{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:58:05Z","timestamp":1790909885582,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007793","name":"Stiftelsen Kristian Gerhard Jebsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.jtha.2023.06.022","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T06:00:22Z","timestamp":1688018422000},"page":"2844-2853","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Combined effect of high factor VIII levels and high mean platelet volume on the risk of future incident venous thromboembolism"],"prefix":"10.1016","volume":"21","author":[{"given":"Ellen-Sofie","family":"Hansen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus S.","family":"Edvardsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e5l","family":"Aukrust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor","family":"Ueland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John-Bjarne","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid K.","family":"Br\u00e6kkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e2nia M.","family":"Morelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2023.06.022_bib1","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1538-7836.2007.02450.x","article-title":"Incidence and mortality of venous thrombosis: a population-based study","volume":"5","author":"Naess","year":"2007","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.022_bib2","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/j.1538-7836.2006.01795.x","article-title":"Post-thrombotic syndrome, recurrence, and death 10 years after the first episode of venous thromboembolism treated with warfarin for 6 weeks or 6 months","volume":"4","author":"Schulman","year":"2006","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.022_bib3","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.blre.2014.07.003","article-title":"The post-PE syndrome: a new concept for chronic complications of pulmonary embolism","volume":"28","author":"Klok","year":"2014","journal-title":"Blood Rev"},{"key":"10.1016\/j.jtha.2023.06.022_bib4","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.amjmed.2004.01.018","article-title":"Deep vein thrombosis and pulmonary embolism in two cohorts: the longitudinal investigation of thromboembolism etiology","volume":"117","author":"Cushman","year":"2004","journal-title":"Am J Med"},{"key":"10.1016\/j.jtha.2023.06.022_bib5","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1182\/blood-2006-06-028241","article-title":"von Willebrand factor and factor VIII are independently required to form stable occlusive thrombi in injured veins","volume":"109","author":"Chauhan","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.06.022_bib6","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1182\/blood-2011-06-362814","article-title":"Procoagulant activity induced by vascular injury determines contribution of elevated factor VIII to thrombosis and thrombus stability in mice","volume":"118","author":"Machlus","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.06.022_bib7","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1160\/TH13-01-0069","article-title":"Elevated plasma factor VIII enhances venous thrombus formation in rabbits: contribution of factor XI, von Willebrand factor and tissue factor","volume":"110","author":"Sugita","year":"2013","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.022_bib8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1182\/blood-2008-01-077909","article-title":"Advances in understanding pathogenic mechanisms of thrombophilic disorders","volume":"112","author":"Dahlb\u00e4ck","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.06.022_bib9","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0140-6736(95)90166-3","article-title":"Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis","volume":"345","author":"Koster","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.jtha.2023.06.022_bib10","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/j.1365-2141.2012.09134.x","article-title":"Elevated factor VIII levels and risk of venous thrombosis","volume":"157","author":"Jenkins","year":"2012","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2023.06.022_bib11","first-page":"169","article-title":"High factor VIII, von Willebrand factor, and fibrinogen levels and risk of venous thromboembolism in blacks and whites","volume":"24","author":"Payne","year":"2014","journal-title":"Ethn Dis"},{"key":"10.1016\/j.jtha.2023.06.022_bib12","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s12288-019-01092-y","article-title":"Elevated von Willebrand factor antigen levels are an independent risk factor for venous thromboembolism: first report from north India","volume":"35","author":"Rajpal","year":"2019","journal-title":"Indian J Hematol Blood Transfus"},{"key":"10.1016\/j.jtha.2023.06.022_bib13","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/jth.14343","article-title":"High levels of coagulation factors and venous thrombosis risk: strongest association for factor VIII and von Willebrand factor","volume":"17","author":"Rietveld","year":"2019","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.022_bib14","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/jth.15127","article-title":"Procoagulant factor levels and risk of venous thrombosis in the elderly","volume":"19","author":"Wang","year":"2021","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.022_bib15","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/S0002-9343(02)01345-1","article-title":"Coagulation factors, inflammation markers, and venous thromboembolism: the longitudinal investigation of thromboembolism etiology (LITE)","volume":"113","author":"Tsai","year":"2002","journal-title":"Am J Med"},{"key":"10.1016\/j.jtha.2023.06.022_bib16","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1111\/jth.14235","article-title":"Mechanisms and mitigating factors for venous thromboembolism in chronic kidney disease: the REGARDS study","volume":"16","author":"Cheung","year":"2018","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.022_bib17","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1111\/jth.15315","article-title":"Hemostatic factors, inflammatory markers, and risk of incident venous thromboembolism: the Multi-Ethnic Study of Atherosclerosis","volume":"19","author":"Evensen","year":"2021","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.022_bib18","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1538-7836.2009.03498.x","article-title":"Mean platelet volume is a risk factor for venous thromboembolism: the Troms\u00f8 Study, Troms\u00f8, Norway","volume":"8","author":"Braekkan","year":"2010","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.022_bib19","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0049-3848(83)90255-4","article-title":"The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration","volume":"32","author":"Martin","year":"1983","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2023.06.022_bib20","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1055\/s-0039-1677875","article-title":"Role of platelet size revisited-function and protein composition of large and small platelets","volume":"119","author":"Handtke","year":"2019","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.022_bib21","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1111\/jth.14788","article-title":"Large and small platelets-(When) do they differ?","volume":"18","author":"Handtke","year":"2020","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.022_bib22","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1093\/ije\/dyr049","article-title":"Cohort profile: the Tromso Study","volume":"41","author":"Jacobsen","year":"2012","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jtha.2023.06.022_bib23","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1093\/aje\/kwq066","article-title":"Body height and risk of venous thromboembolism: the Tromso study","volume":"171","author":"Braekkan","year":"2010","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jtha.2023.06.022_bib24","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1111\/jth.14438","article-title":"Complement activation assessed by the plasma terminal complement complex and future risk of venous thromboembolism","volume":"17","author":"H\u00f8iland","year":"2019","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.022_bib25","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1111\/jth.14539","article-title":"Plasma levels of mannose-binding lectin and future risk of venous thromboembolism","volume":"17","author":"Liang","year":"2019","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.022_bib26","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1182\/bloodadvances.2020003135","article-title":"Plasma levels of von Willebrand factor and future risk of incident venous thromboembolism","volume":"5","author":"Edvardsen","year":"2021","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtha.2023.06.022_bib27","doi-asserted-by":"crossref","first-page":"i969","DOI":"10.1136\/bmj.i969","article-title":"Analysis of matched case-control studies","volume":"352","author":"Pearce","year":"2016","journal-title":"BMJ"},{"key":"10.1016\/j.jtha.2023.06.022_bib28","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1055\/s-0037-1613379","article-title":"Obesity: risk of venous thrombosis and the interaction with coagulation factor levels and oral contraceptive use","volume":"89","author":"Abdollahi","year":"2003","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.022_bib29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.1365-2141.2001.03061.x","article-title":"Interleukin 6 and haemostasis","volume":"115","author":"Kerr","year":"2001","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2023.06.022_bib30","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1161\/ATVBAHA.109.188920","article-title":"Anthropometric measures of obesity and risk of venous thromboembolism: the Tromso study","volume":"30","author":"Borch","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jtha.2023.06.022_bib31","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1111\/jth.13369","article-title":"C-reactive protein, obesity, and the risk of arterial and venous thrombosis","volume":"14","author":"Horvei","year":"2016","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.022_bib32","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1182\/blood.V92.11.3983","article-title":"The life cycle of coagulation factor VIII in view of its structure and function","volume":"92","author":"Lenting","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.06.022_bib33","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/EDE.0b013e318254f5de","article-title":"Quantification of bias in direct effects estimates due to different types of measurement error in the mediator","volume":"23","author":"le Cessie","year":"2012","journal-title":"Epidemiology"},{"key":"10.1016\/j.jtha.2023.06.022_bib34","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1097\/01.coc.0000436088.69084.22","article-title":"Clinical and prognostic significance of coagulation assays in pancreatic cancer patients with absence of venous thromboembolism","volume":"38","author":"Sun","year":"2015","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.jtha.2023.06.022_bib35","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1161\/01.STR.21.1.47","article-title":"Coagulation factors and the increased risk of stroke in nonvalvular atrial fibrillation","volume":"21","author":"Gustafsson","year":"1990","journal-title":"Stroke"},{"key":"10.1016\/j.jtha.2023.06.022_bib36","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1182\/blood-2013-04-460121","article-title":"Epidemiology of cancer-associated venous thrombosis","volume":"122","author":"Timp","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.06.022_bib37","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1111\/jth.13329","article-title":"Impact of incident myocardial infarction on the risk of venous thromboembolism: the Tromso Study","volume":"14","author":"Rinde","year":"2016","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.022_bib38","article-title":"Ischemic stroke and risk of venous thromboembolism in the general population: the Tromso study","volume":"5","author":"Rinde","year":"2016","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jtha.2023.06.022_bib39","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/oxfordjournals.aje.a010013","article-title":"Underestimation of risk associations due to regression dilution in long-term follow-up of prospective studies","volume":"150","author":"Clarke","year":"1999","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jtha.2023.06.022_bib40","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s10654-005-7835-x","article-title":"Calculating measures of biological interaction","volume":"20","author":"Andersson","year":"2005","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.jtha.2023.06.022_bib41","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s10654-011-9554-9","article-title":"Estimating measures of interaction on an additive scale for preventive exposures","volume":"26","author":"Knol","year":"2011","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.jtha.2023.06.022_bib42","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jns.2014.02.001","article-title":"Plasma factor VIII in non-puerperal cerebral venous thrombosis: a prospective case-control study","volume":"339","author":"Anadure","year":"2014","journal-title":"J\u00a0Neurol Sci"},{"key":"10.1016\/j.jtha.2023.06.022_bib43","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1055\/s-0037-1613999","article-title":"The factor VIII acute phase response requires the participation of NFkappaB and C\/EBP","volume":"84","author":"Begbie","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.022_bib44","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1161\/CIRCULATIONAHA.118.034532","article-title":"Genome-wide association transethnic meta-analyses identifies novel associations regulating coagulation factor VIII and von Willebrand factor plasma levels","volume":"139","author":"Sabater-Lleal","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2023.06.022_bib45","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1182\/blood-2012-02-407551","article-title":"Broadening the factor V Leiden paradox: pulmonary embolism and deep-vein thrombosis as 2 sides of the spectrum","volume":"120","author":"van Langevelde","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.06.022_bib46","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1182\/bloodadvances.2019031112","article-title":"Thrombus stability explains the factor V Leiden paradox: a mouse model","volume":"3","author":"Shaya","year":"2019","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtha.2023.06.022_bib47","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1111\/j.1538-7836.2005.01430.x","article-title":"Determinants of the APTT- and ETP-based APC sensitivity tests","volume":"3","author":"de Visser","year":"2005","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.022_bib48","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3389\/fcvm.2020.00015","article-title":"Procoagulant phosphatidylserine-exposing platelets in\u00a0vitro and in\u00a0vivo","volume":"7","author":"Reddy","year":"2020","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jtha.2023.06.022_bib49","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1182\/blood.2021011494","article-title":"Combined effects of plasma von Willebrand factor and platelet measures on the risk of incident venous thromboembolism","volume":"138","author":"Edvardsen","year":"2021","journal-title":"Blood"},{"issue":"Suppl 1","key":"10.1016\/j.jtha.2023.06.022_bib50","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1538-7836.2011.04359.x","article-title":"The genetics of common variation affecting platelet development, function and pharmaceutical targeting","volume":"9","author":"Johnson","year":"2011","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.06.022_bib51","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/09537104.2017.1317732","article-title":"The genetics of platelet count and volume in humans","volume":"29","author":"Eicher","year":"2018","journal-title":"Platelets"},{"key":"10.1016\/j.jtha.2023.06.022_bib52","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/gepi.1370020204","article-title":"Genetic and environmental influences on the size and number of cells in the blood","volume":"2","author":"Whitfield","year":"1985","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.jtha.2023.06.022_bib53","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/ajcp\/90.3.262","article-title":"Stability of hematologic parameters in healthy subjects. Intraindividual versus interindividual variation","volume":"90","author":"Ross","year":"1988","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.jtha.2023.06.022_bib54","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1161\/01.ATV.21.5.731","article-title":"Elevated factor VIII levels and the risk of thrombosis","volume":"21","author":"Kamphuisen","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153878362300507X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153878362300507X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T07:40:19Z","timestamp":1742283619000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S153878362300507X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":54,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S153878362300507X"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2023.06.022","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combined effect of high factor VIII levels and high mean platelet volume on the risk of future incident venous thromboembolism","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2023.06.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}