{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T05:56:22Z","timestamp":1768974982421,"version":"3.49.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021117","name":"Liverpool University Hospitals NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021117","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["NIHR135073"],"award-info":[{"award-number":["NIHR135073"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.jtha.2023.12.008","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T02:18:32Z","timestamp":1702606712000},"page":"1145-1153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Damage-associated cellular markers in the clinical and pathogenic profile of vaccine-induced immune thrombotic thrombocytopenia"],"prefix":"10.1016","volume":"22","author":[{"given":"Simon T.","family":"Abrams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca J.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmara","family":"McGuinness","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Schofield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lance","family":"Turtle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip L.R.","family":"Nicolson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Moxon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guozheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Hock","family":"Toh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2023.12.008_bib1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0140-6736(21)02754-9","article-title":"Two-dose ChAdOx1 nCoV-19 vaccine protection against COVID-19 hospital admissions and deaths over time: a retrospective, population-based cohort study in Scotland and Brazil","volume":"399","author":"Katikireddi","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.jtha.2023.12.008_bib2","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1056\/NEJMoa2104840","article-title":"Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination","volume":"384","author":"Greinacher","year":"2021","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtha.2023.12.008_bib3","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1056\/NEJMoa2109908","article-title":"Clinical features of vaccine-induced immune thrombocytopenia and thrombosis","volume":"385","author":"Pavord","year":"2021","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtha.2023.12.008_bib4","article-title":"Living with vaccine-induced immune thrombocytopenia and thrombosis: a qualitative study","volume":"13","author":"Bennett","year":"2023","journal-title":"BMJ Open"},{"key":"10.1016\/j.jtha.2023.12.008_bib5","first-page":"247","article-title":"Heparin-associated thrombocytopenia: isolation of the antibody and characterization of a multimolecular PF4-heparin complex as the major antigen","volume":"71","author":"Greinacher","year":"1994","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.12.008_bib6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1182\/blood-2004-04-1544","article-title":"Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia","volume":"105","author":"Rauova","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.12.008_bib7","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1161\/01.ATV.0000238350.89477.88","article-title":"Close approximation of two platelet factor 4 tetramers by charge neutralization forms the antigens recognized by HIT antibodies","volume":"26","author":"Greinacher","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jtha.2023.12.008_bib8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1160\/TH13-08-0634","article-title":"Characterisation of the conformational changes in platelet factor 4 induced by polyanions: towards in\u00a0vitro prediction of antigenicity","volume":"112","author":"Brandt","year":"2014","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.12.008_bib9","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1182\/blood-2014-03-559518","article-title":"Binding of anti-platelet factor 4\/heparin antibodies depends on the thermodynamics of conformational changes in platelet factor 4","volume":"124","author":"Kreimann","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.12.008_bib10","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41586-021-03744-4","article-title":"Antibody epitopes in vaccine-induced immune thrombotic thrombocytopaenia","volume":"596","author":"Huynh","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jtha.2023.12.008_bib11","doi-asserted-by":"crossref","first-page":"5206","DOI":"10.1038\/s41467-022-32946-1","article-title":"NETosis and thrombosis in vaccine-induced immune thrombotic thrombocytopenia","volume":"13","author":"Leung","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.jtha.2023.12.008_bib12","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1038\/s41467-019-09160-7","article-title":"Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia","volume":"10","author":"Perdomo","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jtha.2023.12.008_bib13","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/j.1538-7836.2007.02313.x","article-title":"SSC on Disseminated Intravascular Coagulation of the ISTH. The scoring system of the Scientific and Standardisation Committee on Disseminated Intravascular Coagulation of the International Society on Thrombosis and Haemostasis: a 5-year overview","volume":"5","author":"Toh","year":"2007","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.12.008_bib14","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1164\/rccm.201206-1037OC","article-title":"Circulating histones are mediators of trauma-associated lung injury","volume":"187","author":"Abrams","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jtha.2023.12.008_bib15","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1164\/rccm.201811-2111OC","article-title":"A\u00a0novel assay for neutrophil extracellular trap formation independently predicts disseminated intravascular coagulation and mortality in critically ill patients","volume":"200","author":"Abrams","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jtha.2023.12.008_bib16","doi-asserted-by":"crossref","first-page":"e677","DOI":"10.1097\/CCM.0000000000003839","article-title":"Circulating histones are major mediators of multiple organ dysfunction syndrome in acute critical illnesses","volume":"47","author":"Cheng","year":"2019","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jtha.2023.12.008_bib17","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1001\/jama.2016.0136","article-title":"Histone-associated thrombocytopenia in patients who are critically ill","volume":"315","author":"Alhamdi","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.jtha.2023.12.008_bib18","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1182\/blood-2008-04-153288","article-title":"Immune complexes formed following the binding of anti-platelet factor 4 (CXCL4) antibodies to CXCL4 stimulate human neutrophil activation and cell adhesion","volume":"112","author":"Xiao","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.12.008_bib19","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1053\/j.seminhematol.2022.02.005","article-title":"Platelet-activating anti-PF4 disorders: an overview","volume":"59","author":"Warkentin","year":"2022","journal-title":"Semin Hematol"},{"key":"10.1016\/j.jtha.2023.12.008_bib20","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41420-019-0188-0","article-title":"Platelet factor 4-containing immune complexes induce platelet activation followed by calpain-dependent platelet death","volume":"5","author":"Nevzorova","year":"2019","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.jtha.2023.12.008_bib21","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.1093\/eurheartj\/ehab506","article-title":"Immune complexes, innate immunity, and NETosis in ChAdOx1 vaccine-induced thrombocytopenia","volume":"42","author":"Holm","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jtha.2023.12.008_bib22","doi-asserted-by":"crossref","first-page":"140","DOI":"10.7861\/clinmed.2022-0006","article-title":"The aetiopathogenesis of vaccine-induced immune thrombotic thrombocytopenia","volume":"22","author":"Toh","year":"2022","journal-title":"Clin Med (Lond)"},{"key":"10.1016\/j.jtha.2023.12.008_bib23","article-title":"Rethinking coagulation: from enzymatic and cell-based reactions to a convergent model involving innate immune activation","author":"Yong","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.12.008_bib24","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.3324\/haematol.2021.278492","article-title":"Circulating histones play a central role in COVID-19-associated coagulopathy and mortality","volume":"106","author":"Shaw","year":"2021","journal-title":"Haematologica"},{"key":"10.1016\/j.jtha.2023.12.008_bib25","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1182\/blood.2019002973","article-title":"Assembly of alternative prothrombinase by extracellular histones initiates and disseminates intravascular coagulation","volume":"137","author":"Abrams","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.12.008_bib26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.bja.2021.10.039","article-title":"Reduction of NETosis by targeting CXCR1\/2 reduces thrombosis, lung injury, and mortality in experimental human and murine sepsis","volume":"128","author":"Alsabani","year":"2022","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.jtha.2023.12.008_bib27","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1111\/jth.13813","article-title":"Autoimmune heparin-induced thrombocytopenia","volume":"15","author":"Greinacher","year":"2017","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.12.008_bib28","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1182\/blood.2020007208","article-title":"Disseminated intravascular coagulation and its immune mechanisms","volume":"139","author":"Popescu","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.12.008_bib29","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2174\/1566523213666131125095046","article-title":"Adenovirus vectors for gene therapy, vaccination and cancer gene therapy","volume":"13","author":"Wold","year":"2013","journal-title":"Curr Gene Ther"},{"key":"10.1016\/j.jtha.2023.12.008_bib30","doi-asserted-by":"crossref","DOI":"10.1182\/blood.2023022136","article-title":"Anti-PF4 immunothrombosis without proximate heparin or adenovirus vector vaccine exposure","author":"Sch\u00f6nborn","year":"2023","journal-title":"Blood"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783623008735?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783623008735?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T10:32:01Z","timestamp":1711103521000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783623008735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S1538783623008735"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2023.12.008","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Damage-associated cellular markers in the clinical and pathogenic profile of vaccine-induced immune thrombotic thrombocytopenia","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2023.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}]}}