{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:45:40Z","timestamp":1790959540291,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2020-01824"],"award-info":[{"award-number":["2020-01824"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009780","name":"Region Sk\u00e5ne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jtha.2023.11.024","type":"journal-article","created":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T18:13:15Z","timestamp":1702145595000},"page":"775-784","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["The risk for venous thromboembolism and cardiometabolic disorders in offspring from thrombosis-prone pedigrees"],"prefix":"10.1016","volume":"22","author":[{"given":"Bengt","family":"Z\u00f6ller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Sundquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Sundquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Ohlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2023.11.024_bib1","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S0140-6736(98)10266-0","article-title":"Venous thrombosis: a multicausal disease","volume":"353","author":"Rosendaal","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jtha.2023.11.024_bib2","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nrcardio.2015.83","article-title":"Epidemiology of venous thromboembolism","volume":"12","author":"Heit","year":"2015","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jtha.2023.11.024_bib3","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1080\/17474086.2020.1804354","article-title":"Genetic risk factors for venous thromboembolism","volume":"13","author":"Z\u00f6ller","year":"2020","journal-title":"Expert Rev Hematol"},{"key":"10.1016\/j.jtha.2023.11.024_bib4","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1055\/s-0036-1593543","article-title":"Epidemiology of familial aggregation of venous thromboembolism","volume":"42","author":"Z\u00f6ller","year":"2016","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.jtha.2023.11.024_bib5","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1160\/TH15-04-0306","article-title":"Family history of venous thromboembolism as a risk factor and genetic research tool","volume":"114","author":"Z\u00f6ller","year":"2015","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.11.024_bib6","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1160\/TH15-02-0141","article-title":"Classic thrombophilic gene variants","volume":"114","author":"Mannucci","year":"2015","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.11.024_bib7","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/bjh.15004","article-title":"What is currently known about the genetics of venous thromboembolism at the dawn of next generation sequencing technologies","volume":"180","author":"Tr\u00e9gou\u00ebt","year":"2018","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2023.11.024_bib8","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1001\/archinternmed.2008.589","article-title":"The value of family history as a risk indicator for venous thrombosis","volume":"169","author":"Bezemer","year":"2009","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jtha.2023.11.024_bib9","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1182\/blood.2019000435","article-title":"Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism","volume":"134","author":"Lindstr\u00f6m","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.11.024_bib10","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1038\/s41588-019-0519-3","article-title":"Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease","volume":"51","author":"Klarin","year":"2019","journal-title":"Nat Genet"},{"key":"10.1016\/j.jtha.2023.11.024_bib11","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1161\/CIRCULATIONAHA.122.059675","article-title":"Cross-ancestry investigation of venous thromboembolism genomic predictors","volume":"146","author":"Thibord","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2023.11.024_bib12","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41588-022-01286-7","article-title":"Genome-wide meta-analysis identifies 93 risk loci and enables risk prediction equivalent to monogenic forms of venous thromboembolism","volume":"55","author":"Ghouse","year":"2023","journal-title":"Nat Genet"},{"key":"10.1016\/j.jtha.2023.11.024_bib13","article-title":"Familial segregation of venous thromboembolism in Sweden: a nationwide family study of heritability and complex segregation analysis","volume":"10","author":"Z\u00f6ller","year":"2021","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jtha.2023.11.024_bib14","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1161\/CIRCULATIONAHA.110.965020","article-title":"Age- and gender-specific familial risks for venous thromboembolism: a nationwide epidemiological study based on hospitalizations in Sweden","volume":"124","author":"Z\u00f6ller","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2023.11.024_bib15","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1160\/TH12-10-0743","article-title":"Familial risk of venous thromboembolism in first-, second- and third-degree relatives: a nationwide family study in Sweden","volume":"109","author":"Z\u00f6ller","year":"2013","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.11.024_bib16","article-title":"Venous thromboembolism and varicose veins share familial susceptibility: a nationwide family study in Sweden","volume":"3","author":"Z\u00f6ller","year":"2014","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jtha.2023.11.024_bib17","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1136\/heartjnl-2015-308892","article-title":"A\u00a0nationwide family study of venous thromboembolism and risk of arterial vascular disease","volume":"102","author":"Z\u00f6ller","year":"2016","journal-title":"Heart"},{"key":"10.1016\/j.jtha.2023.11.024_bib18","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1161\/CIRCGENETICS.111.959882","article-title":"Venous thromboembolism does not share strong familial susceptibility with ischemic stroke: a nationwide family study in Sweden","volume":"4","author":"Z\u00f6ller","year":"2011","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.jtha.2023.11.024_bib19","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1093\/eurheartj\/ehr223","article-title":"Venous thromboembolism does not share strong familial susceptibility with coronary heart disease: a nationwide family study in Sweden","volume":"32","author":"Z\u00f6ller","year":"2011","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jtha.2023.11.024_bib20","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1111\/1471-0528.12216","article-title":"Venous thromboembolism does not share strong familial susceptibility with pre-eclampsia\/eclampsia: a nationwide family study in Sweden","volume":"120","author":"Z\u00f6ller","year":"2013","journal-title":"BJOG"},{"key":"10.1016\/j.jtha.2023.11.024_bib21","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s11239-016-1387-7","article-title":"Venous thromboembolism does not share familial susceptibility with retinal vascular occlusion or glaucoma: a nationwide family study","volume":"42","author":"Z\u00f6ller","year":"2016","journal-title":"J\u00a0Thromb Thrombolysis"},{"key":"10.1016\/j.jtha.2023.11.024_bib22","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.thromres.2014.03.054","article-title":"Influence of coronary artery disease-associated genetic variants on risk of venous thromboembolism","volume":"134","author":"Bruzelius","year":"2014","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2023.11.024_bib23","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/s41591-019-0492-5","article-title":"Genome-wide association study of peripheral artery disease in the Million Veteran Program","volume":"25","author":"Klarin","year":"2019","journal-title":"Nat Med"},{"key":"10.1016\/j.jtha.2023.11.024_bib24","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1160\/th14-03-0275","article-title":"A\u00a0genomewide study of body mass index and its genetic correlation with thromboembolic risk. Results from the GAIT project","volume":"112","author":"Souto","year":"2014","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.11.024_bib25","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1055\/s-0031-1297369","article-title":"Obesity and venous thrombosis: a review","volume":"37","author":"Allman-Farinelli","year":"2011","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.jtha.2023.11.024_bib26","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1001\/jamacardio.2018.4537","article-title":"Cardiovascular risk factors associated with venous thromboembolism","volume":"4","author":"Gregson","year":"2019","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jtha.2023.11.024_bib27","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejim.2015.10.001","article-title":"Is diabetes mellitus a risk factor for venous thromboembolism? A systematic review and meta-analysis of case-control and cohort studies","volume":"28","author":"Gariani","year":"2016","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.jtha.2023.11.024_bib28","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.diabres.2015.10.019","article-title":"Diabetes mellitus and venous thromboembolism: a systematic review and meta-analysis","volume":"111","author":"Bell","year":"2016","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.jtha.2023.11.024_bib29","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/1756-185X.14524","article-title":"Gout and risk of venous thromboembolism: a systematic review and meta-analysis of cohort studies","volume":"26","author":"Guo","year":"2023","journal-title":"Int J Rheum Dis"},{"key":"10.1016\/j.jtha.2023.11.024_bib30","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1016\/S2352-3026(15)00228-8","article-title":"Heart failure and risk of venous thromboembolism: a systematic review and meta-analysis","volume":"3","author":"Tang","year":"2016","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.jtha.2023.11.024_bib31","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1055\/s-0036-1598005","article-title":"Pulmonary embolism and atrial fibrillation: two sides of the same coin? A systematic review","volume":"43","author":"Bikdeli","year":"2017","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.jtha.2023.11.024_bib32","doi-asserted-by":"crossref","first-page":"e4495","DOI":"10.1097\/MD.0000000000004495","article-title":"Venous thromboembolism has the same risk factors as atherosclerosis: a PRISMA-compliant systemic review and meta-analysis","volume":"95","author":"Mi","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jtha.2023.11.024_bib33","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1038\/s41380-018-0111-8","article-title":"The risk for drug abuse, alcohol use disorder, and psychosocial dysfunction in offspring from high-density pedigrees: its moderation by personal, family, and community factors","volume":"25","author":"Kendler","year":"2020","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.jtha.2023.11.024_bib34","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s10654-009-9350-y","article-title":"The Swedish personal identity number: possibilities and pitfalls in healthcare and medical research","volume":"24","author":"Ludvigsson","year":"2009","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.jtha.2023.11.024_bib35","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/978-1-59745-423-0_10","article-title":"The Swedish multi-generation register","volume":"675","author":"Ekbom","year":"2011","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jtha.2023.11.024_bib36","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1186\/1471-2458-11-450","article-title":"External review and validation of the Swedish national inpatient register","volume":"11","author":"Ludvigsson","year":"2011","journal-title":"BMC Public Health"},{"key":"10.1016\/j.jtha.2023.11.024_bib37","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10654-016-0117-y","article-title":"Registers of the Swedish total population and their use in medical research","volume":"31","author":"Ludvigsson","year":"2016","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.jtha.2023.11.024_bib38","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgast-2017-000156","article-title":"A\u00a0Swedish national adoption study of risk of irritable bowel syndrome (IBS)","volume":"4","author":"Waehrens","year":"2017","journal-title":"BMJ Open Gastroenterol"},{"key":"10.1016\/j.jtha.2023.11.024_bib39","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s12888-017-1381-4","article-title":"Common adult psychiatric disorders in Swedish primary care where most mental health patients are treated","volume":"17","author":"Sundquist","year":"2017","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.jtha.2023.11.024_bib40","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jamacardio.2021.4127","article-title":"Preterm delivery and long-term risk of hypertension in women","volume":"7","author":"Crump","year":"2022","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jtha.2023.11.024_bib41","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1538-7836.2007.02857.x","article-title":"Psychosocial factors and venous thromboembolism: a long-term follow-up study of Swedish men","volume":"6","author":"Rosengren","year":"2008","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.11.024_bib42","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1111\/jth.15630","article-title":"Thrombomodulin (THBD) gene variants and thrombotic risk in a population-based cohort study","volume":"20","author":"Manderstedt","year":"2022","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.11.024_bib43","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1214\/aoms\/1177729756","article-title":"Transformations related to the angular and the square root","volume":"21","author":"Freeman","year":"1950","journal-title":"Ann Math Stat"},{"key":"10.1016\/j.jtha.2023.11.024_bib44","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1109\/TIT.1982.1056489","article-title":"Least squares quantization in PCM","volume":"28","author":"Lloyd","year":"1982","journal-title":"IEEE Trans Inf Theory"},{"key":"10.1016\/j.jtha.2023.11.024_bib45","series-title":"Inc. SAS\/STAT user\u2019s guide","year":"2013"},{"key":"10.1016\/j.jtha.2023.11.024_bib46","series-title":"R Foundation for Statistical Computing. R: a language and environment for statistical computing","year":"2017"},{"key":"10.1016\/j.jtha.2023.11.024_bib47","article-title":"Classic thrombophilias and thrombotic risk among middle-aged and older adults: a population-based cohort study","volume":"11","author":"Manderstedt","year":"2022","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jtha.2023.11.024_bib48","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.thromres.2012.02.002","article-title":"A\u00a0nationwide family study of pulmonary embolism: identification of high risk families with increased risk of hospitalized and fatal pulmonary embolism","volume":"130","author":"Z\u00f6ller","year":"2012","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2023.11.024_bib49","doi-asserted-by":"crossref","first-page":"4209","DOI":"10.1182\/blood.V84.12.4209.bloodjournal84124209","article-title":"Hereditary antithrombin deficiency: heterogeneity of the molecular basis and mortality in Dutch families","volume":"84","author":"van Boven","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.11.024_bib50","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1182\/blood.V85.12.3518.bloodjournal85123518","article-title":"Resistance to activated protein C as an additional genetic risk factor in hereditary deficiency of protein S","volume":"85","author":"Z\u00f6ller","year":"1995","journal-title":"Blood"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783623008620?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783623008620?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:41:40Z","timestamp":1761536500000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783623008620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S1538783623008620"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2023.11.024","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The risk for venous thromboembolism and cardiometabolic disorders in offspring from thrombosis-prone pedigrees","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2023.11.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}]}}