{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:42:26Z","timestamp":1792618946312,"version":"4.5.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2706100"],"award-info":[{"award-number":["2023YFC2706100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970111"],"award-info":[{"award-number":["81970111"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009601","name":"Beijing Municipal Administration of Hospitals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005088","name":"Beijing Municipal Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005088","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.jtha.2023.12.006","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T21:18:04Z","timestamp":1702588684000},"page":"1167-1178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Machine learning models developed and internally validated for predicting chronicity in pediatric immune thrombocytopenia"],"prefix":"10.1016","volume":"22","author":[{"given":"Jingyao","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9333-8200","authenticated-orcid":false,"given":"Yongqiang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyue","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingjuan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxi","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifa","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wensheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5273-145X","authenticated-orcid":false,"given":"Zhenping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4030-209X","authenticated-orcid":false,"given":"Runhui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2023.12.006_bib1","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1182\/bloodadvances.2019000812","article-title":"Updated international consensus report on the investigation and management of primary immune thrombocytopenia","volume":"3","author":"Provan","year":"2019","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtha.2023.12.006_bib2","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/ped.12788","article-title":"Incidence of childhood primary immune thrombocytopenic purpura","volume":"57","author":"Higashigawa","year":"2015","journal-title":"Pediatr Int"},{"key":"10.1016\/j.jtha.2023.12.006_bib3","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.thromres.2017.05.010","article-title":"Epidemiology and management of primary immune thrombocytopenia: a nationwide population-based study in Korea","volume":"155","author":"Lee","year":"2017","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2023.12.006_bib4","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/MOH.0000000000000447","article-title":"Pathophysiology of immune thrombocytopenia","volume":"25","author":"Li","year":"2018","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.jtha.2023.12.006_bib5","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.26646","article-title":"Quantification of specific T and B cells immunological markers in children with chronic and transient ITP","volume":"64","author":"Levy-Mendelovich","year":"2017","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.jtha.2023.12.006_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.26736","article-title":"Predictors of remission in children with newly diagnosed immune thrombocytopenia: data from the Intercontinental Cooperative ITP Study Group Registry II participants","volume":"65","author":"Bennett","year":"2018","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.jtha.2023.12.006_bib7","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/jth.15125","article-title":"A\u00a0clinical prediction score for transient versus persistent childhood immune thrombocytopenia","volume":"19","author":"Schmidt","year":"2021","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.12.006_bib8","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.pedneo.2018.10.002","article-title":"Retrospective evaluation of children with immune thrombocytopenic purpura and factors contributing to chronicity","volume":"60","author":"G\u00fcng\u00f6r","year":"2019","journal-title":"Pediatr Neonatol"},{"key":"10.1016\/j.jtha.2023.12.006_bib9","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1182\/blood-2014-04-570127","article-title":"Clinical and laboratory predictors of chronic immune thrombocytopenia in children: a systematic review and meta-analysis","volume":"124","author":"Heitink-Poll\u00e9","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.12.006_bib10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3390\/ai1020008","article-title":"Artificial intelligence (AI) or intelligence augmentation (IA): what is the future?","volume":"1","author":"Hassani","year":"2020","journal-title":"AI"},{"key":"10.1016\/j.jtha.2023.12.006_bib11","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41598-017-18564-8","article-title":"An application of machine learning to haematological diagnosis","volume":"8","author":"Gun\u010dar","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtha.2023.12.006_bib12","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1021\/acs.jcim.9b00633","article-title":"LightGBM: an effective and scalable algorithm for prediction of chemical toxicity\u2013application to the tox21 and mutagenicity data sets","volume":"59","author":"Zhang","year":"2019","journal-title":"J\u00a0Chem Inf Model"},{"key":"10.1016\/j.jtha.2023.12.006_bib13","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1182\/bloodadvances.2019000966","article-title":"American Society of Hematology 2019 guidelines for immune thrombocytopenia","volume":"3","author":"Neunert","year":"2019","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtha.2023.12.006_bib14","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1467-985X.2004.298_12.x","article-title":"Logistic regression: a self-learning text, 2nd edn","volume":"167","author":"Wooff","year":"2004","journal-title":"J\u00a0R Stat Soc Ser A Stat Soc"},{"key":"10.1016\/j.jtha.2023.12.006_bib15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1023\/A:1010933404324","article-title":"Random forests","volume":"45","author":"Breiman","year":"2001","journal-title":"Mach Learn"},{"key":"10.1016\/j.jtha.2023.12.006_bib16","series-title":"Proceedings of the 22nd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining","first-page":"785","article-title":"XGBoost: a scalable tree boosting system","author":"Chen","year":"2016"},{"key":"10.1016\/j.jtha.2023.12.006_bib17","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1214\/aos\/1013203451","article-title":"Greedy function approximation: a gradient boosting machine","volume":"29","author":"Friedman","year":"2001","journal-title":"Ann Stat"},{"key":"10.1016\/j.jtha.2023.12.006_bib18","first-page":"2825","article-title":"Scikit-learn: machine learning in python","volume":"12","author":"Pedregosa","year":"2013","journal-title":"J\u00a0Mach Learn Res"},{"key":"10.1016\/j.jtha.2023.12.006_bib19","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.1182\/blood-2012-12-466375","article-title":"Intercontinental Cooperative ITP Study Group Registry II Participants. Bleeding manifestations and management of children with persistent and chronic immune thrombocytopenia: data from the Intercontinental Cooperative ITP Study Group (ICIS)","volume":"121","author":"Neunert","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.12.006_bib20","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3389\/fimmu.2018.00880","article-title":"Emerging concepts in immune thrombocytopenia","volume":"9","author":"Swinkels","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jtha.2023.12.006_bib21","first-page":"914","article-title":"Type 1 and type 2 T-cell profiles in idiopathic thrombocytopenic purpura","volume":"90","author":"Wang","year":"2005","journal-title":"Haematologica"},{"key":"10.1016\/j.jtha.2023.12.006_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050909","article-title":"The ratio of Treg\/Th17 cells correlates with the disease activity of primary immune thrombocytopenia","volume":"7","author":"Ji","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jtha.2023.12.006_bib23","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1007\/s00431-021-04121-z","article-title":"Increased proportion of Th17\/Treg cells at the new diagnosed stage of chronic immune thrombocytopenia in pediatrics: the pilot study from a multi-center","volume":"180","author":"Gu","year":"2021","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jtha.2023.12.006_bib24","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.immuni.2009.08.006","article-title":"Gammadelta T cells and the lymphoid stress-surveillance response","volume":"31","author":"Hayday","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.jtha.2023.12.006_bib25","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1038\/mt.2014.104","article-title":"Cytotoxic and regulatory properties of circulating V\u03b41+ \u03b3\u03b4 T cells: a new player on the cell therapy field?","volume":"22","author":"Siegers","year":"2014","journal-title":"Mol Ther"},{"key":"10.1016\/j.jtha.2023.12.006_bib26","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1080\/17476348.2019.1666002","article-title":"Role of IL-17 in asthma pathogenesis and its implications for the clinic","volume":"13","author":"Ramakrishnan","year":"2019","journal-title":"Expert Rev Respir Med"},{"key":"10.1016\/j.jtha.2023.12.006_bib27","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/ped4.12097","article-title":"Platelet-specific antibodies and differences in their expression in childhood immune thrombocytopenic purpura predicts clinical progression","volume":"2","author":"Fu","year":"2018","journal-title":"Pediatr Investig"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783623008711?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783623008711?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:09:22Z","timestamp":1762549762000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783623008711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S1538783623008711"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2023.12.006","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Machine learning models developed and internally validated for predicting chronicity in pediatric immune thrombocytopenia","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2023.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}]}}