{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T16:58:05Z","timestamp":1789232285831,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.jtha.2022.11.044","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T10:24:22Z","timestamp":1674642262000},"page":"963-974","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["NEOnatal Central-venous Line Observational study on Thrombosis (NEOCLOT): evaluation of a national guideline on management of neonatal catheter-related venous thrombosis"],"prefix":"10.1016","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9036-039X","authenticated-orcid":false,"given":"C. Heleen","family":"van Ommen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3002-7285","authenticated-orcid":false,"given":"Klasien A.","family":"Bergman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5660-7133","authenticated-orcid":false,"given":"Marit","family":"Boerma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5962-7604","authenticated-orcid":false,"given":"Heleen A.","family":"Bouma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9852-515X","authenticated-orcid":false,"given":"Albertine E.","family":"Donker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4215-1061","authenticated-orcid":false,"given":"Melissa","family":"Gouvernante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8159-7501","authenticated-orcid":false,"given":"Christian V.","family":"Hulzebos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7407-6679","authenticated-orcid":false,"given":"Dalila","family":"Khandour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2436-3343","authenticated-orcid":false,"given":"Ronny","family":"Knol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5298-7594","authenticated-orcid":false,"given":"Marlou A.","family":"Raets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9987-9104","authenticated-orcid":false,"given":"K. Djien","family":"Liem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6321-3853","authenticated-orcid":false,"given":"Richard A.","family":"van Lingen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9218-7903","authenticated-orcid":false,"given":"Moniek","family":"van de Loo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3513-5066","authenticated-orcid":false,"given":"Enrico","family":"Lopriore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7106-3445","authenticated-orcid":false,"given":"Mayke","family":"van der Putten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9322-3817","authenticated-orcid":false,"given":"Jeanine J.","family":"Sol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8116-838X","authenticated-orcid":false,"given":"Monique H.","family":"Suijker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2682-7386","authenticated-orcid":false,"given":"Daniel C.","family":"Vijlbrief","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4793-3081","authenticated-orcid":false,"given":"Remco","family":"Visser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8086-9552","authenticated-orcid":false,"given":"Mirjam M.","family":"van Weissenbruch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2022.11.044_bib1","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1182\/blood.V83.5.1251.1251","article-title":"Venous thromboembolic complications (VTE) in children: first analyses of the Canadian Registry of VTE","volume":"83","author":"Andrew","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2022.11.044_bib2","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1067\/mpd.2001.118192","article-title":"Venous thromboembolism in childhood: a prospective two-year registry in The Netherlands","volume":"139","author":"van Ommen","year":"2001","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.jtha.2022.11.044_bib3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jpeds.2017.12.015","article-title":"Risk factors for neonatal venous and arterial thromboembolism in the neonatal intensive care unit-a case control study","volume":"195","author":"Bhat","year":"2018","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.jtha.2022.11.044_bib4","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/s41372-020-0678-1","article-title":"Epidemiology of thrombosis in Canadian neonatal intensive care units","volume":"40","author":"El-Naggar","year":"2020","journal-title":"J\u00a0Perinatol"},{"key":"10.1016\/j.jtha.2022.11.044_bib5","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1542\/peds.96.5.939","article-title":"Neonatal thrombosis: report of a prospective Canadian and international registry","volume":"96","author":"Schmidt","year":"1995","journal-title":"Pediatr"},{"key":"10.1016\/j.jtha.2022.11.044_bib6","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1080\/14767058.2017.1285892","article-title":"Incidences, risk factors and outcomes of neonatal thromboembolism","volume":"31","author":"Sirachainan","year":"2018","journal-title":"J\u00a0Maternal Fetal Neonatal Med"},{"key":"10.1016\/j.jtha.2022.11.044_bib7","doi-asserted-by":"crossref","first-page":"e410","DOI":"10.1097\/MPH.0000000000001218","article-title":"Experience and prognosis of systemic neonatal thrombosis at a level III NICU","volume":"40","author":"Unal","year":"2018","journal-title":"J\u00a0Pediatr Hematol Oncol"},{"key":"10.1016\/j.jtha.2022.11.044_bib8","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.thromres.2014.05.036","article-title":"Risk factors for hospital-associated venous thromboembolism in the neonatal intensive care unit","volume":"134","author":"Amankwah","year":"2014","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2022.11.044_bib9","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3389\/fped.2017.00136","article-title":"Neonatal venous thromboembolism","volume":"5","author":"Haley","year":"2017","journal-title":"Front Pediatr"},{"key":"10.1016\/j.jtha.2022.11.044_bib10","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1016\/S0049-3848(13)70019-7","article-title":"Venous thromboembolism in neonates and children\u2014update 2013","volume":"131","author":"Nowak-G\u00f6ttl","year":"2013","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2022.11.044_bib11","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jpeds.2015.12.035","article-title":"Clinical data of neonatal systemic thrombosis","volume":"171","author":"Saracco","year":"2016","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.jtha.2022.11.044_bib12","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/MBC.0000000000001052","article-title":"How to use low-molecular-weight heparin to treat neonatal thrombosis in clinical practice","volume":"32","author":"Ting","year":"2021","journal-title":"Blood Coagul Fibrinol"},{"key":"10.1016\/j.jtha.2022.11.044_bib13","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1182\/blood-2014-04-570531","article-title":"Postthrombotic syndrome following upper extremity deep vein thrombosis in children","volume":"124","author":"Avila","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2022.11.044_bib14","doi-asserted-by":"crossref","first-page":"e737S","DOI":"10.1378\/chest.11-2308","article-title":"Antithrombotic therapy in neonates and children: antithrombotic therapy and prevention of thrombosis: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines","volume":"141","author":"Monagle","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.jtha.2022.11.044_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12887-018-1000-7","article-title":"NEOnatal central-venous line observational study on thrombosis (NEOCLOT): evaluation of a national guideline on management of neonatal catheter-related thrombosis","volume":"18","author":"Sol","year":"2018","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.jtha.2022.11.044_bib17","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1365-2141.2009.07600.x","article-title":"Guidelines for the diagnosis and management of disseminated intravascular coagulation","volume":"145","author":"Levi","year":"2009","journal-title":"B\u00a0J Haematol"},{"key":"10.1016\/j.jtha.2022.11.044_bib18","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1111\/j.1538-7836.2011.04433.x","article-title":"Perinatal and Paediatric Haemostasis Subcommittee of the SSC of the ISTH. Definition of clinical efficacy and safety outcomes for clinical trials in deep venous thrombosis and pulmonary embolism in children","volume":"9","author":"Mitchell","year":"2011","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2022.11.044_bib19","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1056\/NEJMoa1807320","article-title":"Randomized trial of platelet-transfusion thresholds in neonates","volume":"380","author":"Curley","year":"2019","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtha.2022.11.044_bib20","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1177\/1129729820983203","article-title":"Catheter-related venous thrombosis in NICU: a case-control retrospective study","volume":"23","author":"Chojnacka","year":"2022","journal-title":"J\u00a0Vascular Access"},{"key":"10.1016\/j.jtha.2022.11.044_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.29668","article-title":"Risk factors for\u00a0neonatal thrombosis: a retrospective study conducted in a single\u00a0Canadian intensive care unit","volume":"69","author":"Bhatia","year":"2022","journal-title":"Pediatric Blood Cancer"},{"key":"10.1016\/j.jtha.2022.11.044_bib22","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1148\/radiology.219.3.r01jn17645","article-title":"Does umbilical vein catheterization lead to portal venous thrombosis? Prospective US evaluation in 100 neonates","volume":"219","author":"Kim","year":"2001","journal-title":"Radiology"},{"key":"10.1016\/j.jtha.2022.11.044_bib23","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1182\/asheducation-2018.1.399","article-title":"Management of thrombosis in children and neonates: practical use of anticoagulants in children","volume":"2018","author":"Monagle","year":"2018","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.jtha.2022.11.044_bib24","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/jth.15548","article-title":"Symptomatic pulmonary embolus after catheter removal in children with catheter related thrombosis: a report from the CHAT Consortium","volume":"20","author":"Jaffray","year":"2022","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2022.11.044_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.27572","article-title":"Paes B, Thrombosis and Hemostasis in Newborns (THiN) Group. Outcomes following neonatal portal vein thrombosis: a descriptive, single-center study and review of anticoagulant therapy","volume":"66","author":"Bhatt","year":"2019","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.jtha.2022.11.044_bib26","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1542\/peds.2005-1880","article-title":"A\u00a0randomized trial comparing long-term and short-term use of umbilical venous catheters in premature infants with birth weights of less than 1251 grams","volume":"118","author":"Butler-O'Hara","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.jtha.2022.11.044_bib27","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/MBC.0b013e328364f9b0","article-title":"Neonatal central venous catheter thrombosis: diagnosis, management and outcome","volume":"25","author":"Park","year":"2014","journal-title":"Blood Coagul Fibrinol"},{"key":"10.1016\/j.jtha.2022.11.044_bib28","first-page":"1483","article-title":"Effectiveness and safety of nadroparin therapy in preterm and term neonates with venous thromboembolism","volume":"10","author":"Sol","year":"2021","journal-title":"J\u00a0Clin Med"},{"key":"10.1016\/j.jtha.2022.11.044_bib29","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1159\/000513784","article-title":"Dalteparin in newborn thrombosis, time for a new starting dose","volume":"118","author":"Steenman","year":"2021","journal-title":"Neonatology"},{"key":"10.1016\/j.jtha.2022.11.044_bib30","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/MBC.0b013e3283333c7c","article-title":"Neonatal and childhood right atrial thrombosis: recognition and a risk-stratified treatment approach","volume":"21","author":"Yang","year":"2010","journal-title":"Blood Coagul Fibrinol"},{"key":"10.1016\/j.jtha.2022.11.044_bib31","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/MBC.0000000000001052","article-title":"How to use low-molecular-weight heparin to treat neonatal thrombosis in clinical practice","volume":"32","author":"Ting","year":"2021","journal-title":"Blood Coagul Fibrinol"},{"key":"10.1016\/j.jtha.2022.11.044_bib32","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/jth.15260","article-title":"International pediatric thrombosis network to advance pediatric thrombosis research: communication from the ISTH SSC subcommittee on pediatric and neonatal thrombosis and hemostasis","volume":"19","author":"van Ommen","year":"2021","journal-title":"J\u00a0Thromb Haemost"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622128060?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622128060?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:37:16Z","timestamp":1761536236000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622128060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S1538783622128060"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2022.11.044","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NEOnatal Central-venous Line Observational study on Thrombosis (NEOCLOT): evaluation of a national guideline on management of neonatal catheter-related venous thrombosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2022.11.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}