{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:09:14Z","timestamp":1791403754746,"version":"4.3.3"},"reference-count":66,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100008721","name":"University College London Hospitals NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008721","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.jtha.2023.06.020","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T16:52:23Z","timestamp":1687971143000},"page":"2963-2976","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Survey on antiphospholipid syndrome diagnosis and antithrombotic treatment in patients with ischemic stroke, other brain ischemic injury, or arterial thromboembolism in other sites: communication from ISTH SSC Subcommittee on Lupus Anticoagulant\/Antiphospholipid Antibodies"],"prefix":"10.1016","volume":"21","author":[{"given":"Hannah","family":"Cohen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Werring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"Chandratheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabal","family":"Mittal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrien M.J.","family":"Devreese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Isenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahir","family":"Amoura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danieli","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hela","family":"Baccouche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Baldwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Baysal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Michael","family":"Belmont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Laura","family":"Bertolaccini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henny","family":"Billett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricard","family":"Cervera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"Chandratheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Sofia","family":"Cotelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Crowther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrien","family":"Devreese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Dounaevskaia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Doyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro Francisco","family":"Barros Duran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunelle","family":"Engelbrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Efthymiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doruk","family":"Erkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Gatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Gebhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsty","family":"Harkness","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri","family":"Hemelsoet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Hoirisch-Clapauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Inanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Isenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximiliano Villagra","family":"Iturre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dheeraj","family":"Kalladka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter W.","family":"Kamphuisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charalampos","family":"Kartsios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munther","family":"Khamashta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Kouides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Limper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Luchtman-Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhona","family":"Maclean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabal","family":"Mittal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Moll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soledad","family":"Molnar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve Claire","family":"Moyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e1ndido","family":"Mu\u00f1oz Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Nwagha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda A.","family":"Orsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Pardos-Gea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Pengo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athiveeraramapandian","family":"Prabu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anisur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara N.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Ruiz-Irastorza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zara","family":"Sayar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Schulman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savino","family":"Sciascia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Siguret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee-Suan","family":"The","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Tohodi-Esfahani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imad","family":"Uthman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"Vanhooren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Werring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Willis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengde","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee-Seng","family":"Yee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2023.06.020_bib1","series-title":"The top 10 causes of death","year":"2020"},{"key":"10.1016\/j.jtha.2023.06.020_bib2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jstrokecerebrovasdis.2004.06.003","article-title":"Is stroke the most common cause of disability?","volume":"13","author":"Adamson","year":"2004","journal-title":"J\u00a0Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.jtha.2023.06.020_bib3","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1002\/acr.22066","article-title":"Estimated frequency of antiphospholipid antibodies in patients with pregnancy morbidity, stroke, myocardial infarction, and deep vein thrombosis: a critical review of the literature","volume":"65","author":"Andreoli","year":"2013","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.jtha.2023.06.020_bib4","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1136\/annrheumdis-2014-205663","article-title":"The estimated frequency of antiphospholipid antibodies in young adults with cerebrovascular events: a systematic review","volume":"74","author":"Sciascia","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jtha.2023.06.020_bib5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/rheumatology\/keab452","article-title":"Cognitive dysfunction and associated neuroimaging biomarkers in antiphospholipid syndrome: a systematic review","volume":"61","author":"Donnellan","year":"2021","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.jtha.2023.06.020_bib6","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1002\/art.10187","article-title":"Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients","volume":"46","author":"Cervera","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jtha.2023.06.020_bib7","doi-asserted-by":"crossref","first-page":"c3666","DOI":"10.1136\/bmj.c3666","article-title":"The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis","volume":"341","author":"Debette","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.jtha.2023.06.020_bib8","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/MCA.0000000000000476","article-title":"Acute myocardial infarction and antiphospholipid antibody syndrome: a systematic review","volume":"28","author":"Nazir","year":"2017","journal-title":"Coron Artery Dis"},{"key":"10.1016\/j.jtha.2023.06.020_bib9","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.3389\/fimmu.2018.01181","article-title":"Antiphospholipid syndrome nephropathy: from pathogenesis to treatment","volume":"9","author":"Tektonidou","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jtha.2023.06.020_bib10","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1024\/0301-1526\/a000545","article-title":"Antiphospholipid antibodies and lower extremity peripheral arterial disease\u2014a systematic review and meta-analysis","volume":"45","author":"Gavier","year":"2016","journal-title":"Vasa"},{"key":"10.1016\/j.jtha.2023.06.020_bib11","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1006\/jaut.2000.0409","article-title":"Epidemiology of the antiphospholipid antibody syndrome","volume":"15","author":"Petri","year":"2000","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jtha.2023.06.020_bib12","author":"Del Carmelo Gracio Tello"},{"key":"10.1016\/j.jtha.2023.06.020_bib13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1001\/archinte.164.1.77","article-title":"High impact of antiphospholipid syndrome on irreversible organ damage and survival of patients with systemic lupus erythematosus","volume":"164","author":"Ruiz-Irastorza","year":"2004","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jtha.2023.06.020_bib14","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2019-000924","article-title":"Management of thrombotic and obstetric antiphospholipid syndrome: a systematic literature review informing the EULAR recommendations for the management of antiphospholipid syndrome in adults","volume":"5","author":"Tektonidou","year":"2019","journal-title":"RMD Open"},{"key":"10.1016\/j.jtha.2023.06.020_bib15","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1111\/j.1538-7836.2009.03555.x","volume":"7","author":"Pengo","year":"2009","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.020_bib16","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1111\/jth.15047","article-title":"Guidance from the Scientific and Standardization Committee for lupus anticoagulant\/antiphospholipid antibodies of the International Society on Thrombosis and Haemostasis: update of the guidelines for lupus anticoagulant detection and interpretation","volume":"18","author":"Devreese","year":"2020","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.020_bib18","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.semarthrit.2019.04.009","article-title":"The adjusted global antiphospholipid syndrome score (aGAPSS) and the risk of recurrent thrombosis: results from the APS ACTION cohort","volume":"49","author":"Radin","year":"2019","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.jtha.2023.06.020_bib19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.15420\/usc.2017:18:1","article-title":"Update on the management of patent foramen ovale in 2017: indication for closure and literature review","volume":"11","author":"Atianzar","year":"2017","journal-title":"US Cardiology Review"},{"key":"10.1016\/j.jtha.2023.06.020_bib20","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1002\/art.40901","article-title":"The epidemiology of antiphospholipid syndrome: a population-based study","volume":"71","author":"Duarte-Garc\u00eda","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jtha.2023.06.020_bib21","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1093\/rheumatology\/key437","article-title":"Clinical and immunological features of antiphospholipid syndrome in the elderly: a retrospective national multicentre study","volume":"58","author":"Grimaud","year":"2019","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.jtha.2023.06.020_bib22","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/jth.13976","article-title":"Subcommittee on Lupus Anticoagulant\/Antiphospholipid Antibodies. Laboratory criteria for antiphospholipid syndrome: communication from the SSC of the ISTH","volume":"16","author":"Devreese","year":"2018","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.020_bib23","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1538-7836.2006.01753.x","article-title":"International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)","volume":"4","author":"Miyakis","year":"2006","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.020_bib24","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/jth.14633","article-title":"The (non-)sense of detecting anti-cardiolipin and anti-\u03b22glycoprotein I IgM antibodies in the antiphospholipid syndrome","volume":"18","author":"Chayoua","year":"2020","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.020_bib25","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1161\/STROKEAHA.118.023021","article-title":"Antiphospholipid syndrome with isolated isotype M anticardiolipin and\/or anti-B2GPI antibody is associated with stroke","volume":"49","author":"Urbanski","year":"2018","journal-title":"Stroke"},{"key":"10.1016\/j.jtha.2023.06.020_bib26","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1055\/s-0038-1649940","article-title":"Induction of thrombosis in a mouse model by IgG, IgM and IgA immunoglobulins from patients with the antiphospholipid syndrome","volume":"74","author":"Pierangeli","year":"1995","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.020_bib27","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1161\/01.CIR.97.9.900","article-title":"Differential effects of anti-beta2-glycoprotein I antibodies on endothelial cells and on the manifestations of experimental antiphospholipid syndrome","volume":"97","author":"George","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2023.06.020_bib28","first-page":"31","article-title":"Prothrombotic effect of anti-beta-2 glycoprotein-1 antibodies on the expression of tissue factor, thrombomodulin, and plasminogen activator inhibitor-1 in endothelial cells","volume":"47","author":"Rikarni","year":"2015","journal-title":"Acta Med Indones"},{"key":"10.1016\/j.jtha.2023.06.020_bib29","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1093\/rheumatology\/keaa857","article-title":"Antiphospholipid patterns predict risk of thrombosis in systemic lupus erythematosus","volume":"60","author":"Demir","year":"2021","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.jtha.2023.06.020_bib30","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1111\/jth.14846","article-title":"Lupus anticoagulant detection in anticoagulated patients. Guidance from the Scientific and Standardization Committee for lupus anticoagulant\/antiphospholipid antibodies of the International Society on Thrombosis and Haemostasis","volume":"18","author":"Tripodi","year":"2020","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.020_bib31","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1111\/jth.15438","volume":"19","author":"Moore","year":"2021","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.020_bib32","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1111\/jth.12917","article-title":"Interactions between rivaroxaban and antiphospholipid antibodies in thrombotic antiphospholipid syndrome","volume":"13","author":"Arachchillage","year":"2015","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.020_bib33","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1160\/TH16-02-0081","article-title":"Lupus-anticoagulant testing at NOAC trough levels","volume":"116","author":"Ratzinger","year":"2016","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.020_bib34","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1136\/svn-2018-000169","article-title":"Utility of current thrombophilia screening in young patients with stroke and TIA","volume":"3","author":"Alakbarzade","year":"2018","journal-title":"Stroke Vasc Neurol"},{"key":"10.1016\/j.jtha.2023.06.020_bib35","first-page":"926","article-title":"Can inherited thrombophilia modulate the clinical phenotype of patients with antiphospholipid syndrome?","volume":"31","author":"Berman","year":"2013","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jtha.2023.06.020_bib36","doi-asserted-by":"crossref","first-page":"7","DOI":"10.31138\/mjr.30.1.7","article-title":"Cerebrovascular events in systemic lupus erythematosus: diagnosis and management","volume":"30","author":"Nikolopoulos","year":"2019","journal-title":"Mediterr J Rheumatol"},{"key":"10.1016\/j.jtha.2023.06.020_bib37","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1161\/STROKEAHA.108.529503","article-title":"Heart Outcomes Prevention Evaluation 2 Investigators. Homocysteine-lowering therapy and stroke risk, severity, and disability: additional findings from the HOPE 2 trial","volume":"40","author":"Saposnik","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.jtha.2023.06.020_bib38","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1538-7836.2009.03674.x","article-title":"Clinical course of high-risk patients diagnosed with antiphospholipid syndrome","volume":"8","author":"Pengo","year":"2010","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.020_bib39","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1111\/jth.15518","article-title":"Single or triple positivity for antiphospholipid antibodies in \u201ccarriers\u201d or symptomatic patients: untangling the knot","volume":"19","author":"Bertin","year":"2021","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.020_bib40","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.thromres.2007.05.006","article-title":"Detection of shortened activated partial thromboplastin times: an evaluation of different commercial reagents","volume":"121","author":"Ten Boekel","year":"2007","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2023.06.020_bib41","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.thromres.2009.09.001","article-title":"Lupus anticoagulant (LAC) testing in patients with inflammatory status: does C-reactive protein interfere with LAC test results?","volume":"125","author":"Schouwers","year":"2010","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2023.06.020_bib42","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1136\/annrheumdis-2019-215213","article-title":"EULAR recommendations for the management of antiphospholipid syndrome in adults","volume":"78","author":"Tektonidou","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jtha.2023.06.020_bib43","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1136\/annrheumdis-2013-204838","article-title":"Morbidity and mortality in the antiphospholipid syndrome during a 10-year period: a multicentre prospective study of 1000 patients","volume":"74","author":"Cervera","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jtha.2023.06.020_bib44","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/j.1538-7836.2005.01340.x","article-title":"A\u00a0randomized clinical trial of high-intensity warfarin vs. conventional antithrombotic therapy for the prevention of recurrent thrombosis in patients with the antiphospholipid syndrome (WAPS)","volume":"3","author":"Finazzi","year":"2005","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.020_bib45","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1056\/NEJMoa035241","article-title":"A\u00a0comparison of two intensities of warfarin for the prevention of recurrent thrombosis in patients with the antiphospholipid antibody syndrome","volume":"349","author":"Crowther","year":"2003","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtha.2023.06.020_bib46","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1111\/jth.14936","article-title":"Recurrent thrombosis in patients with antiphospholipid antibodies and an initial venous or arterial thromboembolic event: a systematic review and meta-analysis","volume":"18","author":"Ortel","year":"2020","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.020_bib47","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1055\/s-0041-1725057","article-title":"Arterial thrombosis in patients with antiphospholipid syndrome: a review and meta-analysis","volume":"47","author":"Aibar","year":"2021","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.jtha.2023.06.020_bib48","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1182\/blood-2018-04-848333","article-title":"Rivaroxaban vs warfarin in high-risk patients with antiphospholipid syndrome","volume":"132","author":"Pengo","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.06.020_bib49","doi-asserted-by":"crossref","first-page":"685","DOI":"10.7326\/M19-0291","article-title":"Rivaroxaban versus vitamin K Antagonist in antiphospholipid syndrome: a randomized noninferiority trial","volume":"171","author":"Ordi-Ros","year":"2019","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jtha.2023.06.020_bib50","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1182\/bloodadvances.2021005808","article-title":"Apixaban compared with warfarin to prevent thrombosis in thrombotic antiphospholipid syndrome: a randomized trial","volume":"6","author":"Woller","year":"2022","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtha.2023.06.020_bib51","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1111\/jth.14935","article-title":"Use of direct oral anticoagulants in patients with thrombotic antiphospholipid syndrome: guidance from the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis","volume":"18","author":"Zuily","year":"2020","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.020_bib52","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1177\/0961203320950461","article-title":"16th International Congress on Antiphospholipid Antibodies Task Force Report on antiphospholipid syndrome treatment trends","volume":"29","author":"Cohen","year":"2020","journal-title":"Lupus"},{"key":"10.1016\/j.jtha.2023.06.020_bib53","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1182\/blood-2017-09-805689","article-title":"Antiphospholipid antibodies and recurrent thrombosis after a first unprovoked venous thromboembolism","volume":"131","author":"Kearon","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.06.020_bib54","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/jth.14720","article-title":"Prevalence of confirmed antiphospholipid syndrome in 18-50 years unselected patients with first unprovoked venous thromboembolism","volume":"18","author":"Miranda","year":"2020","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.020_bib55","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1182\/blood-2014-04-571232","article-title":"Direct oral anticoagulants compared with vitamin K antagonists for acute venous thromboembolism: evidence from phase 3 trials","volume":"124","author":"van Es","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.06.020_bib56","doi-asserted-by":"crossref","first-page":"e426","DOI":"10.1016\/S2352-3026(16)30079-5","article-title":"RAPS trial investigators. Rivaroxaban versus warfarin to treat patients with thrombotic antiphospholipid syndrome, with or without systemic lupus erythematosus (RAPS): a randomised, controlled, open-label, phase 2\/3, non-inferiority trial","volume":"3","author":"Cohen","year":"2016","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.jtha.2023.06.020_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2020.102711","article-title":"Direct oral anticoagulants in antiphospholipid syndrome: meta-analysis of randomized controlled trials","volume":"20","author":"Dufrost","year":"2021","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jtha.2023.06.020_bib58","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1538-7836.2005.01166.x","article-title":"In\u00a0vitro and in\u00a0vivo studies of the novel antithrombotic agent BAY 59-7939\u2014an oral, direct Factor Xa inhibitor","volume":"3","author":"Perzborn","year":"2005","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.020_bib59","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1016\/j.jcin.2020.09.059","article-title":"Patent foramen ovale attributable cryptogenic embolism with thrombophilia has higher risk for recurrence and responds to closure","volume":"13","author":"Liu","year":"2020","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jtha.2023.06.020_bib60","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1159\/000512184","article-title":"Patent foramen ovale closure among patients with hypercoagulable states maintained on antithrombotic therapy","volume":"146","author":"Buber","year":"2021","journal-title":"Cardiology"},{"key":"10.1016\/j.jtha.2023.06.020_bib61","article-title":"SCAI guidelines for the management of patent foramen ovale","volume":"1","author":"Kavinsky","year":"2022","journal-title":"J\u00a0Soc Cardiovasc Angiogr Interv"},{"key":"10.1016\/j.jtha.2023.06.020_bib62","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1136\/bmj.37991.635266.44","article-title":"Population based study of early risk of stroke after transient ischaemic attack or minor stroke: implications for public education and organisation of services","volume":"328","author":"Coull","year":"2004","journal-title":"BMJ"},{"key":"10.1016\/j.jtha.2023.06.020_bib63","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1161\/STR.0000000000000024","volume":"45","author":"Kernan","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.jtha.2023.06.020_bib64","author":"Efthymiou"},{"key":"10.1016\/j.jtha.2023.06.020_bib65","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1538-7836.2005.01185.x","article-title":"Primary antiphospholipid syndrome in pregnancy: an analysis of outcome in a cohort of 33 women treated with a rigorous protocol","volume":"3","author":"Stone","year":"2005","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.020_bib66","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1177\/0961203312451335","article-title":"Pregnancy outcome in patients with antiphospholipid syndrome after cerebral ischaemic events: an observational study","volume":"21","author":"Fischer-Betz","year":"2012","journal-title":"Lupus"},{"key":"10.1016\/j.jtha.2023.06.020_bib68","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1161\/01.STR.28.7.1507","article-title":"American Heart Association Prevention Conference. IV. Prevention and rehabilitation of stroke. Risk factors","volume":"28","author":"Sacco","year":"1997","journal-title":"Stroke"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783623005056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783623005056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T07:40:25Z","timestamp":1742283625000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783623005056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":66,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S1538783623005056"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2023.06.020","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Survey on antiphospholipid syndrome diagnosis and antithrombotic treatment in patients with ischemic stroke, other brain ischemic injury, or arterial thromboembolism in other sites: communication from ISTH SSC Subcommittee on Lupus Anticoagulant\/Antiphospholipid Antibodies","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2023.06.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}