{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T02:30:14Z","timestamp":1793500214900,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100005902","name":"University of Wisconsin-Madison Institute for Clinical and Translational Research","doi-asserted-by":"publisher","award":["UL1 TR002373"],"award-info":[{"award-number":["UL1 TR002373"]}],"id":[{"id":"10.13039\/100005902","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL149364"],"award-info":[{"award-number":["R01HL149364"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL149855"],"award-info":[{"award-number":["R01HL149855"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UL1 TR002373"],"award-info":[{"award-number":["UL1 TR002373"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jtha.2025.07.036","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T15:20:29Z","timestamp":1754925629000},"page":"3501-3514","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Protease domain exosites regulate extravascular binding of factor IX(a)"],"prefix":"10.1016","volume":"23","author":[{"given":"Pamela R.","family":"Westmark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas S.","family":"Annis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brianna","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina M.","family":"Misenheimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradford S.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Hutson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4328-2613","authenticated-orcid":false,"given":"John P.","family":"Sheehan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2025.07.036_bib1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1365-2141.1987.tb01303.x","article-title":"In vivo evidence of intravascular binding sites for coagulation factor IX","volume":"66","author":"Stern","year":"1987","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2025.07.036_bib2","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1111\/jth.12421","article-title":"Evidence of clinically significant extravascular stores of factor IX","volume":"11","author":"Feng","year":"2013","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.07.036_bib3","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1182\/blood.2018884015","article-title":"Dysfunctional endogenous FIX impairs prophylaxis in a mouse hemophilia B model","volume":"133","author":"Cooley","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.07.036_bib4","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/hae.14300","article-title":"The function of extravascular coagulation factor IX in haemostasis","volume":"27","author":"Mann","year":"2021","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.036_bib5","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1055\/a-2090-9739","article-title":"Modulation of extravascular binding of recombinant factor IX impacts the duration of efficacy in mouse models","volume":"123","author":"Machado","year":"2023","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.07.036_bib6","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1111\/j.1538-7836.2009.03545.x","article-title":"Abnormal hemostasis in a knock-in mouse carrying a variant of factor IX with impaired binding to collagen type IV","volume":"7","author":"Gui","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.07.036_bib7","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.jtha.2023.11.023","article-title":"Extravascular factor IX pool fed by prophylaxis is a true hemostatic barrier against bleeding","volume":"22","author":"Leuci","year":"2024","journal-title":"J Thromb Haemost"},{"issue":"Suppl 2","key":"10.1016\/j.jtha.2025.07.036_bib8","first-page":"33","article-title":"Clinical evaluation of recombinant factor IX","volume":"35","author":"White","year":"1998","journal-title":"Semin Hematol"},{"key":"10.1016\/j.jtha.2025.07.036_bib9","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1055\/s-0038-1653868","article-title":"Variability of in vivo recovery of factor IX after infusion of monoclonal antibody purified factor IX concentrates in patients with hemophilia B. The Mononine Study Group","volume":"73","author":"White","year":"1995","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.07.036_bib10","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1046\/j.1537-2995.2002.00039.x","article-title":"Pharmacokinetic analysis of plasma-derived and recombinant F IX concentrates in previously treated patients with moderate or severe hemophilia B","volume":"42","author":"Ewenstein","year":"2002","journal-title":"Transfusion"},{"key":"10.1016\/j.jtha.2025.07.036_bib11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/17425255.2016.1237504","article-title":"Plasma-derived human factor X concentrate for on-demand and perioperative treatment in factor X-deficient patients: pharmacology, pharmacokinetics, efficacy, and safety","volume":"13","author":"Shapiro","year":"2017","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1016\/j.jtha.2025.07.036_bib12","first-page":"200","article-title":"Factor VII half-life after transfusion of a steam-treated prothrombin complex concentrate in a patient with homozygous factor VII deficiency","volume":"56","author":"K\u00f6hler","year":"1989","journal-title":"Vox Sang"},{"key":"10.1016\/j.jtha.2025.07.036_bib13","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1046\/j.1537-2995.1994.341195065036.x","article-title":"Clinical study of recovery and half-life of vapor-heated factor VII concentrate","volume":"34","author":"Rivard","year":"1994","journal-title":"Transfusion"},{"key":"10.1016\/j.jtha.2025.07.036_bib14","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1365-2516.2011.02552.x","article-title":"Factor IX replacement to cover total knee replacement surgery in haemophilia B: a single-centre experience, 2000-2010","volume":"18","author":"Uprichard","year":"2012","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.036_bib15","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/BF00194400","article-title":"Pharmacokinetics of factor IX in patients with haemophilia B. Methodological aspects and physiological interpretation","volume":"46","author":"Bj\u00f6rkman","year":"1994","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.jtha.2025.07.036_bib16","doi-asserted-by":"crossref","first-page":"4119","DOI":"10.1073\/pnas.80.13.4119","article-title":"Binding of factors IX and IXa to cultured vascular endothelial cells","volume":"80","author":"Stern","year":"1983","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jtha.2025.07.036_bib17","doi-asserted-by":"crossref","first-page":"11068","DOI":"10.1073\/pnas.93.20.11068","article-title":"Identification of the endothelial cell binding site for factor IX","volume":"93","author":"Cheung","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jtha.2025.07.036_bib18","doi-asserted-by":"crossref","first-page":"16717","DOI":"10.1074\/jbc.272.27.16717","article-title":"Human factor IX binds to specific sites on the collagenous domain of collagen IV","volume":"272","author":"Wolberg","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtha.2025.07.036_bib19","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1182\/blood.V100.1.153","article-title":"Circulating and binding characteristics of wild-type factor IX and certain Gla domain mutants in vivo","volume":"100","author":"Gui","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.07.036_bib20","doi-asserted-by":"crossref","first-page":"15198","DOI":"10.1074\/jbc.RA120.015325","article-title":"Exosite binding drives substrate affinity for the activation of coagulation factor X by the intrinsic Xase complex","volume":"295","author":"Basavaraj","year":"2020","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtha.2025.07.036_bib21","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1073\/pnas.0910144107","article-title":"Molecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-a structure of the ternary complex","volume":"107","author":"Johnson","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jtha.2025.07.036_bib22","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/jth.12960","article-title":"Selective disruption of heparin and antithrombin-mediated regulation of human factor IX","volume":"13","author":"Westmark","year":"2015","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.07.036_bib23","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1182\/blood.2020005593","article-title":"Factor VIII-driven changes in activated factor IX explored by hydrogen-deuterium exchange mass spectrometry","volume":"136","author":"Freato","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.07.036_bib24","doi-asserted-by":"crossref","first-page":"12089","DOI":"10.1074\/jbc.273.20.12089","article-title":"Changing residue 338 in human factor IX from arginine to alanine causes an increase in catalytic activity","volume":"273","author":"Chang","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtha.2025.07.036_bib25","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1056\/NEJMoa0904377","article-title":"X-linked thrombophilia with a mutant factor IX (factor IX Padua)","volume":"361","author":"Simioni","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtha.2025.07.036_bib26","article-title":"Hyperactivity of factor IX Padua (R338L) depends on factor VIIIa cofactor activity","volume":"5","author":"Samelson-Jones","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.jtha.2025.07.036_bib27","series-title":"NONMEM Users Guides. (1989-2013)","author":"Beal","year":"2013"},{"key":"10.1016\/j.jtha.2025.07.036_bib28","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1182\/blood-2008-01-136820","article-title":"The heparin-binding exosite of factor IXa is a critical regulator of plasma thrombin generation and venous thrombosis","volume":"112","author":"Buyue","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.07.036_bib29","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/j.1365-2516.2012.02780.x","article-title":"A sensitive venous bleeding model in haemophilia A mice: effects of two recombinant FVIII products (N8 and Advate(\u00ae))","volume":"18","author":"Pastoft","year":"2012","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.036_bib30","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1097\/00005344-199905000-00007","article-title":"Demonstration of flow and platelet dependency in a ferric chloride-induced model of thrombosis","volume":"33","author":"Lockyer","year":"1999","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.jtha.2025.07.036_bib31","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1538-7836.2005.01236.x","article-title":"Effects of factor IX or factor XI deficiency on ferric chloride-induced carotid artery occlusion in mice","volume":"3","author":"Wang","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.07.036_bib32","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1152\/japplphysiol.01068.2011","article-title":"Measurement of plasma volume using fluorescent silica-based nanoparticles","volume":"112","author":"Eisner","year":"2012","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.jtha.2025.07.036_bib33","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1023\/A:1018943613122","article-title":"Physiological parameters in laboratory animals and humans","volume":"10","author":"Davies","year":"1993","journal-title":"Pharm Res"},{"key":"10.1016\/j.jtha.2025.07.036_bib34","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/ame2.12139","article-title":"Clinical hematological and biochemical parameters in Swiss, BALB\/c, C57BL\/6 and B6D2F1 Mus musculus","volume":"3","author":"Silva-Santana","year":"2020","journal-title":"Animal Model Exp Med"},{"key":"10.1016\/j.jtha.2025.07.036_bib35","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1021\/bi047934a","article-title":"The factor IXa heparin-binding exosite is a cofactor interactive site: mechanism for antithrombin-independent inhibition of intrinsic tenase by heparin","volume":"44","author":"Yuan","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.jtha.2025.07.036_bib36","doi-asserted-by":"crossref","first-page":"20529","DOI":"10.1016\/S0021-9258(19)36713-4","article-title":"The binding of human factor IX to endothelial cells is mediated by residues 3-11","volume":"267","author":"Cheung","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtha.2025.07.036_bib37","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jhep.2016.07.009","article-title":"Liver sinusoidal endothelial cells: physiology and role in liver diseases","volume":"66","author":"Poisson","year":"2017","journal-title":"J Hepatol"},{"key":"10.1016\/j.jtha.2025.07.036_bib38","first-page":"693","article-title":"Biodistribution and pharmacokinetics of transgenic pig-produced recombinant human factor IX (rhFIX) in rats","volume":"22","author":"Chang","year":"2008","journal-title":"Vivo"},{"key":"10.1016\/j.jtha.2025.07.036_bib39","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1172\/JCI111377","article-title":"Regulation of factor IXa in vitro in human and mouse plasma and in vivo in the mouse. Role of the endothelium and the plasma proteinase inhibitors","volume":"73","author":"Fuchs","year":"1984","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jtha.2025.07.036_bib40","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/MBC.0000000000001230","article-title":"Biodistribution of recombinant factor IX, extended half-life recombinant factor IX Fc fusion protein, and glycoPEGylated recombinant factor IX in hemophilia B mice","volume":"34","author":"van der Flier","year":"2023","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.jtha.2025.07.036_bib41","doi-asserted-by":"crossref","first-page":"F465","DOI":"10.1152\/ajprenal.00036.2023","article-title":"The unique structural and functional characteristics of glomerular endothelial cell fenestrations and their potential as a therapeutic target in kidney disease","volume":"325","author":"Finch","year":"2023","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.jtha.2025.07.036_bib42","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41581-018-0098-z","article-title":"Endothelium structure and function in kidney health and disease","volume":"15","author":"Jourde-Chiche","year":"2019","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.jtha.2025.07.036_bib43","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1161\/01.RES.0000255691.76142.4a","article-title":"Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms","volume":"100","author":"Aird","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.jtha.2025.07.036_bib44","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a020412","article-title":"The blood-brain barrier","volume":"7","author":"Daneman","year":"2015","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.jtha.2025.07.036_bib45","doi-asserted-by":"crossref","DOI":"10.1177\/1076029619888023","article-title":"Differences in major bleeding events between patients with severe hemophilia A and hemophilia B: a nationwide, population-based cohort study","volume":"25","author":"Shih","year":"2019","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1016\/j.jtha.2025.07.036_bib46","doi-asserted-by":"crossref","first-page":"6523","DOI":"10.1074\/jbc.271.11.6523","article-title":"Cellular internalization and degradation of antithrombin III-thrombin, heparin cofactor II-thrombin, and alpha 1-antitrypsin-trypsin complexes is mediated by the low density lipoprotein receptor-related protein","volume":"271","author":"Kounnas","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtha.2025.07.036_bib47","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1182\/blood.V96.10.3459","article-title":"Activation of factor IX zymogen results in exposure of a binding site for low-density lipoprotein receptor-related protein","volume":"96","author":"Neels","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.07.036_bib48","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1111\/jth.15288","article-title":"Probing activation-driven changes in coagulation factor IX by mass spectrometry","volume":"19","author":"Freato","year":"2021","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.07.036_bib49","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1083\/jcb.111.3.1293","article-title":"Localization of anticoagulantly active heparan sulfate proteoglycans in vascular endothelium: antithrombin binding on cultured endothelial cells and perfused rat aorta","volume":"111","author":"de Agostini","year":"1990","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jtha.2025.07.036_bib50","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1177\/42.10.7930519","article-title":"Immunocytochemical localization of endogenous anti-thrombin III in the vasculature of rat tissues reveals locations of anticoagulantly active heparan sulfate proteoglycans","volume":"42","author":"Xu","year":"1994","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.jtha.2025.07.036_bib51","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1182\/blood.2022018083","article-title":"Factor IXa variants resistant to plasma inhibitors enhance clot formation in vivo","volume":"141","author":"Ivanciu","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.07.036_bib52","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1182\/blood.V91.3.784","article-title":"Human factor IX corrects the bleeding diathesis of mice with hemophilia B","volume":"91","author":"Kung","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.07.036_bib53","doi-asserted-by":"crossref","first-page":"18700","DOI":"10.1074\/jbc.M111.336073","article-title":"The epidermal basement membrane is a composite of separate laminin- or collagen IV-containing networks connected by aggregated perlecan, but not by nidogens","volume":"287","author":"Behrens","year":"2012","journal-title":"J Biol Chem"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625005161?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625005161?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T02:27:29Z","timestamp":1793500049000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783625005161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":53,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S1538783625005161"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2025.07.036","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protease domain exosites regulate extravascular binding of factor IX(a)","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2025.07.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}