{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:15:34Z","timestamp":1762550134649,"version":"build-2065373602"},"reference-count":10,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.jtha.2024.03.028","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T19:39:25Z","timestamp":1721677165000},"page":"2363-2365","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["\u201cProthrombin conversion and thrombin decay in patients with cirrhosis\u2014role of prothrombin and antithrombin deficiencies\u201d: comment from de Laat-Kremers et\u00a0al."],"prefix":"10.1016","volume":"22","author":[{"given":"Romy","family":"de Laat-Kremers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bas","family":"de Laat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2024.03.028_bib1","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.jtha.2024.01.016","article-title":"Prothrombin conversion and thrombin decay in patients with cirrhosis-role of prothrombin and antithrombin deficiencies","volume":"22","author":"Sinegre","year":"2024","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.03.028_bib2","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.jhep.2021.11.004","article-title":"Haemostatic alterations and management of haemostasis in patients with cirrhosis","volume":"76","author":"Lisman","year":"2022","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jtha.2024.03.028_bib3","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1111\/jth.12706","article-title":"Cirrhosis patients have a coagulopathy that is associated with decreased clot formation capacity","volume":"12","author":"Kleinegris","year":"2014","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.03.028_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0177020","article-title":"Decreased prothrombin conversion and reduced thrombin inactivation explain rebalanced thrombin generation in liver cirrhosis","volume":"12","author":"Kremers","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jtha.2024.03.028_bib5","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1111\/jth.14011","article-title":"Increased factor VIII plays a significant role in plasma hypercoagulability phenotype of patients with cirrhosis","volume":"16","author":"Sinegre","year":"2018","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.03.028_bib6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.thromres.2012.10.011","article-title":"Data management in thrombin generation","volume":"131","author":"Hemker","year":"2013","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2024.03.028_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-69415-y","article-title":"Deciphering the coagulation profile through the dynamics of thrombin activity","volume":"10","author":"de Laat-Kremers","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtha.2024.03.028_bib8","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1055\/s-0038-1656338","article-title":"The consumption of antithrombin III during coagulation, its consequences for the calculation of prothrombinase activity and the standardisation of heparin activity","volume":"68","author":"B\u00e9guin","year":"1992","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.03.028_bib9","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/jth.12798","article-title":"The balance of pro- and anticoagulant processes underlying thrombin generation","volume":"13","author":"Kremers","year":"2015","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.03.028_bib10","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1111\/liv.15001","article-title":"Coagulopathy is not predictive of bleeding in patients with acute decompensation of cirrhosis and acute-on-chronic liver failure","volume":"41","author":"Campello","year":"2021","journal-title":"Liver Int"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783624002435?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783624002435?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:11:13Z","timestamp":1762549873000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783624002435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S1538783624002435"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2024.03.028","relation":{},"ISSN":["1538-7836"],"issn-type":[{"type":"print","value":"1538-7836"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u201cProthrombin conversion and thrombin decay in patients with cirrhosis\u2014role of prothrombin and antithrombin deficiencies\u201d: comment from de Laat-Kremers et\u00a0al.","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2024.03.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2024.01.016","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}