{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:38:54Z","timestamp":1792784334641,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Medical and Scientific Fund of the Mayor of the Federal Capital of Vienna","award":["23051"],"award-info":[{"award-number":["23051"]}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jtha.2025.05.024","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T12:26:58Z","timestamp":1748953618000},"page":"2958-2968","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical evidence for antiglycoprotein IIbIIIa antibody-induced platelet desialylation in primary immune thrombocytopenia"],"prefix":"10.1016","volume":"23","author":[{"given":"Theresa","family":"Schramm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Zlamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmin","family":"Rast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Oosterlee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fillitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dino","family":"Mehic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kraemmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Tolios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Haslacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cihan","family":"Ay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Pabinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Althaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamam","family":"Bakchoul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4578-3120","authenticated-orcid":false,"given":"Johanna","family":"Gebhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2025.05.024_bib1","doi-asserted-by":"crossref","first-page":"6511","DOI":"10.1182\/blood-2009-01-129155","article-title":"The ITP syndrome: pathogenic and clinical diversity","volume":"113","author":"Cines","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.05.024_bib2","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1182\/blood-2008-07-162503","article-title":"Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group","volume":"113","author":"Rodeghiero","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.05.024_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.103820","article-title":"Recent advances in the mechanisms and treatment of immune thrombocytopenia","volume":"76","author":"Provan","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jtha.2025.05.024_bib4","doi-asserted-by":"crossref","first-page":"789","DOI":"10.3390\/jcm10040789","article-title":"Primary immune thrombocytopenia: novel insights into pathophysiology and disease management","volume":"10","author":"Singh","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/j.jtha.2025.05.024_bib5","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/MOH.0000000000000447","article-title":"Pathophysiology of immune thrombocytopenia","volume":"25","author":"Li","year":"2018","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.jtha.2025.05.024_bib6","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.autrev.2017.04.012","article-title":"Pathogenesis of immune thrombocytopenia","volume":"16","author":"Audia","year":"2017","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jtha.2025.05.024_bib7","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1055\/s-0035-1564835","article-title":"Platelet ohysiology","volume":"42","author":"Gremmel","year":"2016","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.jtha.2025.05.024_bib8","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1056\/NEJMra010501","article-title":"Immune thrombocytopenic purpura","volume":"346","author":"Cines","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtha.2025.05.024_bib9","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1532\/IJH97.04168","article-title":"The effect of antiplatelet autoantibodies on megakaryocytopoiesis","volume":"81","author":"McMillan","year":"2005","journal-title":"Int J Hematol"},{"key":"10.1016\/j.jtha.2025.05.024_bib10","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3324\/haematol.2014.115634","article-title":"Immune thrombocytopenia: antiplatelet autoantibodies inhibit proplatelet formation by megakaryocytes and impair platelet production in vitro","volume":"100","author":"Iraqi","year":"2015","journal-title":"Haematologica"},{"key":"10.1016\/j.jtha.2025.05.024_bib11","article-title":"Association of platelet desialylation and circulating follicular helper T cells in patients with thrombocytopenia","volume":"13","author":"Chen","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jtha.2025.05.024_bib12","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/cei.12935","article-title":"Fc\u03b3 receptor expression on splenic macrophages in adult immune thrombocytopenia","volume":"188","author":"Audia","year":"2017","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jtha.2025.05.024_bib13","doi-asserted-by":"crossref","first-page":"7737","DOI":"10.1038\/ncomms8737","article-title":"Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia","volume":"6","author":"Li","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.jtha.2025.05.024_bib14","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1182\/blood.V96.7.2520","article-title":"Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice","volume":"96","author":"Nieswandt","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.05.024_bib15","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1182\/blood-2005-06-009761","article-title":"Relative efficacy of intravenous immunoglobulin G in ameliorating thrombocytopenia induced by antiplatelet GPIIbIIIa versus GPIbalpha antibodies","volume":"108","author":"Webster","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.05.024_bib16","article-title":"CD8(+) T cells induce platelet clearance in the liver via platelet desialylation in immune thrombocytopenia","volume":"6","author":"Qiu","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtha.2025.05.024_bib17","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13045-017-0413-3","article-title":"Platelet desialylation correlates with efficacy of first-line therapies for immune thrombocytopenia","volume":"10","author":"Tao","year":"2017","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.jtha.2025.05.024_bib18","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3324\/haematol.2019.240440","article-title":"Desialylation of O-glycans on glycoprotein Ib\u03b1 drives receptor signaling and platelet clearance","volume":"106","author":"Wang","year":"2021","journal-title":"Haematologica"},{"key":"10.1016\/j.jtha.2025.05.024_bib19","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1182\/blood-2015-01-569129","article-title":"Regulating billions of blood platelets: glycans and beyond","volume":"126","author":"Grozovsky","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.05.024_bib20","article-title":"The role of platelet desialylation as a biomarker in primary immune thrombocytopenia: mechanisms and therapeutic perspectives","volume":"15","author":"Zhang","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.jtha.2025.05.024_bib21","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3324\/haematol.2019.236117","article-title":"Autoantibody-mediated desialylation impairs human thrombopoiesis and platelet lifespan","volume":"106","author":"Marini","year":"2021","journal-title":"Haematologica"},{"key":"10.1016\/j.jtha.2025.05.024_bib22","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.3324\/haematol.2021.279751","article-title":"Antiplatelet antibody predicts platelet desialylation and apoptosis in immune thrombocytopenia","volume":"107","author":"Zheng","year":"2022","journal-title":"Haematologica"},{"key":"10.1016\/j.jtha.2025.05.024_bib23","doi-asserted-by":"crossref","first-page":"4579","DOI":"10.1182\/blood.V88.12.4579.bloodjournal88124579","article-title":"Characterization of autoantigenic epitopes on platelet glycoprotein IIb\/IIIa using random peptide libraries","volume":"88","author":"Bowditch","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.05.024_bib24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nm.3770","article-title":"The Ashwell\u2013Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling","volume":"21","author":"Grozovsky","year":"2015","journal-title":"Nat Med"},{"key":"10.1016\/j.jtha.2025.05.024_bib25","doi-asserted-by":"crossref","first-page":"e289","DOI":"10.1016\/S2352-3026(21)00030-2","article-title":"Dexamethasone plus oseltamivir versus dexamethasone in treatment-naive primary immune thrombocytopenia: a multicentre, randomised, open-label, phase 2 trial","volume":"8","author":"Sun","year":"2021","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.jtha.2025.05.024_bib26","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1080\/09537104.2018.1513476","article-title":"Multirefractory primary immune thrombocytopenia; targeting the decreased sialic acid content","volume":"30","author":"Revilla","year":"2019","journal-title":"Platelets"},{"key":"10.1016\/j.jtha.2025.05.024_bib27","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3109\/09537104.2014.948838","article-title":"Successful treatment with oseltamivir phosphate in a patient with chronic immune thrombocytopenia positive for anti-GPIb\/IX autoantibody","volume":"26","author":"Shao","year":"2015","journal-title":"Platelets"},{"key":"10.1016\/j.jtha.2025.05.024_bib29","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1182\/blood-2012-07-442392","article-title":"Standardization of bleeding assessment in immune thrombocytopenia: report from the International Working Group","volume":"121","author":"Rodeghiero","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.05.024_bib30","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1089\/bio.2018.0032","article-title":"Usage data and scientific impact of the prospectively established fluid bioresources at the hospital-based MedUni Wien Biobank","volume":"16","author":"Haslacher","year":"2018","journal-title":"Biopreserv Biobank"},{"key":"10.1016\/j.jtha.2025.05.024_bib31","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1365-2141.2004.05233.x","article-title":"A novel method for simultaneous analysis of specific platelet antibodies: SASPA","volume":"127","author":"Nguyen","year":"2004","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2025.05.024_bib32","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1182\/blood-2016-03-708388","article-title":"Clinical relevance of antiplatelet antibodies and the hepatic clearance of platelets in patients with immune thrombocytopenia","volume":"128","author":"Cantoni","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.05.024_bib33","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1038\/s41598-018-38086-1","article-title":"Multiple concomitant mechanisms contribute to low platelet count in patients with immune thrombocytopenia","volume":"9","author":"Grodzielski","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtha.2025.05.024_bib34","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.3390\/jcm10081661","article-title":"The importance of platelet glycoside residues in the haemostasis of patients with immune thrombocytopaenia","volume":"10","author":"Ram\u00edrez\u2013L\u00f3pez","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/j.jtha.2025.05.024_bib35","first-page":"72","article-title":"Gruppo Italiano per lo Studio delle Malattie Ematologiche dell\u2019Adulto. Efficacy and safety of splenectomy in immune thrombocytopenic purpura: long-term results of 402 cases","volume":"90","author":"Vianelli","year":"2005","journal-title":"Haematologica"},{"key":"10.1016\/j.jtha.2025.05.024_bib36","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/bjh.19145","article-title":"Study of platelet kinetics in immune thrombocytopenia to predict splenectomy response","volume":"204","author":"Mendoza","year":"2024","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2025.05.024_bib37","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/jth.12524","article-title":"Association of autoantibody specificity and response to intravenous immunoglobulin G therapy in immune thrombocytopenia: a multicenter cohort study","volume":"12","author":"Peng","year":"2014","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.05.024_bib38","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/ajh.22211","article-title":"Relative efficacy of steroid therapy in immune thrombocytopenia mediated by anti-platelet GPIIbIIIa versus GPIb\u03b1 antibodies","volume":"87","author":"Zeng","year":"2012","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jtha.2025.05.024_bib39","doi-asserted-by":"crossref","first-page":"E94","DOI":"10.1002\/ajh.23953","article-title":"Sialidase inhibition to increase platelet counts: a new treatment option for thrombocytopenia","volume":"90","author":"Jansen","year":"2015","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jtha.2025.05.024_bib40","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s11239-022-02651-3","article-title":"Oseltamivir as rescue therapy for persistent, chronic, or refractory immune thrombocytopenia: a case series and review of the literature","volume":"54","author":"Colunga\u2013Pedraza","year":"2022","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.jtha.2025.05.024_bib41","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00277-023-05581-z","article-title":"Successful treatment with oseltamivir phosphate in children with ITP who failed first-line therapy: a case series report","volume":"103","author":"Liu","year":"2024","journal-title":"Ann Hematol"},{"key":"10.1016\/j.jtha.2025.05.024_bib42","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1111\/j.1537-2995.2010.02610.x","article-title":"The detection of platelet antibodies by simultaneous analysis of specific platelet antibodies and the monoclonal antibody-specific immobilization of platelet antigens: an interlaboratory comparison","volume":"50","author":"Nguyen","year":"2010","journal-title":"Transfusion"},{"key":"10.1016\/j.jtha.2025.05.024_bib43","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1515\/cclm-2014-1037","article-title":"Comparison of the bead-based simultaneous analysis of specific platelet antibodies assay (SASPA) and Pak Lx Luminex technology with the monoclonal antibody immobilization of platelet antigens assay (MAIPA) to detect platelet alloantibodies","volume":"53","author":"Rockenbauer","year":"2015","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.jtha.2025.05.024_bib44","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1182\/blood.V70.6.1722.1722","article-title":"Monoclonal antibody--specific immobilization of platelet antigens (MAIPA): a new tool for the identification of platelet-reactive antibodies","volume":"70","author":"Kiefel","year":"1987","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.05.024_bib45","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1182\/bloodadvances.2022007751","article-title":"The interplay between GPIb\/IX antibodies, platelet hepatic sequestration, and TPO levels in patients with chronic ITP","volume":"7","author":"Amini","year":"2023","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtha.2025.05.024_bib46","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.intimp.2018.11.011","article-title":"Increased GPIb\u03b1 shedding from platelets treated with immune thrombocytopenia plasma","volume":"66","author":"Wei","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jtha.2025.05.024_bib47","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1080\/09537104.2016.1235690","article-title":"Basic mechanisms of platelet receptor shedding","volume":"28","author":"Andrews","year":"2017","journal-title":"Platelets"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625003435?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625003435?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T18:03:28Z","timestamp":1778868208000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783625003435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":46,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S1538783625003435"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2025.05.024","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical evidence for antiglycoprotein IIbIIIa antibody-induced platelet desialylation in primary immune thrombocytopenia","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2025.05.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}]}}