{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:58:52Z","timestamp":1790888332333,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.jtemb.2026.127963","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:24:07Z","timestamp":1790205847000},"page":"127963","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Fermented wheat germ extract modulates organic selenium availability to regulate programmed cell death and metabolic reprogramming through the ATM\/ATR\/p53 pathway"],"prefix":"10.1016","volume":"98","author":[{"given":"HuiJun","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syeda Anber","family":"Zahra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ShuJun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jtemb.2026.127963_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41575-023-00840-w","article-title":"Therapeutic developments in pancreatic cancer","volume":"21","author":"Hu","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127963_bib2","first-page":"17","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127963_bib3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s13046-020-01608-9","article-title":"2,6-DMBQ is a novel mTOR inhibitor that reduces gastric cancer growth in vitro and in vivo","volume":"39","author":"Zu","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.jtemb.2026.127963_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2025.1677464","article-title":"A systematic review on the health effects of fermented wheat germ extract with emphasis on cancer","volume":"12","author":"Berkel Kasikci","year":"2025","journal-title":"Front. Nutr."},{"issue":"9","key":"10.1016\/j.jtemb.2026.127963_bib5","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1021\/acs.jafc.5b00041","article-title":"Effect of fermented wheat germ extract with lactobacillus plantarum dy-1 on HT-29 cell proliferation and apoptosis","volume":"63","author":"Zhang","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jtemb.2026.127963_bib6","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12906-016-1138-5","article-title":"Antiproliferative and antimetabolic effects behind the anticancer property of fermented wheat germ extract","volume":"16","author":"Otto","year":"2016","journal-title":"BMC Complement. Altern. Med."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127963_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0190860","article-title":"A purified, fermented, extract of Triticum aestivum has lymphomacidal activity mediated via natural killer cell activation","volume":"13","author":"Barisone","year":"2018","journal-title":"PLoS. One"},{"issue":"3","key":"10.1016\/j.jtemb.2026.127963_bib8","first-page":"563","article-title":"Fermented wheat germ extract induces apoptosis and downregulation of major histocompatibility complex class I proteins in tumor T and B cell lines","volume":"20","author":"Fajka-Boja","year":"2002","journal-title":"Int. J. Oncol."},{"issue":"9","key":"10.1016\/j.jtemb.2026.127963_bib9","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.jnutbio.2014.04.003","article-title":"Hepatic metabolite profiles in mice with a suboptimal selenium status","volume":"25","author":"Geillinger","year":"2014","journal-title":"J. Nutr. Biochem."},{"issue":"9822","key":"10.1016\/j.jtemb.2026.127963_bib10","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/S0140-6736(11)61452-9","article-title":"Selenium and human health","volume":"379","author":"Rayman","year":"2012","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.jtemb.2026.127963_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/molecules30010050","article-title":"Effects and impact of selenium on human health, a review","volume":"30","author":"Bai","year":"2024","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.jtemb.2026.127963_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-66553-5","article-title":"A U-shaped association between selenium intake and cancer risk","volume":"14","author":"Le","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jtemb.2026.127963_bib13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13053-019-0131-7","article-title":"Serum selenium level and cancer risk: a nested case-control study","volume":"17","author":"Narod","year":"2019","journal-title":"Hered. Cancer Clin. Pract."},{"issue":"3","key":"10.1016\/j.jtemb.2026.127963_bib14","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1080\/01635581.2016.1153668","article-title":"Inhibitory effects of AVEMAR on proliferation and metastasis of oral cancer cells","volume":"68","author":"Yang","year":"2016","journal-title":"Nutr. Cancer"},{"issue":"1","key":"10.1016\/j.jtemb.2026.127963_bib15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12943-024-01933-z","article-title":"The DNA damage sensor ATM kinase interacts with the p53 mRNA and guides the DNA damage response pathway","volume":"23","author":"Karakostis","year":"2024","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.jtemb.2026.127963_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jnutbio.2007.02.005","article-title":"Selenium as an anticancer nutrient: roles in cell proliferation and tumor cell invasion","volume":"19","author":"Zeng","year":"2008","journal-title":"J. Nutr. Biochem."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127963_bib17","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bbrc.2020.05.005","article-title":"CD147 promotes DNA damage response and gemcitabine resistance via targeting ATM\/ATR\/p53 and affects prognosis in pancreatic cancer","volume":"528","author":"Zhou","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.jtemb.2026.127963_bib18","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrm3546","article-title":"The ATM protein kinase: regulating the cellular response to genotoxic stress, and more","volume":"14","author":"Shiloh","year":"2013","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"6922","key":"10.1016\/j.jtemb.2026.127963_bib19","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nature01368","article-title":"DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation","volume":"421","author":"Bakkenist","year":"2003","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.jtemb.2026.127963_bib20","first-page":"718","article-title":"Antitumor Activities and Apoptosis-regulated Mechanisms of Fermented Wheat Germ Extract in the Transplantation Tumor Model of Human HT-29 Cells in Nude Mice","volume":"28","author":"Zhang","year":"2015","journal-title":"Biomed. Environ. Sci."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127963_bib21","doi-asserted-by":"crossref","first-page":"6465","DOI":"10.1038\/s41598-017-06979-2","article-title":"Selenocysteine induces apoptosis in human glioma cells: evidence for TrxR1-targeted inhibition and signaling crosstalk","volume":"7","author":"Fan","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.jtemb.2026.127963_bib22","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/00006676-200108000-00004","article-title":"Wheat germ extract decreases glucose uptake and RNA ribose formation but increases fatty acid synthesis in MIA pancreatic adenocarcinoma cells","volume":"23","author":"Boros","year":"2001","journal-title":"Pancreas"},{"issue":"4A","key":"10.1016\/j.jtemb.2026.127963_bib23","first-page":"2353","article-title":"Effect of Avemar and Avemar + vitamin C on tumor growth and metastasis in experimental animals","volume":"18","author":"Hidvegi","year":"1998","journal-title":"Anticancer. Res."},{"issue":"32","key":"10.1016\/j.jtemb.2026.127963_bib24","first-page":"393","article-title":"First clinical data of a natural immunomodulator in colorectal cancer","volume":"47","author":"Jakab","year":"2000","journal-title":"Hepatogastroenterology"},{"issue":"15","key":"10.1016\/j.jtemb.2026.127963_bib25","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1089\/ars.2017.7406","article-title":"Redox-active quinone chelators: properties, mechanisms of action, cell delivery, and cell toxicity","volume":"28","author":"Polyakov","year":"2018","journal-title":"Antioxid. Redox Signal."},{"issue":"9","key":"10.1016\/j.jtemb.2026.127963_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/nu10091203","article-title":"Selenium, selenoproteins, and immunity","volume":"10","author":"Avery","year":"2018","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.jtemb.2026.127963_bib27","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.tibs.2013.12.007","article-title":"Selenium and selenocysteine: roles in cancer, health, and development","volume":"39","author":"Hatfield","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jtemb.2026.127963_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2025.1611848","article-title":"Dietary antioxidants and flavonoids are inversely associated with prostate cancer risk and mortality: evidence from NHANES and machine learning","volume":"12","author":"Jin","year":"2025","journal-title":"Front. Nutr."},{"issue":"3","key":"10.1016\/j.jtemb.2026.127963_bib29","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1152\/physrev.00039.2013","article-title":"Selenoproteins: molecular pathways and physiological roles","volume":"94","author":"Labunskyy","year":"2014","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.jtemb.2026.127963_bib30","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1756-9966-30-42","article-title":"Promising cytotoxic activity profile of fermented wheat germ extract (Avemar(R)) in human cancer cell lines","volume":"30","author":"Mueller","year":"2011","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"4","key":"10.1016\/j.jtemb.2026.127963_bib31","first-page":"477","article-title":"Adjuvant fermented wheat germ extract (Avemar) nutraceutical improves survival of high-risk skin melanoma patients: a randomized, pilot, phase II clinical study with a 7-year follow-up","volume":"23","author":"Demidov","year":"2008","journal-title":"Cancer Biother. Radiopharm."},{"key":"10.1016\/j.jtemb.2026.127963_bib32","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1146\/annurev-nutr-071714-034250","article-title":"Regulation of selenium metabolism and transport","volume":"35","author":"Burk","year":"2015","journal-title":"Annu. Rev. Nutr."},{"issue":"19","key":"10.1016\/j.jtemb.2026.127963_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27196613","article-title":"Selenium: an antioxidant with a critical role in anti-aging","volume":"27","author":"Bjorklund","year":"2022","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.jtemb.2026.127963_bib34","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1089\/dna.2023.0099","article-title":"Selenium nanoparticles show anticancer activity through regulation of HIF-1alpha and HIF-2alpha under hypoxic condition in liver cancer cells","volume":"42","author":"Acharya","year":"2023","journal-title":"DNA Cell. Biol."},{"issue":"48","key":"10.1016\/j.jtemb.2026.127963_bib35","doi-asserted-by":"crossref","first-page":"46408","DOI":"10.1074\/jbc.M206150200","article-title":"Fermented wheat germ extract inhibits glycolysis\/pentose cycle enzymes and induces apoptosis through poly(ADP-ribose) polymerase activation in Jurkat T-cell leukemia tumor cells","volume":"277","author":"Comin-Anduix","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.jtemb.2026.127963_bib36","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.molcel.2017.05.015","article-title":"ATM, ATR, and DNA-PK: the trinity at the Heart of the DNA damage response","volume":"66","author":"Blackford","year":"2017","journal-title":"Mol. Cell."},{"issue":"8","key":"10.1016\/j.jtemb.2026.127963_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0329272","article-title":"Premature termination of DNA Damage Repair by 3-Methyladenine potentiates cisplatin cytotoxicity in nasopharyngeal carcinoma cells","volume":"20","author":"Zhou","year":"2025","journal-title":"PLoS. One"},{"issue":"4","key":"10.1016\/j.jtemb.2026.127963_bib38","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1097\/MOH.0000000000000715","article-title":"Role of p53 in regulation of hematopoiesis in health and disease","volume":"29","author":"Barajas","year":"2022","journal-title":"Curr. Opin. Hematol."}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X26001495?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X26001495?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:23:52Z","timestamp":1790886232000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X26001495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":38,"alternative-id":["S0946672X26001495"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2026.127963","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fermented wheat germ extract modulates organic selenium availability to regulate programmed cell death and metabolic reprogramming through the ATM\/ATR\/p53 pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2026.127963","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"127963"}}