{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:33:09Z","timestamp":1792251189527,"version":"4.4.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.jtha.2024.12.006","type":"journal-article","created":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T03:35:38Z","timestamp":1734147338000},"page":"997-1008","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Assessment of a next generation sequencing gene panel strategy in 133 patients with negative thrombophilia screening"],"prefix":"10.1016","volume":"23","author":[{"given":"Pierre","family":"Suchon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Soukarieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Mariotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Ernest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Barthet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9mie","family":"Saut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Theron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Biron-Andr\u00e9ani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie Y.","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Catella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Simon","family":"Rohrlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Blanc-Jouvan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Le Cam Duchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loubna","family":"Dari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David-Alexandre","family":"Tr\u00e9gou\u00ebt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Emmanuel","family":"Morange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2024.12.006_bib1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/01.EDE.0000060457.51194.BC","article-title":"Major genetic susceptibility for venous thromboembolism in men: a study of Danish twins","volume":"14","author":"Larsen","year":"2003","journal-title":"Epidemiology"},{"key":"10.1016\/j.jtha.2024.12.006_bib2","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1161\/01.CIR.101.13.1546","article-title":"Genetic determinants of hemostasis phenotypes in Spanish families","volume":"101","author":"Souto","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2024.12.006_bib3","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1161\/CIRCULATIONAHA.110.965020","article-title":"Age- and gender-specific familial risks for venous thromboembolism: a nationwide epidemiological study based on hospitalizations in Sweden","volume":"124","author":"Z\u00f6ller","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2024.12.006_bib4","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1161\/CIRCULATIONAHA.122.059675","article-title":"Cross-ancestry investigation of venous thromboembolism genomic predictors","volume":"146","author":"Thibord","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2024.12.006_bib5","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1056\/NEJMoa0904377","article-title":"X-linked thrombophilia with a mutant factor IX (factor IX Padua)","volume":"361","author":"Simioni","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtha.2024.12.006_bib6","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1111\/jth.15274","article-title":"Severe thrombophilia in a factor V-deficient patient homozygous for the Ala2086Asp mutation (FV Besan\u00e7on)","volume":"19","author":"Castoldi","year":"2021","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.12.006_bib7","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1056\/NEJMoa1201994","article-title":"Thrombosis from a prothrombin mutation conveying antithrombin resistance","volume":"366","author":"Miyawaki","year":"2012","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtha.2024.12.006_bib8","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1111\/jth.12367","article-title":"A\u00a0novel prothrombin mutation in two families with prominent thrombophilia\u2013the first cases of antithrombin resistance in a Caucasian population","volume":"11","author":"Djordjevic","year":"2013","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.12.006_bib9","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1161\/ATVBAHA.115.306914","article-title":"New prothrombin mutation (Arg596Trp, Prothrombin Padua 2) associated with venous thromboembolism","volume":"36","author":"Bulato","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jtha.2024.12.006_bib10","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1182\/blood.2020008168","article-title":"Partial F8 gene duplication (factor VIII Padua) associated with high factor VIII levels and familial thrombophilia","volume":"137","author":"Simioni","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2024.12.006_bib11","first-page":"133","article-title":"Prescribing and performing a biological assessment for thrombophilia: GFHT 2022 proposals Part I: clinical aspects and prescription in classic venous thromboembolic disease","volume":"4","author":"Trillot","year":"2022","journal-title":"Rev Francoph H\u00e9most Thromb"},{"key":"10.1016\/j.jtha.2024.12.006_bib12","doi-asserted-by":"crossref","first-page":"e1009284","DOI":"10.1371\/journal.pgen.1009284","article-title":"A\u00a0rare coding mutation in the MAST2 gene causes venous thrombosis in a French family with unexplained thrombophilia: the Breizh MAST2 Arg89Gln variant","volume":"17","author":"Morange","year":"2021","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jtha.2024.12.006_bib13","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.ajhg.2015.01.019","article-title":"Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism","volume":"96","author":"Germain","year":"2015","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jtha.2024.12.006_bib14","doi-asserted-by":"crossref","first-page":"W545","DOI":"10.1093\/nar\/gky471","article-title":"VarAFT: a variant annotation and filtration system for human next generation sequencing data","volume":"46","author":"Desvignes","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jtha.2024.12.006_bib15","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41431-020-00755-z","article-title":"MobiDetails: online DNA variants interpretation","volume":"29","author":"Baux","year":"2021","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.jtha.2024.12.006_bib16","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1002\/humu.24491","article-title":"SPiP: Splicing Prediction Pipeline, a machine learning tool for massive detection of exonic and intronic variant effects on mRNA splicing","volume":"43","author":"Leman","year":"2022","journal-title":"Hum Mutat"},{"key":"10.1016\/j.jtha.2024.12.006_bib17","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.cell.2018.12.015","article-title":"Predicting splicing from primary sequence with deep learning","volume":"176","author":"Jaganathan","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jtha.2024.12.006_bib18","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1002\/humu.24091","article-title":"Large-scale comparative evaluation of user-friendly tools for predicting variant-induced alterations of splicing regulatory elements","volume":"41","author":"Tubeuf","year":"2020","journal-title":"Hum Mutat"},{"key":"10.1016\/j.jtha.2024.12.006_bib19","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"ACMG Laboratory Quality Assurance Committee. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"10.1016\/j.jtha.2024.12.006_bib20","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0014-5793(91)80809-H","article-title":"Antithrombin Cambridge II, 384 Ala to Ser. Further evidence of the role of the reactive centre loop in the inhibitory function of the serpins","volume":"285","author":"Perry","year":"1991","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jtha.2024.12.006_bib21","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1365-2141.1987.tb04150.x","article-title":"Identification and characterization of a new antithrombin III familial variant (AT Dublin) with possible increased frequency in children with cancer","volume":"65","author":"Daly","year":"1987","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2024.12.006_bib22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0049-3848(00)00291-7","article-title":"A\u00a0novel type of mutation at the propeptide cleavage site (AlA+1Thr) causing symptomatic protein C type II deficiency","volume":"100","author":"Dodojacek","year":"2000","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2024.12.006_bib23","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1111\/j.1538-7836.2010.04073.x","article-title":"Geht Genetic Thrombophilia Group. Protein S inherited qualitative deficiency: novel mutations and phenotypic influence","volume":"8","author":"Alhenc-Gelas","year":"2010","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.12.006_bib24","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1161\/01.ATV.0000181760.55269.6b","article-title":"In\u00a0vivo clearance of human protein S in a mouse model: influence of C4b-binding protein and the Heerlen polymorphism","volume":"25","author":"Denis","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jtha.2024.12.006_bib25","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/humu.20136","article-title":"Protein S Italian Team. Molecular diversity and thrombotic risk in protein S deficiency: the PROSIT study","volume":"25","author":"Biguzzi","year":"2005","journal-title":"Hum Mutat"},{"key":"10.1016\/j.jtha.2024.12.006_bib26","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1182\/blood.V88.5.1700.bloodjournal8851700","article-title":"Molecular basis of protein S deficiency in three families also showing independent inheritance of factor V leiden","volume":"88","author":"Beauchamp","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2024.12.006_bib27","doi-asserted-by":"crossref","DOI":"10.1177\/1076029620912028","article-title":"Laboratory limitations of excluding hereditary protein C deficiency by chromogenic assay: discrepancies of phenotype and genotype","volume":"26","author":"Seidel","year":"2020","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1016\/j.jtha.2024.12.006_bib28","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1161\/ATVBAHA.119.313373","article-title":"Prothrombin Arg541Trp mutation leads to defective PC (Protein C) Pathway activation and constitutes a novel genetic risk factor for venous thrombosis","volume":"40","author":"Wu","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jtha.2024.12.006_bib29","doi-asserted-by":"crossref","first-page":"e370","DOI":"10.3324\/haematol.2019.232504","article-title":"Linkage analysis combined with whole-exome sequencing identifies a novel prothrombin (F2) gene mutation in a Dutch Caucasian family with unexplained thrombosis","volume":"105","author":"Mulder","year":"2020","journal-title":"Haematologica"},{"key":"10.1016\/j.jtha.2024.12.006_bib30","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41439-021-00145-x","article-title":"Venous thromboembolism is caused by prothrombin p.Arg541Trp mutation in Japanese individuals","volume":"8","author":"Yamamoto","year":"2021","journal-title":"Hum Genome Var"},{"key":"10.1016\/j.jtha.2024.12.006_bib31","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1182\/blood.V91.4.1140","article-title":"Factor V Cambridge: a new mutation (Arg306-->Thr) associated with resistance to activated protein C","volume":"91","author":"Williamson","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2024.12.006_bib32","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/j.1365-2516.2010.02228.x","article-title":"Spectrum of F8 gene mutations in haemophilia A patients from a region of Italy: identification of 23 new mutations","volume":"16","author":"Riccardi","year":"2010","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2024.12.006_bib33","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/humu.9439","article-title":"Spectrum of factor XI (F11) mutations in the UK population\u2013116 index cases and 140 mutations","volume":"27","author":"Mitchell","year":"2006","journal-title":"Hum Mutat"},{"key":"10.1016\/j.jtha.2024.12.006_bib34","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1532\/IJH97.NA0507","article-title":"Identification of a novel mutation combination in factor XIII deficiency: genetic update to the first reported case in the United States","volume":"83","author":"Halverstadt","year":"2006","journal-title":"Int J Hematol"},{"key":"10.1016\/j.jtha.2024.12.006_bib35","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/ijlh.13258","article-title":"Molecular and clinical profile of congenital fibrinogen disorders in Iran, identification of two novel mutations","volume":"42","author":"Tavasoli","year":"2020","journal-title":"Int J Lab Hematol"},{"key":"10.1016\/j.jtha.2024.12.006_bib36","doi-asserted-by":"crossref","first-page":"9016","DOI":"10.3390\/ijms21239016","article-title":"Mutations causing mild or no structural damage in interfaces of multimerization of the fibrinogen \u03b3-module more likely confer negative dominant behaviors","volume":"21","author":"Bellacchio","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtha.2024.12.006_bib37","doi-asserted-by":"crossref","first-page":"e12842","DOI":"10.1002\/rth2.12842","article-title":"Regeneron Genetics Center. Genetic variation of the blood coagulation regulator tissue factor pathway inhibitor and venous thromboembolism among middle-aged and older adults: a population-based cohort study","volume":"6","author":"Manderstedt","year":"2022","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.12.006_bib38","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1755-8794-5-7","article-title":"Identification of genetic risk variants for deep vein thrombosis by multiplexed next-generation sequencing of 186 hemostatic\/pro-inflammatory genes","volume":"5","author":"Lotta","year":"2012","journal-title":"BMC Med Genomics"},{"key":"10.1016\/j.jtha.2024.12.006_bib39","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1182\/bloodadvances.2017005249","article-title":"Whole-exome sequencing in evaluation of patients with venous thromboembolism","volume":"1","author":"Lee","year":"2017","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtha.2024.12.006_bib40","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.jtha.2022.12.007","article-title":"Clinical application of multigene panel testing for bleeding, thrombotic, and platelet disorders: a 3-year Belgian experience","volume":"21","author":"Van Laer","year":"2023","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.12.006_bib41","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1182\/blood-2015-12-688267","article-title":"A\u00a0high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders","volume":"127","author":"Simeoni","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2024.12.006_bib42","doi-asserted-by":"crossref","first-page":"e0187699","DOI":"10.1371\/journal.pone.0187699","article-title":"Whole exome sequencing in thrombophilic pedigrees to identify genetic risk factors for venous thromboembolism","volume":"12","author":"Cunha","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jtha.2024.12.006_bib43","doi-asserted-by":"crossref","first-page":"4258","DOI":"10.1182\/blood-2006-08-040774","article-title":"Antithrombin Cambridge II (A384S): an underestimated genetic risk factor for venous thrombosis","volume":"109","author":"Corral","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2024.12.006_bib44","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1160\/TH15-11-0871","article-title":"Antithrombin Dublin (p.Val30Glu): a relatively common variant with moderate thrombosis risk of causing transient antithrombin deficiency","volume":"116","author":"Navarro-Fern\u00e1ndez","year":"2016","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.12.006_bib45","doi-asserted-by":"crossref","first-page":"45507","DOI":"10.1038\/srep45507","article-title":"Heerlen mutation heterozygosity is associated with venous thrombosis risk","volume":"7","author":"Suchon","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtha.2024.12.006_bib46","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.3324\/haematol.2018.211326","article-title":"MPI-CDG with transient hypoglycosylation and antithrombin deficiency","volume":"104","author":"de la Morena-Barrio","year":"2019","journal-title":"Haematologica"},{"key":"10.1016\/j.jtha.2024.12.006_bib47","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1042\/CS20200403","volume":"134","author":"Labrouche-Colomer","year":"2020","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.jtha.2024.12.006_bib48","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.jtha.2022.12.005","article-title":"Whole F9 gene sequencing identified deep intronic variations in genetically unresolved hemophilia B patients","volume":"21","author":"Dericquebourg","year":"2023","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jtha.2024.12.006_bib49","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1016\/j.jtha.2024.04.004","article-title":"Next-generation sequencing strategies in venous thromboembolism: in whom and for what purpose?","volume":"22","author":"Tr\u00e9gou\u00ebt","year":"2024","journal-title":"J\u00a0Thromb Haemost"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783624007268?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783624007268?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T14:58:20Z","timestamp":1741273100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783624007268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S1538783624007268"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2024.12.006","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessment of a next generation sequencing gene panel strategy in 133 patients with negative thrombophilia screening","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2024.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}]}}