{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:22:34Z","timestamp":1785799354593,"version":"3.56.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:00:00Z","timestamp":1703721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/00065-PI22\/00436"],"award-info":[{"award-number":["PI19\/00065-PI22\/00436"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031670","name":"Sociedad Espa\u00f1ola de Trombosis y Hemostasia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031670","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004435","name":"Universidad de Navarra","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004435","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012513","name":"CIBERCV","doi-asserted-by":"publisher","award":["CB16\/11\/00483"],"award-info":[{"award-number":["CB16\/11\/00483"]}],"id":[{"id":"10.13039\/501100012513","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.jtha.2023.12.029","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T21:29:36Z","timestamp":1703885376000},"page":"1080-1093","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Role of factor XIII in ischemic stroke: a key molecule promoting thrombus stabilization and resistance to lysis"],"prefix":"10.1016","volume":"22","author":[{"given":"Juan","family":"Marta-Enguita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Navarro-Oviedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencio J.D.M.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca","family":"Bermejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Aymerich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Zandio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Pagola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Juega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Marta-Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose-Antonio","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose-Antonio","family":"P\u00e1ramo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Roncal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6300-7670","authenticated-orcid":false,"given":"Josune","family":"Orbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2023.12.029_bib1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1474-4422(19)30030-4","article-title":"The global burden of stroke: persistent and disabling","volume":"18","author":"Gorelick","year":"2019","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jtha.2023.12.029_bib2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1042\/CS20120233","article-title":"Substrates of factor XIII-A: roles in thrombosis and wound healing","volume":"124","author":"Richardson","year":"2013","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.jtha.2023.12.029_bib3","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/jth.12455","article-title":"The effect of blood coagulation factor XIII on fibrin clot structure and fibrinolysis","volume":"12","author":"Hethershaw","year":"2014","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.12.029_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2020.608899","article-title":"Alpha2-antiplasmin: the devil you don\u2019t know in cerebrovascular and cardiovascular disease","volume":"7","author":"Singh","year":"2020","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jtha.2023.12.029_bib5","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1212\/01.wnl.0000171704.50395.ba","article-title":"Hemostatic markers of recanalization in patients with ischemic stroke treated with rt-PA","volume":"65","author":"Mart\u00ed-Fabregas","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.jtha.2023.12.029_bib6","doi-asserted-by":"crossref","first-page":"6371","DOI":"10.1182\/blood-2011-02-333203","article-title":"The antifibrinolytic function of factor XIII is exclusively expressed through \u03b1\u2082-antiplasmin cross-linking","volume":"117","author":"Fraser","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.12.029_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.610696","article-title":"Insights into immunothrombosis: the interplay among neutrophil extracellular trap, von Willebrand factor, and ADAMTS13","volume":"11","author":"Yang","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jtha.2023.12.029_bib8","doi-asserted-by":"crossref","first-page":"27220","DOI":"10.1074\/jbc.273.42.27220","article-title":"Human procarboxypeptidase U, or thrombin-activable fibrinolysis inhibitor, is a substrate for transglutaminases. Evidence for transglutaminase-catalyzed cross-linking to fibrin","volume":"273","author":"Valnickova","year":"1998","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jtha.2023.12.029_bib9","doi-asserted-by":"crossref","first-page":"7520","DOI":"10.1074\/jbc.M109677200","article-title":"Incorporation of vitronectin into fibrin clots. Evidence for a binding interaction between vitronectin and gamma A\/gamma\u2019 fibrinogen","volume":"277","author":"Podor","year":"2002","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jtha.2023.12.029_bib10","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1055\/s-0040-1718760","article-title":"Extracellular histones inhibit fibrinolysis through noncovalent and covalent interactions with fibrin","volume":"121","author":"Locke","year":"2021","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.12.029_bib11","doi-asserted-by":"crossref","first-page":"7662","DOI":"10.1038\/s41598-018-26025-z","article-title":"Low factor XIII levels after intravenous thrombolysis predict short-term mortality in ischemic stroke patients","volume":"8","author":"Sz\u00e9kely","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtha.2023.12.029_bib12","doi-asserted-by":"crossref","first-page":"5089","DOI":"10.1182\/blood-2009-11-253062","article-title":"Sensitive and selective detection of free FXIII activation peptide: a potential marker of acute thrombotic events","volume":"115","author":"Ortner","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.12.029_bib13","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1160\/TH03-07-0031","article-title":"Role of blood coagulation factor XIII in patients with acute pulmonary embolism. Correlation of factor XIII antigen levels with pulmonary occlusion rate, fibrinogen, D-dimer, and clot firmness","volume":"90","author":"Kucher","year":"2003","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.12.029_bib14","doi-asserted-by":"crossref","first-page":"7579","DOI":"10.21037\/apm-21-1174","article-title":"Predictive value of coagulation factor XIII on bleeding risk in ischemic stroke patients treated with intravenous thrombolysis","volume":"10","author":"Zhang","year":"2021","journal-title":"Ann Palliat Med"},{"key":"10.1016\/j.jtha.2023.12.029_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biom11030347","article-title":"Incorporation of \u03b12-plasmin inhibitor into fibrin clots and its association with the clinical outcome of acute ischemic stroke patients","volume":"11","author":"Bagoly","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.jtha.2023.12.029_bib16","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1161\/STROKEAHA.108.541128","article-title":"Update of the stroke therapy academic industry roundtable preclinical recommendations","volume":"40","author":"Fisher","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.jtha.2023.12.029_bib17","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/jcbfm.2011.8","article-title":"Thrombotic distal middle cerebral artery occlusion produced by topical FeCl(3) application: a novel model suitable for intravital microscopy and thrombolysis studies","volume":"31","author":"Karatas","year":"2011","journal-title":"J\u00a0Cereb Blood Flow Metab"},{"key":"10.1016\/j.jtha.2023.12.029_bib18","doi-asserted-by":"crossref","first-page":"11930","DOI":"10.1002\/anie.201305133","article-title":"Structure of active coagulation factor XIII triggered by calcium binding: basis for the design of next-generation anticoagulants","volume":"52","author":"Stieler","year":"2013","journal-title":"Angew Chem Int Ed Engl"},{"key":"10.1016\/j.jtha.2023.12.029_bib19","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.jtha.2023.12.029_bib20","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1161\/CIRCRESAHA.121.319948","article-title":"Advances in acute ischemic stroke therapy","volume":"130","author":"Xiong","year":"2022","journal-title":"Circ Res"},{"key":"10.1016\/j.jtha.2023.12.029_bib21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/jth.14646","article-title":"Novel inhibitor ZED3197 as potential drug candidate in anticoagulation targeting coagulation FXIIIa (F13a)","volume":"18","author":"Pasternack","year":"2020","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.12.029_bib22","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41582-019-0221-1","article-title":"Thrombo-inflammation in acute ischaemic stroke - implications for treatment","volume":"15","author":"Stoll","year":"2019","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.jtha.2023.12.029_bib23","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1111\/jth.15668","article-title":"Activation mechanism dependent surface exposure of cellular factor XIII on activated platelets and platelet microparticles","volume":"20","author":"Somodi","year":"2022","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.12.029_bib24","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12959-023-00540-0","article-title":"Tranexamic acid for haemostasis and beyond: does dose matter?","volume":"21","author":"Lam","year":"2023","journal-title":"Thromb J"},{"key":"10.1016\/j.jtha.2023.12.029_bib25","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1161\/01.CIR.99.18.2440","article-title":"Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in mice","volume":"99","author":"Nagai","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2023.12.029_bib26","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nm1787","article-title":"Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke","volume":"14","author":"Su","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.jtha.2023.12.029_bib27","doi-asserted-by":"crossref","first-page":"4752","DOI":"10.1182\/blood-2011-07-369512","article-title":"t-PA\u2013specific modulation of a human blood-brain barrier model involves plasmin-mediated activation of the Rho kinase pathway in astrocytes","volume":"119","author":"Niego","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.12.029_bib28","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1046\/j.1460-9568.2000.00991.x","article-title":"Tissue plasminogen activator controls multiple forms of synaptic plasticity and memory","volume":"12","author":"Calabresi","year":"2000","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.jtha.2023.12.029_bib29","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/jcbfm.2014.99","article-title":"Plasmin-dependent modulation of the blood-brain barrier: a major consideration during tPA-induced thrombolysis?","volume":"34","author":"Niego","year":"2014","journal-title":"J\u00a0Cereb Blood Flow Metab"},{"key":"10.1016\/j.jtha.2023.12.029_bib30","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1172\/JCI200319212","article-title":"Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein","volume":"112","author":"Yepes","year":"2003","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jtha.2023.12.029_bib31","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/nm0295-138","article-title":"In\u00a0vitro stimulation of tissue-type plasminogen activator by Alzheimer amyloid beta-peptide analogues","volume":"1","author":"Kingston","year":"1995","journal-title":"Nat Med"},{"key":"10.1016\/j.jtha.2023.12.029_bib32","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1016\/j.febslet.2009.06.013","article-title":"Physiological responses to protein aggregates: fibrinolysis, coagulation and inflammation (new roles for old factors)","volume":"583","author":"Gebbink","year":"2009","journal-title":"FEBS Lett"},{"issue":"Suppl 3","key":"10.1016\/j.jtha.2023.12.029_bib33","first-page":"S168","article-title":"Anti-fibrinolytic agent tranexamic acid suppresses the endotoxin-induced expression of TNF\u03b1 and Il1\u03b1 genes in a plasmin-independent manner","volume":"63","author":"Kacer","year":"2023","journal-title":"Transfusion"},{"key":"10.1016\/j.jtha.2023.12.029_bib34","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1177\/1076029617713872","article-title":"The effect of ex\u00a0vivo factor XIII supplementation on clot formation in blood samples from cardiac and scoliosis surgery patients","volume":"24","author":"Hakimi","year":"2018","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1016\/j.jtha.2023.12.029_bib35","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1161\/STROKEAHA.117.019896","article-title":"Thrombus neutrophil extracellular traps content impair tPA-induced thrombolysis in acute ischemic stroke","volume":"49","author":"Ducroux","year":"2018","journal-title":"Stroke"},{"key":"10.1016\/j.jtha.2023.12.029_bib36","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1161\/STROKEAHA.119.026848","article-title":"Pharmacological modulation of neutrophil extracellular traps reverses thrombotic stroke tPA (tissue-type plasminogen activator) resistance","volume":"50","author":"Pe\u00f1a-Mart\u00ednez","year":"2019","journal-title":"Stroke"},{"key":"10.1016\/j.jtha.2023.12.029_bib37","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/1209676","article-title":"Inhibition of fibrinolysis by coagulation factor XIII","volume":"2017","author":"Rijken","year":"2017","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.jtha.2023.12.029_bib38","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1182\/blood-2015-06-652263","article-title":"Factor XIIIa-dependent retention of red blood cells in clots is mediated by fibrin \u03b1-chain crosslinking","volume":"126","author":"Byrnes","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.12.029_bib39","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1111\/j.1538-7836.2011.04203.x","article-title":"Hindered dissolution of fibrin formed under mechanical stress","volume":"9","author":"Varj\u00fa","year":"2011","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2023.12.029_bib40","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1172\/JCI110479","article-title":"Significance of cross-linking of alpha 2-plasmin inhibitor to fibrin in inhibition of fibrinolysis and in hemostasis","volume":"69","author":"Sakata","year":"1982","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jtha.2023.12.029_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112442","article-title":"Factor XIIIa inhibitors as potential novel drugs for venous thromboembolism","volume":"200","author":"Al-Horani","year":"2020","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.jtha.2023.12.029_bib42","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.1182\/blood-2014-06-583070","article-title":"Functional factor XIII-A is exposed on the stimulated platelet surface","volume":"124","author":"Mitchell","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2023.12.029_bib43","doi-asserted-by":"crossref","first-page":"e1686","DOI":"10.1212\/WNL.0000000000008395","article-title":"Acute ischemic stroke thrombi have an outer shell that impairs fibrinolysis","volume":"93","author":"Di Meglio","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.jtha.2023.12.029_bib44","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1161\/STROKEAHA.122.038733","article-title":"Thromboinflammation in brain ischemia: recent updates and future perspectives","volume":"53","author":"De Meyer","year":"2022","journal-title":"Stroke"},{"key":"10.1016\/j.jtha.2023.12.029_bib45","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/neurintsurg-2019-015410","article-title":"Platelet-rich emboli are associated with von Willebrand factor levels and have poorer revascularization outcomes","volume":"12","author":"Douglas","year":"2020","journal-title":"J\u00a0Neurointerv Surg"},{"key":"10.1016\/j.jtha.2023.12.029_bib46","doi-asserted-by":"crossref","first-page":"C951","DOI":"10.1152\/ajpcell.00252.2022","article-title":"Procoagulant platelets: novel players in thromboinflammation","volume":"323","author":"Denorme","year":"2022","journal-title":"Am J Physiol Cell Physiol"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783623009315?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783623009315?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:08:56Z","timestamp":1778818136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783623009315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S1538783623009315"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2023.12.029","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of factor XIII in ischemic stroke: a key molecule promoting thrombus stabilization and resistance to lysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2023.12.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}]}}