{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:59:41Z","timestamp":1789581581917,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300540"],"award-info":[{"award-number":["82300540"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100422"],"award-info":[{"award-number":["82100422"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170509"],"award-info":[{"award-number":["82170509"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170411"],"award-info":[{"award-number":["82170411"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["21YF1423100"],"award-info":[{"award-number":["21YF1423100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018625","name":"Science and Technology Innovation Plan Of Shanghai Science and Technology Commission","doi-asserted-by":"publisher","award":["21Y11909500"],"award-info":[{"award-number":["21Y11909500"]}],"id":[{"id":"10.13039\/501100018625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018625","name":"Science and Technology Innovation Plan Of Shanghai Science and Technology Commission","doi-asserted-by":"publisher","award":["20Y11909600"],"award-info":[{"award-number":["20Y11909600"]}],"id":[{"id":"10.13039\/501100018625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007279","name":"Shanghai Municipal Health Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007279","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jtha.2024.09.012","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T19:04:14Z","timestamp":1727723054000},"page":"325-340","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Antiproliferative agent attenuates postthrombotic vein wall remodeling in murine and human subjects"],"prefix":"10.1016","volume":"23","author":[{"given":"Hongji","family":"Pu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junchao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenshu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoliang","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijue","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinwu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2024.09.012_bib1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/jth.13569","article-title":"The postthrombotic syndrome: current evidence and future challenges","volume":"15","author":"Rabinovich","year":"2017","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.09.012_bib2","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1161\/CIR.0000000000000130","article-title":"Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing. The postthrombotic syndrome: evidence-based prevention, diagnosis, and treatment strategies: a scientific statement from the American Heart Association","volume":"130","author":"Kahn","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2024.09.012_bib3","first-page":"441","article-title":"The occurrence of the post-thrombotic changes after an acute deep venous thrombosis. A prospective two-year follow-up study","volume":"41","author":"Saarinen","year":"2000","journal-title":"J\u00a0Cardiovasc Surg (Torino)"},{"key":"10.1016\/j.jtha.2024.09.012_bib4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/ajh.21917","article-title":"Prevalence of clinical venous thromboembolism in the USA: current trends and future projections","volume":"86","author":"Deitelzweig","year":"2011","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jtha.2024.09.012_bib5","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1111\/j.1538-7836.2011.04516.x","article-title":"Economic burden and cost determinants of deep vein thrombosis during 2 years following diagnosis: a prospective evaluation","volume":"9","author":"Guanella","year":"2011","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.09.012_bib6","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/pbc.24840","article-title":"Health-related quality of life in children and young adults with post-thrombotic syndrome: results from a cross-sectional study","volume":"61","author":"Kumar","year":"2014","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.jtha.2024.09.012_bib7","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.2146\/ajhp060388","article-title":"Economic burden of deep-vein thrombosis, pulmonary embolism, and post-thrombotic syndrome","volume":"63","author":"MacDougall","year":"2006","journal-title":"Am J Health Syst Pharm"},{"key":"10.1016\/j.jtha.2024.09.012_bib8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejvs.2020.09.023","article-title":"Editor\u2019s choice\u2014European Society for Vascular Surgery (ESVS) 2021 clinical practice guidelines on the management of venous thrombosis","volume":"61","author":"Kakkos","year":"2021","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jtha.2024.09.012_bib9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1177\/1526602816676803","article-title":"Patency and clinical outcomes of a dedicated, self-expanding, hybrid oblique stent used in the treatment of common iliac vein compression","volume":"24","author":"Stuck","year":"2017","journal-title":"J\u00a0Endovasc Ther"},{"key":"10.1016\/j.jtha.2024.09.012_bib10","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.ejvs.2015.05.011","article-title":"Short-term clinical experience with a dedicated venous nitinol stent: initial results with the sinus-venous stent","volume":"50","author":"de Wolf","year":"2015","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jtha.2024.09.012_bib11","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.thromres.2017.07.008","article-title":"Prevention and treatment of the post-thrombotic syndrome","volume":"164","author":"Pikovsky","year":"2018","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2024.09.012_bib12","doi-asserted-by":"crossref","first-page":"550","DOI":"10.2174\/1381612828666220131094655","article-title":"Management of post-thrombotic syndrome: a comprehensive review","volume":"28","author":"Chaitidis","year":"2022","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.jtha.2024.09.012_bib13","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jvs.2005.04.014","article-title":"Vein wall remodeling after deep vein thrombosis involves matrix metalloproteinases and late fibrosis in a mouse model","volume":"42","author":"Deatrick","year":"2005","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jtha.2024.09.012_bib14","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1160\/TH05-02-0099","article-title":"Neutrophils modulate post-thrombotic vein wall remodeling but not thrombus neovascularization","volume":"95","author":"Henke","year":"2006","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.09.012_bib15","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1160\/TH10-03-0183","article-title":"The vessel wall: a forgotten player in post thrombotic syndrome","volume":"104","author":"Deroo","year":"2010","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.09.012_bib16","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jvs.2010.07.043","article-title":"Postthrombotic vein wall remodeling: preliminary observations","volume":"53","author":"Deatrick","year":"2011","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jtha.2024.09.012_bib17","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s42003-023-04492-z","article-title":"A\u00a0vein wall cell atlas of murine venous thrombosis determined by single-cell RNA sequencing","volume":"6","author":"DeRoo","year":"2023","journal-title":"Commun Biol"},{"key":"10.1016\/j.jtha.2024.09.012_bib18","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s11239-015-1312-5","article-title":"Guidance for the prevention and treatment of the post-thrombotic syndrome","volume":"41","author":"Kahn","year":"2016","journal-title":"J\u00a0Thromb Thrombolysis"},{"key":"10.1016\/j.jtha.2024.09.012_bib19","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1161\/CIRCULATIONAHA.120.049096","article-title":"Time-restricted salutary effects of blood flow restoration on venous thrombosis and vein wall injury in mouse and human subjects","volume":"143","author":"Li","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2024.09.012_bib20","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/j.1538-7836.2009.03294.x","article-title":"Definition of post-thrombotic syndrome of the leg for use in clinical investigations: a recommendation for standardization","volume":"7","author":"Kahn","year":"2009","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.09.012_bib21","doi-asserted-by":"crossref","first-page":"2s","DOI":"10.1016\/j.jvs.2011.05.117","article-title":"Validation of Venous Clinical Severity Score (VCSS) with other venous severity assessment tools from the American Venous Forum, National Venous Screening Program","volume":"54","author":"Passman","year":"2011","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jtha.2024.09.012_bib22","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1161\/01.RES.86.8.879","article-title":"Arterial paclitaxel distribution and deposition","volume":"86","author":"Creel","year":"2000","journal-title":"Circ Res"},{"key":"10.1016\/j.jtha.2024.09.012_bib23","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jconrel.2016.08.018","article-title":"Materials technology in drug eluting balloons: current and future perspectives","volume":"239","author":"Xiong","year":"2016","journal-title":"J\u00a0Control Release"},{"key":"10.1016\/j.jtha.2024.09.012_bib24","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.jvsv.2019.01.062","article-title":"Update on diagnosis and treatment strategies in patients with post-thrombotic syndrome due to chronic venous obstruction and role of endovenous recanalization","volume":"7","author":"Schleimer","year":"2019","journal-title":"J\u00a0Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.jtha.2024.09.012_bib25","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1161\/01.CIR.96.2.636","article-title":"Paclitaxel inhibits arterial smooth muscle cell proliferation and migration in\u00a0vitro and in\u00a0vivo using local drug delivery","volume":"96","author":"Axel","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2024.09.012_bib26","first-page":"132","article-title":"Vascular, downstream, and pharmacokinetic responses to treatment with a low dose drug-coated balloon in a swine femoral artery model","volume":"83","author":"Yazdani","year":"2014","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jtha.2024.09.012_bib27","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1161\/CIRCULATIONAHA.114.011004","article-title":"Drug-coated balloon versus standard percutaneous transluminal angioplasty for the treatment of superficial femoral and popliteal peripheral artery disease: 12-month results from the IN.PACT SFA randomized trial","volume":"131","author":"Tepe","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2024.09.012_bib28","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jacc.2022.10.016","article-title":"Comparison of drug-coated balloons vs bare-metal stents in patients with femoropopliteal arterial disease","volume":"81","author":"Shishehbor","year":"2023","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jtha.2024.09.012_bib29","first-page":"170","article-title":"Structural and temporal dynamics analysis on drug-eluting stents: history, research hotspots and emerging trends","volume":"23","author":"Tan","year":"2023","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jtha.2024.09.012_bib30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1056\/NEJMoa1406235","article-title":"Trial of a Paclitaxel-Coated Balloon for Femoropopliteal Artery Disease","volume":"373","author":"Rosenfield","year":"2015","journal-title":"New Engl J Med"},{"key":"10.1016\/j.jtha.2024.09.012_bib31","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.jvsv.2016.03.005","article-title":"Alterations in macrophage phenotypes in experimental venous thrombosis","volume":"4","author":"Gallagher","year":"2016","journal-title":"J\u00a0Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.jtha.2024.09.012_bib32","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/jth.15134","article-title":"The role of platelets in thrombus fibrosis and vessel wall remodeling after venous thrombosis","volume":"19","author":"DeRoo","year":"2021","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.09.012_bib33","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/MBC.0000000000000567","article-title":"Simvastatin ameliorates deep vein thrombosis in rabbits by regulating the fibrinolytic system","volume":"27","author":"Feng","year":"2016","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.jtha.2024.09.012_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116621","article-title":"Statins improve the resolution of established murine venous thrombosis: reductions in thrombus burden and vein wall scarring","volume":"10","author":"Kessinger","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jtha.2024.09.012_bib35","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jvsv.2018.10.020","article-title":"Statin therapy associated with improved thrombus resolution in patients with deep vein thrombosis","volume":"7","author":"Hsu","year":"2019","journal-title":"J\u00a0Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.jtha.2024.09.012_bib36","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-\u03b2: the master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.jtha.2024.09.012_bib37","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.210356","article-title":"Functions of exogenous FGF signals in regulation of fibroblast to myofibroblast differentiation and extracellular matrix protein expression","volume":"12","author":"Sun","year":"2022","journal-title":"Open Biol"},{"key":"10.1016\/j.jtha.2024.09.012_bib38","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00109-022-02194-3","article-title":"Anti-fibrotic effects of pharmacologic FGF-2: a review of recent literature","volume":"100","author":"Dolivo","year":"2022","journal-title":"J\u00a0Mol Med"},{"key":"10.1016\/j.jtha.2024.09.012_bib39","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abe0407","article-title":"TGF\u03b22 and TGF\u03b23 isoforms drive fibrotic disease pathogenesis","volume":"13","author":"Sun","year":"2021","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jtha.2024.09.012_bib40","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1152\/physrev.00021.2018","article-title":"Endothelial to mesenchymal transition: role in physiology and in the pathogenesis of human diseases","volume":"99","author":"Piera-Velazquez","year":"2019","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jtha.2024.09.012_bib41","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1111\/jth.13793","article-title":"Vein wall remodeling in patients with acute deep vein thrombosis and chronic postthrombotic changes","volume":"15","author":"Chandrashekar","year":"2017","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.09.012_bib42","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1161\/ATVBAHA.118.311818","article-title":"Choosing a mouse model of venous thrombosis","volume":"39","author":"Diaz","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783624005592?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783624005592?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T02:39:06Z","timestamp":1767235146000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783624005592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S1538783624005592"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2024.09.012","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antiproliferative agent attenuates postthrombotic vein wall remodeling in murine and human subjects","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2024.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}