{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:21:38Z","timestamp":1787869298011,"version":"build-2784847793"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jtemb.2026.127883","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:47:22Z","timestamp":1778050042000},"page":"127883","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["L-arginine mitigates against cisplatin-induced defective cardiac metabolic flexibility by activating Nrf2\/HO-1 and upregulating glutathione in male Wistar rat"],"prefix":"10.1016","volume":"95","author":[{"given":"W.A.","family":"Saka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.A.","family":"Adegbola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.M.","family":"Akhigbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.A.","family":"Ayandele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.J.","family":"Ashonibare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.E.","family":"Akhigbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.jtemb.2026.127883_bib1","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1351\/pac200779122243","article-title":"Metal-based anticancer drugs: from a past anchored in platinum chemistry to a post-genomic future of diverse chemistry and biology","volume":"79","author":"Hannon","year":"2007","journal-title":"Pure Appl. Chem."},{"key":"10.1016\/j.jtemb.2026.127883_bib2","series-title":"The Chemical Database","author":"Akron","year":"2009"},{"issue":"1","key":"10.1016\/j.jtemb.2026.127883_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1476-5829.2007.00142.x","article-title":"Cisplatin: a review of toxicities and therapeutic applications","volume":"6","author":"Barabas","year":"2008","journal-title":"Vet. Comp. Oncol."},{"key":"10.1016\/j.jtemb.2026.127883_bib4","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","article-title":"Cisplatin in cancer therapy: molecular mechanisms of action","volume":"740","author":"Dasari","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jtemb.2026.127883_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.102925","article-title":"Cisplatin: the first metal based anticancer drug","volume":"88","author":"Ghosh","year":"2019","journal-title":"Bioorg. Chem."},{"issue":"3","key":"10.1016\/j.jtemb.2026.127883_bib6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1742-7843.2006.00024.x","article-title":"Carnitine deficiency provokes cisplatin-induced hepatotoxicity in rats","volume":"100","author":"Al-Majed","year":"2007","journal-title":"Basic & Clin. Pharmacol. & Toxicol."},{"issue":"6","key":"10.1016\/j.jtemb.2026.127883_bib7","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.fct.2009.02.007","article-title":"Protective effect of grape seed proanthocyanidin extract against oxidative stress induced by cisplatin in rats","volume":"47","author":"Yousef","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jtemb.2026.127883_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2024.127489","article-title":"Testicular toxicity in cisplatin-treated Wistar rats is mitigated by Daflon and associated with modulation of Nrf2\/HO-1 and TLR4\/NF-kB signaling","volume":"85","author":"Akhigbe","year":"2024","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.jtemb.2026.127883_bib9","first-page":"1","article-title":"Mechanisms of ferroptotic and non-ferroptotic organ toxicity of chemotherapy: protective and therapeutic effects of ginger, 6-gingerol and zingerone in preclinical studies","author":"Famurewa","year":"2024","journal-title":"Naunyn-Schmiede 's. Arch. Pharmacol."},{"key":"10.1016\/j.jtemb.2026.127883_bib10","doi-asserted-by":"crossref","DOI":"10.2165\/00002018-200022040-00002","article-title":"Cardiotoxicity of chemotherapeutic agents: incidence, treatment and prevention","volume":"22","author":"Pai","year":"2000","journal-title":"Drug Saf."},{"key":"10.1016\/j.jtemb.2026.127883_bib11","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.phrs.2005.12.005","article-title":"Propionyl-L-Carnitine prevents the progression of cisplatin-induced cardiotoxicity in a carnitine-depleted rat model","volume":"53","author":"Al-Majed","year":"2006","journal-title":"Pharm. Res"},{"key":"10.1016\/j.jtemb.2026.127883_bib12","doi-asserted-by":"crossref","first-page":"330","DOI":"10.4103\/0971-5851.125262","article-title":"Cisplatin induced paroxysmal supraventricular tachycardia","volume":"34","author":"Raja","year":"2013","journal-title":"Indian J. Med Paediatr. Oncol."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127883_bib13","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.ejphar.2010.09.085","article-title":"Cisplatin-induced cardiotoxicity: mechanisms and cardioprotective strategies","volume":"650","author":"El-Awady","year":"2011","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127883_bib14","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s12012-022-09773-3","article-title":"Sinapic acid attenuated cisplatin-induced cardiotoxicity by inhibiting oxidative stress and inflammation with GPX4-mediated NF-kB modulation","volume":"23","author":"Yildirim","year":"2023","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.jtemb.2026.127883_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117136","article-title":"L-arginine attenuates dichlorvos-induced testicular toxicity in male Wistar rats by suppressing oxidative stress-dependent activation of caspase 3-mediated apoptosis","volume":"178","author":"Saka","year":"2024","journal-title":"Biomed. & Pharmacother."},{"key":"10.1016\/j.jtemb.2026.127883_bib16","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/978-3-030-74180-8_10","article-title":"Role of L-arginine in nitric oxide synthesis and health in humans","author":"Wu","year":"2021","journal-title":"Amino acids nutrition health Amino acids gene expression metabolic regulation exercising performance"},{"issue":"1","key":"10.1016\/j.jtemb.2026.127883_bib17","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.advms.2018.08.018","article-title":"Metabolic pathways of L-arginine and therapeutic consequences in tumors","volume":"64","author":"Szefel","year":"2019","journal-title":"Adv. Med. Sci."},{"key":"10.1016\/j.jtemb.2026.127883_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111443","article-title":"Suppression of uric acid generation and blockade of glutathione dysregulation by L-arginine ameliorates dichlorvos-induced oxidative hepatorenal damage in rats","volume":"138","author":"Saka","year":"2021","journal-title":"Biomed. & Pharmacother."},{"issue":"8","key":"10.1016\/j.jtemb.2026.127883_bib19","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1152\/japplphysiol.00225.2013","article-title":"L-Arginine supplementation improves antioxidant defenses through L-arginine\/nitric oxide pathways in exercised rats","volume":"115","author":"Shan","year":"2013","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.jtemb.2026.127883_bib20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.fct.2018.03.029","article-title":"L-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway","volume":"115","author":"Liang","year":"2018","journal-title":"Food Chem. Toxicol."},{"issue":"9","key":"10.1016\/j.jtemb.2026.127883_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0274411","article-title":"L-Arginine reverses maternal and pre-pubertal codeine exposure-induced sexual dysfunction via upregulation of androgen receptor gene and NO\/cGMP signaling","volume":"17","author":"Akhigbe","year":"2022","journal-title":"Plos One"},{"key":"10.1016\/j.jtemb.2026.127883_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1180085","article-title":"L-Arginine abrogates maternal and pre-pubertal codeine exposure-induced impaired spermatogenesis and sperm quality by modulating the levels of mRNA encoding spermatogenic genes","volume":"14","author":"Akhigbe","year":"2023","journal-title":"Front. Endocrinol."},{"issue":"2","key":"10.1016\/j.jtemb.2026.127883_bib23","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1258\/002367781780959107","article-title":"Ketamine alone and combined with diazepam or xylazine in laboratory animals: a 10 year experience","volume":"15","author":"Green","year":"1981","journal-title":"Lab. Anim."},{"key":"10.1016\/j.jtemb.2026.127883_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.116019","article-title":"Acetate attenuates cyclophosphamide-induced cardiac injury via inhibition of NF-kB signaling and suppression of caspase 3-dependent apoptosis in Wistar rats","volume":"170","author":"Adeyemi","year":"2024","journal-title":"Biomed. & Pharmacother."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127883_bib25","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00210-023-02620-4","article-title":"Sodium acetate ameliorates doxorubicin-induced cardiac injury via upregulation of Nrf2\/HO-1 signaling and downregulation of NFkB-mediated apoptotic signaling in Wistar rats","volume":"397","author":"Adeyemi","year":"2024","journal-title":"Naunyn-Schmiede 's. Arch. Pharmacol."},{"key":"10.1016\/j.jtemb.2026.127883_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12944-021-01493-x","article-title":"Co-administration of HAART and antikoch triggers cardiometabolic dysfunction through an oxidative stress-mediated pathway","volume":"20","author":"Akhigbe","year":"2021","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.jtemb.2026.127883_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2024.1416641","article-title":"Andrographis paniculata improves glucose regulation by enhancing insulin sensitivity and upregulating GLUT 4 expression in Wistar rats","volume":"11","author":"Saka","year":"2024","journal-title":"Front. Nutr."},{"issue":"3","key":"10.1016\/j.jtemb.2026.127883_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0224052","article-title":"Testicular toxicity following chronic codeine administration is via oxidative DNA damage and up-regulation of NO\/TNF-\u03b1 and caspase 3 activities","volume":"15","author":"Akhigbe","year":"2020","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jtemb.2026.127883_bib29","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jtemb.2026.127883_bib30","series-title":"Methods of Enzymatic Analysis","first-page":"673","article-title":"Catalase","author":"Aebi","year":"1974"},{"issue":"1","key":"10.1016\/j.jtemb.2026.127883_bib31","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/srep00387","article-title":"Engineering a thermo-stable superoxide dismutase functional at sub-zero to> 50C, which also tolerates autoclaving","volume":"2","author":"Kumar","year":"2012","journal-title":"Sci. Rep."},{"issue":"22","key":"10.1016\/j.jtemb.2026.127883_bib32","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferases: the first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"issue":"4073","key":"10.1016\/j.jtemb.2026.127883_bib33","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","article-title":"Selenium: biochemical role as a component of glutathione peroxidase","volume":"179","author":"Rotruck","year":"1973","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.jtemb.2026.127883_bib34","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/0003-9861(72)90164-6","article-title":"Guinea pig heterophil and eosinophil peroxidase","volume":"148","author":"Desser","year":"1972","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jtemb.2026.127883_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120789","article-title":"Repurposing FDA-approved drugs against the toxicity of platinum-based anticancer drugs","volume":"305","author":"Famurewa","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.jtemb.2026.127883_bib36","doi-asserted-by":"crossref","first-page":"v366","DOI":"10.1093\/annonc\/mdx373.034","article-title":"L-arginine\u2013targeted for the anthracycline cardiotoxicity prevention in patients with acute leukemia of high cardiological risk","volume":"28","author":"Lymanets","year":"2017","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.jtemb.2026.127883_bib37","doi-asserted-by":"crossref","DOI":"10.31768\/2312-8852.2017.39(4):308-311","article-title":"L-arginine is an effective medication for prevention of endothelial dysfunction, a predictor of anthracycline cardiotoxicity in patients with acute leukemia","author":"Skrypnyk","year":"2017","journal-title":"Exp. Oncol."},{"key":"10.1016\/j.jtemb.2026.127883_bib38","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s12012-021-09636-3","article-title":"The effect of curcumin nanoparticles on cisplatin-induced cardiotoxicity in male wistar albino rats","volume":"21","author":"Khadrawy","year":"2021","journal-title":"Cardiovasc. Toxicol."},{"issue":"7","key":"10.1016\/j.jtemb.2026.127883_bib39","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1039\/D2FO00298A","article-title":"Hesperidin protects against cisplatin-induced cardiotoxicity in mice by regulating the p62\u2013Keap1\u2013Nrf2 pathway","volume":"13","author":"Jia","year":"2022","journal-title":"Food & Funct."},{"issue":"7","key":"10.1016\/j.jtemb.2026.127883_bib40","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1191\/096032799678840255","article-title":"Hyperlipidaemia in cisplatin-induced nephrotic rats","volume":"18","author":"Abdel-Gayoum","year":"1999","journal-title":"Hum. & Exp. Toxicol."},{"issue":"4","key":"10.1016\/j.jtemb.2026.127883_bib41","doi-asserted-by":"crossref","first-page":"354","DOI":"10.4103\/0253-7613.115016","article-title":"Amelioration of cisplatin-induced nephrotoxicity by statins","volume":"45","author":"Maheshwari","year":"2013","journal-title":"Indian J. Pharmacol."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127883_bib42","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s12672-022-00598-8","article-title":"Atorvastatin improves cisplatin sensitivity through modulation of cholesteryl ester homeostasis in breast cancer cells","volume":"13","author":"Zipinotti dos Santos","year":"2022","journal-title":"Discov. Oncol."},{"issue":"1-3","key":"10.1016\/j.jtemb.2026.127883_bib43","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ejphar.2005.12.018","article-title":"Neurogenic insulin resistance in guinea-pigs with cisplatin-induced neuropathy","volume":"531","author":"Szilv\u00e1ssy","year":"2006","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.jtemb.2026.127883_bib44","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3109\/0284186X.2013.819116","article-title":"Abdominal visceral and subcutaneous fat increase, insulin resistance and hyperlipidemia in testicular cancer patients treated with cisplatin-based chemotherapy","volume":"53","author":"Willemse","year":"2014","journal-title":"Acta Oncol."},{"issue":"5","key":"10.1016\/j.jtemb.2026.127883_bib45","doi-asserted-by":"crossref","first-page":"875","DOI":"10.2337\/diacare.24.5.875","article-title":"Long-term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients","volume":"24","author":"Piatti","year":"2001","journal-title":"Diabetes Care"},{"issue":"7","key":"10.1016\/j.jtemb.2026.127883_bib46","first-page":"10358","article-title":"Effect of L-arginine supplementation on insulin resistance and serum adiponectin concentration in rats with fat diet","volume":"8","author":"Miczke","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"6","key":"10.1016\/j.jtemb.2026.127883_bib47","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3390\/ijms18061321","article-title":"Adiponectin, is a therapeutic target for obesity, diabetes, and endothelial dysfunction","volume":"18","author":"Achari","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127883_bib48","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12944-021-01435-7","article-title":"The impact of reactive oxygen species in the development of cardiometabolic disorders: a review","volume":"20","author":"Akhigbe","year":"2021","journal-title":"Lipids Health Dis."},{"issue":"13","key":"10.1016\/j.jtemb.2026.127883_bib49","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.3390\/ijms21134777","article-title":"NRF2, a transcription factor for stress response and beyond","volume":"21","author":"He","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.jtemb.2026.127883_bib50","first-page":"213","article-title":"Protective effects of curcumin and beta-carotene on cisplatin-induced cardiotoxicity: an experimental rat model","volume":"19","author":"Bahad\u0131r","year":"2018","journal-title":"Anatol. J. Cardiol."},{"key":"10.1016\/j.jtemb.2026.127883_bib51","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00210-018-1506-4","article-title":"Cardioprotective effect of zingerone against oxidative stress, inflammation, and apoptosis induced by cisplatin or gamma radiation in rats","volume":"391","author":"Soliman","year":"2018","journal-title":"Naunyn-Schmiede 's. Arch. Pharmacol."},{"issue":"6","key":"10.1016\/j.jtemb.2026.127883_bib52","doi-asserted-by":"crossref","first-page":"828","DOI":"10.3390\/antiox10060828","article-title":"Keap1\/Nrf2 signaling pathway","volume":"10","author":"Sykiotis","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.jtemb.2026.127883_bib53","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.phrs.2018.06.013","article-title":"Canonical and non-canonical mechanisms of Nrf2 activation","volume":"134","author":"Silva-Islas","year":"2018","journal-title":"Pharmacol. Res."},{"issue":"10","key":"10.1016\/j.jtemb.2026.127883_bib54","doi-asserted-by":"crossref","first-page":"9252","DOI":"10.1039\/D0FO01223H","article-title":"Inflammation response after the cessation of chronic arsenic exposure and post-treatment of natural astaxanthin in liver: potential role of cytokine-mediated cell\u2013cell interactions","volume":"11","author":"Zhang","year":"2020","journal-title":"Food & Funct."},{"key":"10.1016\/j.jtemb.2026.127883_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.598549","article-title":"Inflammation as a risk factor in cardiotoxicity: an important consideration for screening during drug development","volume":"12","author":"Campana","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jtemb.2026.127883_bib56","article-title":"Estrogen replacement therapy reverses spatial memory loss and pyramidal cell neurodegeneration in the prefrontal cortex of lead-exposed ovariectomized Wistar rats","volume":"7","author":"Lasisi-Sholola","year":"2024","journal-title":"Curr. Res. Toxicol."},{"issue":"7","key":"10.1016\/j.jtemb.2026.127883_bib57","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.3390\/cancers12071791","article-title":"Interleukin-1\u03b2 and cancer","volume":"12","author":"R\u00e9b\u00e9","year":"2020","journal-title":"Cancers"},{"issue":"4","key":"10.1016\/j.jtemb.2026.127883_bib58","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00580-021-03256-7","article-title":"Cytoprotective effect of ginger extract on cisplatin-induced hepatorenal toxicity in rats via modulation of oxidative stress, inflammation and apoptosis: histopathological, biochemical and immunohistochemical study","volume":"30","author":"Tahoun","year":"2021","journal-title":"Comp. Clin. Pathol."},{"issue":"2","key":"10.1016\/j.jtemb.2026.127883_bib59","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.bbadis.2016.11.005","article-title":"Nrf2 signaling pathway: Pivotal roles in inflammation","volume":"1863","author":"Ahmed","year":"2017","journal-title":"Biochim. Et. Biophys. Acta (BBA)-Mol. basis Dis."},{"issue":"22","key":"10.1016\/j.jtemb.2026.127883_bib60","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.3390\/molecules25225474","article-title":"An overview of Nrf2 signaling pathway and its role in inflammation","volume":"25","author":"Saha","year":"2020","journal-title":"Molecules"}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X26000696?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X26000696?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:30:19Z","timestamp":1787866219000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X26000696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":60,"alternative-id":["S0946672X26000696"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2026.127883","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"L-arginine mitigates against cisplatin-induced defective cardiac metabolic flexibility by activating Nrf2\/HO-1 and upregulating glutathione in male Wistar rat","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2026.127883","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"127883"}}