{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:01:52Z","timestamp":1792728112367,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jtha.2025.05.022","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T11:16:08Z","timestamp":1748430968000},"page":"2944-2957","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mitogen-activated protein kinase 1 regulates platelet function and thrombus formation"],"prefix":"10.1016","volume":"23","author":[{"given":"Xiaoqi","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyue","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0456-0940","authenticated-orcid":false,"given":"Jianlin","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2025.05.022_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232112772","article-title":"Platelets and their role in hemostasis and thrombosis\u2014from physiology to pathophysiology and therapeutic implications","volume":"23","author":"Scridon","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtha.2025.05.022_bib2","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/j.jtha.2024.02.018","article-title":"Redox regulation of platelet function and thrombosis","volume":"22","author":"Jiang","year":"2024","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.05.022_bib3","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1182\/blood-2017-03-773614","article-title":"Integrin \u03b1IIb\u03b23 outside-in signaling","volume":"130","author":"Durrant","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.05.022_bib4","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/s41392-023-01705-z","article-title":"Targeting the RAS\/RAF\/MAPK pathway for cancer therapy: from mechanism to clinical studies","volume":"8","author":"Bahar","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.jtha.2025.05.022_bib5","first-page":"153","article-title":"Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions","volume":"22","author":"Pearson","year":"2001","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jtha.2025.05.022_bib6","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1111\/j.1538-7836.2008.03169.x","article-title":"Mitogen-activated protein kinases in hemostasis and thrombosis","volume":"6","author":"Adam","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.05.022_bib7","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1111\/jth.14967","article-title":"Platelet MAPKs-a 20+ year history: what do we really know?","volume":"18","author":"Patel","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.05.022_bib8","doi-asserted-by":"crossref","first-page":"26002","DOI":"10.1074\/jbc.M414083200","article-title":"Differential involvement of ERK2 and p38 in platelet adhesion to collagen","volume":"280","author":"Mazharian","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtha.2025.05.022_bib9","doi-asserted-by":"crossref","first-page":"28766","DOI":"10.1074\/jbc.273.44.28766","article-title":"Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. SB 203580 also inhibits thromboxane synthase","volume":"273","author":"Borsch\u2013Haubold","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtha.2025.05.022_bib10","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1182\/blood-2008-05-155978","article-title":"Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK-dependent integrin outside-in retractile signaling pathway","volume":"113","author":"Flevaris","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.05.022_bib11","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1182\/blood-2002-03-0812","article-title":"P2X(1)-mediated activation of extracellular signal-regulated kinase 2 contributes to platelet secretion and aggregation induced by collagen","volume":"100","author":"Oury","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.05.022_bib12","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1538-7836.2006.01745.x","article-title":"ERK2 activation in arteriolar and venular murine thrombosis: platelet receptor GPIb vs P2X","volume":"4","author":"Oury","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.05.022_bib13","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S0301-472X(01)00623-3","article-title":"Role of phosphatidylinositol-3 kinase and its association with Gab1 in thrombopoietin-mediated up-regulation of platelet function","volume":"29","author":"Kojima","year":"2001","journal-title":"Exp Hematol"},{"key":"10.1016\/j.jtha.2025.05.022_bib14","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1046\/j.1365-2141.2000.02126.x","article-title":"Porcine von Willebrand factor and thrombin induce the activation of c-Jun amino-terminal kinase (JNK\/SAPK) whereas only thrombin induces activation of extracellular signal-related kinase 2 (ERK2) in human platelets","volume":"109","author":"Song","year":"2000","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2025.05.022_bib15","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1160\/TH13-09-0726","article-title":"P2X1-initiated p38 signalling enhances thromboxane A2-induced platelet secretion and aggregation","volume":"112","author":"Huang","year":"2014","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.05.022_bib16","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/cvr\/cvr226","article-title":"Monomeric C-reactive protein is prothrombotic and dissociates from circulating pentameric C-reactive protein on adhered activated platelets under flow","volume":"92","author":"Molins","year":"2011","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jtha.2025.05.022_bib17","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1182\/blood-2005-05-1933","article-title":"Src family kinase-mediated and Erk-mediated thromboxane A2 generation are essential for VWF\/GPIb-induced fibrinogen receptor activation in human platelets","volume":"106","author":"Garcia","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.05.022_bib18","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/j.1538-7836.2006.01789.x","article-title":"P2Y12 receptor-mediated potentiation of thrombin-induced thromboxane A2 generation in platelets occurs through regulation of Erk1\/2 activation","volume":"4","author":"Shankar","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.05.022_bib19","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1111\/j.1432-1033.1997.t01-1-00751.x","article-title":"Phosphorylation and activation of cytosolic phospholipase A2 by 38-kDa mitogen-activated protein kinase in collagen-stimulated human platelets","volume":"245","author":"Borsch\u2013Haubold","year":"1997","journal-title":"Eur J Biochem"},{"issue":"Pt 2","key":"10.1016\/j.jtha.2025.05.022_bib20","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1042\/bj3440359","article-title":"Stress stimuli increase calcium-induced arachidonic acid release through phosphorylation of cytosolic phospholipase A2","volume":"344","author":"Buschbeck","year":"1999","journal-title":"Biochem J"},{"key":"10.1016\/j.jtha.2025.05.022_bib21","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.thromres.2011.01.004","article-title":"Male mice have increased thrombotic potential: sex differences in a mouse model of venous thrombosis","volume":"127","author":"Alvarado","year":"2011","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2025.05.022_bib22","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.1038\/s41467-023-40600-7","article-title":"MTH1 protects platelet mitochondria from oxidative damage and regulates platelet function and thrombosis","volume":"14","author":"Ding","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.jtha.2025.05.022_bib23","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1182\/blood.2023023559","article-title":"Notch1 regulates hepatic thrombopoietin production","volume":"143","author":"Sun","year":"2024","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.05.022_bib24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1055\/a-1962-1613","article-title":"Impaired platelet function and thrombus formation in PDE5A-deficient mice","volume":"123","author":"Gui","year":"2023","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.05.022_bib25","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1182\/blood.2022015554","article-title":"Protein tyrosine phosphatase PTPN22 negatively modulates platelet function and thrombus formation","volume":"140","author":"Wang","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.05.022_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101569","article-title":"p47phox deficiency impairs platelet function and protects mice against arterial and venous thrombosis","volume":"34","author":"Wang","year":"2020","journal-title":"Redox Biology"},{"key":"10.1016\/j.jtha.2025.05.022_bib27","doi-asserted-by":"crossref","first-page":"20913","DOI":"10.1074\/jbc.M009047200","article-title":"Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation","volume":"276","author":"Zhang","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtha.2025.05.022_bib28","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1083\/jcb.83.1.126","article-title":"Transformation and motility of human platelets: details of the shape change and release reaction observed by optical and electron microscopy","volume":"83","author":"Allen","year":"1979","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jtha.2025.05.022_bib29","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.thromres.2006.09.003","article-title":"Involvement of Src kinases and PLC\u03b32 in clot retraction","volume":"120","author":"Suzuki\u2013Inoue","year":"2007","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2025.05.022_bib30","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1093\/embo-reports\/kve046","article-title":"ASK1 is required for sustained activations of JNK\/p38 MAP kinases and apoptosis","volume":"2","author":"Tobiume","year":"2001","journal-title":"EMBO Rep"},{"key":"10.1016\/j.jtha.2025.05.022_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.prostaglandins.2019.106382","article-title":"Oxidative pathways of arachidonic acid as targets for regulation of platelet activation","volume":"145","author":"Trostchansky","year":"2019","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.jtha.2025.05.022_bib32","first-page":"2087","article-title":"Apoptosis signal-regulating kinase (ASK1) regulates thrombosis in part by regulating cPLA phosphorylation-dependent TxA generation","volume":"128","author":"Patel","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.05.022_bib33","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13045-019-0709-6","article-title":"Platelet integrin \u03b1IIb\u03b23: signal transduction, regulation, and its therapeutic targeting","volume":"12","author":"Huang","year":"2019","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.jtha.2025.05.022_bib34","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.bbamcr.2006.10.005","article-title":"The MEK\/ERK cascade: from signaling specificity to diverse functions","volume":"1773","author":"Shaul","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jtha.2025.05.022_bib35","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/MMBR.00031-10","article-title":"Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases","volume":"75","author":"Cargnello","year":"2011","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.jtha.2025.05.022_bib36","doi-asserted-by":"crossref","first-page":"26722","DOI":"10.1074\/jbc.273.41.26722","article-title":"Extracellular signal-regulated protein kinase\/Jun kinase cross-talk underlies vascular endothelial cell growth factor-induced endothelial cell proliferation","volume":"273","author":"Pedram","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtha.2025.05.022_bib37","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1177\/039463200902200409","article-title":"Effect of PD98059, a selective MAPK3\/MAPK1 inhibitor, on acute lung injury in mice","volume":"22","author":"Di Paola","year":"2009","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.jtha.2025.05.022_bib38","doi-asserted-by":"crossref","first-page":"28071","DOI":"10.1074\/jbc.274.40.28071","article-title":"The Talin head domain binds to integrin \u03b2 subunit cytoplasmic tails and regulates integrin activation","volume":"274","author":"Calderwood","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtha.2025.05.022_bib39","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1042\/BST0320831","article-title":"Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion","volume":"32","author":"Critchley","year":"2004","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.jtha.2025.05.022_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034056","article-title":"Kindlins, integrin activation and the regulation of talin recruitment to \u03b1IIb\u03b23","volume":"7","author":"Kahner","year":"2012","journal-title":"PLOS One"},{"key":"10.1016\/j.jtha.2025.05.022_bib41","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1042\/BST0360229","article-title":"Integrin activation","volume":"36","author":"Banno","year":"2008","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.jtha.2025.05.022_bib42","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1006\/bbrc.2001.5497","article-title":"Analysis of the mammalian talin2 gene TLN2","volume":"286","author":"Monkley","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jtha.2025.05.022_bib43","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1084\/jem.20071800","article-title":"Talin is required for integrin-mediated platelet function in hemostasis and thrombosis","volume":"204","author":"Petrich","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.jtha.2025.05.022_bib44","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1084\/jem.20071827","article-title":"Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo","volume":"204","author":"Nieswandt","year":"2007","journal-title":"J Exp Med"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625003411?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625003411?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:03:19Z","timestamp":1788235399000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783625003411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S1538783625003411"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2025.05.022","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitogen-activated protein kinase 1 regulates platelet function and thrombus formation","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2025.05.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}