{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:33:59Z","timestamp":1792154039643,"version":"4.4.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Espa\u00f1a Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["RyC-2017-23437"],"award-info":[{"award-number":["RyC-2017-23437"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.jtha.2023.04.015","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T02:11:30Z","timestamp":1682388690000},"page":"2894-2907","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["The thrombus proteome in stroke reveals a key role of the innate immune system and new insights associated with its etiology, severity, and prognosis"],"prefix":"10.1016","volume":"21","author":[{"given":"Chary","family":"Lopez-Pedrera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Oteros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Ib\u00e1\u00f1ez-Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Luque-T\u00e9var","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mu\u00f1oz-Barrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Barbarroja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Chicano-G\u00e1lvez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Marta-Enguita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josune","family":"Orbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Velasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Perez-Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2023.04.015_bib1","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart disease and stroke statistics-2020 update: a report from the American Heart Association","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2023.04.015_bib2","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1503\/cmaj.140355","article-title":"Diagnosis and management of acute ischemic stroke: speed is critical","volume":"187","author":"Musuka","year":"2015","journal-title":"CMAJ"},{"key":"10.1016\/j.jtha.2023.04.015_bib3","doi-asserted-by":"crossref","first-page":"7609","DOI":"10.3390\/ijms21207609","article-title":"Pathophysiology and treatment of stroke: present status and future perspectives","volume":"21","author":"Kuriakose","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtha.2023.04.015_bib4","doi-asserted-by":"crossref","first-page":"e696","DOI":"10.1002\/ams2.696","article-title":"Acute ischemic stroke biomarkers: a new era with diagnostic promise?","volume":"8","author":"Bsat","year":"2021","journal-title":"Acute Med Surg"},{"key":"10.1016\/j.jtha.2023.04.015_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.918473","article-title":"A\u00a0systematic review of body fluids biomarkers associated with early neurological deterioration following acute ischemic stroke","volume":"14","author":"Ji","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.jtha.2023.04.015_bib6","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/S0140-6736(16)00163-X","article-title":"Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials","volume":"387","author":"Goyal","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jtha.2023.04.015_bib7","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s12551-021-00849-y","article-title":"Human disease biomarker panels through systems biology","volume":"13","author":"Smith","year":"2021","journal-title":"Biophys Rev"},{"key":"10.1016\/j.jtha.2023.04.015_bib8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nrg3356","article-title":"Next-generation proteomics: towards an integrative view of proteome dynamics","volume":"14","author":"Altelaar","year":"2013","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jtha.2023.04.015_bib9","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.O111.016717","article-title":"Targeted data extraction of the MS\/MS spectra generated by data-independent acquisition: a new concept for consistent and accurate proteome analysis","volume":"11","author":"Gillet","year":"2012","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.jtha.2023.04.015_bib10","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/prca.201400117","article-title":"Using data-independent, high-resolution mass spectrometry in protein biomarker research: perspectives and clinical applications","volume":"9","author":"Sajic","year":"2015","journal-title":"Proteomics Clin Appl"},{"key":"10.1016\/j.jtha.2023.04.015_bib11","doi-asserted-by":"crossref","first-page":"272","DOI":"10.12688\/f1000research.2-272.v1","article-title":"The beauty of being (label)-free: sample preparation methods for SWATH-MS and next-generation targeted proteomics","volume":"2","author":"Vowinckel","year":"2013","journal-title":"F1000Res"},{"key":"10.1016\/j.jtha.2023.04.015_bib12","doi-asserted-by":"crossref","first-page":"138","DOI":"10.4103\/0976-500X.81919","article-title":"FigShare","volume":"2","author":"Singh","year":"2011","journal-title":"J\u00a0Pharmacol Pharmacother"},{"key":"10.1016\/j.jtha.2023.04.015_bib13","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1038\/s41596-022-00710-w","article-title":"Using MetaboAnalyst 5.0 for LC-HRMS spectra processing, multi-omics integration and covariate adjustment of global metabolomics data","volume":"17","author":"Pang","year":"2022","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jtha.2023.04.015_bib14","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1161\/STROKEAHA.113.004307","article-title":"Baseline National Institutes of Health stroke scale-adjusted time window for intravenous tissue-type plasminogen activator in acute ischemic stroke","volume":"45","author":"Muchada","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.jtha.2023.04.015_bib15","article-title":"Predictive Value of the Alberta Stroke Program Early CT Score (ASPECTS) in the outcome of the acute ischemic stroke and its correlation with stroke subtypes, NIHSS, and cognitive impairment","volume":"2021","author":"Esmael","year":"2021","journal-title":"Stroke Res Treat"},{"key":"10.1016\/j.jtha.2023.04.015_bib16","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1161\/01.STR.0000258355.23810.c6","article-title":"Outcomes validity and reliability of the modified Rankin scale: implications for stroke clinical trials: a literature review and synthesis","volume":"38","author":"Banks","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.jtha.2023.04.015_bib17","first-page":"118","article-title":"Blood coagulation following an acute ischemic stroke","volume":"44","author":"Sfredel","year":"2018","journal-title":"Curr Health Sci J"},{"key":"10.1016\/j.jtha.2023.04.015_bib18","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s12551-021-00835-4","article-title":"Striated muscle proteins are regulated both by mechanical deformation and by chemical post-translational modification","volume":"13","author":"Sol\u00eds","year":"2021","journal-title":"Biophys Rev"},{"key":"10.1016\/j.jtha.2023.04.015_bib19","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev.biochem.67.1.425","article-title":"The ubiquitin system","volume":"67","author":"Hershko","year":"1998","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.jtha.2023.04.015_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.854846","article-title":"Potential biomarkers of acute ischemic stroke etiology revealed by mass spectrometry-based proteomic characterization of formalin-fixed paraffin-embedded blood clots","volume":"13","author":"Rossi","year":"2022","journal-title":"Front Neurol"},{"key":"10.1016\/j.jtha.2023.04.015_bib21","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1007\/s12272-020-01281-8","article-title":"Ubiquitin\u2013proteasome system (UPS) as a target for anticancer treatment","volume":"43","author":"Park","year":"2020","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.jtha.2023.04.015_bib22","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.2174\/1871527313666141023094720","article-title":"Inflammation in ischemic stroke: mechanisms, consequences and possible drug targets","volume":"13","author":"Ahmad","year":"2014","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1016\/j.jtha.2023.04.015_bib23","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s12975-013-0299-5","article-title":"Protein misfolding, aggregation, and autophagy after brain ischemia","volume":"4","author":"Luo","year":"2013","journal-title":"Transl Stroke Res"},{"key":"10.1016\/j.jtha.2023.04.015_bib24","article-title":"Exploration on the mechanism of ubiquitin proteasome system in cerebral stroke","volume":"14","author":"Li","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.jtha.2023.04.015_bib25","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/ana.24993","article-title":"Neutrophil extracellular traps in ischemic stroke thrombi","volume":"82","author":"Laridan","year":"2017","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jtha.2023.04.015_bib26","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.12659\/MSM.908441","article-title":"The role of von Willebrand factor, ADAMTS13, and cerebral artery thrombus composition in patient outcome following mechanical thrombectomy for acute ischemic stroke","volume":"24","author":"Prochazka","year":"2018","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.jtha.2023.04.015_bib27","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40478-022-01313-y","article-title":"Neutrophils predominate the immune signature of cerebral thrombi in COVID-19 stroke patients","volume":"10","author":"Genchi","year":"2022","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.jtha.2023.04.015_bib28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12883-020-01706-3","article-title":"A\u00a0case report of thrombolysis resistance: thrombus ultrastructure in an ischemic stroke patient","volume":"20","author":"Li","year":"2020","journal-title":"BMC Neurol"},{"key":"10.1016\/j.jtha.2023.04.015_bib29","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1172\/JCI135530","article-title":"Immune responses to stroke: mechanisms, modulation, and therapeutic potential","volume":"130","author":"Iadecola","year":"2020","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jtha.2023.04.015_bib30","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1007\/s11064-021-03423-w","article-title":"Autophagy inhibition by ATG3 knockdown remits oxygen-glucose deprivation\/reoxygenation-induced injury and inflammation in brain microvascular endothelial cells","volume":"46","author":"Peng","year":"2021","journal-title":"Neurochem Res"},{"key":"10.1016\/j.jtha.2023.04.015_bib31","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12950-019-0212-4","article-title":"Role of autophagy in atherosclerosis: foe or friend?","volume":"16","author":"Hassanpour","year":"2019","journal-title":"J\u00a0Inflamm (Lond)"},{"key":"10.1016\/j.jtha.2023.04.015_bib32","doi-asserted-by":"crossref","first-page":"6756","DOI":"10.3390\/ijms21186756","article-title":"Red blood cells and hemoglobin in human atherosclerosis and related arterial diseases","volume":"21","author":"Michel","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtha.2023.04.015_bib33","doi-asserted-by":"crossref","first-page":"74","DOI":"10.5603\/PJNNS.a2020.0094","article-title":"The role of fibrinogen in acute ischaemic stroke","volume":"55","author":"Peycheva","year":"2021","journal-title":"Neurol Neurochir Pol"},{"key":"10.1016\/j.jtha.2023.04.015_bib34","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1007\/s11010-020-04035-8","article-title":"Astragaloside IV alleviates atherosclerosis through targeting circ_0000231\/miR-135a-5p\/CLIC4 axis in AS cell model in\u00a0vitro","volume":"476","author":"Shao","year":"2021","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.jtha.2023.04.015_bib35","doi-asserted-by":"crossref","first-page":"12029","DOI":"10.1002\/jcp.27864","article-title":"microRNA-107 protects against inflammation and endoplasmic reticulum stress of vascular endothelial cells via KRT1-dependent Notch signaling pathway in a mouse model of coronary atherosclerosis","volume":"234","author":"Gao","year":"2019","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.jtha.2023.04.015_bib36","article-title":"Utility of the SERPINC1 gene test in ischemic stroke patients with antithrombin deficiency","volume":"13","author":"Kim","year":"2022","journal-title":"Front Neurol"},{"key":"10.1016\/j.jtha.2023.04.015_bib37","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1080\/1061186X.2019.1693576","article-title":"Serpina3n: potential drug and challenges, mini review","volume":"28","author":"Aslam","year":"2020","journal-title":"J\u00a0Drug Target"},{"issue":"5","key":"10.1016\/j.jtha.2023.04.015_bib38","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1161\/STROKEAHA.120.029036","article-title":"Blood vitronectin induces detrimental brain interleukin-6 and correlates with outcomes after stroke only in female mice","volume":"51","author":"Jia","year":"2020","journal-title":"Stroke"},{"key":"10.1016\/j.jtha.2023.04.015_bib39","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1161\/STROKEAHA.108.536714","article-title":"Ceruloplasmin\/transferrin system is related to clinical status in acute stroke","volume":"40","author":"Altamura","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.jtha.2023.04.015_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.104670","article-title":"Apolipoproteins B and A1 in ischemic stroke subtypes","volume":"29","author":"Kalani","year":"2020","journal-title":"J\u00a0Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.jtha.2023.04.015_bib41","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.brainresbull.2012.05.006","article-title":"Clusterin in neurological disorders: molecular perspectives and clinical relevance","volume":"88","author":"Charnay","year":"2012","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.jtha.2023.04.015_bib42","article-title":"MLIF modulates microglia polarization in ischemic stroke by targeting eEF1A1","volume":"12","author":"Liu","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jtha.2023.04.015_bib70","doi-asserted-by":"crossref","first-page":"748","DOI":"10.3390\/neurolint14040063","article-title":"Is composition of brain clot retrieved by mechanical thrombectomy associated with stroke aetiology and clinical outcomes in acute ischemic stroke?-A systematic review and meta-analysis","volume":"14","author":"Huang","year":"2022","journal-title":"Neurol Int"},{"key":"10.1016\/j.jtha.2023.04.015_bib43","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3324\/haematol.2019.219881","article-title":"Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance","volume":"105","author":"Staessens","year":"2020","journal-title":"Haematologica"},{"key":"10.1016\/j.jtha.2023.04.015_bib44","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1161\/STROKEAHA.107.505354","article-title":"Etiologic diagnosis of ischemic stroke subtypes with plasma biomarkers","volume":"39","author":"Montaner","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.jtha.2023.04.015_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.989856","article-title":"Blood-based protein biomarkers for the diagnosis of acute stroke: a discovery-based SWATH-MS proteomic approach","volume":"13","author":"Misra","year":"2022","journal-title":"Front Neurol"},{"key":"10.1016\/j.jtha.2023.04.015_bib46","first-page":"602","article-title":"The impact of genetic polymorphisms in glutamate-cysteine ligase, a key enzyme of glutathione biosynthesis, on ischemic stroke risk and brain infarct size","volume":"12","author":"Polonikov","year":"2022","journal-title":"Life (Basel)"},{"key":"10.1016\/j.jtha.2023.04.015_bib47","doi-asserted-by":"crossref","first-page":"4348","DOI":"10.1007\/s12035-021-02427-5","article-title":"The roles of peroxiredoxin 6 in brain diseases","volume":"58","author":"Liao","year":"2021","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jtha.2023.04.015_bib48","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1002\/emmm.201202258","article-title":"Role of stress-inducible protein-1 in recruitment of bone marrow derived cells into the ischemic brains","volume":"5","author":"Lee","year":"2013","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.jtha.2023.04.015_bib49","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/cvr\/cvw049","article-title":"Hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis without increased bleeding risk","volume":"110","author":"Allende","year":"2016","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jtha.2023.04.015_bib50","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neuroscience.2021.11.026","article-title":"De novo lipogenesis in astrocytes promotes the repair of blood-brain barrier after transient cerebral\u00a0ischemia through interleukin-33","volume":"481","author":"Wei","year":"2022","journal-title":"Neuroscience"},{"key":"10.1016\/j.jtha.2023.04.015_bib51","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.3390\/ijms22031232","article-title":"Targeting the WNK-SPAK\/OSR1 pathway and cation-chloride cotransporters for the therapy of stroke","volume":"22","author":"Josiah","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtha.2023.04.015_bib52","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.atherosclerosis.2009.05.003","article-title":"Association of neutrophil count with microembolization in patients with symptomatic carotid artery stenosis","volume":"207","author":"Nasr","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jtha.2023.04.015_bib53","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.1161\/STROKEAHA.119.026743","article-title":"Leukocytes, collateral circulation, and reperfusion in ischemic stroke patients treated with mechanical thrombectomy","volume":"50","author":"Semerano","year":"2019","journal-title":"Stroke"},{"key":"10.1016\/j.jtha.2023.04.015_bib54","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000489401","article-title":"ACTUAL Investigators. Neutrophil-lymphocyte ratio Predicts functional and safety outcomes after endovascular treatment for acute ischemic stroke","volume":"45","author":"Duan","year":"2018","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.jtha.2023.04.015_bib55","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.3389\/fneur.2019.01032","article-title":"Clinical significance of baseline neutrophil-to-lymphocyte ratio in patients with ischemic stroke or hemorrhagic stroke: an updated meta-analysis","volume":"10","author":"Song","year":"2019","journal-title":"Front Neurol"},{"key":"10.1016\/j.jtha.2023.04.015_bib56","article-title":"Prognostic power of a chaperonin containing TCP-1 subunit genes panel for hepatocellular carcinoma","volume":"12","author":"Li","year":"2021","journal-title":"Front Genet"},{"key":"10.1016\/j.jtha.2023.04.015_bib57","doi-asserted-by":"crossref","first-page":"32833","DOI":"10.18632\/oncotarget.15834","article-title":"KPNB1-mediated nuclear import is required for motility and inflammatory transcription factor activity in cervical cancer cells","volume":"8","author":"Stelma","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jtha.2023.04.015_bib58","doi-asserted-by":"crossref","first-page":"40156","DOI":"10.1074\/jbc.M104138200","article-title":"The role of CD47 in neutrophil transmigration. Increased rate of migration correlates with increased cell surface expression of CD47","volume":"276","author":"Liu","year":"2001","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jtha.2023.04.015_bib59","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1182\/blood-2012-06-437772","article-title":"Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation","volume":"120","author":"Darbousset","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.04.015_bib60","article-title":"Soluble CD40 ligand stimulates CD40-dependent activation of the \u03b22 integrin Mac-1 and protein kinase C zeda (PKC\u03b6) in neutrophils: implications for neutrophil-platelet interactions and neutrophil oxidative burst","volume":"8","author":"Jin","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jtha.2023.04.015_bib61","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1161\/ATVBAHA.111.242859","article-title":"Neutrophil extracellular trap (NET) impact on deep vein thrombosis","volume":"32","author":"Fuchs","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jtha.2023.04.015_bib62","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1084\/jem.20112322","article-title":"Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in\u00a0vivo","volume":"209","author":"von Br\u00fchl","year":"2012","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jtha.2023.04.015_bib63","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature10146","article-title":"Progress and challenges in translating the biology of atherosclerosis","volume":"473","author":"Libby","year":"2011","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jtha.2023.04.015_bib64","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12883-022-02707-0","article-title":"Stroke-derived neutrophils demonstrate higher formation potential and impaired resolution of CD66b\u00a0+ driven neutrophil extracellular traps","volume":"22","author":"Datsi","year":"2022","journal-title":"BMC Neurol"},{"key":"10.1016\/j.jtha.2023.04.015_bib65","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1160\/TH17-02-0130","article-title":"Neutrophil extracellular traps are increased in patients with acute ischemic stroke: prognostic significance","volume":"117","author":"Vall\u00e9s","year":"2017","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.04.015_bib66","doi-asserted-by":"crossref","first-page":"e2346","DOI":"10.1212\/WNL.0000000000009532","article-title":"Thrombus NET content is associated with clinical outcome in stroke and myocardial infarction","volume":"94","author":"Novotny","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.jtha.2023.04.015_bib67","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/01.STR.24.1.35","article-title":"Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment","volume":"24","author":"Adams","year":"1993","journal-title":"Stroke"},{"key":"10.1016\/j.jtha.2023.04.015_bib68","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1136\/neurintsurg-2012-010313","article-title":"UCLA Stroke Investigators. The hyperdense vessel sign on CT predicts successful recanalization with the Merci device in acute ischemic stroke","volume":"5","author":"Froehler","year":"2013","journal-title":"J\u00a0Neurointerv Surg"},{"key":"10.1016\/j.jtha.2023.04.015_bib69","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.3174\/ajnr.A2485","article-title":"Mechanical characterization of thromboemboli in acute ischemic stroke and laboratory embolus analogs","volume":"32","author":"Chueh","year":"2011","journal-title":"AJNR Am J Neuroradiol"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783623003379?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783623003379?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T02:58:28Z","timestamp":1742266708000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783623003379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":70,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S1538783623003379"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2023.04.015","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The thrombus proteome in stroke reveals a key role of the innate immune system and new insights associated with its etiology, severity, and prognosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2023.04.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}