{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:22:09Z","timestamp":1787869329824,"version":"build-2784847793"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jtemb.2026.127899","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T16:09:06Z","timestamp":1779984546000},"page":"127899","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Protective effects of zinc and Prunus amygdalus against cadmium-induced nephrotoxicity in male Albino rats"],"prefix":"10.1016","volume":"95","author":[{"given":"Muhammad Talha","family":"Ishaq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiza","family":"Zubair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naila","family":"Riaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hira","family":"Kanwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha Tehreem","family":"Shahbaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tooba","family":"Tahir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nudrat","family":"Rafique","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehwish","family":"Perveen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabia","family":"Irfan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naila","family":"Amjad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jtemb.2026.127899_bib1","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20212516","article-title":"Histomorphological and ultrastructural cadmium-induced kidney injuries and precancerous lesions in rats and screening for biomarkers","volume":"42","author":"Wan","year":"2022","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.jtemb.2026.127899_bib2","article-title":"A hypoxia-driven occurrence of chronic kidney disease and osteoporosis in COPD individuals: new insights into environmental cadmium exposure","volume":"479","author":"Cirovic","year":"2022","journal-title":"Toxicology"},{"key":"10.1016\/j.jtemb.2026.127899_bib3","article-title":"The overlooked impact of cadmium on the progression of chronic hepatitis and the onset of renal failure in advanced cirrhosis","volume":"82","author":"Cirovic","year":"2024","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.jtemb.2026.127899_bib4","article-title":"Factors moderating cadmium bioavailability: key considerations for comparing blood cadmium levels between groups","volume":"188","author":"Cirovic","year":"2024","journal-title":"Food Chem. Toxicol."},{"issue":"8","key":"10.1016\/j.jtemb.2026.127899_bib5","doi-asserted-by":"crossref","first-page":"8202","DOI":"10.1007\/s11356-019-04276-1","article-title":"Protective effects of quercetin supplementation against short-term toxicity of cadmium-induced hematological impairment, hypothyroidism, and testicular disturbances in albino rats","volume":"26","author":"Badr","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"6","key":"10.1016\/j.jtemb.2026.127899_bib6","article-title":"Chronic cadmium toxicity in rats: treatment with combined administration of vitamins, amino acids, antioxidants and essential metals","volume":"18","author":"Gaurav","year":"2020","journal-title":"J. Food Drug. Anal."},{"key":"10.1016\/j.jtemb.2026.127899_bib7","doi-asserted-by":"crossref","unstructured":"J.-C. Lv and L.-X. Zhang, \u201cPrevalence and Disease Burden of Chronic Kidney Disease,\u201d 2019, pp. 3\u201315. doi: 10.1007\/978-981-13-8871-2_1.","DOI":"10.1007\/978-981-13-8871-2_1"},{"key":"10.1016\/j.jtemb.2026.127899_bib8","article-title":"Cadmium-induced kidney injury: oxidative damage as a unifying mechanism","author":"Yan","year":"2021","journal-title":"MDPI"},{"issue":"1","key":"10.1016\/j.jtemb.2026.127899_bib9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.kisu.2021.11.003","article-title":"Epidemiology of chronic kidney disease: an update 2022","volume":"12","author":"Kovesdy","year":"2022","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.jtemb.2026.127899_bib10","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.toxrep.2016.07.005","article-title":"Calcium, zinc and vitamin E ameliorate cadmium-induced renal oxidative damage in albino Wistar rats","volume":"3","author":"Adi","year":"2016","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.jtemb.2026.127899_bib11","article-title":"Isorhoifolin Attenuates cadmium-induced renal toxicity in rats via regulating biochemical and histological profiles","author":"H. Q. M. Z. S. K. A. K. A. A.-G","year":"2025","journal-title":"Pak. Vet. J."},{"key":"10.1016\/j.jtemb.2026.127899_bib12","doi-asserted-by":"crossref","DOI":"10.2174\/012210299X319204240918054725","article-title":"Therapeutic effectiveness of Prunus dulcis for nephroprotective and hepatoprotective in albino mice","volume":"02","author":"Sharma","year":"2024","journal-title":"Curr. Indian. Sci."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127899_bib13","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s12011-016-0671-x","article-title":"Protective role of zinc and magnesium against cadmium nephrotoxicity in male wistar rats","volume":"174","author":"Babaknejad","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"issue":"28","key":"10.1016\/j.jtemb.2026.127899_bib14","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.14260\/jemds\/2021\/426","article-title":"Comparison of protective effect of apium graveolens and aloe vera supplemented with zinc on cadmium induced hepato and nephro-toxicity in wistar rats","volume":"10","author":"S. N.K","year":"2021","journal-title":"J. Evol. Med. Dent. Sci."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127899_bib15","first-page":"1","article-title":"Amelioration effect of zinc and iron supplementation on selected oxidative stress enzymes in liver and kidney of cadmium-treated male albino rat","volume":"22","author":"Jamakala","year":"2015","journal-title":"Toxicol. Int."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127899_bib16","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s12011-017-1218-5","article-title":"Cadmium testicular toxicity in male wistar rats: protective roles of zinc and magnesium","volume":"185","author":"Babaknejad","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127899_bib17","doi-asserted-by":"crossref","DOI":"10.1186\/s41936-020-00146-2","article-title":"Toxicological effects of the concurrent administration of cadmium and arsenic through the food chain on the liver and kidney of rats","volume":"81","author":"Ezedom","year":"2020","journal-title":"J. Basic. Appl. Zool."},{"issue":"2","key":"10.1016\/j.jtemb.2026.127899_bib18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.21307\/ane-2019-015","article-title":"Prevention of cadmium-induced neurotoxicity in rats by essential nutrients present in nuts","volume":"79","author":"Batool","year":"2019","journal-title":"Acta Neurobiol. Exp. (Wars. )"},{"issue":"8","key":"10.1016\/j.jtemb.2026.127899_bib19","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/j.sjbs.2018.09.009","article-title":"Bioremediation of cadmium induced renal toxicity in Rattus norvegicus by medicinal plant Catharanthus roseus","volume":"25","author":"Hashim","year":"2018","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.jtemb.2026.127899_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.dib.2022.108394","article-title":"Dataset on biochemical markers and histological alterations in rat kidney intoxicated with cadmium chloride and treated with antioxidant","volume":"43","author":"Karami","year":"2022","journal-title":"Data Brief."},{"issue":"8","key":"10.1016\/j.jtemb.2026.127899_bib21","doi-asserted-by":"crossref","DOI":"10.21037\/atm.2019.03.66","article-title":"Effects of sub-chronic, low-dose cadmium exposure on kidney damage and potential mechanisms","volume":"7","author":"Liu","year":"2019","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.jtemb.2026.127899_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115674","article-title":"Cadmium exposure exacerbates kidney damage by inhibiting autophagy in diabetic rats","volume":"267","author":"Ma","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"11","key":"10.1016\/j.jtemb.2026.127899_bib23","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.3390\/bioengineering11111141","article-title":"Metabolomic analysis and biochemical profiling of cadmium-induced metabolic impairment and its amelioration by resveratrol","volume":"11","author":"Ilyas","year":"2024","journal-title":"Bioengineering"},{"issue":"4","key":"10.1016\/j.jtemb.2026.127899_bib24","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.3390\/ijms21041218","article-title":"Disruption of bone zinc metabolism during postnatal development of rats after early life exposure to cadmium","volume":"21","author":"Boughammoura","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127899_bib25","article-title":"Nephroprotective Potential of Rhamnazin Against Cadmium-Induced Kidney Damages via Activation of Nrf2\/Keap1 Pathway","volume":"20","author":"Anjum","year":"2025","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.jtemb.2026.127899_bib26","article-title":"Zn(II)\u2013curcumin prevents cadmium-aggravated diabetic nephropathy by regulating gut microbiota and zinc homeostasis","volume":"15","author":"Sun","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"In Press","key":"10.1016\/j.jtemb.2026.127899_bib27","doi-asserted-by":"crossref","DOI":"10.17795\/zjrms-4290","article-title":"Protective effects of long term administration of zinc on bone metabolism parameters in male wistar rats treated with cadmium","volume":"In Press","author":"Najafi","year":"2016","journal-title":"Zahedan J. Res. Med. Sci."}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X26000854?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X26000854?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:31:28Z","timestamp":1787866288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X26000854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":27,"alternative-id":["S0946672X26000854"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2026.127899","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effects of zinc and Prunus amygdalus against cadmium-induced nephrotoxicity in male Albino rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2026.127899","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"127899"}}