{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T09:43:49Z","timestamp":1778319829192,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20K17734"],"award-info":[{"award-number":["JP20K17734"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.jtha.2023.03.018","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T11:56:21Z","timestamp":1680004581000},"page":"1934-1942","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["In\u00a0vitro study on the effect of fibrinogen \u03b3-chain peptide-coated ADP-encapsulated liposomes on postcardiopulmonary bypass coagulopathy using patient blood"],"prefix":"10.1016","volume":"21","author":[{"given":"Osamu","family":"Ishida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohsuke","family":"Hagisawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomu","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley M.","family":"Kearney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Tsutsumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Takeoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl 2","key":"10.1016\/j.jtha.2023.03.018_bib1","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1016\/S0140-6736(15)60823-6","article-title":"The global blood supply: a literature review","volume":"385","author":"Kralievits","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.jtha.2023.03.018_bib2","doi-asserted-by":"crossref","first-page":"e606","DOI":"10.1016\/S2352-3026(19)30200-5","article-title":"The global need and availability of blood products: a modelling study","volume":"6","author":"Roberts","year":"2019","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.jtha.2023.03.018_bib3","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1111\/trf.13780","article-title":"Predicting future blood supply and demand in Japan with a Markov model: application to the sex- and age-specific probability of blood donation","volume":"56","author":"Akita","year":"2016","journal-title":"Transfusion"},{"key":"10.1016\/j.jtha.2023.03.018_bib4","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/bjh.14338","article-title":"Alternatives to allogeneic platelet transfusion","volume":"175","author":"Desborough","year":"2016","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2023.03.018_bib5","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1038\/549S12a","article-title":"Bioengineering: doing without donors","volume":"549","author":"Dolgin","year":"2017","journal-title":"Nat"},{"key":"10.1016\/j.jtha.2023.03.018_bib6","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1097\/ALN.0000000000003550","article-title":"A\u00a0pilot trial of platelets stored cold versus at room temperature for complex cardiothoracic surgery","volume":"133","author":"Strandenes","year":"2020","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jtha.2023.03.018_bib7","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1111\/trf.15423","volume":"59","author":"Reade","year":"2019","journal-title":"Transfusion"},{"key":"10.1016\/j.jtha.2023.03.018_bib8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/09537104.2021.1961711","article-title":"Current challenges in platelet transfusion","volume":"33","author":"Smethurst","year":"2022","journal-title":"Platelets"},{"key":"10.1016\/j.jtha.2023.03.018_bib9","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/jth.15181","article-title":"Platelet production using adipose-derived mesenchymal stem cells: mechanistic studies and clinical application","volume":"19","author":"Ono-Uruga","year":"2021","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.03.018_bib10","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.cell.2018.06.011","article-title":"Turbulence activates platelet biogenesis to enable clinical scale ex\u00a0vivo production","volume":"174","author":"Ito","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jtha.2023.03.018_bib11","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1080\/09537104.2020.1769051","article-title":"In\u00a0vitro-derived platelets: the challenges we will have to face to assess quality and safety","volume":"31","author":"Mookerjee","year":"2020","journal-title":"Platelets"},{"key":"10.1016\/j.jtha.2023.03.018_bib12","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.biomaterials.2012.09.074","article-title":"Approaches to synthetic platelet analogs","volume":"34","author":"Modery-Pawlowski","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.jtha.2023.03.018_bib13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/09537104.2021.1967916","article-title":"Bioinspired artificial platelets: past, present and future","volume":"33","author":"Luc","year":"2022","journal-title":"Platelets"},{"key":"10.1016\/j.jtha.2023.03.018_bib14","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.1538-7836.2008.03269.x","article-title":"Development of fibrinogen gamma-chain peptide-coated, adenosine diphosphate-encapsulated liposomes as a synthetic platelet substitute","volume":"7","author":"Okamura","year":"2009","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.03.018_bib15","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.thromres.2011.07.031","article-title":"Ultrastructural analysis of thrombin-induced interaction between human platelets and liposomes carrying fibrinogen gamma-chain dodecapeptide as a synthetic platelet substitute","volume":"128","author":"Suzuki","year":"2011","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2023.03.018_bib16","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1002\/jps.23692","article-title":"Pharmacokinetic study of adenosine diphosphate-encapsulated liposomes coated with fibrinogen gamma-chain dodecapeptide as a synthetic platelet substitute in an anticancer drug-induced thrombocytopenia rat model","volume":"102","author":"Taguchi","year":"2013","journal-title":"J\u00a0Pharm Sci"},{"key":"10.1016\/j.jtha.2023.03.018_bib17","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1124\/dmd.112.050005","article-title":"Pharmacokinetic study of the structural components of adenosine diphosphate-encapsulated liposomes coated with fibrinogen gamma-chain dodecapeptide as a synthetic platelet substitute","volume":"41","author":"Taguchi","year":"2013","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.jtha.2023.03.018_bib18","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jconrel.2010.09.013","article-title":"Release abilities of adenosine diphosphate from phospholipid vesicles with different membrane properties and their hemostatic effects as a platelet substitute","volume":"148","author":"Okamura","year":"2010","journal-title":"J\u00a0Control Release"},{"key":"10.1016\/j.jtha.2023.03.018_bib19","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1111\/j.1538-7836.2012.04889.x","article-title":"Fibrinogen gamma-chain peptide-coated, ADP-encapsulated liposomes rescue thrombocytopenic rabbits from non-compressible liver hemorrhage","volume":"10","author":"Nishikawa","year":"2012","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.03.018_bib20","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/trf.12829","article-title":"Treatment with fibrinogen gamma-chain peptide-coated, adenosine 5'-diphosphate-encapsulated liposomes as an infusible hemostatic agent against active liver bleeding in rabbits with acute thrombocytopenia","volume":"55","author":"Hagisawa","year":"2015","journal-title":"Transfusion"},{"key":"10.1016\/j.jtha.2023.03.018_bib21","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1111\/trf.15427","article-title":"Combination therapy using fibrinogen gamma-chain peptide-coated, ADP-encapsulated liposomes and hemoglobin vesicles for trauma-induced massive hemorrhage in thrombocytopenic rabbits","volume":"59","author":"Hagisawa","year":"2019","journal-title":"Transfusion"},{"key":"10.1016\/j.jtha.2023.03.018_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/rth2.12659","article-title":"H12-(ADP)-liposomes for hemorrhagic shock in thrombocytopenia: mesenteric artery injury model in rabbits","volume":"6","author":"Hagisawa","year":"2022","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.03.018_bib23","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3109\/10408363.2010.549291","article-title":"The coagulopathy of cardiopulmonary bypass","volume":"47","author":"Besser","year":"2010","journal-title":"Crit Rev Clin Lab Sci"},{"key":"10.1016\/j.jtha.2023.03.018_bib24","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1177\/1076029616651146","article-title":"A\u00a0snapshot of coagulopathy after cardiopulmonary bypass","volume":"22","author":"Hofer","year":"2016","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1016\/j.jtha.2023.03.018_bib25","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/jth.15195","article-title":"Managing the coagulopathy associated with cardiopulmonary bypass","volume":"19","author":"Bartoszko","year":"2021","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.03.018_bib26","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jtcvs.2016.04.097","article-title":"How detrimental is reexploration for bleeding after cardiac surgery?","volume":"154","author":"Ruel","year":"2017","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtha.2023.03.018_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-68307-5","article-title":"Therapeutic potential of fibrinogen gamma-chain peptide-coated, ADP-encapsulated liposomes as a haemostatic adjuvant for post-cardiopulmonary bypass coagulopathy","volume":"10","author":"Ishida","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtha.2023.03.018_bib28","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/bjh.15524","article-title":"The use of viscoelastic haemostatic assays in the management of major bleeding: a British Society for Haematology guideline","volume":"182","author":"Curry","year":"2018","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2023.03.018_bib29","article-title":"Viscoelastic hemostatic assays: moving from the laboratory to the site of care: a review of established and emerging technologies","volume":"10","author":"Hartmann","year":"2020","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.jtha.2023.03.018_bib30","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s11010-015-2515-y","article-title":"Activation and shedding of platelet glycoprotein IIb\/IIIa under non-physiological shear stress","volume":"409","author":"Chen","year":"2015","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.jtha.2023.03.018_bib31","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3389\/fcvm.2018.00157","article-title":"Platelet function during extracorporeal membrane oxygenation in adult patients: a systematic review","volume":"5","author":"Balle","year":"2018","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jtha.2023.03.018_bib32","first-page":"10","article-title":"Quantitative and qualitative platelet derangements in cardiac surgery and extracorporeal life support","author":"Squiccimarro","year":"2021","journal-title":"J\u00a0Clin Med"},{"key":"10.1016\/j.jtha.2023.03.018_bib33","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41569-018-0110-0","article-title":"Platelet biology and functions: new concepts and clinical perspectives","volume":"16","author":"van der Meijden","year":"2019","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jtha.2023.03.018_bib34","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1053\/j.jvca.2017.06.026","article-title":"2017 EACTS\/EACTA guidelines on patient blood management for adult cardiac surgery","volume":"32","author":"Boer","year":"2018","journal-title":"J\u00a0Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.jtha.2023.03.018_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.766513","article-title":"Emerging microfluidic approaches for platelet mechanobiology and interplay with circulatory systems","volume":"8","author":"Zhang","year":"2021","journal-title":"Front Cardiovasc Med"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783623002490?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783623002490?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:37:23Z","timestamp":1761536243000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783623002490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S1538783623002490"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2023.03.018","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In\u00a0vitro study on the effect of fibrinogen \u03b3-chain peptide-coated ADP-encapsulated liposomes on postcardiopulmonary bypass coagulopathy using patient blood","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2023.03.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}