{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:44:39Z","timestamp":1791834279941,"version":"4.3.4"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.jtemb.2026.127973","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:09:36Z","timestamp":1791151776000},"page":"127973","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Integrated multi-omics analysis reveals shared genetic and immunological biomarkers linking arsenic-induced autophagy to carcinogenesis"],"prefix":"10.1016","volume":"98","author":[{"given":"Fakher","family":"Rahim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzieh","family":"Zeinvand-Lorestani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"\u00d6rs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtemb.2026.127973_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2024.120457","article-title":"A comprehensive review on arsenic contamination in groundwater: Sources, detection, mitigation strategies and cost analysis","volume":"265","author":"Sultan","year":"2025","journal-title":"Environ. Res."},{"key":"10.1016\/j.jtemb.2026.127973_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2024.116808","article-title":"Arsenic in drinking water and lung cancer: a systematic review of 35 years of evidence","volume":"483","author":"Issanov","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jtemb.2026.127973_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.crtox.2025.100268","article-title":"Toxicological impacts and mitigation strategies of food contaminants: a global perspective and comprehensive narrative review","volume":"9","author":"Bereda","year":"2025","journal-title":"Curr. Res. Toxicol."},{"key":"10.1016\/j.jtemb.2026.127973_bib4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1023\/B:MCBI.0000007261.04684.78","article-title":"Molecular mechanisms of arsenic carcinogenesis","volume":"255","author":"Huang","year":"2004","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.jtemb.2026.127973_bib5","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.7150\/ijbs.95122","article-title":"Autophagy in its (proper) context: Molecular basis, biological relevance, pharmacological modulation, and lifestyle medicine","volume":"20","author":"Ortega","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jtemb.2026.127973_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2025.104820","article-title":"Autophagy and oxidative stress in solid tumors: Mechanisms and therapeutic opportunities","volume":"212","author":"Carretero-Fern\u00e1ndez","year":"2025","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.jtemb.2026.127973_bib7","series-title":"in: Autophagy and Metabolism","first-page":"141","article-title":"Autophagy in arsenic exposed population and cancer patients","author":"Kumar","year":"2022"},{"key":"10.1016\/j.jtemb.2026.127973_bib8","doi-asserted-by":"crossref","first-page":"11542","DOI":"10.1002\/cam4.5577","article-title":"Autophagy: A challengeable paradox in cancer treatment","volume":"12","author":"Ahmadi-Dehlaghi","year":"2023","journal-title":"Cancer Med."},{"key":"10.1016\/j.jtemb.2026.127973_bib9","doi-asserted-by":"crossref","first-page":"7459","DOI":"10.3390\/ijms25137459","article-title":"Blockage of autophagy for cancer therapy: A comprehensive review","volume":"25","author":"Hassan","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jtemb.2026.127973_bib10","doi-asserted-by":"crossref","DOI":"10.1007\/s00204-025-04230-w","article-title":"Arsenic disrupts autophagosome-lysosome fusion in a zinc dependent manner across multiple human skin and lung cell lines","author":"Goff","year":"2026","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.jtemb.2026.127973_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2025.106929","article-title":"Integrated multi-omics insight into the molecular networks of oxidative stress in triggering multiple sclerosis","volume":"210","author":"Xu","year":"2025","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jtemb.2026.127973_bib12","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.037203","article-title":"Multi-omic insight into the molecular networks in the pathogenesis of coronary artery disease","volume":"14","author":"Fang","year":"2025","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.jtemb.2026.127973_bib13","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbaf595","article-title":"SynOmics: integrating multi-omics data through feature interaction networks","volume":"26","author":"Alif","year":"2025","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.jtemb.2026.127973_bib14","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1083\/jcb.139.7.1687","article-title":"Two distinct pathways for targeting proteins from the cytoplasm to the vacuole\/lysosome","volume":"139","author":"Baba","year":"1997","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.jtemb.2026.127973_bib15","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1126\/science.290.5497.1717","article-title":"Autophagy as a regulated pathway of cellular degradation","volume":"290","author":"Klionsky","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.jtemb.2026.127973_bib16","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1080\/15548627.2017.1415189","article-title":"Exploring autophagy with Gene Ontology","volume":"14","author":"Denny","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.jtemb.2026.127973_bib17","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1007\/s00204-021-03084-2","article-title":"Dynamic alteration in miRNA and mRNA expression profiles at different stages of chronic arsenic exposure-induced carcinogenesis in a human cell culture model of skin cancer","volume":"95","author":"Banerjee","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.jtemb.2026.127973_bib18","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/toxsci\/kfr199","article-title":"Concentration- and time-dependent genomic changes in the mouse urinary bladder following exposure to arsenate in drinking water for up to 12 weeks","volume":"123","author":"Clewell","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.jtemb.2026.127973_bib19","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1158\/0008-5472.CAN-17-0836","article-title":"YAP1 and COX2 coordinately regulate urothelial cancer stem-like cells","volume":"78","author":"Ooki","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.jtemb.2026.127973_bib20","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein--protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jtemb.2026.127973_bib21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.jtemb.2026.127973_bib22","doi-asserted-by":"crossref","first-page":"D672","DOI":"10.1093\/nar\/gkad1025","article-title":"The Reactome Pathway Knowledgebase 2024","volume":"52","author":"Milacic","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jtemb.2026.127973_bib23","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jtemb.2026.127973_bib24","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2105-4-2","article-title":"An automated method for finding molecular complexes in large protein interaction networks","volume":"4","author":"Bader","year":"2003","journal-title":"BMC Bioinform"},{"key":"10.1016\/j.jtemb.2026.127973_bib25","doi-asserted-by":"crossref","first-page":"D147","DOI":"10.1093\/nar\/gkae1072","article-title":"miRTarBase 2025: updates to the collection of experimentally validated microRNA--target interactions","volume":"53","author":"Cui","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jtemb.2026.127973_bib26","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.cels.2018.03.001","article-title":"Systematic evaluation of molecular networks for discovery of disease genes","volume":"6","author":"Huang","year":"2018","journal-title":"Cell. Syst."},{"key":"10.1016\/j.jtemb.2026.127973_bib27","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/s41419-023-06154-8","article-title":"Autophagy: Regulator of cell death","volume":"14","author":"Liu","year":"2023","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.jtemb.2026.127973_bib28","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.febslet.2010.01.009","article-title":"Autophagy in cellular growth control","volume":"584","author":"Wang","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jtemb.2026.127973_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.113954","article-title":"Arsenic-induced autophagy-dependent apoptosis in hippocampal neurons via AMPK\/mTOR signaling pathway","volume":"179","author":"Chen","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jtemb.2026.127973_bib30","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1038\/s12276-023-01056-3","article-title":"The stress-responsive protein REDD1 and its pathophysiological functions","volume":"55","author":"Kim","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jtemb.2026.127973_bib31","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.semcancer.2021.05.009","article-title":"Arsenic co-carcinogenesis: Inhibition of DNA repair and interaction with zinc finger proteins","volume":"76","author":"Zhou","year":"2021","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.jtemb.2026.127973_bib32","doi-asserted-by":"crossref","DOI":"10.1093\/toxres\/tfae136","article-title":"Research progress on the regulatory mechanism of cell senescence in arsenic toxicity: A systematic review","volume":"13","author":"Gu","year":"2024","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.jtemb.2026.127973_bib33","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3390\/toxics13040287","article-title":"Mechanistic studies on the role of IL-17\/NLRP3 in arsenic-induced activation of hepatic stellate cells through hepatocyte proptosis","volume":"13","author":"Hu","year":"2025","journal-title":"Toxics"},{"key":"10.1016\/j.jtemb.2026.127973_bib34","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s12943-023-01893-w","article-title":"Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies","volume":"22","author":"Giansanti","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jtemb.2026.127973_bib35","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s41392-025-02280-1","article-title":"Immune evasion in cancer: Mechanisms and cutting-edge therapeutic approaches","volume":"10","author":"Tufail","year":"2025","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.jtemb.2026.127973_bib36","article-title":"Crosstalk between autophagy and immune cell infiltration in the tumor microenvironment","volume":"10","author":"Yang","year":"2023","journal-title":"Front. Med."},{"key":"10.1016\/j.jtemb.2026.127973_bib37","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.trsl.2022.11.007","article-title":"Arsenic trioxide sensitizes pancreatic cancer cells to gemcitabine through downregulation of the TIMP1\/PI3K\/AKT\/mTOR axis","volume":"255","author":"Tian","year":"2023","journal-title":"Transl. Res."},{"key":"10.1016\/j.jtemb.2026.127973_bib38","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.3390\/biomedicines11061721","article-title":"Arsenic inhibits proliferation and induces autophagy of tumor cells in pleural effusion of patients with non-small cell lung cancer expressing EGFR with or without mutations via PI3K\/AKT\/mTOR pathway","volume":"11","author":"Mao","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.jtemb.2026.127973_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.117093","article-title":"Arsenic compounds in cancer therapy: Mechanistic insights and antitumor activity","volume":"240","author":"Zhang","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jtemb.2026.127973_bib40","article-title":"The autophagy switch: A critical determinant of arsenic-induced carcinogenesis and cancer therapy","volume":"16","author":"Zeinvand-Lorestani","year":"2026","journal-title":"Toxicol. Rep."}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X26001598?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X26001598?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:47:06Z","timestamp":1791830826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X26001598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":40,"alternative-id":["S0946672X26001598"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2026.127973","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated multi-omics analysis reveals shared genetic and immunological biomarkers linking arsenic-induced autophagy to carcinogenesis","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2026.127973","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"127973"}}