{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T09:04:22Z","timestamp":1774256662779,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.jtha.2024.11.005","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T21:49:04Z","timestamp":1732312144000},"page":"1207-1214","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Choosing the optimal oral anticoagulant for stroke prevention in atrial fibrillation: direct oral anticoagulants vs vitamin K antagonists"],"prefix":"10.1016","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1111-919X","authenticated-orcid":false,"given":"Stephanie","family":"Carlin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noel","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Godoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinai","family":"Bhagirath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Hirsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Eikelboom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2024.11.005_bib1","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJMoa0905561","article-title":"Dabigatran versus warfarin in patients with atrial fibrillation","volume":"361","author":"Connolly","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtha.2024.11.005_bib2","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJMoa1009638","article-title":"Rivaroxaban versus warfarin in nonvalvular atrial fibrillation","volume":"365","author":"Patel","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtha.2024.11.005_bib3","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1056\/NEJMoa1107039","article-title":"Apixaban versus warfarin in patients with atrial fibrillation","volume":"365","author":"Granger","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtha.2024.11.005_bib4","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1056\/NEJMoa1310907","article-title":"Edoxaban versus warfarin in patients with atrial fibrillation","volume":"369","author":"Giugliano","year":"2013","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtha.2024.11.005_bib5","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0140-6736(13)62343-0","article-title":"Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials","volume":"383","author":"Ruff","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.jtha.2024.11.005_bib6","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jacc.2023.10.038","article-title":"When direct oral anticoagulants should not be standard treatment: JACC state-of-the-art review","volume":"83","author":"Bejjani","year":"2024","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jtha.2024.11.005_bib7","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1136\/heartjnl-2017-311425","article-title":"Management of atrial fibrillation in patients with rheumatic mitral stenosis","volume":"104","author":"Iung","year":"2018","journal-title":"Heart"},{"key":"10.1016\/j.jtha.2024.11.005_bib8","doi-asserted-by":"crossref","first-page":"857","DOI":"10.7326\/0003-4819-146-12-200706190-00007","article-title":"Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation","volume":"146","author":"Hart","year":"2007","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jtha.2024.11.005_bib9","first-page":"e72","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"143","author":"Otto","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2024.11.005_bib10","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"43","author":"Vahanian","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jtha.2024.11.005_bib11","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1093\/eurheartj\/ehu449","article-title":"Characteristics, complications, and gaps in evidence-based interventions in rheumatic heart disease: the Global Rheumatic Heart Disease Registry (the REMEDY study)","volume":"36","author":"Z\u00fchlke","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jtha.2024.11.005_bib12","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1056\/NEJMoa2209051","article-title":"Rivaroxaban in rheumatic heart disease-associated atrial fibrillation","volume":"387","author":"Connolly","year":"2022","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtha.2024.11.005_bib13","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/CIR.0000000000001193","article-title":"2023 ACC\/AHA\/ACCP\/HRS Guideline for the diagnosis and management of atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"149","author":"Joglar","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2024.11.005_bib14","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1093\/eurheartj\/ehae176","article-title":"2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"45","author":"Van Gelder","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jtha.2024.11.005_bib15","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1001\/jamacardio.2016.0199","article-title":"Outcomes in a warfarin-treated population with atrial fibrillation","volume":"1","author":"Bj\u00f6rck","year":"2016","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jtha.2024.11.005_bib16","first-page":"16","article-title":"Comparison of anticoagulation clinic patient outcomes with outcomes from traditional care in a family medicine clinic","volume":"14","author":"Chamberlain","year":"2001","journal-title":"J\u00a0Am Board Fam Pract"},{"key":"10.1016\/j.jtha.2024.11.005_bib17","first-page":"293","article-title":"Comparing the quality of oral anticoagulant management by anticoagulation clinics and by family physicians: a randomized controlled trial","volume":"169","author":"Wilson","year":"2003","journal-title":"CMAJ"},{"key":"10.1016\/j.jtha.2024.11.005_bib18","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1056\/NEJMoa1300615","article-title":"Dabigatran versus warfarin in patients with mechanical heart valves","volume":"369","author":"Eikelboom","year":"2013","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtha.2024.11.005_bib19","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1160\/th14-03-0284","article-title":"Efficacy and safety of early parenteral anticoagulation as a bridge to warfarin after mechanical valve replacement","volume":"112","author":"Mathew","year":"2014","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.11.005_bib20","doi-asserted-by":"crossref","DOI":"10.1056\/EVIDoa2300067","article-title":"Apixaban or warfarin in patients with an on-X mechanical aortic valve","volume":"2","author":"Wang","year":"2023","journal-title":"NEJM Evid"},{"key":"10.1016\/j.jtha.2024.11.005_bib21","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1056\/NEJMoa2029603","article-title":"Rivaroxaban in patients with atrial fibrillation and a bioprosthetic mitral valve","volume":"383","author":"Guimar\u00e3es","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtha.2024.11.005_bib22","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1055\/s-0040-1716540","article-title":"Edoxaban versus warfarin in patients with atrial fibrillation at the extremes of body weight: an analysis from the ENGAGE AF-TIMI 48 trial","volume":"121","author":"Boriani","year":"2021","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.11.005_bib23","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1002\/psp4.12347","article-title":"Population pharmacokinetics of apixaban in subjects with nonvalvular atrial fibrillation","volume":"7","author":"Cirincione","year":"2018","journal-title":"CPT Pharmacometrics Syst Pharmacol"},{"key":"10.1016\/j.jtha.2024.11.005_bib24","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1161\/CIRCULATIONAHA.118.037955","article-title":"Efficacy and safety of apixaban versus warfarin in patients with atrial fibrillation and extremes in body weight","volume":"139","author":"Hohnloser","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2024.11.005_bib25","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.jacep.2021.02.002","article-title":"Outcomes of direct oral anticoagulants in atrial fibrillation patients across different body mass index categories","volume":"7","author":"Barakat","year":"2021","journal-title":"JACC Clin Electrophysiol"},{"issue":"24","key":"10.1016\/j.jtha.2024.11.005_bib26","article-title":"Treatment of atrial fibrillation and venous thromboembolism with factor Xa inhibitors in severely obese patients","volume":"S1538-7836","author":"Dobry","year":"2024","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.11.005_bib27","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1161\/CIRCULATIONAHA.123.066279","article-title":"Efficacy and safety of non-vitamin-K antagonist oral anticoagulants versus warfarin across the spectrum of body mass index and body weight: an individual patient data meta-analysis of 4 randomized clinical trials of patients with atrial fibrillation","volume":"149","author":"Patel","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2024.11.005_bib28","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1161\/HYPERTENSIONAHA.115.06254","article-title":"Growth arrest-specific 6 exacerbates pressure overload-induced cardiac hypertrophy","volume":"67","author":"Zhao","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.jtha.2024.11.005_bib29","first-page":"279","article-title":"Safety of switching from a vitamin K antagonist to a non-vitamin K antagonist oral anticoagulant in frail older patients with atrial fibrillation: results of the FRAIL-AF randomized controlled trial","volume":"149","author":"Joosten","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2024.11.005_bib30","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.arr.2018.10.006","article-title":"Overview of oral antithrombotic treatment in elderly patients with atrial fibrillation","volume":"49","author":"Kato","year":"2019","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jtha.2024.11.005_bib31","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1093\/eurheartj\/ehad200","article-title":"Outcomes of patients with atrial fibrillation and ischemic stroke while on oral anticoagulation","volume":"44","author":"Benz","year":"2023","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jtha.2024.11.005_bib32","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.jfma.2023.10.007","article-title":"Direct oral anticoagulants compared with other strategies in patients with atrial fibrillation and stroke or transient ischemic attack: systematic review","volume":"123","author":"Lee","year":"2024","journal-title":"J\u00a0Formos Med Assoc"},{"key":"10.1016\/j.jtha.2024.11.005_bib33","first-page":"e358","article-title":"Association of alternative anticoagulation strategies and outcomes in patients with ischemic stroke while taking a direct oral anticoagulant","volume":"101","author":"Ip","year":"2023","journal-title":"Neurology"},{"key":"10.1016\/j.jtha.2024.11.005_bib34","article-title":"Changing or retaining direct oral anticoagulant after ischemic stroke despite direct oral anticoagulant treatment","volume":"13","author":"Lin","year":"2024","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jtha.2024.11.005_bib35","article-title":"Anticoagulation strategy for patients presenting with ischemic strokes while using a direct oral anticoagulant: a systematic review and meta-analysis","author":"Mota Telles","year":"2024","journal-title":"Int J Stroke"},{"key":"10.1016\/j.jtha.2024.11.005_bib36","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1056\/NEJMoa2101897","article-title":"Left atrial appendage occlusion during cardiac surgery to prevent stroke","volume":"384","author":"Whitlock","year":"2021","journal-title":"N\u00a0Engl J Med"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783624006950?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783624006950?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T08:23:28Z","timestamp":1774254208000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783624006950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S1538783624006950"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2024.11.005","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Choosing the optimal oral anticoagulant for stroke prevention in atrial fibrillation: direct oral anticoagulants vs vitamin K antagonists","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2024.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}]}}