{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:40:29Z","timestamp":1792795229915,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp &amp; Dohme Ltd","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jtha.2025.08.025","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T16:07:14Z","timestamp":1757347634000},"page":"3920-3931","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Major adverse thrombotic events and bleeding in stage 4 and 5 chronic kidney disease and dialysis-dependent end-stage kidney disease"],"prefix":"10.1016","volume":"23","author":[{"given":"James B.","family":"Wetmore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanyu","family":"Kou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazleen F.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Barash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Brandon","family":"Atkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dena R.","family":"Ramey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas S.","family":"Roetker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2025.08.025_bib1","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1161\/CIRCULATIONAHA.108.816082","article-title":"Impact of proteinuria and glomerular filtration rate on risk of thromboembolism in atrial fibrillation: the anticoagulation and risk factors in atrial fibrillation (ATRIA) study","volume":"119","author":"Go","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2025.08.025_bib2","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1161\/CIRCULATIONAHA.112.113944","article-title":"Association of mild to moderate chronic kidney disease with venous thromboembolism: pooled analysis of five prospective general population cohorts","volume":"126","author":"Mahmoodi","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2025.08.025_bib3","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1056\/NEJMoa1105594","article-title":"Stroke and bleeding in atrial fibrillation with chronic kidney disease","volume":"367","author":"Olesen","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtha.2025.08.025_bib4","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1378\/chest.13-2103","article-title":"A prospective study of estimated glomerular filtration rate and outcomes in patients with atrial fibrillation: the Loire Valley Atrial Fibrillation Project","volume":"145","author":"Banerjee","year":"2014","journal-title":"Chest"},{"key":"10.1016\/j.jtha.2025.08.025_bib5","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1161\/CIRCULATIONAHA.113.002385","article-title":"Role of hemostatic factors on the risk of venous thrombosis in people with impaired kidney function","volume":"129","author":"Ocak","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2025.08.025_bib6","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1053\/j.ajkd.2016.10.039","article-title":"Measures of kidney disease and the risk of venous thromboembolism in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) study","volume":"70","author":"Cheung","year":"2017","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.jtha.2025.08.025_bib7","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.009995","article-title":"Albuminuria, reduced kidney function, and the risk of ST - and non-ST-segment-elevation myocardial infarction","volume":"7","author":"de Chickera","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jtha.2025.08.025_bib8","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1159\/000504877","article-title":"Risk of stroke, bleeding, and death in patients with nonvalvular atrial fibrillation and chronic kidney disease","volume":"145","author":"Arnson","year":"2020","journal-title":"Cardiology"},{"key":"10.1016\/j.jtha.2025.08.025_bib9","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1177\/15266028221134887","article-title":"Impact of chronic kidney disease on in-hospital outcomes of hospitalizations with acute limb ischemia undergoing endovascular therapy","volume":"31","author":"Patel","year":"2024","journal-title":"J Endovasc Ther"},{"key":"10.1016\/j.jtha.2025.08.025_bib10","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1681\/ASN.2008070802","article-title":"Kidney function influences warfarin responsiveness and hemorrhagic complications","volume":"20","author":"Limdi","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.jtha.2025.08.025_bib11","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1159\/000336107","article-title":"Chronic kidney disease and end-stage renal disease predict higher risk of mortality in patients with primary upper gastrointestinal bleeding","volume":"35","author":"Sood","year":"2012","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.jtha.2025.08.025_bib12","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.2215\/CJN.02170216","article-title":"Chronic kidney disease and risk for gastrointestinal bleeding in the community: the atherosclerosis risk in communities (ARIC) study","volume":"11","author":"Ishigami","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.jtha.2025.08.025_bib13","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1681\/ASN.2015050535","article-title":"The risk of major hemorrhage with CKD","volume":"27","author":"Molnar","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.jtha.2025.08.025_bib14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/jth.13904","article-title":"Chronic kidney disease and bleeding risk in patients at high cardiovascular risk: a cohort study","volume":"16","author":"Ocak","year":"2018","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.08.025_bib15","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ijcard.2019.01.089","article-title":"Longitudinal kidney function trajectories predict major bleeding, hospitalization and death in patients with atrial fibrillation and chronic kidney disease","volume":"282","author":"Posch","year":"2019","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jtha.2025.08.025_bib16","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1001\/jamaneurol.2022.2299","article-title":"Association of chronic kidney disease with risk of intracerebral hemorrhage","volume":"79","author":"Vanent","year":"2022","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.jtha.2025.08.025_bib17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ecl.2017.10.006","article-title":"Managing diabetes and cardiovascular risk in chronic kidney disease patients","volume":"47","author":"Lovre","year":"2018","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.jtha.2025.08.025_bib18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/ndt\/gft209","article-title":"Haemostasis in chronic kidney disease","volume":"29","author":"Lutz","year":"2014","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.jtha.2025.08.025_bib19","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.blre.2011.07.001","article-title":"Bleeding and thrombotic complications of kidney disease","volume":"25","author":"Pavord","year":"2011","journal-title":"Blood Rev"},{"key":"10.1016\/j.jtha.2025.08.025_bib20","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1182\/asheducation-2016.1.188","article-title":"Thrombosis and anticoagulation in the setting of renal or liver disease","volume":"2016","author":"Ribic","year":"2016","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.jtha.2025.08.025_bib21","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1055\/s-2004-835678","article-title":"Platelet dysfunction in renal failure","volume":"30","author":"Boccardo","year":"2004","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.jtha.2025.08.025_bib22","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1016\/j.kint.2023.10.018","article-title":"KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"105","year":"2024","journal-title":"Kidney Int"},{"key":"10.1016\/j.jtha.2025.08.025_bib23","first-page":"437","article-title":"Factor XI\/XIa inhibition: the arsenal in development for a new therapeutic target in cardio- and cerebrovascular disease","volume":"9","author":"Badimon","year":"2022","journal-title":"J Cardiovasc Dev Dis"},{"key":"10.1016\/j.jtha.2025.08.025_bib24","first-page":"53","article-title":"Statistical methods for accommodating immortal time: a selective review and comparison","volume":"2","author":"Wang","year":"2024"},{"key":"10.1016\/j.jtha.2025.08.025_bib25","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.2215\/CJN.03680411","article-title":"Early outcomes among those initiating chronic dialysis in the United States","volume":"6","author":"Chan","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.jtha.2025.08.025_bib27","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/pds.2109","article-title":"An automated database case definition for serious bleeding related to oral anticoagulant use","volume":"20","author":"Cunningham","year":"2011","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.jtha.2025.08.025_bib28","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1053\/j.ajkd.2023.07.023","article-title":"Kidney function, albuminuria, and risk of incident atrial fibrillation: a systematic review and meta-analysis","volume":"83","author":"Ha","year":"2024","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.jtha.2025.08.025_bib29","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s11606-010-1511-x","article-title":"Chronic kidney disease and the risk of end-stage renal disease versus death","volume":"26","author":"Dalrymple","year":"2011","journal-title":"J Gen Intern Med"},{"key":"10.1016\/j.jtha.2025.08.025_bib31","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.jacc.2022.11.057","article-title":"Clinical evaluation of factor XIa inhibitor drugs: JACC review topic of the week","volume":"81","author":"Harrington","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jtha.2025.08.025_bib32","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/S0140-6736(22)00456-1","article-title":"Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study","volume":"399","author":"Piccini","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.jtha.2025.08.025_bib33","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1161\/CIRCULATIONAHA.122.061612","article-title":"A multicenter, phase 2, randomized, placebo-controlled, double-blind, parallel-group, dose-finding trial of the oral factor XIa inhibitor asundexian to prevent adverse cardiovascular outcomes after acute myocardial infarction","volume":"146","author":"Rao","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2025.08.025_bib34","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1056\/NEJMoa2113194","article-title":"Milvexian for the prevention of venous thromboembolism","volume":"385","author":"Weitz","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtha.2025.08.025_bib37","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41591-023-02794-7","article-title":"Anticoagulation with osocimab in patients with kidney failure undergoing hemodialysis: a randomized phase 2 trial","volume":"30","author":"Weitz","year":"2024","journal-title":"Nat Med"},{"key":"10.1016\/j.jtha.2025.08.025_bib38","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.kint.2024.02.024","article-title":"A Phase II randomized controlled trial evaluated antithrombotic treatment with fesomersen in patients with kidney failure on hemodialysis","volume":"106","author":"Winkelmayer","year":"2024","journal-title":"Kidney Int"},{"key":"10.1016\/j.jtha.2025.08.025_bib39","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1159\/000504040","article-title":"Association between dialysis modality and cardiovascular diseases: a comparison between peritoneal dialysis and hemodialysis","volume":"49","author":"Banshodani","year":"2020","journal-title":"Blood Purif"},{"key":"10.1016\/j.jtha.2025.08.025_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fneph.2023.1198560","article-title":"Pathophysiological concepts and screening of cardiovascular disease in dialysis patients","volume":"3","author":"Echefu","year":"2023","journal-title":"Front Nephrol"},{"key":"10.1016\/j.jtha.2025.08.025_bib41","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.2215\/CJN.01750309","article-title":"Association of dialysis modality and cardiovascular mortality in incident dialysis patients","volume":"4","author":"Johnson","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.jtha.2025.08.025_bib42","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s41100-024-00536-0","article-title":"Nontraditional risk factors for cardiovascular disease in patients on peritoneal dialysis","volume":"10","author":"Nitta","year":"2024","journal-title":"Ren Replace Ther"},{"key":"10.1016\/j.jtha.2025.08.025_bib43","doi-asserted-by":"crossref","first-page":"205","DOI":"10.34067\/KID.0000000000000360","article-title":"Cardiovascular outcomes in patients on home hemodialysis and peritoneal dialysis","volume":"5","author":"Shah","year":"2024","journal-title":"Kidney360"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625005501?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625005501?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:39:36Z","timestamp":1773157176000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783625005501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S1538783625005501"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2025.08.025","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Major adverse thrombotic events and bleeding in stage 4 and 5 chronic kidney disease and dialysis-dependent end-stage kidney disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2025.08.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}