{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:51:26Z","timestamp":1791579086206,"version":"4.3.4"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005001","name":"Ahvaz Jundishapur University of Medical Sciences","doi-asserted-by":"publisher","award":["TRC-0141"],"award-info":[{"award-number":["TRC-0141"]}],"id":[{"id":"10.13039\/501100005001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.jtemb.2026.127968","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:27:26Z","timestamp":1790954846000},"page":"127968","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Rosmarinic acid attenuates arsenic-associated neurotoxicity in mice: Behavioral, biochemical, and histopathological evidence"],"prefix":"10.1016","volume":"98","author":[{"given":"Parand","family":"Mehran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shokooh","family":"Mohtadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza","family":"Rashidi Nooshabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Azadnasab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layasadat","family":"Khorsandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9518-1286","authenticated-orcid":false,"given":"Mohammad Javad","family":"Khodayar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtemb.2026.127968_bib1","first-page":"1","article-title":"Antioxidant and anti-inflammatory potential of vanillic acid improves nephrotoxicity induced by sodium arsenite in mice","author":"Khodayar","year":"2024","journal-title":"Int. J. Environ. Health Res."},{"key":"10.1016\/j.jtemb.2026.127968_bib2","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.toxrep.2021.05.015","article-title":"Effects of arsenic and heavy metals on metabolic pathways in cells of human origin: similarities and differences","volume":"8","author":"Fatema","year":"2021","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.jtemb.2026.127968_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2024.127562","article-title":"Zingerone effects on arsenic-induced glucose intolerance and hepatotoxicity in mice via suppression of oxidative stress-mediated hepatic inflammation and apoptosis","volume":"86","author":"Hafezizadeh","year":"2024","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.jtemb.2026.127968_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.113691","article-title":"The protective effect of natural or chemical compounds against arsenic-induced neurotoxicity: Cellular and molecular mechanisms","volume":"175","author":"Shayan","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jtemb.2026.127968_bib5","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1515\/reveh.2011.010","article-title":"Arsenic geochemistry and human health in South East Asia","volume":"26","author":"McCarty","year":"2011","journal-title":"Rev. Environ. Health"},{"key":"10.1016\/j.jtemb.2026.127968_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40726-019-0102-7","article-title":"Arsenic in drinking water: is 10 \u03bcg\/L a safe limit?","volume":"5","author":"Ahmad","year":"2019","journal-title":"Curr. Pollut. Rep."},{"key":"10.1016\/j.jtemb.2026.127968_bib7","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.12810","article-title":"Neurocognitive analysis of low-level arsenic exposure and executive function mediated by brain anomalies among children, adolescents, and young adults in India","volume":"6","author":"Vaidya","year":"2023","journal-title":"JAMA Netw. Open."},{"key":"10.1016\/j.jtemb.2026.127968_bib8","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s40572-014-0012-1","article-title":"The effects of arsenic exposure on neurological and cognitive dysfunction in human and rodent studies: a review","volume":"1","author":"Tyler","year":"2014","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.jtemb.2026.127968_bib9","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s10534-022-00482-6","article-title":"A review of mechanisms underlying the protective effects of natural compounds against arsenic-induced neurotoxicity","volume":"36","author":"Najafi","year":"2023","journal-title":"Biometals"},{"key":"10.1016\/j.jtemb.2026.127968_bib10","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.3390\/ijms20143418","article-title":"Arsenic neurotoxicity in humans","volume":"20","author":"Mochizuki","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jtemb.2026.127968_bib11","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.envpol.2017.11.083","article-title":"Cortex and hippocampus DNA epigenetic response to a long-term arsenic exposure via drinking water","volume":"234","author":"Du","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jtemb.2026.127968_bib12","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1007\/s12035-014-8753-2","article-title":"Excitotoxicity induced by realgar in the rat hippocampus: the involvement of learning memory injury, dysfunction of glutamate metabolism and NMDA receptors","volume":"51","author":"Huo","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jtemb.2026.127968_bib13","article-title":"Exposure to arsenic and cognitive impairment in children: a systematic review","volume":"20","author":"Tian","year":"2025","journal-title":"Plos. One"},{"key":"10.1016\/j.jtemb.2026.127968_bib14","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1007\/s00775-019-01740-8","article-title":"Arsenic-induced neurotoxicity: a mechanistic appraisal","volume":"24","author":"Garza-Lomb\u00f3","year":"2019","journal-title":"J. Biol. Inorg. Chem."},{"key":"10.1016\/j.jtemb.2026.127968_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113468","article-title":"TNF-\u03b1 derived from arsenite-induced microglia activation mediated neuronal necroptosis","volume":"236","author":"Wang","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jtemb.2026.127968_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2024.110076","article-title":"Betaine ameliorates arsenic-induced kidney injury in mice by mitigating oxidative stress-mediated inflammation","volume":"758","author":"Norouzzadeh","year":"2024","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jtemb.2026.127968_bib17","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3109\/15376516.2012.748116","article-title":"Sodium arsenite-induced cardiotoxicity in rats: protective role of p-coumaric acid, a common dietary polyphenol","volume":"23","author":"Prasanna","year":"2013","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.jtemb.2026.127968_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150258","article-title":"Hepatoprotective effects of zingerone on sodium arsenite-induced hepatotoxicity in rats: modulating the levels of caspase-3\/Bax\/Bcl-2, NLRP3\/NF-\u03baB\/TNF-\u03b1 and ATF6\/IRE1\/PERK\/GRP78 signaling pathways","volume":"725","author":"Eriten","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jtemb.2026.127968_bib19","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.neuro.2010.05.001","article-title":"Neuroprotective effect of curcumin in arsenic-induced neurotoxicity in rats","volume":"31","author":"Yadav","year":"2010","journal-title":"NeuroToxicology"},{"key":"10.1016\/j.jtemb.2026.127968_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109392","article-title":"Neuroprotective effects of protocatechuic acid on sodium arsenate induced toxicity in mice: role of oxidative stress, inflammation, and apoptosis","volume":"337","author":"Li","year":"2021","journal-title":"Chem. -Biol. Interact."},{"key":"10.1016\/j.jtemb.2026.127968_bib21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.lfs.2018.02.022","article-title":"The possible neuroprotective effect of ellagic acid on sodium arsenate-induced neurotoxicity in rats","volume":"198","author":"Goudarzi","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.jtemb.2026.127968_bib22","article-title":"Recent advances in the analysis of rosmarinic acid from herbs in the Lamiaceae family","volume":"14","author":"Sik","year":"2019","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.jtemb.2026.127968_bib23","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.3390\/app9153139","article-title":"Therapeutic potential of rosmarinic acid: a comprehensive review","volume":"9","author":"Nadeem","year":"2019","journal-title":"Appl. Sci."},{"key":"10.1016\/j.jtemb.2026.127968_bib24","doi-asserted-by":"crossref","first-page":"10138","DOI":"10.1007\/s12035-024-04206-4","article-title":"Rosmarinic acid ameliorated oxidative stress, neuronal injuries, and mitochondrial dysfunctions mediated by polyglutamine and \u0251-synuclein in Caenorhabditis elegans models","volume":"61","author":"Chen","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jtemb.2026.127968_bib25","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1002\/ptr.7825","article-title":"Molecular mechanisms of neuroprotective offerings by rosmarinic acid against neurodegenerative and other CNS pathologies","volume":"37","author":"Ravaria","year":"2023","journal-title":"Phytother. Res."},{"key":"10.1016\/j.jtemb.2026.127968_bib26","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.fitote.2013.09.012","article-title":"Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase activities in rat brain","volume":"91","author":"Ozarowski","year":"2013","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jtemb.2026.127968_bib27","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1007\/s00210-020-01935-w","article-title":"Effects of rosmarinic acid on nervous system disorders: an updated review","volume":"393","author":"Ghasemzadeh Rahbardar","year":"2020","journal-title":"Naunyn-Schmiede 's. Arch. Pharmacol."},{"key":"10.1016\/j.jtemb.2026.127968_bib28","doi-asserted-by":"crossref","first-page":"338","DOI":"10.4062\/biomolther.2015.135","article-title":"The neuro-protective effect of the methanolic extract of Perilla frutescens var. japonica and rosmarinic acid against H2O2-induced oxidative stress in C6 glial cells","volume":"24","author":"Lee","year":"2016","journal-title":"Biomol. Ther."},{"key":"10.1016\/j.jtemb.2026.127968_bib29","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.fct.2012.10.021","article-title":"Rosmarinic acid ameliorates acute liver damage and fibrogenesis in carbon tetrachloride-intoxicated mice","volume":"51","author":"Domitrovi\u0107","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jtemb.2026.127968_bib30","doi-asserted-by":"crossref","first-page":"10143","DOI":"10.1007\/s00210-024-03274-6","article-title":"Epicatechin as a promising agent against arsenic-induced neurobehavioral toxicity in NMRI mice: behavioral and biochemical alterations","author":"Shariati","year":"2024","journal-title":"Naunyn-Schmiede 's. Arch. Pharmacol."},{"key":"10.1016\/j.jtemb.2026.127968_bib31","series-title":"Animal Models for the Study of Human Disease (Second Edition)","first-page":"991","article-title":"Chapter 38 - animal models of mood disorders: focus on bipolar disorder and depression","author":"Valvassori","year":"2017"},{"key":"10.1016\/j.jtemb.2026.127968_bib32","doi-asserted-by":"crossref","unstructured":"T.D. Gould, D.T. Dao, C.E. Kovacsics, The open field test, In: Gould, T. (eds) Mood and Anxiety Related Phenotypes in Mice, Neuromethods 42 (2009) pp. 1\u201320.","DOI":"10.1007\/978-1-60761-303-9_1"},{"key":"10.1016\/j.jtemb.2026.127968_bib33","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1007\/s11064-013-1092-2","article-title":"Antioxidant effects of nerolidol in mice hippocampus after open field test","volume":"38","author":"Nogueira Neto","year":"2013","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.jtemb.2026.127968_bib34","article-title":"Intermittent hypoxia can aggravate motor neuronal loss and cognitive dysfunction in ALS mice","volume":"8","author":"Kim","year":"2013","journal-title":"PLoS. One"},{"key":"10.1016\/j.jtemb.2026.127968_bib35","series-title":"Movement Disorders (Second Edition)","first-page":"139","article-title":"Chapter 8 - techniques for motor assessment in rodents","author":"Mann","year":"2015"},{"key":"10.1016\/j.jtemb.2026.127968_bib36","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jneumeth.2010.03.026","article-title":"A rotarod test for evaluation of motor skill learning","volume":"189","author":"Shiotsuki","year":"2010","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jtemb.2026.127968_bib37","first-page":"127","article-title":"Enriched environment restores passive avoidance memory impairment in a rat model of neuroinflammation","volume":"26","author":"Keymoradzadeh","year":"2022","journal-title":"Physiol. Pharmacol."},{"key":"10.1016\/j.jtemb.2026.127968_bib38","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jtemb.2026.127968_bib39","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jtemb.2026.127968_bib40","series-title":"Methods in enzymology","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0076-6879(94)33044-1","article-title":"[41] Measurement of protein thiol groups and glutathione in plasma","author":"Hu","year":"1994"},{"key":"10.1016\/j.jtemb.2026.127968_bib41","series-title":"Methods in enzymology","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"[30] Microsomal lipid peroxidation","author":"Buege","year":"1978"},{"key":"10.1016\/j.jtemb.2026.127968_bib42","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ijdevneu.2014.01.007","article-title":"Reversibility of changes in brain cholinergic receptors and acetylcholinesterase activity in rats following early life arsenic exposure","volume":"34","author":"Chandravanshi","year":"2014","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.jtemb.2026.127968_bib43","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.aogh.2014.09.005","article-title":"The developmental neurotoxicity of arsenic: cognitive and behavioral consequences of early life exposure","volume":"80","author":"Tolins","year":"2014","journal-title":"Ann. Glob. Health"},{"key":"10.1016\/j.jtemb.2026.127968_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.ntt.2021.106981","article-title":"Neuroprotective effect of hesperidin against emamectin benzoate-induced neurobehavioral toxicity in rats","volume":"86","author":"Noshy","year":"2021","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.jtemb.2026.127968_bib45","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s00580-020-03097-w","article-title":"Neuroprotective effects of gallic acid against neurotoxicity induced by sodium arsenite in rats","volume":"29","author":"Hosseinzadeh","year":"2020","journal-title":"Comp. Clin. Pathol."},{"key":"10.1016\/j.jtemb.2026.127968_bib46","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0361-9230(01)00477-4","article-title":"The effects of sodium arsenite exposure on behavioral parameters in the rat","volume":"55","author":"Rodr\u0131guez","year":"2001","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.jtemb.2026.127968_bib47","doi-asserted-by":"crossref","first-page":"894","DOI":"10.4103\/1673-5374.268927","article-title":"Rosmarinic acid ameliorates hypoxia\/ischemia induced cognitive deficits and promotes remyelination","volume":"15","author":"Li","year":"2020","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.jtemb.2026.127968_bib48","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/1028415X.2016.1203125","article-title":"Rosmarinic acid protects against chronic ethanol-induced learning and memory deficits in rats","volume":"20","author":"Hasanein","year":"2017","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.jtemb.2026.127968_bib49","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/jat.3256","article-title":"Mitochondrial oxidative stress and dysfunction in arsenic neurotoxicity: A review","volume":"36","author":"Prakash","year":"2016","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.jtemb.2026.127968_bib50","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/npp.2015.171","article-title":"Stress effects on neuronal structure: hippocampus, amygdala, and prefrontal cortex","volume":"41","author":"McEwen","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jtemb.2026.127968_bib51","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3389\/fnmol.2017.00286","article-title":"Sodium arsenite-induced learning and memory impairment is associated with endoplasmic reticulum stress-mediated apoptosis in rat hippocampus","volume":"10","author":"Sun","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.jtemb.2026.127968_bib52","doi-asserted-by":"crossref","first-page":"970","DOI":"10.3390\/toxics11120970","article-title":"Subchronic arsenic exposure induces behavioral impairments and hippocampal damage in rats","volume":"11","author":"Chu","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.jtemb.2026.127968_bib53","doi-asserted-by":"crossref","first-page":"10077","DOI":"10.3390\/ijms221810077","article-title":"Molecular mechanism of arsenic-induced neurotoxicity including neuronal dysfunctions","volume":"22","author":"Thakur","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jtemb.2026.127968_bib54","article-title":"Evaluation of the neuroprotective activity of P. amarus in attenuating arsenic-induced neurotoxicity-an in vivo study","volume":"2","author":"Hashim","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jtemb.2026.127968_bib55","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.neuro.2011.07.004","article-title":"Neuroprotective efficacy of curcumin in arsenic induced cholinergic dysfunctions in rats","volume":"32","author":"Yadav","year":"2011","journal-title":"NeuroToxicology"},{"key":"10.1016\/j.jtemb.2026.127968_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2020.104202","article-title":"Chlorogenic acid confers robust neuroprotection against arsenite toxicity in mice by reversing oxidative stress, inflammation, and apoptosis","volume":"75","author":"Metwally","year":"2020","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.jtemb.2026.127968_bib57","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jnutbio.2017.11.010","article-title":"Ameliorative role of genistein against age-dependent chronic arsenic toxicity in murine brains via the regulation of oxidative stress and inflammatory signaling cascades","volume":"55","author":"Saha","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.jtemb.2026.127968_bib58","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.toxrep.2018.02.017","article-title":"Ellagic acid attenuates arsenic induced neuro-inflammation and mitochondrial dysfunction associated apoptosis","volume":"5","author":"Firdaus","year":"2018","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.jtemb.2026.127968_bib59","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.taap.2009.07.017","article-title":"Attenuation of arsenic neurotoxicity by curcumin in rats","volume":"240","author":"Yadav","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jtemb.2026.127968_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115014","article-title":"Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2\/HO-1 and TLR4\/NF-\u03baB pathways","volume":"397","author":"Ma","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jtemb.2026.127968_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110928","article-title":"Regulation of SIRT3 on mitochondrial functions and oxidative stress in Parkinson\u2019s disease","volume":"132","author":"Shen","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jtemb.2026.127968_bib62","doi-asserted-by":"crossref","first-page":"341","DOI":"10.5607\/en21021","article-title":"Overexpression of SIRT3 suppresses oxidative stress-induced neurotoxicity and mitochondrial dysfunction in dopaminergic neuronal cells","volume":"30","author":"Lee","year":"2021","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.jtemb.2026.127968_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2025.110461","article-title":"Luteolin attenuates trimethyltin chloride-induced hippocampal neurotoxicity through SIRT3\/NRF2\/HO-1 activation","author":"Ding","year":"2025","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jtemb.2026.127968_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2019.114639","article-title":"Icariin protects rotenone-induced neurotoxicity through induction of SIRT3","volume":"379","author":"Zeng","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jtemb.2026.127968_bib65","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.toxlet.2018.10.025","article-title":"SirT3 regulates diabetogenic effects caused by arsenic: an implication for mitochondrial complex II modification","volume":"301","author":"Rezaei","year":"2019","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.jtemb.2026.127968_bib66","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.4103\/1673-5374.241463","article-title":"Rosmarinic acid elicits neuroprotection in ischemic stroke via Nrf2 and heme oxygenase 1 signaling","volume":"13","author":"Cui","year":"2018","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.jtemb.2026.127968_bib67","first-page":"1","article-title":"Neuroprotective efficacy of silymarin against oxidative stress, inflammation, and structural changes mediated by arsenic-induced toxicity in rats","author":"Verma","year":"2024","journal-title":"Indian. J. Clin. Biochem."},{"key":"10.1016\/j.jtemb.2026.127968_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2023.105652","article-title":"Nephroprotective effect of diosmin against sodium arsenite-induced renal toxicity is mediated via attenuation of oxidative stress and inflammation in mice","volume":"197","author":"Mohtadi","year":"2023","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.jtemb.2026.127968_bib69","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.neuro.2019.10.009","article-title":"Neuroprotective mechanisms of selenium against arsenic-induced behavioral impairments in rats","volume":"76","author":"Adedara","year":"2020","journal-title":"NeuroToxicology"},{"key":"10.1016\/j.jtemb.2026.127968_bib70","doi-asserted-by":"crossref","first-page":"tfae203","DOI":"10.1093\/toxres\/tfae203","article-title":"Role of vitamin D3 in mitigating sodium arsenite-induced neurotoxicity in male rats","volume":"13","author":"Abdou","year":"2024","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.jtemb.2026.127968_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchemneu.2021.102008","article-title":"Rosmarinic acid attenuates lipopolysaccharide-induced neuroinflammation and cognitive impairment in rats","volume":"117","author":"Hassanzadeh-Taheri","year":"2021","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.jtemb.2026.127968_bib72","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.envres.2010.01.007","article-title":"Arsenic species, AS3MT amount, and AS3MT gen expression in different brain regions of mouse exposed to arsenite","volume":"110","author":"S\u00e1nchez-Pe\u00f1a","year":"2010","journal-title":"Environ. Res."},{"key":"10.1016\/j.jtemb.2026.127968_bib73","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1146\/annurev-pharmtox-051921-020936","article-title":"The duality of arsenic metabolism: impact on human health","volume":"63","author":"El-Ghiaty","year":"2023","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.jtemb.2026.127968_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152800","article-title":"Arsenic methylation\u2013lessons from three decades of research","volume":"457","author":"Thomas","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.jtemb.2026.127968_bib75","doi-asserted-by":"crossref","first-page":"23905","DOI":"10.18632\/oncotarget.14733","article-title":"Metabolism, toxicity and anticancer activities of arsenic compounds","volume":"8","author":"Khairul","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jtemb.2026.127968_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.144046","article-title":"A comprehensive review of arsenic-induced neurotoxicity: exploring the role of glial cell pathways and mechanisms","volume":"372","author":"Garg","year":"2025","journal-title":"Chemosphere"},{"key":"10.1016\/j.jtemb.2026.127968_bib77","doi-asserted-by":"crossref","first-page":"37287","DOI":"10.1038\/srep37287","article-title":"Association of arsenic methylation capacity with developmental delays and health status in children: a prospective case\u2013control trial","volume":"6","author":"Hsueh","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jtemb.2026.127968_bib78","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/595307","article-title":"Nutritional manipulation of one-carbon metabolism: effects on arsenic methylation and toxicity","volume":"2012","author":"Hall","year":"2012","journal-title":"J. Toxicol."},{"key":"10.1016\/j.jtemb.2026.127968_bib79","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/3924581","article-title":"Effects of proanthocyanidins on arsenic methylation metabolism and efflux in human hepatocytes L-02","volume":"2019","author":"Ren","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.jtemb.2026.127968_bib80","first-page":"1","article-title":"Rosmarinic acid-A potential therapeutic agent for sleep disorders","volume":"3","author":"Morde","year":"2023","journal-title":"Int. J. Pharm. Sci."},{"key":"10.1016\/j.jtemb.2026.127968_bib81","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.3390\/pharmaceutics14112401","article-title":"Journey of rosmarinic acid as biomedicine to nano-biomedicine for treating cancer: current strategies and future perspectives","volume":"14","author":"Chaitanya","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jtemb.2026.127968_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2024.115430","article-title":"Bioavailability of encapsulated rosmarinic acid and \u03b2-carotene in beef Sausages: a caco-2 cell study","volume":"200","author":"Bako","year":"2025","journal-title":"Food Res. Int."},{"key":"10.1016\/j.jtemb.2026.127968_bib83","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0126422","article-title":"Pharmacokinetics, safety and tolerability of Melissa officinalis extract which contained rosmarinic acid in healthy individuals: a randomized controlled trial","volume":"10","author":"Noguchi-Shinohara","year":"2015","journal-title":"PloS. One"},{"key":"10.1016\/j.jtemb.2026.127968_bib84","doi-asserted-by":"crossref","first-page":"121","DOI":"10.14200\/jrm.2014.3.0109","article-title":"Rosmarinic acid as a novel agent in the treatment of allergies and asthma","volume":"3","author":"Stansbury","year":"2014","journal-title":"J. Restor. Med."},{"key":"10.1016\/j.jtemb.2026.127968_bib85","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic. Clin. Pharma."}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X26001549?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X26001549?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:14:16Z","timestamp":1791576856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X26001549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":85,"alternative-id":["S0946672X26001549"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2026.127968","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rosmarinic acid attenuates arsenic-associated neurotoxicity in mice: Behavioral, biochemical, and histopathological evidence","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2026.127968","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"127968"}}