{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T22:49:44Z","timestamp":1776379784822,"version":"3.51.2"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001422","name":"American Society of Hematology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001422","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012866","name":"University of Calgary Cumming School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012866","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008322","name":"CSL Behring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031571","name":"Libin Cardiovascular Institute, University of Calgary","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031571","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jtha.2024.09.037","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T11:59:02Z","timestamp":1729684742000},"page":"429-439","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pregnancy loss in individuals with von Willebrand disease and unspecified mucocutaneous bleeding disorders: a multicenter cohort study"],"prefix":"10.1016","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5587-398X","authenticated-orcid":false,"given":"Leslie","family":"Skeith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"James","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kouides","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelsey","family":"Uminski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Duffett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Sholzberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret V.","family":"Ragni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Cuker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maeve","family":"O\u2019Beirne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Hews-Girard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Rydz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn M.","family":"Goodyear","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"Baxter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andra","family":"James","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara K.","family":"Vesely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man-Chiu","family":"Poon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2024.09.037_bib1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1182\/bloodadvances.2020003265","article-title":"ASH ISTH NHF WFH 2021 guidelines on the diagnosis of von Willebrand disease","volume":"5","author":"James","year":"2021","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtha.2024.09.037_bib2","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1365-2516.2012.02750.x","article-title":"Assessment of von Willebrand disease as a risk factor for primary postpartum haemorrhage","volume":"18","author":"Chee","year":"2012","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2024.09.037_bib3","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1097\/MBC.0b013e3283566af9","article-title":"Impact of inherited bleeding disorders on pregnancy and postpartum hemorrhage","volume":"23","author":"Shahbazi","year":"2012","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.jtha.2024.09.037_bib4","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1111\/hae.14594","article-title":"Determining the incidence of postpartum haemorrhage among Ontario women with and without inherited bleeding disorders: a population-based cohort study","volume":"28","author":"Hews-Girard","year":"2022","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2024.09.037_bib5","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1111\/j.1538-7836.2007.02563.x","article-title":"Bleeding events and other complications during pregnancy and childbirth in women with von Willebrand disease","volume":"5","author":"James","year":"2007","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.09.037_bib6","doi-asserted-by":"crossref","first-page":"e399","DOI":"10.1111\/hae.12029","article-title":"Reply to von Willebrand\u2019s disease and postpartum haemorrhage by Chee et\u00a0al","volume":"18","author":"Davies","year":"2012","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2024.09.037_bib7","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1365-2516.2011.02625.x","article-title":"Changes in the levels of factor VIII and von Willebrand factor in the puerperium","volume":"18","author":"Huq","year":"2012","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2024.09.037_bib8","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1046\/j.1365-2516.2003.00756.x","article-title":"Medical, reproductive and psychosocial experiences of women diagnosed with von Willebrand\u2019s disease receiving care in haemophilia treatment centres: a case-control study","volume":"9","author":"Kirtava","year":"2003","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2024.09.037_bib9","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1471-0528.1998.tb10093.x","article-title":"Pregnancy in women with von Willebrand\u2019s disease or factor XI deficiency","volume":"105","author":"Kadir","year":"1998","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.jtha.2024.09.037_bib10","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1111\/j.1365-2141.2000.02507.x","article-title":"Clinical manifestations and complications of childbirth and replacement therapy in 385 Iranian patients with type 3 von Willebrand disease","volume":"111","author":"Lak","year":"2000","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2024.09.037_bib11","first-page":"944","article-title":"Significant improvement of live birth rate in VWD patients with repetitive reproductive failure treated with VWF concentrate","volume":"11","author":"Von Depka Prondzinski","year":"2013","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.09.037_bib12","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.1016\/S0049-3848(13)70143-9","article-title":"P-097 Von Willebrand\u2019s disease and recurrent 1st trimester miscarriage: successful outcome after administration of von Willebrand factor","volume":"131","author":"Vakalopoulou","year":"2013","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2024.09.037_bib13","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.repbio.2019.09.007","article-title":"Expression of angiogenic factors in the uteroplacental unit is altered at time of placentation in a porcine model of von Willebrand disease type 1","volume":"19","author":"Allerkamp","year":"2019","journal-title":"Reprod Biol"},{"key":"10.1016\/j.jtha.2024.09.037_bib14","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.placenta.2014.01.007","article-title":"Increased placental angiogenesis in late and early onset pre-eclampsia is associated with differential activation of vascular endothelial growth factor receptor 2","volume":"35","author":"Escudero","year":"2014","journal-title":"Placenta"},{"key":"10.1016\/j.jtha.2024.09.037_bib15","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/MBC.0000000000000620","article-title":"Pregnancy loss in women with von Willebrand disease: a single-center pilot study","volume":"28","author":"Skeith","year":"2017","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.jtha.2024.09.037_bib16","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1111\/j.1538-7836.2008.03182.x","article-title":"Generation and validation of the condensed MCMDM-1VWD bleeding questionnaire for von Willebrand disease","volume":"6","author":"Bowman","year":"2008","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.09.037_bib17","first-page":"1","article-title":"Fitting linear mixed-effects models using lme4","volume":"6","author":"Bates","year":"2015","journal-title":"J\u00a0Stat Softw"},{"key":"10.1016\/j.jtha.2024.09.037_bib18","series-title":"A\u00a0language and environment for statistical computing","year":"2023"},{"key":"10.1016\/j.jtha.2024.09.037_bib19","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/S0140-6736(21)00682-6","article-title":"Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss","volume":"397","author":"Quenby","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jtha.2024.09.037_bib20","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1136\/bmj.320.7251.1708","article-title":"Maternal age and fetal loss: population based register linkage study","volume":"320","author":"Nybo Andersen","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.jtha.2024.09.037_bib21","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1182\/blood-2010-01-264507","article-title":"Endothelial von Willebrand factor regulates angiogenesis","volume":"117","author":"Starke","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2024.09.037_bib22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/bjh.12272","article-title":"Von Willebrand disease-associated angiodysplasia: a few answers, still many questions","volume":"161","author":"Franchini","year":"2013","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2024.09.037_bib23","article-title":"Disrupted balance of angiogenic and antiangiogenic signalings in preeclampsia","volume":"2011","author":"Furuya","year":"2011","journal-title":"J\u00a0Pregnancy"},{"key":"10.1016\/j.jtha.2024.09.037_bib24","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1007\/s43032-021-00763-4","article-title":"Placenta percreta presents with neoangiogenesis of arteries with von Willebrand factor-negative endothelium","volume":"29","author":"Schwickert","year":"2022","journal-title":"Reprod Sci"},{"key":"10.1016\/j.jtha.2024.09.037_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.repbio.2022.100700","article-title":"Influence of Von Willebrand Disease (VWD) and pregnancy on the expression of angiogenic factors in the porcine female reproductive tract","volume":"22","author":"M\u00f6ller","year":"2022","journal-title":"Reprod Biol"},{"key":"10.1016\/j.jtha.2024.09.037_bib26","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1182\/blood.2020010038","article-title":"How I treat bleeding disorder of unknown cause","volume":"138","author":"Baker","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2024.09.037_bib27","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1111\/jth.15871","article-title":"Outcomes and management of pregnancy in women with bleeding disorder of unknown cause","volume":"20","author":"Castle","year":"2022","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.09.037_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.transci.2023.103730","article-title":"Bleeding disorder of unknown cause: results from Iranian study","volume":"62","author":"Zafarani","year":"2023","journal-title":"Transfus Apher Sci"},{"key":"10.1016\/j.jtha.2024.09.037_bib29","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1111\/hae.13775","article-title":"The bleeding score: useful in predicting spontaneous bleeding events in adults with bleeding of unknown cause?","volume":"26","author":"Relke","year":"2020","journal-title":"Haemophilia"},{"issue":"Suppl 1","key":"10.1016\/j.jtha.2024.09.037_bib30","first-page":"615","article-title":"Unclassified bleeding disorder (UBD)-bleeding phenotype and management","volume":"4","author":"Turan","year":"2020","journal-title":"Res Pract Thromb Haemost"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783624006275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783624006275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:10:59Z","timestamp":1762549859000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783624006275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S1538783624006275"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2024.09.037","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pregnancy loss in individuals with von Willebrand disease and unspecified mucocutaneous bleeding disorders: a multicenter cohort study","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2024.09.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}]}}