{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T12:17:08Z","timestamp":1785845828229,"version":"3.56.0"},"reference-count":100,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jtha.2025.07.037","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T02:16:25Z","timestamp":1755742585000},"page":"3424-3436","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["The underexplored crosstalk between hemostasis and bone metabolism: from mechanisms to clinical implications"],"prefix":"10.1016","volume":"23","author":[{"given":"Gaetano Paride","family":"Arcidiacono","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0377-3741","authenticated-orcid":false,"given":"Elena","family":"Campello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Simion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Giannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Simioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2025.07.037_bib1","series-title":"Physiology, hemostasis. StatPearls. Treasure Island (FL)","author":"LaPelusa","year":"2025"},{"key":"10.1016\/j.jtha.2025.07.037_bib2","doi-asserted-by":"crossref","first-page":"25001","DOI":"10.1038\/s41598-024-75747-w","article-title":"Effects of coagulation factors on bone cells and consequences of their absence in haemophilia a patients","volume":"14","author":"Battafarano","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtha.2025.07.037_bib3","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1177\/0004563218759371","article-title":"The bone remodelling cycle","volume":"55","author":"Kenkre","year":"2018","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.jtha.2025.07.037_bib4","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1161\/ATVBAHA.124.320151","article-title":"Global health burden of venous thromboembolism","volume":"44","author":"Wendelboe","year":"2024","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jtha.2025.07.037_bib5","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11657-020-0706-y","article-title":"Fragility fractures in Europe: burden, management and opportunities","volume":"15","author":"Borgstr\u00f6m","year":"2020","journal-title":"Arch Osteoporos"},{"key":"10.1016\/j.jtha.2025.07.037_bib6","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1160\/TH17-08-0596","article-title":"Contact system activation and cancer: new insights in the pathophysiology of cancer-associated thrombosis","volume":"118","author":"Campello","year":"2018","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.07.037_bib7","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41416-019-0510-x","article-title":"The relationship between pancreatic cancer and hypercoagulability: a comprehensive review on epidemiological and biological issues","volume":"121","author":"Campello","year":"2019","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jtha.2025.07.037_bib8","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.abb.2008.03.018","article-title":"Functions of RANKL\/RANK\/OPG in bone modeling and remodeling","volume":"473","author":"Boyce","year":"2008","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jtha.2025.07.037_bib9","doi-asserted-by":"crossref","first-page":"E436","DOI":"10.1210\/jc.2010-1886","article-title":"Relationship between Vitamin D, Parathyroid Hormone, and Bone Health","volume":"96","author":"Sai","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jtha.2025.07.037_bib10","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.3390\/ijms21051762","article-title":"Platelet features and derivatives in osteoporosis: a rational and systematic review on the best evidence","volume":"21","author":"Salamanna","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtha.2025.07.037_bib11","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.bone.2004.12.006","article-title":"Megakaryocytes modulate osteoblast synthesis of type-l collagen, osteoprotegerin, and RANKL","volume":"36","author":"Bord","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.jtha.2025.07.037_bib12","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.bone.2008.08.117","article-title":"The role of gap junctions in megakaryocyte-mediated osteoblast proliferation and differentiation","volume":"44","author":"Ciovacco","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.jtha.2025.07.037_bib13","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.bone.2006.05.004","article-title":"Megakaryocyte-mediated inhibition of osteoclast development","volume":"39","author":"Kacena","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.jtha.2025.07.037_bib14","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S8756-3282(00)00336-7","article-title":"Megakaryocyte population in human bone marrow increases with estrogen treatment: a role in bone remodeling?","volume":"27","author":"Bord","year":"2000","journal-title":"Bone"},{"key":"10.1016\/j.jtha.2025.07.037_bib15","doi-asserted-by":"crossref","first-page":"31704","DOI":"10.1074\/jbc.M109.030312","article-title":"Factor VIII-von Willebrand factor complex inhibits osteoclastogenesis and controls cell survival","volume":"284","author":"Baud\u2019huin","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtha.2025.07.037_bib16","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/s12020-024-03774-8","article-title":"Deficiency of protein C or protein S as a possible cause of osteoporosis","volume":"85","author":"Cirovic","year":"2024","journal-title":"Endocrine"},{"key":"10.1016\/j.jtha.2025.07.037_bib17","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.3390\/nu12123625","article-title":"Vitamin K and osteoporosis","volume":"12","author":"Fusaro","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jtha.2025.07.037_bib18","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1182\/blood.V93.6.1798.406k22_1798_1808","article-title":"Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid","volume":"93","author":"Furie","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.07.037_bib19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.thromres.2005.07.025","article-title":"Vitamins and minerals that affect hemostasis and antithrombotic therapies","volume":"117","author":"Rebecca Couris","year":"2005","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2025.07.037_bib20","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s00223-010-9441-5","article-title":"Vitamin K2 Prevents Hyperglycemia and Cancellous Osteopenia in Rats with Streptozotocin-Induced Type 1 Diabetes","volume":"88","author":"Iwamoto","year":"2011","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jtha.2025.07.037_bib21","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1160\/TH14-08-0675","article-title":"Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women: a double-blind randomised clinical trial","volume":"113","author":"Knapen","year":"2015","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.07.037_bib22","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1093\/nutrit\/nuab061","article-title":"the OEMONOM researchers and collaborators. Vitamin K\u2014sources, physiological role, kinetics, deficiency, detection, therapeutic use, and toxicity","volume":"80","author":"Mlad\u011bnka","year":"2022","journal-title":"Nutr Rev"},{"key":"10.1016\/j.jtha.2025.07.037_bib23","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1055\/s-0034-1543999","article-title":"Oral anticoagulant drugs and the risk of osteoporosis: new anticoagulants better than old?","volume":"41","author":"Tufano","year":"2015","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.jtha.2025.07.037_bib24","doi-asserted-by":"crossref","first-page":"829","DOI":"10.7326\/0003-4819-128-10-199805150-00006","article-title":"Warfarin use and risk for osteoporosis in elderly women","volume":"128","author":"Jamal","year":"1998","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jtha.2025.07.037_bib25","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1515\/cclm-2016-0783","article-title":"Vitamin K plasma levels determination in human health","volume":"55","author":"Fusaro","year":"2017","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.jtha.2025.07.037_bib26","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.3390\/biomedicines10051048","article-title":"Effect of vitamin K on bone mineral density and fracture risk in adults: systematic review and meta-analysis","volume":"10","author":"Salma","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.jtha.2025.07.037_bib27","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1001\/jamaneurol.2016.2252","article-title":"Association between serum calcium level and extent of bleeding in patients with intracerebral hemorrhage","volume":"73","author":"Morotti","year":"2016","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.jtha.2025.07.037_bib28","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1055\/s-2008-1065365","article-title":"Blood coagulation, fibrinolysis and lipid profile in patients with primary hyperparathyroidism: increased plasma factor VII and X activities and D-dimer levels","volume":"116","author":"Erem","year":"2008","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"10.1016\/j.jtha.2025.07.037_bib29","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/BF03346669","article-title":"Acute hyperparathyroidism and vascular thrombosis; an unrecognized association","volume":"33","author":"Franchello","year":"2010","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.jtha.2025.07.037_bib30","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1093\/ndt\/gfg414","article-title":"Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality","volume":"18","author":"London","year":"2003","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.jtha.2025.07.037_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241914724","article-title":"Platelets in renal disease","volume":"24","author":"Gomchok","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtha.2025.07.037_bib32","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1530\/EC-19-0429","article-title":"Thrombin generation and fibrin clot structure after vitamin D supplementation","volume":"8","author":"Blondon","year":"2019","journal-title":"Endocr Connect"},{"key":"10.1016\/j.jtha.2025.07.037_bib33","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3390\/biom9110649","article-title":"Emerging role of vitamin D and its associated molecules in pathways related to pathogenesis of thrombosis","volume":"9","author":"Mohammad","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.jtha.2025.07.037_bib34","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3390\/nu17010090","article-title":"Recent updates and advances in the association between vitamin D deficiency and risk of thrombotic disease","volume":"17","author":"Ojaroodi","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.jtha.2025.07.037_bib35","doi-asserted-by":"crossref","DOI":"10.1177\/10760296231201855","article-title":"Vitamin D deficiency is associated with increased plasminogen activator inhibitor 1\/plasminogen activator inhibitor 2 ratio in pregnancy","volume":"29","author":"Andersen","year":"2023","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1016\/j.jtha.2025.07.037_bib36","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3390\/nu15020334","article-title":"Role of vitamin D deficiency in the pathogenesis of cardiovascular and cerebrovascular diseases","volume":"15","author":"P\u00e1l","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.jtha.2025.07.037_bib37","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/hae.13986","article-title":"Biomarkers of bone disease in persons with haemophilia","volume":"27","author":"Goldscheitter","year":"2021","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.037_bib38","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.blre.2018.05.002","article-title":"Increased bone resorption in hemophilia","volume":"33","author":"Rodriguez-Merchan","year":"2019","journal-title":"Blood Rev"},{"key":"10.1016\/j.jtha.2025.07.037_bib39","doi-asserted-by":"crossref","first-page":"e870","DOI":"10.1111\/j.1365-2516.2011.02514.x","article-title":"Role of exercise and physical activity on haemophilic arthropathy, fall prevention and osteoporosis","volume":"17","author":"Forsyth","year":"2011","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.037_bib40","doi-asserted-by":"crossref","first-page":"e308","DOI":"10.1111\/hae.12187","article-title":"Vitamin D deficiency in patients with haemophilia: an underestimated commorbidity","volume":"19","author":"Anagnostis","year":"2013","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.037_bib41","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1365-2516.2008.01963.x","article-title":"Prevalence and risk factors associated with decreased bone mineral density in patients with haemophilia","volume":"15","author":"Gerstner","year":"2009","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.037_bib42","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/hae.14951","article-title":"Bone mineral density in haemophilia patients: a systematic review and meta-analysis","volume":"30","author":"Zhang","year":"2024","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.037_bib43","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/hae.70033","article-title":"Fracture risk in people with haemophilia A and B: a systematic review and meta-analysis","volume":"31","author":"Divaris","year":"2025","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.037_bib44","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11657-022-01203-9","article-title":"Pathogenesis and treatment of osteoporosis in patients with hemophilia","volume":"18","author":"Lin","year":"2023","journal-title":"Arch Osteoporos"},{"key":"10.1016\/j.jtha.2025.07.037_bib45","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1160\/TH13-01-0030","article-title":"The effect of monthly ibandronate on bone mineral density and bone turnover markers in patients with haemophilia A and B and increased risk for fracture","volume":"110","author":"Anagnostis","year":"2013","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.07.037_bib46","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/bjh.13481","article-title":"High serum sclerostin levels in children with haemophilia A","volume":"172","author":"Giordano","year":"2016","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2025.07.037_bib47","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1365-2516.2008.01912.x","article-title":"Long-term prophylaxis in severe haemophilia seems to preserve bone mineral density","volume":"15","author":"Khawaji","year":"2009","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.037_bib48","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1111\/hae.14642","article-title":"Effect of emicizumab prophylaxis on bone and joint health markers in people with haemophilia A without factor VIII inhibitors in the HAVEN 3 study","volume":"28","author":"Kiialainen","year":"2022","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.037_bib49","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/hae.14565","article-title":"Bone health in haemophilia carriers and persons with von Willebrand disease: a large database analysis","volume":"28","author":"Citla-Sridhar","year":"2022","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.07.037_bib50","first-page":"1599","article-title":"Protein-S, a vitamin K-dependent protein, is a bone matrix component synthesized and secreted by osteoblasts","volume":"130","author":"Maillard","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.jtha.2025.07.037_bib51","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00223-018-0483-4","article-title":"Assessing the genetic correlations between blood plasma proteins and osteoporosis: a polygenic risk score analysis","volume":"104","author":"Liang","year":"2019","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jtha.2025.07.037_bib52","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0049-3848(90)90092-Q","article-title":"Bone mineral density and its association with inherited protein S deficiency","volume":"58","author":"Pan","year":"1990","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2025.07.037_bib53","doi-asserted-by":"crossref","first-page":"7348","DOI":"10.3390\/ijerph19127348","article-title":"Avascular necrosis of femoral head\u2014overview and current state of the art","volume":"19","author":"Konarski","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.jtha.2025.07.037_bib54","first-page":"376","article-title":"Thrombophilia, hypofibrinolysis and osteonecrosis","volume":"54","author":"Glueck","year":"2025","journal-title":"Orthopadie (Heidelb)"},{"key":"10.1016\/j.jtha.2025.07.037_bib55","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1177\/0961203316636467","article-title":"Musculoskeletal manifestations of the antiphospholipid syndrome","volume":"25","author":"Noureldine","year":"2016","journal-title":"Lupus"},{"key":"10.1016\/j.jtha.2025.07.037_bib56","doi-asserted-by":"crossref","first-page":"i3","DOI":"10.1093\/ckj\/sfae431","article-title":"Pathophysiology of chronic kidney disease\u2013mineral bone disorder (CKD-MBD): from adaptive to maladaptive mineral homeostasis","volume":"18","author":"Salera","year":"2025","journal-title":"Clin Kidney J"},{"key":"10.1016\/j.jtha.2025.07.037_bib57","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3390\/toxins13030223","article-title":"Thrombolome and its emerging role in chronic kidney diseases","volume":"13","author":"Fryc","year":"2021","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.jtha.2025.07.037_bib58","doi-asserted-by":"crossref","first-page":"7149","DOI":"10.3390\/jcm13237149","article-title":"Role of uremic toxins in vascular inflammation associated with chronic kidney disease","volume":"13","author":"Chermiti","year":"2024","journal-title":"J Clin Med"},{"key":"10.1016\/j.jtha.2025.07.037_bib59","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.3390\/biomedicines10112737","article-title":"Tissue factor, thrombosis, and chronic kidney disease","volume":"10","author":"Oe","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.jtha.2025.07.037_bib60","doi-asserted-by":"crossref","DOI":"10.1210\/clinem\/dgaf138","article-title":"Platelet function and markers of atherothrombotic risk in subjects with parathyroid disorders: a cross-sectional study","author":"Naciu","year":"2025","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jtha.2025.07.037_bib61","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1681\/ASN.2020101440","article-title":"Platelet function in CKD: a systematic review and meta-analysis","volume":"32","author":"Baaten","year":"2021","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.jtha.2025.07.037_bib62","doi-asserted-by":"crossref","first-page":"8705","DOI":"10.3390\/ijms25168705","article-title":"Hallmarks for thrombotic and hemorrhagic risks in chronic kidney disease patients","volume":"25","author":"Saeed","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtha.2025.07.037_bib63","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1365-2265.2012.04485.x","article-title":"Endothelial function in mild primary hyperparathyroidism","volume":"78","author":"Carrelli","year":"2013","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.jtha.2025.07.037_bib64","doi-asserted-by":"crossref","first-page":"6718","DOI":"10.3390\/jcm12216718","article-title":"Primary hyperparathyroidism and cardiovascular disease: an association study using clinical natural language processing systems and big data analytics","volume":"12","author":"Iglesias","year":"2023","journal-title":"J Clin Med"},{"key":"10.1016\/j.jtha.2025.07.037_bib65","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00198-009-1050-7","article-title":"Osteoporosis and venous thromboembolism: a retrospective cohort study in the UK General Practice Research Database","volume":"21","author":"Breart","year":"2010","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jtha.2025.07.037_bib66","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232415722","article-title":"Endothelial dysfunction and chronic inflammation: the cornerstones of vascular alterations in age-related diseases","volume":"23","author":"Pacinella","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtha.2025.07.037_bib67","doi-asserted-by":"crossref","first-page":"8682","DOI":"10.3390\/ijms21228682","article-title":"The role of extracellular vesicles (EVs) in the epigenetic regulation of bone metabolism and osteoporosis","volume":"21","author":"Muraca","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtha.2025.07.037_bib68","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bone.2007.08.029","article-title":"Genetics, pathogenesis and complications of osteopetrosis","volume":"42","author":"Del Fattore","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.jtha.2025.07.037_bib69","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s11914-024-00863-5","article-title":"Osteocytes and Paget\u2019s disease of bone","volume":"22","author":"Tenshin","year":"2024","journal-title":"Curr Osteoporos Rep"},{"key":"10.1016\/j.jtha.2025.07.037_bib70","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2014-208653","article-title":"Metastatic extramammary Paget\u2019s disease responding to weekly paclitaxel","volume":"2015","author":"Phuoc","year":"2015","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.jtha.2025.07.037_bib71","doi-asserted-by":"crossref","first-page":"5275","DOI":"10.3390\/ijms20215275","article-title":"Anticoagulants and osteoporosis","volume":"20","author":"Signorelli","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtha.2025.07.037_bib72","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.3390\/jcm14051647","article-title":"Anticoagulation management: current landscape and future trends","volume":"14","author":"Kholmukhamedov","year":"2025","journal-title":"J Clin Med"},{"key":"10.1016\/j.jtha.2025.07.037_bib73","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.molmed.2004.05.003","article-title":"Warfarin and the vitamin K-dependent gamma-carboxylation system","volume":"10","author":"Wallin","year":"2004","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.jtha.2025.07.037_bib74","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1001\/archinte.166.2.241","article-title":"Risk of osteoporotic fracture in elderly patients taking warfarin: results from the National Registry of Atrial Fibrillation 2","volume":"166","author":"Gage","year":"2006","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jtha.2025.07.037_bib75","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1756-185X.2009.01395.x","article-title":"Reduced bone density in patients on long-term warfarin","volume":"12","author":"Rezaieyazdi","year":"2009","journal-title":"Int J Rheum Dis"},{"key":"10.1016\/j.jtha.2025.07.037_bib76","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1007\/s00198-014-2662-0","article-title":"Incident long-term warfarin use and risk of osteoporotic fractures: propensity-score matched cohort of elders with new onset atrial fibrillation","volume":"25","author":"Misra","year":"2014","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jtha.2025.07.037_bib77","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s11606-018-4758-2","article-title":"A systematic review and meta-analysis of the association between vitamin K antagonist use and fracture","volume":"34","author":"Fiordellisi","year":"2019","journal-title":"J Gen Intern Med"},{"key":"10.1016\/j.jtha.2025.07.037_bib78","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0133847","article-title":"Differential effects of dabigatran and warfarin on bone volume and structure in rats with normal renal function","volume":"10","author":"Fusaro","year":"2015","journal-title":"PLOS One"},{"key":"10.1016\/j.jtha.2025.07.037_bib79","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.013845","article-title":"risk of osteoporosis in patients with atrial fibrillation using non\u2013vitamin K antagonist oral anticoagulants or warfarin","volume":"9","author":"Huang","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jtha.2025.07.037_bib80","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1001\/jamainternmed.2019.5679","article-title":"Association of anticoagulant therapy with risk of fracture among patients with atrial fibrillation","volume":"180","author":"Lutsey","year":"2020","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.jtha.2025.07.037_bib81","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/europace\/euaa242","article-title":"Non-vitamin K oral anticoagulants and risk of fractures: a systematic review and meta-analysis","volume":"23","author":"Mongkhon","year":"2021","journal-title":"Europace"},{"key":"10.1016\/j.jtha.2025.07.037_bib82","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.896952","article-title":"Comparative risks of fracture among direct oral anticoagulants and warfarin: a systematic review and network meta-analysis","volume":"9","author":"Tsai","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jtha.2025.07.037_bib83","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.thromres.2006.10.025","article-title":"The effects of heparin and low molecular weight heparins on bone","volume":"122","author":"Rajgopal","year":"2008","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2025.07.037_bib84","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bone.2007.04.190","article-title":"Heparin enhances osteoclastic bone resorption by inhibiting osteoprotegerin activity","volume":"41","author":"Irie","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.jtha.2025.07.037_bib85","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/S0002-9378(94)70299-3","article-title":"A prospective study of heparin-induced osteoporosis in pregnancy using bone densitometry","volume":"170","author":"Barbour","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jtha.2025.07.037_bib86","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1055\/s-0038-1650255","article-title":"The effects of long-term heparin therapy during pregnancy on bone density. A prospective matched cohort study","volume":"75","author":"Douketis","year":"1996","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.07.037_bib87","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/S0002-9378(13)90457-9","article-title":"Bone mineral density during long-term prophylaxis with heparin in pregnancy","volume":"170","author":"Dahlman","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jtha.2025.07.037_bib88","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1093\/humrep\/deh115","article-title":"Prospective observational study of bone mineral density during pregnancy: low molecular weight heparin versus control","volume":"19","author":"Carlin","year":"2004","journal-title":"Hum Reprod Oxf Engl"},{"key":"10.1016\/j.jtha.2025.07.037_bib89","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1055\/s-0037-1612970","article-title":"Postpartum bone mineral density in women treated for thromboprophylaxis with unfractionated heparin or LMW heparin","volume":"87","author":"Pettil\u00e4","year":"2002","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.07.037_bib90","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1159\/000073848","article-title":"Changes in bone density during long-term administration of low-molecular-weight heparins or acenocoumarol for secondary prophylaxis of venous thromboembolism","volume":"33","author":"Wawrzy\u0144ska","year":"2003","journal-title":"Pathophysiol Haemost Thromb"},{"key":"10.1016\/j.jtha.2025.07.037_bib91","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s11606-016-3603-8","article-title":"Effects of long-term low-molecular-weight heparin on fractures and bone density in non-pregnant adults: a systematic review with meta-analysis","volume":"31","author":"Gajic-Veljanoski","year":"2016","journal-title":"J Gen Intern Med"},{"key":"10.1016\/j.jtha.2025.07.037_bib92","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1055\/a-2325-5658","article-title":"Anticoagulant therapy in pregnant women with mechanical heart valves: Italian Federation of Centers for Diagnosis and Surveillance of the Antithrombotic Therapies (FCSA) Position Paper","volume":"124","author":"Campello","year":"2024","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.07.037_bib93","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2478\/s11658-009-0012-6","article-title":"The effects of disodium pamidronate on human polymorphonuclear leukocytes and platelets: an in vitro study","volume":"14","author":"Salvolini","year":"2009","journal-title":"Cell Mol Biol Lett"},{"key":"10.1016\/j.jtha.2025.07.037_bib94","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.yjmcc.2016.08.017","article-title":"Vascular action of bisphosphonates: in vitro effect of alendronate on the regulation of cellular events involved in vessel pathogenesis","volume":"100","author":"Cutini","year":"2016","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jtha.2025.07.037_bib95","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jss.2012.10.033","article-title":"Differential effect of zoledronic acid on human vascular smooth muscle cells","volume":"182","author":"Albadawi","year":"2013","journal-title":"J Surg Res"},{"key":"10.1016\/j.jtha.2025.07.037_bib96","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.atherosclerosis.2016.06.039","article-title":"Bisphosphonates for cardiovascular risk reduction: a systematic review and meta-analysis","volume":"252","author":"Kranenburg","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jtha.2025.07.037_bib97","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bone.2010.11.008","article-title":"Biochemical and molecular mechanisms of action of bisphosphonates","volume":"49","author":"Rogers","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.jtha.2025.07.037_bib98","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s00198-017-4308-5","article-title":"Risk of venous thromboembolism among users of different anti-osteoporosis drugs: a population-based cohort analysis including over 200,000 participants from Spain and the UK","volume":"29","author":"Mart\u00edn-Merino","year":"2018","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jtha.2025.07.037_bib99","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1177\/1076029614568715","article-title":"The effect of high-dose vitamin D3 on soluble P-selectin and hs-CRP level in patients with venous thromboembolism: a randomized clinical trial","volume":"22","author":"Gholami","year":"2016","journal-title":"Clin Appl Thromb"},{"key":"10.1016\/j.jtha.2025.07.037_bib100","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1160\/TH14-05-0478","article-title":"The effect of calcium plus vitamin D supplementation on the risk of venous thromboembolism: From the Women\u2019s Health Initiative Randomized Controlled Trial","volume":"113","author":"Blondon","year":"2015","journal-title":"Thromb Haemost"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625005173?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625005173?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:13:33Z","timestamp":1778818413000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783625005173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":100,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S1538783625005173"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2025.07.037","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The underexplored crosstalk between hemostasis and bone metabolism: from mechanisms to clinical implications","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2025.07.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}]}}