng","year":"2020","journal-title":"Braz. J. Biol."},{"key":"10.1016\/j.jtemb.2026.127836_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135615","article-title":"Sulfiredoxin-1 protects spinal cord neurons against oxidative stress in the oxygen-glucose deprivation\/reoxygenation model through the bax\/cytochrome c\/caspase 3 apoptosis pathway","volume":"744","author":"Lan","year":"2021","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jtemb.2026.127836_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111670","article-title":"Captopril downregulates expression of Bax\/cytochrome C\/caspase-3 apoptotic pathway, reduces inflammation, and oxidative stress in cisplatin-induced acute hepatic injury","volume":"139","author":"Eid","year":"2021","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.jtemb.2026.127836_bib55","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s13238-014-0089-1","article-title":"Mitochondria-mediated apoptosis in mammals","volume":"5","author":"Xiong","year":"2014","journal-title":"Protein Cell"},{"key":"10.1016\/j.jtemb.2026.127836_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2020.118688","article-title":"Targeting apoptotic caspases in cancer","volume":"1867","author":"Boice","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127836_bib57","doi-asserted-by":"crossref","DOI":"10.4254\/wjh.v10.i1.1","article-title":"Role of inflammatory response in liver diseases: therapeutic strategies","volume":"10","author":"Campo","year":"2018","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.jtemb.2026.127836_bib58","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.3748\/wjg.v20.i10.2564","article-title":"Immune dysfunction in cirrhosis","volume":"20","author":"Sipeki","year":"2014","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127836_bib59","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12868-021-00611-w","article-title":"Docosahexaenoic fatty acid reduces the pro-inflammatory response induced by IL-1\u03b2 in astrocytes through inhibition of NF-\u03baB and AP-1 transcription factor activation","volume":"22","author":"Zg\u00f3rzy\u0144ska","year":"2021","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.jtemb.2026.127836_bib60","doi-asserted-by":"crossref","first-page":"116","DOI":"10.15586\/qas.v14i3.1093","article-title":"Rhoifolin attenuates damage to hippocampal neuronal culture model of acquired epilepsy in vitro by regulating NF-\u03baB\/iNOS\/COX-2 axis","volume":"14","author":"Qi","year":"2022","journal-title":"Qual. Assur. Saf. Crop. Foods"},{"key":"10.1016\/j.jtemb.2026.127836_bib61","article-title":"Reactive oxygen species induce fatty liver and ischemia-reperfusion injury by promoting inflammation and cell death","volume":"13","author":"Tang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtemb.2026.127836_bib62","article-title":"PPAR\u03b3 alleviates sepsis-induced liver injury by inhibiting hepatocyte Pyroptosis via inhibition of the ROS\/TXNIP\/NLRP3 signaling pathway","volume":"2022","author":"Li","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jtemb.2026.127836_bib63","article-title":"Regulation of SIRT1 and its roles in inflammation","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtemb.2026.127836_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2026.117708","article-title":"Sinapic acid attenuates colistin-driven nephrotoxicity by targeting the miRNA-21\/SIRT1\/NF-\u03baB pathway and facilitating tubular repair and inflammation in a rat model","volume":"507","author":"\u00d6z","year":"2026","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jtemb.2026.127836_bib65","first-page":"1098","article-title":"Protective effects of zingerone against sodium arsenite-induced lung toxicity: a multi-biomarker approach","volume":"26","author":"\u015eim\u015fek","year":"2023","journal-title":"Iran. J. Basic Med. Sci."},{"key":"10.1016\/j.jtemb.2026.127836_bib66","doi-asserted-by":"crossref","DOI":"10.1590\/acb391124","article-title":"Protective effects of hesperidin in gastric damage caused by experimental ischemia-reperfusion injury model in rats","volume":"39","author":"Ozyigit","year":"2024","journal-title":"Acta Cir. Bras."}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X26000222?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X26000222?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:50:46Z","timestamp":1777593046000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X26000222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":66,"alternative-id":["S0946672X26000222"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2026.127836","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ayanin combats against barium sulphate nanoparticles induced hepatotoxicity via modulating SIRT1\/FOXO3a and HO-1\/ferritin pathways: A biochemical, histopathological and computational approaches","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2026.127836","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"127836"}}