{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:36:01Z","timestamp":1792672561012,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL101917"],"award-info":[{"award-number":["HL101917"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.jtha.2022.10.012","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T19:21:37Z","timestamp":1673292097000},"page":"133-144","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Activated protein C inhibits mesothelial-to-mesenchymal transition in experimental peritoneal fibrosis"],"prefix":"10.1016","volume":"21","author":[{"given":"Hemant","family":"Giri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indranil","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza R.","family":"Rezaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2022.10.012_bib1","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1073\/pnas.78.4.2249","article-title":"Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C","volume":"78","author":"Esmon","year":"1981","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jtha.2022.10.012_bib2","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1096\/fasebj.6.8.1317308","article-title":"Regulation of blood coagulation by the protein C system","volume":"6","author":"Walker","year":"1992","journal-title":"FASEB J"},{"key":"10.1016\/j.jtha.2022.10.012_bib3","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1126\/science.1071699","article-title":"Activation of endothelial cell protease activated receptor 1 by the protein C pathway","volume":"296","author":"Riewald","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.jtha.2022.10.012_bib4","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1182\/blood-2006-09-003004","article-title":"The cytoprotective protein C pathway","volume":"109","author":"Mosnier","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2022.10.012_bib5","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1182\/blood-2014-05-578328","article-title":"Endothelial cell protein C receptor: a multiliganded and multifunctional receptor","volume":"124","author":"Mohan Rao","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2022.10.012_bib6","doi-asserted-by":"crossref","first-page":"25493","DOI":"10.1074\/jbc.M702131200","article-title":"Identification of a specific exosite on activated protein C for interaction with protease-activated receptor 1","volume":"282","author":"Yang","year":"2007","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jtha.2022.10.012_bib7","doi-asserted-by":"crossref","first-page":"9251","DOI":"10.1074\/jbc.M610547200","article-title":"Engineering a disulfide bond to stabilize the calcium-binding loop of activated protein C eliminates its anticoagulant but not its protective signaling properties","volume":"282","author":"Bae","year":"2007","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jtha.2022.10.012_bib8","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1111\/j.1538-7836.2012.04833.x","article-title":"Activated protein C modulates cardiac metabolism and augments autophagy in the ischemic heart","volume":"10","author":"Costa","year":"2012","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2022.10.012_bib9","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1182\/blood-2014-10-609339","article-title":"Intraperitoneal administration of activated protein C prevents postsurgical adhesion band formation","volume":"125","author":"Dinarvand","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2022.10.012_bib10","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1160\/TH15-07-0584","article-title":"Activated protein C protects against renal ischaemia\/reperfusion injury, independent of its anticoagulant properties","volume":"116","author":"Lattenist","year":"2016","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2022.10.012_bib11","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/ki.2011.305","article-title":"Pleiotrophin triggers inflammation and increased peritoneal permeability leading to peritoneal fibrosis","volume":"81","author":"Yokoi","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.jtha.2022.10.012_bib12","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/ki.2013.81","article-title":"Mesenchymal stem cells ameliorate experimental peritoneal fibrosis by suppressing inflammation and inhibiting TGF-\u03b21 signaling","volume":"84","author":"Ueno","year":"2013","journal-title":"Kidney Int"},{"key":"10.1016\/j.jtha.2022.10.012_bib13","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1016\/j.ajpath.2015.08.009","article-title":"Myofibroblastic conversion and regeneration of mesothelial cells in peritoneal and liver fibrosis","volume":"185","author":"Lua","year":"2015","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jtha.2022.10.012_bib14","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1124\/jpet.114.215228","article-title":"Suramin inhibits the development and progression of peritoneal fibrosis","volume":"351","author":"Xiong","year":"2014","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.jtha.2022.10.012_bib15","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJMoa020809","article-title":"Peritoneal dialysis and epithelial-to-mesenchymal transition of mesothelial cells","volume":"348","author":"Yanez-Mo","year":"2003","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtha.2022.10.012_bib16","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s11684-017-0571-2","article-title":"Strategies for preventing peritoneal fibrosis in peritoneal dialysis patients: new insights based on peritoneal inflammation and angiogenesis","volume":"11","author":"Zhang","year":"2017","journal-title":"Front Med"},{"key":"10.1016\/j.jtha.2022.10.012_bib17","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jtha.2022.10.012_bib18","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1055\/s-0037-1613239","article-title":"Mice with a severe deficiency of the endothelial protein C receptor gene develop, survive, and reproduce normally, and do not present with enhanced arterial thrombosis after challenge","volume":"88","author":"Castellino","year":"2002","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2022.10.012_bib19","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1055\/s-0038-1650676","article-title":"Biological consequences of thrombin receptor deficiency in mice","volume":"76","author":"Darrow","year":"1996","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2022.10.012_bib20","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/381516a0","article-title":"Role of the thrombin receptor in development and evidence for a second receptor","volume":"381","author":"Connolly","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.jtha.2022.10.012_bib21","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1046\/j.1365-2141.1996.d01-1935.x","article-title":"Thrombomodulin activity on mesothelial cells: perspectives for mesothelial cells as an alternative for endothelial cells for cell seeding on vascular grafts","volume":"95","author":"Verhagen","year":"1996","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2022.10.012_bib22","doi-asserted-by":"crossref","first-page":"97","DOI":"10.5301\/ijao.5000174","article-title":"PAR-1 mediates the thrombin-induced mesothelial cell overproduction of VEGF and PAI-1","volume":"36","author":"Belling","year":"2013","journal-title":"Int J Artif Organs"},{"key":"10.1016\/j.jtha.2022.10.012_bib23","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1160\/TH07-03-0223","article-title":"Thrombomodulin-mediated catabolism of protein C by pleural mesothelial and vascular endothelial cells","volume":"98","author":"Iakhiaev","year":"2007","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2022.10.012_bib24","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.157701","article-title":"EPCR-PAR1 biased signaling regulates perfusion recovery and neovascularization in peripheral ischemia","volume":"7","author":"Bochenek","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.jtha.2022.10.012_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026514","article-title":"The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer","volume":"6","author":"Dhasarathy","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jtha.2022.10.012_bib26","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/ncb1173","article-title":"Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition","volume":"6","author":"Zhou","year":"2004","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jtha.2022.10.012_bib27","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.3390\/cells8101118","article-title":"The E-cadherin and N-cadherin switch in epithelial-to-mesenchymal transition: signaling, therapeutic implications, and challenges","volume":"8","author":"Loh","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jtha.2022.10.012_bib28","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1172\/JCI57349","article-title":"G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer","volume":"122","author":"Dong","year":"2012","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jtha.2022.10.012_bib29","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1084\/jem.20020077","article-title":"The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor \u03baB and mitogen-activated protein kinase pathways","volume":"196","author":"Conway","year":"2002","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jtha.2022.10.012_bib30","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1538-7836.2011.04319.x","article-title":"Thrombomodulin: protectorate God of the vasculature in thrombosis and inflammation","volume":"9","author":"Ito","year":"2011","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2022.10.012_bib31","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.1128\/MCB.01021-09","article-title":"Downregulation of thrombomodulin, a novel target of Snail, induces tumorigenesis through epithelial-mesenchymal transition","volume":"30","author":"Kao","year":"2010","journal-title":"Mol Cell Biol"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622071811?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622071811?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:34:08Z","timestamp":1761536048000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622071811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S1538783622071811"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2022.10.012","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activated protein C inhibits mesothelial-to-mesenchymal transition in experimental peritoneal fibrosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2022.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}