{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:56:49Z","timestamp":1789012609766,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jtha.2023.08.035","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T22:26:43Z","timestamp":1694816803000},"page":"90-100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of collagen turnover biomarkers as an objective measure for efficacy of treatment with rurioctocog alfa pegol in patients with hemophilia A: a secondary analysis of a randomized controlled trial"],"prefix":"10.1016","volume":"22","author":[{"given":"Tina","family":"Manon-Jensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srilatha","family":"Tangada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilie","family":"Bager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratima","family":"Chowdary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Klamroth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"von Drygalski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Windyga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Escobar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peder","family":"Frederiksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Engl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Ewenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Karsdal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2023.08.035_bib1","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1111\/jth.14567","article-title":"Mechanisms of vascular permeability and remodeling associated with hemarthrosis in factor VIII-deficient mice","volume":"17","author":"Cooke","year":"2019","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.08.035_bib2","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1111\/jth.13518","article-title":"Altered collagen turnover in factor VIII-deficient rats with hemophilic arthropathy identifies potential novel serological biomarkers in hemophilia","volume":"14","author":"Manon-Jensen","year":"2016","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.08.035_bib3","doi-asserted-by":"crossref","first-page":"e294","DOI":"10.1111\/hae.13196","article-title":"Serological biomarkers detect active joint destruction and inflammation in patients with haemophilic arthropathy","volume":"23","author":"Hua","year":"2017","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2023.08.035_bib4","doi-asserted-by":"crossref","first-page":"e515","DOI":"10.1111\/hae.13329","article-title":"Increased basement membrane turnover and strongly attenuated interstitial matrix turnover is a key pathological feature of haemophilia","volume":"23","author":"Manon-Jensen","year":"2017","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2023.08.035_bib5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.transci.2007.12.006","article-title":"Hemophilic joint disease - current perspective and potential future strategies","volume":"38","author":"Acharya","year":"2008","journal-title":"Transfus Apher Sci"},{"key":"10.1016\/j.jtha.2023.08.035_bib6","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1055\/s-0038-1641755","article-title":"Vascular permeability and remodelling coincide with inflammatory and reparative processes after joint bleeding in factor VIII-deficient mice","volume":"118","author":"Cooke","year":"2018","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.08.035_bib7","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1182\/blood.2020005673","article-title":"Rurioctocog alfa pegol PK-guided prophylaxis in hemophilia A: results from the phase 3 PROPEL study","volume":"137","author":"Klamroth","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.08.035_bib8","series-title":"Base SAS\u00ae 9.4 Procedures Guide","author":"Inc","year":"2017"},{"key":"10.1016\/j.jtha.2023.08.035_bib9","series-title":"SAS\/STAT\u00ae 14.3 User\u2019s Guide","author":"Inc","year":"2017"},{"key":"10.1016\/j.jtha.2023.08.035_bib10","doi-asserted-by":"crossref","first-page":"j3683","DOI":"10.1136\/bmj.j3683","article-title":"Statistics notes: percentage differences, symmetry, and natural logarithms","volume":"358","author":"Cole","year":"2017","journal-title":"BMJ"},{"key":"10.1016\/j.jtha.2023.08.035_bib11","series-title":"A\u00a0language and environment for statistical computing","author":"Team","year":"2022"},{"key":"10.1016\/j.jtha.2023.08.035_bib12","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/jth.13249","article-title":"Collagen-mediated hemostasis","volume":"14","author":"Manon-Jensen","year":"2016","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.08.035_bib13","series-title":"Biochemistry of collagens, laminins and elastin: structure, function and biomarkers","author":"Karsdal","year":"2019"},{"key":"10.1016\/j.jtha.2023.08.035_bib14","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1111\/jth.15268","article-title":"Systemic vascular basement membrane markers linked to synovial vascular remodeling are biomarkers of hemarthrosis in patients with hemophilia","volume":"19","author":"Gopal","year":"2021","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.08.035_bib15","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1053\/S0270-9295(03)00131-1","article-title":"Pathogenesis of Goodpasture syndrome: a molecular perspective","volume":"23","author":"Borza","year":"2003","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.jtha.2023.08.035_bib16","first-page":"829","article-title":"Type IV collagen metabolism is associated with disease activity, radiographic progression and response to tocilizumab in rheumatoid arthritis","volume":"36","author":"Gudmann","year":"2018","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jtha.2023.08.035_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0084934","article-title":"MMP mediated degradation of type IV collagen alpha 1 and alpha 3 chains reflects basement membrane remodeling in experimental and clinical fibrosis--validation of two novel biomarker assays","volume":"8","author":"Sand","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jtha.2023.08.035_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0190375","article-title":"The endothelial specific isoform of type XVIII collagen correlates to annual bleeding rate in haemophilia patients","volume":"13","author":"Kjeld","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jtha.2023.08.035_bib19","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/micc.12273","article-title":"Persistent vascular remodeling and leakiness are important components of the pathobiology of re-bleeding in hemophilic joints: two informative cases","volume":"23","author":"Kidder","year":"2016","journal-title":"Microcirculation"},{"key":"10.1016\/j.jtha.2023.08.035_bib20","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/ajh.24133","article-title":"Vascular remodeling underlies rebleeding in hemophilic arthropathy","volume":"90","author":"Bhat","year":"2015","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jtha.2023.08.035_bib21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.addr.2017.07.014","article-title":"The good and the bad collagens of fibrosis - their role in signaling and organ function","volume":"121","author":"Karsdal","year":"2017","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.jtha.2023.08.035_bib22","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1136\/ard.48.11.953","article-title":"Ehlers-Danlos syndrome, clotting disorders and muscular dystrophy","volume":"48","author":"Bertin","year":"1989","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jtha.2023.08.035_bib23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/1479-5876-10-195","article-title":"Matrix metalloproteinase-dependent turnover of cartilage, synovial membrane, and connective tissue is elevated in rats with collagen induced arthritis","volume":"10","author":"Siebuhr","year":"2012","journal-title":"J Transl Med"},{"key":"10.1016\/j.jtha.2023.08.035_bib24","doi-asserted-by":"crossref","first-page":"547","DOI":"10.3109\/1354750X.2015.1105497","article-title":"Synovitis biomarkers: ex\u00a0vivo characterization of three biomarkers for identification of inflammatory osteoarthritis","volume":"20","author":"Kjelgaard-Petersen","year":"2015","journal-title":"Biomarkers"},{"key":"10.1016\/j.jtha.2023.08.035_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054504","article-title":"Circulating protein fragments of cartilage and connective tissue degradation are diagnostic and prognostic markers of rheumatoid arthritis and ankylosing spondylitis","volume":"8","author":"Bay-Jensen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jtha.2023.08.035_bib26","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.semarthrit.2013.07.008","article-title":"Effect of tocilizumab combined with methotrexate on circulating biomarkers of synovium, cartilage, and bone in the LITHE study","volume":"43","author":"Bay-Jensen","year":"2014","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.jtha.2023.08.035_bib27","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.clinbiochem.2012.02.007","article-title":"MMP mediated type V collagen degradation (C5M) is elevated in ankylosing spondylitis","volume":"45","author":"Veidal","year":"2012","journal-title":"Clin Biochem"},{"key":"10.1016\/j.jtha.2023.08.035_bib28","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S8756-3282(01)00504-X","article-title":"Collagen type II C-telopeptide fragments as an index of cartilage degradation","volume":"29","author":"Christgau","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.jtha.2023.08.035_bib29","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.clinbiochem.2011.01.001","article-title":"Enzyme-linked immunosorbent assay (ELISAs) for metalloproteinase derived type II collagen neoepitope, CIIM--increased serum CIIM in subjects with severe radiographic osteoarthritis","volume":"44","author":"Bay-Jensen","year":"2011","journal-title":"Clin Biochem"},{"key":"10.1016\/j.jtha.2023.08.035_bib30","doi-asserted-by":"crossref","first-page":"6011","DOI":"10.1038\/s41598-020-63216-z","article-title":"Sprifermin (rhFGF18) versus vehicle induces a biphasic process of extracellular matrix remodeling in human knee OA articular cartilage ex\u00a0vivo","volume":"10","author":"Reker","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtha.2023.08.035_bib31","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1186\/s12967-017-1356-8","article-title":"Sprifermin (rhFGF18) modulates extracellular matrix turnover in cartilage explants ex\u00a0vivo","volume":"15","author":"Reker","year":"2017","journal-title":"J\u00a0Transl Med"},{"key":"10.1016\/j.jtha.2023.08.035_bib32","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.joca.2021.10.008","article-title":"Low levels of type II collagen formation (PRO-C2) are associated with response to sprifermin: a pre-defined, exploratory biomarker analysis from the FORWARD study","volume":"30","author":"Bay-Jensen","year":"2022","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jtha.2023.08.035_bib33","first-page":"10","article-title":"A\u00a0low cartilage formation and repair endotype predicts radiographic progression of symptomatic knee osteoarthritis","volume":"22","author":"Luo","year":"2021","journal-title":"J\u00a0Orthop Traumatol"},{"key":"10.1016\/j.jtha.2023.08.035_bib34","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/hae.12175","article-title":"Rapid musculoskeletal ultrasound for painful episodes in adult haemophilia patients","volume":"19","author":"Ceponis","year":"2013","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2023.08.035_bib35","doi-asserted-by":"crossref","first-page":"e124","DOI":"10.1111\/hae.13439","article-title":"Use of ultrasound for evaluation of painful joint episodes perceived as haemarthrosis in adult patients with severe haemophilia","volume":"24","author":"Berro","year":"2018","journal-title":"Haemophilia"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783623006992?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783623006992?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:39:09Z","timestamp":1761536349000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783623006992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S1538783623006992"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2023.08.035","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of collagen turnover biomarkers as an objective measure for efficacy of treatment with rurioctocog alfa pegol in patients with hemophilia A: a secondary analysis of a randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2023.08.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}]}}