{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:42:23Z","timestamp":1761536543627,"version":"build-2065373602"},"reference-count":29,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006451","name":"Hospices Civils de Lyon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006451","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006687","name":"Universit\u00e9 Claude Bernard Lyon 1","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014255","name":"Fonds de dotation CSL Behring pour la recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014255","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.jtha.2023.08.019","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T04:54:28Z","timestamp":1692939268000},"page":"3117-3123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["In\u00a0vivo intranasal delivery of coagulation factor IX: a proof-of-concept study"],"prefix":"10.1016","volume":"21","author":[{"given":"Maxime","family":"Fieux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renaud","family":"Rovera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Coiffier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyne","family":"Colomb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Enjolras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie","family":"B\u00e9quignon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Monge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Le Quellec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2023.08.019_bib1","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0140-6736(20)32722-7","article-title":"The changing treatment landscape in haemophilia: from standard half-life clotting factor concentrates to gene editing","volume":"397","author":"Mancuso","year":"2021","journal-title":"Lancet Lond Engl"},{"key":"10.1016\/j.jtha.2023.08.019_bib2","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/S0140-6736(03)13405-8","article-title":"Haemophilias A and B","volume":"361","author":"Bolton-Maggs","year":"2003","journal-title":"Lancet Lond Engl"},{"key":"10.1016\/j.jtha.2023.08.019_bib3","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1111\/jth.14847","article-title":"Performance of factor IX extended half-life product measurements in external quality control assessment programs","volume":"18","author":"Nederlof","year":"2020","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.08.019_bib4","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/jth.15570","article-title":"Invisible bleeds: lived experiences and barriers to care for men with hemophilia","volume":"20","author":"Arya","year":"2022","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.08.019_bib5","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1055\/s-0038-1675787","article-title":"Fusion of factor IX to factor XIII-B sub-unit improves the pharmacokinetic profile of factor IX","volume":"118","author":"Le Quellec","year":"2018","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.08.019_bib6","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.thromres.2015.02.034","article-title":"Expression and characterization of a novel human recombinant factor IX molecule with enhanced in\u00a0vitro and in\u00a0vivo clotting activity","volume":"135","author":"Perot","year":"2015","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2023.08.019_bib7","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1056\/NEJMoa2211644","article-title":"Gene therapy with etranacogene dezaparvovec for hemophilia B","volume":"388","author":"Pipe","year":"2023","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtha.2023.08.019_bib8","first-page":"1969","article-title":"Intracranial haemorrhage in haemophilia patients is still an open issue: the final results of the Italian EMO.REC Registry","volume":"11","author":"Zanon","year":"2022","journal-title":"J\u00a0Clin Med"},{"key":"10.1016\/j.jtha.2023.08.019_bib9","doi-asserted-by":"crossref","first-page":"4083","DOI":"10.2337\/db14-0477","article-title":"Central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men","volume":"63","author":"Heni","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.jtha.2023.08.019_bib10","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/ddr.21343","article-title":"Effects of intranasal oxytocin on long-term memory in healthy humans: a systematic review","volume":"77","author":"Brambilla","year":"2016","journal-title":"Drug Dev Res"},{"key":"10.1016\/j.jtha.2023.08.019_bib11","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1542\/peds.106.5.989","article-title":"A\u00a0randomized, double-blind, placebo-controlled study of sumatriptan nasal spray in the treatment of acute migraine in adolescents","volume":"106","author":"Winner","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.jtha.2023.08.019_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abb0580","article-title":"An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics","volume":"12","author":"Bern","year":"2020","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jtha.2023.08.019_bib13","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.jconrel.2018.08.006","article-title":"Delivery of immunoglobulin G antibodies to the rat nervous system following intranasal administration: distribution, dose-response, and mechanisms of delivery","volume":"286","author":"Kumar","year":"2018","journal-title":"J\u00a0Control Release"},{"key":"10.1016\/j.jtha.2023.08.019_bib14","first-page":"249","article-title":"FcRn: from molecular interactions to regulation of IgG pharmacokinetics and functions","volume":"382","author":"Challa","year":"2014","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.jtha.2023.08.019_bib15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.yrtph.2018.10.003","article-title":"Bioavailability of protein therapeutics in rats following inhalation exposure: Relevance to occupational exposure limit calculations","volume":"100","author":"Gould","year":"2018","journal-title":"Regul Toxicol Pharmacol"},{"key":"10.1016\/j.jtha.2023.08.019_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20061379","article-title":"FcRn-dependent transcytosis of monoclonal antibody in human nasal epithelial cells in\u00a0vitro: a prerequisite for a new delivery route for therapy?","volume":"20","author":"Bequignon","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtha.2023.08.019_bib17","doi-asserted-by":"crossref","first-page":"6475","DOI":"10.3390\/ijms22126475","article-title":"FcRn as a transporter for nasal delivery\u00a0of biologics: a systematic review","volume":"22","author":"Fieux","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtha.2023.08.019_bib18","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1182\/blood-2011-07-367003","article-title":"Recombinant factor IX-Fc fusion protein (rFIXFc) demonstrates safety and prolonged activity in a phase 1\/2a study in hemophilia B patients","volume":"119","author":"Shapiro","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.08.019_bib19","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1182\/blood-2012-05-429688","article-title":"Safety and pharmacokinetics of a novel\u00a0recombinant fusion protein linking coagulation factor IX with\u00a0albumin (rIX-FP) in hemophilia B patients","volume":"120","author":"Santagostino","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.08.019_bib20","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1182\/blood-2009-08-239665","article-title":"Prolonged activity of factor IX as a monomeric Fc fusion protein","volume":"115","author":"Peters","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.08.019_bib21","doi-asserted-by":"crossref","first-page":"6363","DOI":"10.1074\/jbc.M117.817064","article-title":"Half-life-extended recombinant coagulation factor IX-albumin fusion protein is recycled via the FcRn-mediated pathway","volume":"293","author":"Chia","year":"2018","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jtha.2023.08.019_bib22","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1182\/blood.V97.5.1258","article-title":"Factors influencing in\u00a0vivo transduction by recombinant adeno-associated viral vectors expressing the human factor IX cDNA","volume":"97","author":"Nathwani","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.08.019_bib23","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1182\/blood-2002-02-0589","article-title":"Sustained high-level expression of human factor IX (hFIX) after liver-targeted delivery of recombinant adeno-associated virus encoding the hFIX gene in rhesus macaques","volume":"100","author":"Nathwani","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.08.019_bib24","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1055\/s-0040-1717114","article-title":"Pharmacokinetics and pharmacodynamics of emicizumab in persons with hemophilia A with factor VIII inhibitors: HAVEN 1 study","volume":"121","author":"Schmitt","year":"2021","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.08.019_bib25","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/sj.npp.1301193","article-title":"Intranasal insulin improves memory in humans: superiority of insulin aspart","volume":"32","author":"Benedict","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jtha.2023.08.019_bib26","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.biomaterials.2018.07.006","article-title":"Receptor mediated transcytosis in biological barrier: the influence of receptor character and their ligand density on the transmembrane pathway of active-targeting nanocarriers","volume":"180","author":"Song","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.jtha.2023.08.019_bib27","doi-asserted-by":"crossref","first-page":"179","DOI":"10.30802\/AALAS-JAALAS-22-000091","article-title":"Intranasal administration of a polymeric biodegradable film to C57BL\/6 mice","volume":"62","author":"Balafas","year":"2023","journal-title":"J\u00a0Am Assoc Lab Anim Sci"},{"key":"10.1016\/j.jtha.2023.08.019_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics10030107","article-title":"Allogenic Fc domain-facilitated uptake of IgG in nasal lamina propria: friend or foe for intranasal CNS delivery?","volume":"10","author":"Ladel","year":"2018","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jtha.2023.08.019_bib29","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1160\/TH13-03-0213","article-title":"Extending the pharmacokinetic half-life of coagulation factors by fusion to recombinant albumin","volume":"110","author":"Metzner","year":"2013","journal-title":"Thromb Haemost"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783623006475?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783623006475?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:38:36Z","timestamp":1761536316000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783623006475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S1538783623006475"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2023.08.019","relation":{},"ISSN":["1538-7836"],"issn-type":[{"type":"print","value":"1538-7836"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In\u00a0vivo intranasal delivery of coagulation factor IX: a proof-of-concept study","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2023.08.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}]}}