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Lett."},{"issue":"2","key":"10.1016\/j.jtemb.2026.127849_bib76","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1289\/ehp.7337","article-title":"Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements","volume":"113","author":"Barr","year":"2005","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"10.1016\/j.jtemb.2026.127849_bib77","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1289\/ehp.1307234","article-title":"Urinary polycyclic aromatic hydrocarbons and childhood obesity: NHANES (2001-2006)","volume":"122","author":"Scinicariello","year":"2014","journal-title":"Environ. Health Perspect."},{"issue":"190","key":"10.1016\/j.jtemb.2026.127849_bib78","first-page":"2022","article-title":"National Health and Nutrition Examination Survey, 2017\u2013March 2020 prepandemic file: sample design, estimation, and analytic guidelines. National Center for Health Statistics","volume":"2","author":"Akinbami","year":"2022","journal-title":"Vital. Health Stat."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127849_bib79","first-page":"1","article-title":"Analysis of complex survey samples","volume":"9","author":"Lumley","year":"2004","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.jtemb.2026.127849_bib80","doi-asserted-by":"crossref","unstructured":"Lumley, T. (2010) \"Complex Surveys: A Guide to Analysis Using R,\" John Wiley and Sons, Hoboken, NJ, USA.","DOI":"10.1002\/9780470580066"},{"key":"10.1016\/j.jtemb.2026.127849_bib81","unstructured":"Lumley, T. (2022) \"survey: analysis of complex survey samples\". R package version 4.0, \u3008https:\/\/cran.r-project.org\/web\/packages\/survey\/survey.pdf\u3009, retrieved Feb 2023."},{"key":"10.1016\/j.jtemb.2026.127849_bib82","unstructured":"RStudio (2022) 2022.07.1 Build 554, \"Spotted Wakerobin\" Release (7872775e, 2022-07-22) for macOS."},{"key":"10.1016\/j.jtemb.2026.127849_bib83","unstructured":"R Core Team (2022). \"R: A language and environment for statistical computing,\" R Foundation for Statistical Computing, Vienna, Austria. URL \u3008https:\/\/www.R-project.org\/\u3009."},{"key":"10.1016\/j.jtemb.2026.127849_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105000","article-title":"Hepatotoxic effects of inhalation exposure to polycyclic aromatic hydrocarbons on lipid metabolism of C57BL\/6 mice","volume":"134","author":"Li","year":"2020","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127849_bib85","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12944-020-01248-0","article-title":"The abnormal lipid profile in obesity and coronary heart disease (CHD) in Pakistani subjects","volume":"19","author":"Shabana","year":"2020","journal-title":"Lipids Health Dis."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127849_bib86","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1186\/s12889-018-5196-0","article-title":"Lipid profile and dyslipidemia among school-age children in urban Ghana","volume":"18","author":"Lartey","year":"2018","journal-title":"BMC Public Health"},{"key":"10.1016\/j.jtemb.2026.127849_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijheh.2023.114215","article-title":"Firefighters and the liver: Exposure to PFAS and PAHs in relation to liver function and serum lipids (CELSPAC-FIREexpo study)","volume":"252","author":"P\u00e1le\u0161ov\u00e1","year":"2023","journal-title":"Int. J. Hyg. Environ. Health"},{"issue":"11","key":"10.1016\/j.jtemb.2026.127849_bib88","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1039\/C9EW00765B","article-title":"Towards the development of a standardized method for extraction and analysis of PFAS in biological tissues","volume":"5","author":"Point","year":"2019","journal-title":"Environ.l Sci. Water Res. Technol."},{"key":"10.1016\/j.jtemb.2026.127849_bib89","doi-asserted-by":"crossref","unstructured":"Zhou, S., Li, X., Dai, Y., Guo, C., Peng, R., Qin, P., & Tan, L. (2023). Association between polycyclic aromatic hydrocarbon exposure and blood lipid levels: the indirect effects of inflammation and oxidative stress. Environ. Sci. Pollut. Res. Int. 10.1007\/s11356-023-31020-7. Advance online publication. \u3008https:\/\/doi.org\/10.1007\/s11356-023-31020-7\u3009.","DOI":"10.1007\/s11356-023-31020-7"},{"issue":"7","key":"10.1016\/j.jtemb.2026.127849_bib90","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.3390\/nu5072708","article-title":"Obesity and dyslipidemia in South Asians","volume":"5","author":"Misra","year":"2013","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.jtemb.2026.127849_bib91","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1067\/mlc.2000.106453","article-title":"Hypertension, hormones, and aging","volume":"135","author":"Sowers","year":"2000","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.jtemb.2026.127849_bib92","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.arr.2014.12.001","article-title":"Aging and dyslipidemia: a review of potential mechanisms","volume":"19","author":"Liu","year":"2015","journal-title":"Aging Res. Rev."},{"issue":"7","key":"10.1016\/j.jtemb.2026.127849_bib93","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1097\/HJH.0000000000001730","volume":"36","author":"Kotsis","year":"2018","journal-title":"J. Hypertens."},{"issue":"2","key":"10.1016\/j.jtemb.2026.127849_bib94","doi-asserted-by":"crossref","first-page":"184","DOI":"10.2337\/db21-0490","article-title":"Metabolic and metabo-clinical signatures of type 2 diabetes, obesity, retinopathy, and dyslipidemia","volume":"71","author":"Yousri","year":"2022","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.jtemb.2026.127849_bib95","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1210\/er.2018-00184","article-title":"The forgotten lipids: triglycerides, remnant cholesterol, and atherosclerotic cardiovascular disease risk","volume":"40","author":"Sandesara","year":"2019","journal-title":"Endocr. Rev."},{"issue":"10","key":"10.1016\/j.jtemb.2026.127849_bib96","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.5551\/jat.63166","article-title":"Sex difference in the association between lipid profile and incident cardiovascular disease among young adults","volume":"29","author":"Kamon","year":"2022","journal-title":"J. Atheroscler. Thromb."},{"key":"10.1016\/j.jtemb.2026.127849_bib97","first-page":"e29","article-title":"American Heart Association Statistics Committee and Stroke Statistics Subcommittee: Heart disease and stroke statistics--2015 update: a report from the American Heart Association","volume":"131","author":"Mozaffarian","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jtemb.2026.127849_bib98","series-title":"The Global Economic Burden of Non-communicable Diseases","year":"2011"},{"key":"10.1016\/j.jtemb.2026.127849_bib99","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.111747","article-title":"Associations between exposure to polycyclic aromatic hydrocarbons and metabolic syndrome in U.S. adolescents: cross-sectional results from the National Health and Nutrition Examination Survey (2003-2016) data","volume":"202","author":"Li","year":"2021","journal-title":"Environ. Res."},{"issue":"18","key":"10.1016\/j.jtemb.2026.127849_bib100","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1007\/s00018-018-2860-6","article-title":"Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease","volume":"75","author":"Ipsen","year":"2018","journal-title":"Cell. Mol. life Sci. CMLS"},{"issue":"9","key":"10.1016\/j.jtemb.2026.127849_bib101","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/s41419-020-03003-w","article-title":"Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?","volume":"11","author":"Rada","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jtemb.2026.127849_bib102","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.146563","article-title":"Serum lipids mediate the relationship of multiple polyaromatic hydrocarbons on non-alcoholic fatty liver disease: a population-based study","volume":"780","author":"Hu","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jtemb.2026.127849_bib103","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.envint.2016.02.006","article-title":"The association of urinary polycyclic aromatic hydrocarbon biomarkers and cardiovascular disease in the US population","volume":"89-90","author":"Alshaarawy","year":"2016","journal-title":"Environ. Int."},{"issue":"2","key":"10.1016\/j.jtemb.2026.127849_bib104","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1007\/s11356-021-17091-4","article-title":"The association between urinary metabolites of polycyclic aromatic hydrocarbons (PAHs) and cardiovascular diseases and blood pressure: a systematic review and meta-analysis of observational studies","volume":"29","author":"Mirzababaei","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.jtemb.2026.127849_bib105","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106132","article-title":"PAH exposure is associated with enhanced risk for pediatric dyslipidemia through serum SOD reduction","volume":"145","author":"Wang","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.jtemb.2026.127849_bib106","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.scitotenv.2013.06.098","article-title":"Biomarkers of occupational exposure to air pollution, inflammation and oxidative damage in taxi drivers","volume":"463-464","author":"Brucker","year":"2013","journal-title":"Sci. Total Environ."},{"issue":"3","key":"10.1016\/j.jtemb.2026.127849_bib107","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/jn\/nxab425","article-title":"Marginal zinc deficiency alters essential fatty acid metabolism in healthy men","volume":"152","author":"Suh","year":"2022","journal-title":"J. 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