{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:18:40Z","timestamp":1787509120365,"version":"build-2736575974"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.jtha.2022.11.025","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T10:24:15Z","timestamp":1674642255000},"page":"606-615","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Noninvasive diagnostic work-up for suspected acute pulmonary embolism during pregnancy: a systematic review and meta-analysis of individual patient data"],"prefix":"10.1016","volume":"21","author":[{"given":"Milou A.M.","family":"Stals","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Moumneh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fionnuala Ni","family":"Ainle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drahomir","family":"Aujesky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"van Bemmel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Bertoletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid M.","family":"Bistervels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Chauleur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Couturaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yordi P.A.","family":"van Dooren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Elias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"Faber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Le Gall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman M.A.","family":"Hofstee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"van der Hulle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke J.H.A.","family":"Kruip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Maignan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert T.A.","family":"Mairuhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Middeldorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Le Moigne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Nijkeuter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liselotte M.","family":"van der Pol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helia","family":"Robert-Ebadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Marie","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannot","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"van Smeden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecile","family":"Tromeur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marije ten","family":"Wolde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Righini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire","family":"Le Gal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menno V.","family":"Huisman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederikus A.","family":"Klok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2022.11.025_bib1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/jog.12954","article-title":"Incidence and causes of maternal mortality in the USA","volume":"42","author":"Kuriya","year":"2016","journal-title":"J\u00a0Obstet Gynaecol Res"},{"key":"10.1016\/j.jtha.2022.11.025_bib2","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/S0140-6736(06)68397-9","article-title":"WHO analysis of causes of maternal death: a systematic review","volume":"367","author":"Khan","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jtha.2022.11.025_bib3","first-page":"1","article-title":"Pregnancy-related mortality surveillance-United States, 1991\u20131999","volume":"52","author":"Berg","year":"2003","journal-title":"MMWR Surveill Summ"},{"key":"10.1016\/j.jtha.2022.11.025_bib4","doi-asserted-by":"crossref","first-page":"697","DOI":"10.7326\/0003-4819-143-10-200511150-00006","article-title":"Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population\u2013based study","volume":"143","author":"Heit","year":"2005","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jtha.2022.11.025_bib5","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1538-7836.2008.02921.x","article-title":"Pregnancy, the postpartum period and prothrombotic defects: risk of venous thrombosis in the MEGA study","volume":"6","author":"Pomp","year":"2008","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2022.11.025_bib6","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1111\/acem.12471","article-title":"Systematic review and meta-analysis of pregnant patients investigated for suspected pulmonary embolism in the emergency department","volume":"21","author":"Kline","year":"2014","journal-title":"Acad Emerg Med"},{"key":"10.1016\/j.jtha.2022.11.025_bib7","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1111\/jth.15432","article-title":"D-dimer to rule out venous thromboembolism during pregnancy: a systematic review and meta-analysis","volume":"19","author":"Bellesini","year":"2021","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2022.11.025_bib8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.7326\/M16-0031","article-title":"Wells rule and d-dimer testing to rule out pulmonary embolism: a systematic review and individual-patient data meta-analysis","volume":"165","author":"van Es","year":"2016","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jtha.2022.11.025_bib9","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.1016\/j.thromres.2009.11.009","article-title":"Safety of excluding acute pulmonary embolism based on an unlikely clinical probability by the Wells rule and normal D-dimer concentration: a meta-analysis","volume":"125","author":"Pasha","year":"2010","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2022.11.025_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2018.28","article-title":"Pulmonary embolism","volume":"4","author":"Huisman","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jtha.2022.11.025_bib11","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0140-6736(17)30885-1","article-title":"Simplified diagnostic management of suspected pulmonary embolism (the YEARS study): a prospective, multicentre, cohort study","volume":"390","author":"van der Hulle","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jtha.2022.11.025_bib12","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1056\/NEJMoa1909159","article-title":"Diagnosis of pulmonary embolism with d-dimer adjusted to clinical probability","volume":"381","author":"Kearon","year":"2019","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtha.2022.11.025_bib13","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1001\/jama.2014.2135","article-title":"Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study","volume":"311","author":"Righini","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.jtha.2022.11.025_bib14","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1161\/CIRCULATIONAHA.120.052780","article-title":"Impact of the age-adjusted D-dimer cutoff to exclude pulmonary embolism","volume":"143","author":"Robert-Ebadi","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2022.11.025_bib15","first-page":"CD011053","article-title":"Imaging for the exclusion of pulmonary embolism in pregnancy","volume":"1","author":"Van Mens","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jtha.2022.11.025_bib16","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1182\/bloodadvances.2018024802","article-title":"American Society of Hematology 2018 guidelines for management of venous thromboembolism: venous thromboembolism in the context of pregnancy","volume":"2","author":"Bates","year":"2018","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtha.2022.11.025_bib17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.thromres.2017.06.025","article-title":"Guidance for the diagnosis of pulmonary embolism during pregnancy: Consensus and controversies","volume":"157","author":"Wan","year":"2017","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2022.11.025_bib18","unstructured":"Royal College of Obstetricians & Gynaecologists. Thromboembolic disease in pregnancy and the puerperium: acute management (green-top guideline No. 37b),\u00a02015."},{"key":"10.1016\/j.jtha.2022.11.025_bib19","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/eurheartj\/ehz405","article-title":"2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS)","volume":"41","author":"Konstantinides","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jtha.2022.11.025_bib20","doi-asserted-by":"crossref","first-page":"e247","DOI":"10.1016\/S2352-3026(19)30250-9","article-title":"Comparison of international societal guidelines for the diagnosis of suspected pulmonary embolism during pregnancy","volume":"7","author":"Cohen","year":"2020","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.jtha.2022.11.025_bib21","doi-asserted-by":"crossref","first-page":"766","DOI":"10.7326\/M18-1670","article-title":"Diagnosis of pulmonary embolism during pregnancy: a multicenter prospective management outcome study","volume":"169","author":"Righini","year":"2018","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jtha.2022.11.025_bib22","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJMoa1813865","article-title":"Pregnancy-adapted YEARS algorithm for diagnosis of suspected pulmonary embolism","volume":"380","author":"Van Der Pol","year":"2019","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtha.2022.11.025_bib23","unstructured":"Special Issue: Abstracts of the ISTH 2020 Virtual Congress of the International Society on Thrombosis and Haemostasis, July 12\u201314, 2020. Volume 4, Issue S1, p. 1-70."},{"key":"10.1016\/j.jtha.2022.11.025_bib24","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1001\/jama.2015.3656","article-title":"Preferred reporting items for systematic review and meta-analyses of individual participant data: the PRISMA-IPD statement","volume":"313","author":"Khan","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.jtha.2022.11.025_bib25","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1001\/jama.2017.19163","article-title":"Preferred reporting items for a systematic review and meta-analysis of diagnostic test accuracy studies: the PRISMA-DTA statement","volume":"319","author":"McInnes","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.jtha.2022.11.025_bib26","doi-asserted-by":"crossref","first-page":"529","DOI":"10.7326\/0003-4819-155-8-201110180-00009","article-title":"QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies","volume":"155","author":"Whiting","year":"2011","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jtha.2022.11.025_bib27","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1111\/jth.13654","article-title":"Towards a tailored diagnostic standard for future diagnostic studies in pulmonary embolism: communication from the SSC of the ISTH","volume":"15","author":"Dronkers","year":"2017","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2022.11.025_bib28","doi-asserted-by":"crossref","first-page":"244","DOI":"10.7326\/M21-2625","article-title":"Safety and efficiency of diagnostic strategies for ruling out pulmonary embolism in clinically relevant patient subgroups : a systematic review and individual-patient data meta\u2013analysis","volume":"175","author":"Stals","year":"2022","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jtha.2022.11.025_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003905","article-title":"Ruling out pulmonary embolism across different healthcare settings: a systematic review and individual patient data meta-analysis","volume":"19","author":"Geersing","year":"2022","journal-title":"PLoS Med"},{"key":"10.1016\/j.jtha.2022.11.025_bib30","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1111\/jth.14483","article-title":"Could the YEARS algorithm be used to exclude pulmonary embolism during pregnancy? Data from the CT\u2013PE-pregnancy study","volume":"17","author":"Langlois","year":"2019","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2022.11.025_bib31","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1164\/rccm.201108-1575ST","article-title":"An official American Thoracic Society\/Society of Thoracic Radiology clinical practice guideline: evaluation of suspected pulmonary embolism in pregnancy","volume":"184","author":"Leung","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jtha.2022.11.025_bib32","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/jth.13980","article-title":"Risk of early-onset breast cancer among women exposed to thoracic computed tomography in pregnancy or early postpartum","volume":"16","author":"Burton","year":"2018","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2022.11.025_bib33","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3324\/haematol.2018.196121","article-title":"Computed tomography pulmonary angiography versus ventilation-perfusion lung scanning for diagnosing pulmonary embolism during pregnancy: a systematic review and meta-analysis","volume":"104","author":"Tromeur","year":"2019","journal-title":"Haematologica"},{"key":"10.1016\/j.jtha.2022.11.025_bib34","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.chest.2017.08.005","article-title":"Performance of low-dose perfusion scintigraphy and CT pulmonary angiography for pulmonary embolism in pregnancy","volume":"153","author":"Sheen","year":"2018","journal-title":"Chest"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622076395?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622076395?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:36:41Z","timestamp":1761536201000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622076395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S1538783622076395"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2022.11.025","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Noninvasive diagnostic work-up for suspected acute pulmonary embolism during pregnancy: a systematic review and meta-analysis of individual patient data","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2022.11.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}