{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T23:31:44Z","timestamp":1763767904036,"version":"3.45.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jtha.2025.08.034","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T07:42:26Z","timestamp":1763624546000},"page":"3802-3805","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Soluble platelet activation markers in coronary artery disease: a step toward precision thrombosis risk assessment?"],"prefix":"10.1016","volume":"23","author":[{"given":"Francesca","family":"Santilli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Simeone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2025.08.034_bib1","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1093\/eurheartj\/ehaf289","article-title":"Acute coronary syndromes: mechanisms, challenges, and new opportunities","volume":"46","author":"Kraler","year":"2025","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jtha.2025.08.034_bib2","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/j.jacc.2022.08.766","article-title":"Ischemic risk prediction scores: practice-changing or just practice?","volume":"80","author":"Korjian","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jtha.2025.08.034_bib3","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1093\/eurheartj\/ehab484","article-title":"2021 ESC guidelines on cardiovascular disease prevention in clinical practice","volume":"42","author":"Visseren","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jtha.2025.08.034_bib4","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1056\/NEJMra071014","article-title":"Platelet activation and atherothrombosis","volume":"357","author":"Dav\u00ec","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtha.2025.08.034_bib5","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.prostaglandins.2015.05.002","article-title":"Platelets and diabetes mellitus","volume":"120","author":"Santilli","year":"2015","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.jtha.2025.08.034_bib6","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1160\/TH12-08-0550","article-title":"Biomarkers of platelet activation in acute coronary syndromes","volume":"108","author":"Ferroni","year":"2012","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.08.034_bib7","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1016\/j.jtha.2025.07.014","article-title":"Biomarkers of in vivo platelet activation in coronary artery disease: a systematic review and meta-analysis: communication from the SSC of the ISTH","volume":"23","author":"Brambilla","year":"2025","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.08.034_bib8","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jacc.2005.03.079","article-title":"Thromboxane-dependent CD40 ligand release in type 2 diabetes mellitus","volume":"47","author":"Santilli","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jtha.2025.08.034_bib9","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s11739-007-0076-0","article-title":"CD40\/CD40L system and vascular disease","volume":"2","author":"Santilli","year":"2007","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.jtha.2025.08.034_bib10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/PL00000776","article-title":"The CD40\/CD154 receptor\/ligand dyad","volume":"58","author":"Sch\u00f6nbeck","year":"2001","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jtha.2025.08.034_bib11","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1161\/hc4401.099447","article-title":"Soluble CD40L and cardiovascular risk in women","volume":"104","author":"Sch\u00f6nbeck","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2025.08.034_bib12","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1161\/01.CIR.0000074043.46437.44","article-title":"Elevated plasma levels of the atherogenic mediator soluble CD40 ligand in diabetic patients: a novel target of thiazolidinediones","volume":"107","author":"Varo","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2025.08.034_bib13","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1083\/jcb.101.3.880","article-title":"A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation","volume":"101","author":"Stenberg","year":"1985","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jtha.2025.08.034_bib14","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0092-8674(89)90292-4","article-title":"PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes","volume":"59","author":"Larsen","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.jtha.2025.08.034_bib15","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1161\/01.CIR.97.10.953","article-title":"Increased levels of soluble P-selectin in hypercholesterolemic patients","volume":"97","author":"Dav\u00ec","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2025.08.034_bib16","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1182\/blood-2004-07-2617","article-title":"Endothelial expression of E-selectin is induced by the platelet-specific chemokine platelet factor 4 through LRP in an NF-kappaB-dependent manner","volume":"105","author":"Yu","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.08.034_bib17","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1093\/ehjcvp\/pvad051","article-title":"Platelet activation and endothelial dysfunction biomarkers in acute coronary syndrome: the impact of PCSK9 inhibition","volume":"9","author":"Ziogos","year":"2023","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"key":"10.1016\/j.jtha.2025.08.034_bib18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.arr.2018.09.004","article-title":"Significance of urinary 11-dehydro-thromboxane B2 in age-related diseases: focus on atherothrombosis","volume":"48","author":"Simeone","year":"2018","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jtha.2025.08.034_bib19","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jacc.2024.09.010","article-title":"Association of systemic thromboxane generation with risk of developing heart failure","volume":"85","author":"Rade","year":"2025","journal-title":"J Am Coll Cardiol"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625005598?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625005598?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T23:22:25Z","timestamp":1763767345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783625005598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S1538783625005598"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2025.08.034","relation":{},"ISSN":["1538-7836"],"issn-type":[{"type":"print","value":"1538-7836"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Soluble platelet activation markers in coronary artery disease: a step toward precision thrombosis risk assessment?","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2025.08.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2025.07.014","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}]}}