{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T21:03:56Z","timestamp":1789851836519,"version":"4.0.1"},"reference-count":91,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013373","name":"NIHR Oxford Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","award":["MR\/T024054\/1"],"award-info":[{"award-number":["MR\/T024054\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jtha.2025.07.020","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T15:11:49Z","timestamp":1753369909000},"page":"3409-3423","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Frailty and frailty syndromes in persons with hemophilia: a review"],"prefix":"10.1016","volume":"23","author":[{"given":"William","family":"McKeown","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0402-0802","authenticated-orcid":false,"given":"Susan","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2025.07.020_bib1","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1056\/NEJM200106073442307","article-title":"The hemophilias\u2014from royal genes to gene therapy","volume":"344","author":"Mannucci","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtha.2025.07.020_bib2","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/bjh.16704","article-title":"Guidelines on the use of prophylactic factor replacement for children and adults with haemophilia A and B","volume":"190","author":"Rayment","year":"2020","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2025.07.020_bib3","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1365-2141.1985.tb07353.x","article-title":"Life expectancy of Swedish haemophiliacs, 1831-1980","volume":"59","author":"Larsson","year":"1985","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2025.07.020_bib4","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/jth.15182","article-title":"Mortality, life expectancy, and causes of death of persons with hemophilia in the Netherlands 2001-2018","volume":"19","author":"Hassan","year":"2021","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.07.020_bib5","doi-asserted-by":"crossref","first-page":"e98","DOI":"10.1111\/bjh.15928","article-title":"The top 10 research priorities in bleeding disorders: a James Lind Alliance Priority Setting Partnership","volume":"186","author":"Shapiro","year":"2019","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2025.07.020_bib6","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/bjh.15745","article-title":"Haemophilia and ageing","volume":"184","author":"Shapiro","year":"2019","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2025.07.020_bib7","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1160\/TH12-05-0313","article-title":"Increased prevalence of hypertension in haemophilia patients","volume":"108","author":"Fransen van de Putte","year":"2012","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.07.020_bib8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1161\/HYPERTENSIONAHA.113.01174","article-title":"Prevalence and risk factors for hypertension in hemophilia","volume":"62","author":"von Drygalski","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.jtha.2025.07.020_bib9","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.thromres.2019.07.017","article-title":"Hypertension and cardiovascular diseases in Swedish persons with haemophilia\u2014a longitudinal registry study","volume":"181","author":"L\u00f6vdahl","year":"2019","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2025.07.020_bib10","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/bjh.18085","article-title":"Cardiovascular disease in hereditary haemophilia: the challenges of longevity","volume":"197","author":"Shapiro","year":"2022","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2025.07.020_bib11","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/hae.13960","article-title":"Mental health disorders in haemophilia: systematic literature review and meta-analysis","volume":"26","author":"Al-Huniti","year":"2020","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.020_bib12","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1159\/000528561","article-title":"Frailty: pathophysiology, theoretical and operational definition(s), impact, prevalence, management and prevention, in an increasingly economically developed and ageing world","volume":"69","author":"Doody","year":"2023","journal-title":"Gerontology"},{"key":"10.1016\/j.jtha.2025.07.020_bib13","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1056\/NEJMra2301292","article-title":"Frailty in older adults","volume":"391","author":"Kim","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtha.2025.07.020_bib14","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0140-6736(12)62167-9","article-title":"Frailty in elderly people","volume":"381","author":"Clegg","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.jtha.2025.07.020_bib15","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S0140-6736(19)31786-6","article-title":"Frailty: implications for clinical practice and public health","volume":"394","author":"Hoogendijk","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.jtha.2025.07.020_bib16","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/ageing\/afaa219","article-title":"Prevalence of frailty in 62 countries across the world: a systematic review and meta-analysis of population-level studies","volume":"50","author":"O\u2019Caoimh","year":"2021","journal-title":"Age Ageing"},{"key":"10.1016\/j.jtha.2025.07.020_bib17","doi-asserted-by":"crossref","first-page":"289","DOI":"10.4235\/agmr.22.0148","article-title":"Trajectories, transitions, and trends in frailty among older adults: a review","volume":"26","author":"Hoogendijk","year":"2022","journal-title":"Ann Geriatr Med Res"},{"key":"10.1016\/j.jtha.2025.07.020_bib18","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1503\/cmaj.050051","article-title":"A global clinical measure of fitness and frailty in elderly people","volume":"173","author":"Rockwood","year":"2005","journal-title":"CMAJ"},{"key":"10.1016\/j.jtha.2025.07.020_bib19","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-047051","article-title":"Measuring frailty in younger populations: a rapid review of evidence","volume":"11","author":"Spiers","year":"2021","journal-title":"BMJ Open"},{"key":"10.1016\/j.jtha.2025.07.020_bib20","doi-asserted-by":"crossref","first-page":"210","DOI":"10.5770\/cgj.23.463","article-title":"Using the Clinical Frailty Scale in allocating scarce health care resources","volume":"23","author":"Rockwood","year":"2020","journal-title":"Can Geriatr J"},{"key":"10.1016\/j.jtha.2025.07.020_bib21","doi-asserted-by":"crossref","first-page":"235","DOI":"10.5770\/cgj.23.398","article-title":"Interrater reliability of the clinical frailty scale by geriatrician and intensivist in patients admitted to the intensive care unit","volume":"23","author":"Surkan","year":"2020","journal-title":"Can Geriatr J"},{"key":"10.1016\/j.jtha.2025.07.020_bib22","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1093\/ageing\/afu138","article-title":"Best practice guidelines for the management of frailty: a British Geriatrics Society, Age UK and Royal College of General Practitioners report","volume":"43","author":"Turner","year":"2014","journal-title":"Age Ageing"},{"key":"10.1016\/j.jtha.2025.07.020_bib24","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.d6553","article-title":"Comprehensive geriatric assessment for older adults admitted to hospital: meta-analysis of randomised controlled trials","volume":"343","author":"Ellis","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.jtha.2025.07.020_bib25","doi-asserted-by":"crossref","first-page":"E728","DOI":"10.9778\/cmajo.20200222","article-title":"Effectiveness of physical activity interventions in older adults with frailty or prefrailty: a systematic review and meta-analysis","volume":"9","author":"Racey","year":"2021","journal-title":"CMAJ Open"},{"key":"10.1016\/j.jtha.2025.07.020_bib26","doi-asserted-by":"crossref","first-page":"E744","DOI":"10.9778\/cmajo.20200248","article-title":"Effectiveness of nutrition interventions and combined nutrition and physical activity interventions in older adults with frailty or prefrailty: a systematic review and meta-analysis","volume":"9","author":"Racey","year":"2021","journal-title":"CMAJ Open"},{"key":"10.1016\/j.jtha.2025.07.020_bib27","doi-asserted-by":"crossref","first-page":"afac104","DOI":"10.1093\/ageing\/afac104","article-title":"Comprehensive geriatric assessment in older people: an umbrella review of health outcomes","volume":"51","author":"Veronese","year":"2022","journal-title":"Age Ageing"},{"key":"10.1016\/j.jtha.2025.07.020_bib28","article-title":"Comprehensive Geriatric Assessment for community-dwelling, high-risk, frail, older people","volume":"5","author":"Briggs","year":"2022","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jtha.2025.07.020_bib29","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1007\/s11606-020-06089-2","article-title":"Deprescribing for community-dwelling older adults: a systematic review and meta-analysis","volume":"35","author":"Bloomfield","year":"2020","journal-title":"J Gen Intern Med"},{"key":"10.1016\/j.jtha.2025.07.020_bib30","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/s12877-021-02208-8","article-title":"A systematic review of the evidence for deprescribing interventions among older people living with frailty","volume":"21","author":"Ibrahim","year":"2021","journal-title":"BMC Geriatr"},{"key":"10.1016\/j.jtha.2025.07.020_bib31","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s40520-018-1004-z","article-title":"Outpatient comprehensive geriatric assessment: effects on frailty and mortality in old people with multimorbidity and high health care utilization","volume":"31","author":"Mazya","year":"2019","journal-title":"Aging Clin Exp Res"},{"key":"10.1016\/j.jtha.2025.07.020_bib32","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1111\/hae.14839","article-title":"Frailty and haemophilia; speaking the language of geriatricians","volume":"29","author":"Sangha","year":"2023","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.020_bib33","series-title":"Silver Book: quality care for older people with urgent and emergency care needs","author":"Conroy","year":"2012"},{"key":"10.1016\/j.jtha.2025.07.020_bib34","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/j.1538-7836.2009.03318.x","article-title":"Health status and quality of life of elderly person. Health status and quality of life of elderly persons with severe hemophilia born before the advent of modern replacement therapy","volume":"7","author":"Siboni","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.07.020_bib35","first-page":"699","article-title":"WFH Guidelines for the Management of Hemophilia panelists and co-authors. WFH guidelines for the management of hemophilia, 3rd edition","volume":"27","author":"Srivastava","year":"2021","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.020_bib36","article-title":"Prevention of falls in older people living in the community","volume":"353","author":"Vieira","year":"2016","journal-title":"BMJ"},{"key":"10.1016\/j.jtha.2025.07.020_bib38","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1093\/gerona\/glac130","article-title":"Natural history trajectories of frailty in community-dwelling older Japanese adults","volume":"77","author":"Tange","year":"2022","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.jtha.2025.07.020_bib39","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14283\/jfa.2020.44","article-title":"Prevalence of falls and associated factors among community-dwelling older adults: a cross-sectional study","volume":"10","author":"Almada","year":"2021","journal-title":"J Frailty Aging"},{"key":"10.1016\/j.jtha.2025.07.020_bib40","doi-asserted-by":"crossref","first-page":"i3","DOI":"10.1136\/injuryprev-2019-043286","article-title":"The global burden of falls: global, regional and national estimates of morbidity and mortality from the Global Burden of Disease Study 2017","volume":"26","author":"James","year":"2020","journal-title":"Inj Prev"},{"key":"10.1016\/j.jtha.2025.07.020_bib41","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/S0140-6736(18)32335-3","article-title":"Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.jtha.2025.07.020_bib42","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/jcsm.13115","article-title":"Consensus guidelines for sarcopenia prevention, diagnosis and management in Australia and New Zealand","volume":"14","author":"Zanker","year":"2023","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.jtha.2025.07.020_bib43","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.maturitas.2020.10.021","article-title":"Risk factors for recurrent falls in older adults: a systematic review with meta-analysis","volume":"144","author":"Jehu","year":"2021","journal-title":"Maturitas"},{"key":"10.1016\/j.jtha.2025.07.020_bib44","doi-asserted-by":"crossref","DOI":"10.1093\/ageing\/afac205","article-title":"World guidelines for falls prevention and management for older adults: a global initiative","volume":"51","author":"Montero-Odasso","year":"2022","journal-title":"Age Ageing"},{"key":"10.1016\/j.jtha.2025.07.020_bib45","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/hae.12512","article-title":"Falling and fall risk factors in adults with haemophilia: an exploratory study","volume":"20","author":"Sammels","year":"2014","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.020_bib46","doi-asserted-by":"crossref","first-page":"97","DOI":"10.5482\/HAMO-16-03-0009","article-title":"Falling and fall risk in adult patients with severe haemophilia","volume":"37","author":"Rehm","year":"2017","journal-title":"Hamostaseologie"},{"key":"10.1016\/j.jtha.2025.07.020_bib47","doi-asserted-by":"crossref","first-page":"7237","DOI":"10.1080\/09638288.2021.1988731","article-title":"Past the tipping point: a qualitative study of the views and experiences of men with haemophilia regarding mobility, balance, and falls","volume":"44","author":"Taylor","year":"2022","journal-title":"Disabil Rehabil"},{"key":"10.1016\/j.jtha.2025.07.020_bib48","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1007\/s11096-022-01401-y","article-title":"Polypharmacy and medication regimen complexity in older patients with hemophilia or von willebrand disease: the M\u2019HEMORRH-AGE study","volume":"44","author":"Novais","year":"2022","journal-title":"Int J Clin Pharm"},{"key":"10.1016\/j.jtha.2025.07.020_bib49","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/hae.13595","article-title":"Rate and appropriateness of polypharmacy in older patients with hemophilia compared with age-matched controls","volume":"24","author":"Mannucci","year":"2018","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.020_bib50","first-page":"59","article-title":"Evaluation of bone mineral density and related parameters in patients with haemophilia: a single center cross-sectional study","volume":"7","author":"Kiper Unal","year":"2017","journal-title":"Am J Blood Res"},{"key":"10.1016\/j.jtha.2025.07.020_bib51","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1160\/TH09-09-0629","article-title":"Bone mineral density in haemophilia patients. A meta-analysis","volume":"103","author":"Iorio","year":"2010","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.07.020_bib52","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.3390\/ijms26052172","article-title":"Bone and hemophilia: the role of factor VIII-systematic review","volume":"26","author":"Berni","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtha.2025.07.020_bib53","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/hae.14653","article-title":"Physical activity, physical fitness and cardiometabolic risk amongst adults with moderate and severe haemophilia","volume":"29","author":"Kennedy","year":"2023","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.020_bib54","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/hae.14009","article-title":"Physical activity levels in men with haemophilia A single centre UK survey","volume":"26","author":"Taylor","year":"2020","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.020_bib55","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/hae.14556","article-title":"Effectiveness of physical exercise on postural balance in patients with haemophilia: a systematic review","volume":"28","author":"Chimeno-Hern\u00e1ndez","year":"2022","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.020_bib56","doi-asserted-by":"crossref","first-page":"8420","DOI":"10.1080\/09638288.2021.2018054","article-title":"The experiences and beliefs of people with severe haemophilia and healthcare professionals on pain management, and their views of using exercise as an aspect of intervention: a qualitative study","volume":"44","author":"McLaughlin","year":"2022","journal-title":"Disabil Rehabil"},{"key":"10.1016\/j.jtha.2025.07.020_bib57","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/hae.14972","article-title":"Using evidence-based co-design to develop a hybrid delivered exercise intervention that aims to increase confidence to exercise in people with haemophilia","volume":"30","author":"Taylor","year":"2024","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.020_bib58","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1007\/s00198-021-05900-y","article-title":"The clinician\u2019s guide to prevention and treatment of osteoporosis","volume":"33","author":"LeBoff","year":"2022","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jtha.2025.07.020_bib59","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1210\/jc.2011-3045","article-title":"Osteoporosis in men: an Endocrine Society clinical practice guideline","volume":"97","author":"Watts","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jtha.2025.07.020_bib60","first-page":"145","article-title":"Male urinary incontinence: prevalence, risk factors, and preventive interventions","volume":"11","author":"Shamliyan","year":"2009","journal-title":"Rev Urol"},{"key":"10.1016\/j.jtha.2025.07.020_bib61","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1186\/s12877-023-04249-7","article-title":"A scoping review of risk factors for urinary incontinence in older men","volume":"23","author":"Olagundoye","year":"2023","journal-title":"BMC Geriatr"},{"key":"10.1016\/j.jtha.2025.07.020_bib62","first-page":"843","article-title":"Current treatment for benign prostatic hyperplasia","volume":"117","author":"Miernik","year":"2020","journal-title":"Dtsch Arztebl Int"},{"key":"10.1016\/j.jtha.2025.07.020_bib63","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12894-016-0191-1","article-title":"Intermittent catheterisation with hydrophilic and non-hydrophilic urinary catheters: systematic literature review and meta-analyses","volume":"17","author":"Rognoni","year":"2017","journal-title":"BMC Urol"},{"key":"10.1016\/j.jtha.2025.07.020_bib64","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/785263","article-title":"Efficacy of physiotherapy for urinary incontinence following prostate cancer surgery","volume":"2014","author":"Rajkowska-Labon","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.jtha.2025.07.020_bib65","doi-asserted-by":"crossref","first-page":"11","DOI":"10.33235\/anzcj.30.1.11-14","article-title":"Did you know... occupational therapists assist in assessment and management of continence across the lifespan?","volume":"30","author":"Brandis","year":"2024","journal-title":"ANZCJ"},{"key":"10.1016\/j.jtha.2025.07.020_bib66","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1111\/j.1464-410X.2012.11022.x","article-title":"Lower urinary tract symptoms and urinary incontinence in a geriatric cohort - a population-based analysis","volume":"110","author":"Wehrberger","year":"2012","journal-title":"BJU Int"},{"key":"10.1016\/j.jtha.2025.07.020_bib67","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12877-021-02135-8","article-title":"Prevalence and factors related to urinary incontinence in older adults women worldwide: a comprehensive systematic review and meta-analysis of observational studies","volume":"21","author":"Batmani","year":"2021","journal-title":"BMC Geriatr"},{"key":"10.1016\/j.jtha.2025.07.020_bib68","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.maturitas.2020.09.005","article-title":"Management of urinary incontinence in postmenopausal women: an EMAS clinical guide","volume":"143","author":"Russo","year":"2021","journal-title":"Maturitas"},{"key":"10.1016\/j.jtha.2025.07.020_bib69","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/hae.14519","article-title":"Managing prostatic illness in persons with haemophilia","volume":"28","author":"Mannucci","year":"2022","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.020_bib70","article-title":"Evaluating the potential of a new low-profile urinary catheter in preventing catheter-associated urinary tract infections: a prospective randomized blinded clinical trial","volume":"10","author":"Ramezani","year":"2023","journal-title":"Health Serv Res Manag Epidemiol"},{"key":"10.1016\/j.jtha.2025.07.020_bib71","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/hae.14507","article-title":"Prostate biopsy and prostate cancer management in patients with haemophilia: the experience of French haemophilia treatment centres","volume":"28","author":"Gautier","year":"2022","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.020_bib72","doi-asserted-by":"crossref","first-page":"e659","DOI":"10.1111\/hae.14388","article-title":"Prostate interventions in patients with mild haemophilia: safe and feasible","volume":"27","author":"Mesnard","year":"2021","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.020_bib73","doi-asserted-by":"crossref","DOI":"10.3748\/wjg.v31.i3.97963","article-title":"Controversies in fecal incontinence","volume":"31","author":"Albuquerque","year":"2025","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jtha.2025.07.020_bib74","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.cgh.2023.09.004","article-title":"Global prevalence of fecal incontinence in community-dwelling adults: a systematic review and meta-analysis","volume":"22","author":"Mack","year":"2024","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jtha.2025.07.020_bib75","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1053\/j.gastro.2009.04.054","article-title":"Fecal incontinence in US adults: epidemiology and risk factors","volume":"137","author":"Whitehead","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jtha.2025.07.020_bib76","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s00508-024-02369-7","article-title":"Treatment of fecal incontinence-is there a light in the end of the tunnel?","volume":"137","author":"Riss","year":"2025","journal-title":"Wien Klin Wochenschr"},{"key":"10.1016\/j.jtha.2025.07.020_bib77","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1007\/s10439-016-1572-z","article-title":"Artificial muscle devices: innovations and prospects for fecal incontinence treatment","volume":"44","author":"Fattorini","year":"2016","journal-title":"Ann Biomed Eng"},{"key":"10.1016\/j.jtha.2025.07.020_bib80","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/s41562-023-01585-x","article-title":"Identifying modifiable factors and their joint effect on dementia risk in the UK Biobank","volume":"7","author":"Zhang","year":"2023","journal-title":"Nat Hum Behav"},{"key":"10.1016\/j.jtha.2025.07.020_bib81","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1001\/jamaoto.2017.2513","article-title":"Association of age-related hearing loss with cognitive function, cognitive impairment, and dementia: a systematic review and meta-analysis","volume":"144","author":"Loughrey","year":"2018","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jtha.2025.07.020_bib82","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.neuron.2020.08.003","article-title":"How can hearing loss cause dementia?","volume":"108","author":"Griffiths","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.jtha.2025.07.020_bib83","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/hae.14013","article-title":"Management of comorbidities in haemophilia","volume":"27","author":"Kempton","year":"2021","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.020_bib84","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1365-2516.2011.02611.x","article-title":"Intracranial haemorrhage in the Italian population of haemophilia patients with and without inhibitors","volume":"18","author":"Zanon","year":"2012","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.020_bib85","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.neurobiolaging.2017.02.018","article-title":"Cerebral microbleeds and risk of incident dementia: the Framingham Heart Study","volume":"54","author":"Romero","year":"2017","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.jtha.2025.07.020_bib86","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.thromres.2014.08.005","article-title":"Cognitive dysfunctions and cerebral microbleeds in adult patients with haemophilia A: a clinical and MRI pilot-study","volume":"134","author":"Zanon","year":"2014","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2025.07.020_bib87","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/hae.13398","article-title":"Prevalence of and risk factors for cerebral microbleeds among adult patients with haemophilia A or B","volume":"24","author":"Husseinzadeh","year":"2018","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.020_bib88","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1111\/hex.12083","article-title":"Self-management and skills acquisition in boys with haemophilia","volume":"18","author":"Khair","year":"2015","journal-title":"Health Expect"},{"key":"10.1016\/j.jtha.2025.07.020_bib90","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1111\/bcp.16200","article-title":"The effect of deprescribing interventions on mortality and health outcomes in older people: an updated systematic review and meta-analysis","volume":"90","author":"Quek","year":"2024","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.jtha.2025.07.020_bib91","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/ejhf.2333","volume":"24","author":"McDonagh","year":"2022","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jtha.2025.07.020_bib92","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0317907","article-title":"The impact of polypharmacy on health outcomes in the aged: a retrospective cohort study","volume":"20","author":"Boateng","year":"2025","journal-title":"PloS One"},{"key":"10.1016\/j.jtha.2025.07.020_bib93","article-title":"Deprescribing in older adults with polypharmacy","volume":"385","author":"Hung","year":"2024","journal-title":"BMJ"},{"key":"10.1016\/j.jtha.2025.07.020_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102661","article-title":"Medication reviews in hospitalised patients for reduced hospital readmission and mortality. Systematic review, meta-analysis and meta-regression of RCTs","volume":"104","author":"Degen","year":"2025","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jtha.2025.07.020_bib95","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s40266-023-01032-6","article-title":"Impact of a comprehensive intervention bundle including the drug burden index on deprescribing anticholinergic and sedative drugs in older acute inpatients: a non-randomised controlled before-and-after pilot study","volume":"40","author":"Fujita","year":"2023","journal-title":"Drugs Aging"},{"key":"10.1016\/j.jtha.2025.07.020_bib96","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1186\/s12877-022-03279-x","article-title":"Prevalence and factors associated with polypharmacy: a systematic review and Meta-analysis","volume":"22","author":"Delara","year":"2022","journal-title":"BMC Geriatr"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625004702?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625004702?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:58:25Z","timestamp":1786132705000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783625004702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":91,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S1538783625004702"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2025.07.020","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Frailty and frailty syndromes in persons with hemophilia: a review","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2025.07.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}]}}