{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:17:01Z","timestamp":1790777821788,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["IIBSP-TCN-2018-109"],"award-info":[{"award-number":["IIBSP-TCN-2018-109"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008666","name":"Marathon Foundation of Tv3","doi-asserted-by":"publisher","award":["EC\/19017\/5418"],"award-info":[{"award-number":["EC\/19017\/5418"]}],"id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jtha.2025.09.006","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T06:46:00Z","timestamp":1759301160000},"page":"282-297","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["A distinctive immunophenotypic signature in thrombocytopenic septic patients: platelet and neutrophil dysregulations as key contributors to disease severity"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3639-3291","authenticated-orcid":false,"given":"Maria","family":"Mulet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n","family":"Osuna-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mart\u00ednez-Espa\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Artesero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pol","family":"Duch-Llorach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Vera-Art\u00e1zcoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Torrens-Sonet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Rodr\u00edguez-Farr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"Vilalta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Abril-Gamboa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Seres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Cant\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma.","family":"\u00c0ngels Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"L\u00f3pez-Contreras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3909-6682","authenticated-orcid":false,"given":"Silvia","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2025.09.006_bib1","article-title":"Sepsis\u2014pathophysiology and therapeutic concepts","volume":"8","author":"Jarczak","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jtha.2025.09.006_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104363","article-title":"Immunopathophysiology of human sepsis","volume":"86","author":"Wiersinga","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jtha.2025.09.006_bib3","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1097\/CCM.0b013e31819def97","article-title":"The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation","volume":"37","author":"Jones","year":"2009","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jtha.2025.09.006_bib4","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1182\/blood-2005-04-1512","article-title":"Platelet PECAM-1 inhibits thrombus formation in vivo","volume":"107","author":"Falati","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.09.006_bib5","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1007\/s12026-022-09302-y","article-title":"Soluble PD-L1 in blood correlates positively with neutrophil and negatively with lymphocyte mRNA markers and implies adverse sepsis outcome","volume":"70","author":"Derigs","year":"2022","journal-title":"Immunol Res"},{"key":"10.1016\/j.jtha.2025.09.006_bib6","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.84752","article-title":"CD31 signaling promotes the detachment at the uropod of extravasating neutrophils allowing their migration to sites of inflammation","volume":"12","author":"Andreata","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.jtha.2025.09.006_bib7","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.thromres.2016.11.007","article-title":"Coagulation and sepsis","volume":"149","author":"Levi","year":"2017","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2025.09.006_bib8","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1182\/blood-2015-01-624023","article-title":"P-selectin promotes neutrophil extracellular trap formation in mice","volume":"126","author":"Etulain","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.09.006_bib9","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s13075-017-1443-5","article-title":"Soluble CD40L is associated with increased oxidative burst and neutrophil extracellular trap release in Beh\u00e7et\u2019s disease","volume":"19","author":"Perazzio","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jtha.2025.09.006_bib10","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.thromres.2007.12.019","article-title":"Neutrophil CD40 enhances platelet-mediated inflammation","volume":"122","author":"Vanichakarn","year":"2008","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2025.09.006_bib11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/MOH.0000000000000297","article-title":"Platelets in neutrophil recruitment to sites of inflammation","volume":"24","author":"Pitchford","year":"2017","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.jtha.2025.09.006_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105792","article-title":"Platelet-derived growth factor B attenuates lethal sepsis through inhibition of inflammatory responses","volume":"75","author":"Wang","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jtha.2025.09.006_bib13","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1080\/09537104.2021.1970124","article-title":"Thrombocytopenia and platelet count recovery in patients with sepsis-3: a retrospective observational study","volume":"33","author":"Zhou","year":"2021","journal-title":"Platelets"},{"key":"10.1016\/j.jtha.2025.09.006_bib14","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/imm.13676","article-title":"Dysregulated neutrophil extracellular traps formation in sepsis","volume":"170","author":"Mulet","year":"2023","journal-title":"Immunology"},{"key":"10.1016\/j.jtha.2025.09.006_bib15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/2052-0492-1-9","article-title":"Thrombocytopenia in adult patients with sepsis: incidence, risk factors, and its association with clinical outcome","volume":"1","author":"Venkata","year":"2013","journal-title":"J Intensive Care"},{"key":"10.1016\/j.jtha.2025.09.006_bib16","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.jtha.2025.09.006_bib17","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/jre.12793","article-title":"Peripheral neutrophil phenotypes during management of periodontitis","volume":"56","author":"Medara","year":"2021","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.jtha.2025.09.006_bib18","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.3390\/cancers14102529","article-title":"Influence of malignant pleural fluid from lung adenocarcinoma patients on neutrophil response","volume":"14","author":"Mulet","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jtha.2025.09.006_bib19","first-page":"1","article-title":"Sandwich ELISA for circulating myeloperoxidase- and neutrophil elastase-DNA complexes released from neutrophil extracellular traps","volume":"5","author":"Kano","year":"2016","journal-title":"Adv Tech Biol Med"},{"key":"10.1016\/j.jtha.2025.09.006_bib20","author":"Wei"},{"key":"10.1016\/j.jtha.2025.09.006_bib21","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1001\/jama.286.14.1754","article-title":"Serial evaluation of the SOFA score to predict outcome in critically ill patients","volume":"286","author":"Ferreira","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.jtha.2025.09.006_bib22","doi-asserted-by":"crossref","first-page":"026","DOI":"10.23937\/2469-5777\/1510026","article-title":"Association between Sequential Organ Failure Assessment Score and in-hospital deaths of surgical, critically ill patients with sepsis","volume":"2","author":"Harada","year":"2016","journal-title":"Trauma Cases Rev"},{"key":"10.1016\/j.jtha.2025.09.006_bib23","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1111\/liv.12520","article-title":"Impact of infection on the prognosis of critically ill cirrhotic patients: results from a large worldwide study","volume":"34","author":"Gustot","year":"2014","journal-title":"Liver Int"},{"key":"10.1016\/j.jtha.2025.09.006_bib24","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1111\/jth.14788","article-title":"Large and small platelets\u2014(when) do they differ?","volume":"18","author":"Handtke","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.09.006_bib25","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.thromres.2022.12.004","article-title":"Platelet ageing: a review","volume":"231","author":"Allan","year":"2023","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2025.09.006_bib26","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1055\/s-0039-3400256","article-title":"Immature platelets as a predictor of disease severity and mortality in sepsis and septic shock: a systematic review","volume":"46","author":"Thorup","year":"2020","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.jtha.2025.09.006_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0223553","article-title":"Kinetics of mean platelet volume predicts mortality in patients with septic shock","volume":"14","author":"Vardon-Bounes","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jtha.2025.09.006_bib28","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cca.2008.09.018","article-title":"Soluble P-selectin as a marker of in vivo platelet activation","volume":"399","author":"Ferroni","year":"2009","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jtha.2025.09.006_bib29","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s001340050344","article-title":"Platelet function in septic multiple organ dysfunction syndrome","volume":"23","author":"Gawaz","year":"1997","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jtha.2025.09.006_bib30","doi-asserted-by":"crossref","first-page":"13835","DOI":"10.1073\/pnas.250475997","article-title":"Pro-coagulant state resulting from high levels of soluble","volume":"97","author":"Andr\u00e9","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jtha.2025.09.006_bib31","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/j.1365-2362.1995.tb01694.x","article-title":"Platelet activation and interaction with leucocytes in patients with sepsis or multiple organ failure","volume":"25","author":"Gawaz","year":"1995","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.jtha.2025.09.006_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-31910-8","article-title":"Platelet activation and prothrombotic properties in a mouse model of peritoneal sepsis","volume":"8","author":"Vardon Bounes","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtha.2025.09.006_bib33","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1084\/jem.20060375","article-title":"Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality","volume":"203","author":"Yano","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.jtha.2025.09.006_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.941257","article-title":"Prognostic role of elevated VEGF in sepsis: a systematic review and meta-analysis","volume":"13","author":"Tang","year":"2022","journal-title":"Front Physiol"},{"key":"10.1016\/j.jtha.2025.09.006_bib35","doi-asserted-by":"crossref","first-page":"7005","DOI":"10.1038\/s41467-021-27303-7","article-title":"Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer","volume":"12","author":"Hinterleitner","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jtha.2025.09.006_bib36","article-title":"PD-L1 regulates platelet activation and thrombosis via caspase-3\/GSDME pathway","volume":"13","author":"Li","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jtha.2025.09.006_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1276353","article-title":"Chemokines, molecular drivers of thromboinflammation and immunothrombosis","volume":"14","author":"Leberzammer","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.jtha.2025.09.006_bib38","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.3389\/fimmu.2020.01299","article-title":"Early activation of myeloid-derived suppressor cells participate in sepsis-induced immune suppression via PD-L1\/PD-1 axis","volume":"11","author":"Ruan","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jtha.2025.09.006_bib39","doi-asserted-by":"crossref","first-page":"R70","DOI":"10.1186\/cc10059","article-title":"Upregulation of programmed death-1 on T cells and programmed death ligand-1 on monocytes in septic shock patients","volume":"15","author":"Zhang","year":"2011","journal-title":"Crit Care"},{"key":"10.1016\/j.jtha.2025.09.006_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112130","article-title":"HMGB1 promotes neutrophil PD-L1 expression through TLR2 and mediates T cell apoptosis leading to immunosuppression in sepsis","volume":"133","author":"Liu","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jtha.2025.09.006_bib41","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1097\/ALN.0000000000000525","article-title":"Up-regulation of programmed cell death 1 ligand 1 on neutrophils may be involved in sepsis-induced immunosuppression: an animal study and a prospective case-control study","volume":"122","author":"Wang","year":"2015","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jtha.2025.09.006_bib42","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s10753-023-01897-0","article-title":"PD-L1 blockade improves survival in sepsis by reversing monocyte dysfunction and immune disorder","volume":"47","author":"Yang","year":"2024","journal-title":"Inflammation"},{"key":"10.1016\/j.jtha.2025.09.006_bib43","doi-asserted-by":"crossref","DOI":"10.1186\/cc9354","article-title":"PD-L1 blockade improves survival in experimental sepsis by inhibiting lymphocyte apoptosis and reversing monocyte dysfunction","volume":"14","author":"Zhang","year":"2010","journal-title":"Crit Care"},{"key":"10.1016\/j.jtha.2025.09.006_bib44","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3892\/mmr.2020.11783","article-title":"Atezolizumab alleviates the immunosuppression induced by PD-L1-positive neutrophils and improves the survival of mice during sepsis","volume":"23","author":"Chen","year":"2021","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.jtha.2025.09.006_bib45","doi-asserted-by":"crossref","first-page":"R3","DOI":"10.1186\/cc13176","article-title":"Targeting the programmed cell death 1: programmed cell death ligand 1 pathway reverses T cell exhaustion in patients with sepsis","volume":"18","author":"Chang","year":"2014","journal-title":"Crit Care"},{"key":"10.1016\/j.jtha.2025.09.006_bib46","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1097\/CCM.0000000000003685","article-title":"Immune checkpoint inhibition in sepsis: a phase 1b randomized, placebo-controlled, single ascending dose study of antiprogrammed cell death-ligand 1 antibody (BMS-936559)","volume":"47","author":"Hotchkiss","year":"2019","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jtha.2025.09.006_bib47","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1097\/SHK.0000000000001443","article-title":"Pharmacokinetics, pharmacodynamics, and safety of nivolumab in patients with sepsis-induced immunosuppression: a multicenter, open-label phase 1\/2 study","volume":"53","author":"Watanabe","year":"2020","journal-title":"Shock"},{"key":"10.1016\/j.jtha.2025.09.006_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0148142","article-title":"Neutrophil extracellular traps induce organ damage during experimental and clinical sepsis","volume":"11","author":"Czaikoski","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jtha.2025.09.006_bib49","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/4065362","article-title":"Sepsis induces a dysregulated neutrophil phenotype that is associated with increased mortality","volume":"2018","author":"Patel","year":"2018","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.jtha.2025.09.006_bib50","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13613-023-01204-y","article-title":"Association of pronounced elevation of NET formation and nucleosome biomarkers with mortality in patients with septic shock","volume":"13","author":"Haem Rahimi","year":"2023","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.jtha.2025.09.006_bib51","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s13054-018-2109-7","article-title":"Plasma myeloperoxidase-conjugated DNA level predicts outcomes and organ dysfunction in patients with septic shock","volume":"22","author":"Maruchi","year":"2018","journal-title":"Crit Care"},{"key":"10.1016\/j.jtha.2025.09.006_bib52","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/s41390-022-02219-0","article-title":"Neutrophil extracellular trap inhibition improves survival in neonatal mouse infectious peritonitis","volume":"93","author":"Denorme","year":"2023","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jtha.2025.09.006_bib53","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1182\/blood.2021011525","article-title":"Gasdermin D inhibition prevents multiple organ dysfunction during sepsis by blocking NET formation","volume":"138","author":"Silva","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.09.006_bib54","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.celrep.2014.06.044","article-title":"A myeloperoxidase-containing complex regulates neutrophil elastase release and actin dynamics during NETosis","volume":"8","author":"Metzler","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.jtha.2025.09.006_bib55","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s40635-017-0157-y","article-title":"Myeloperoxidase can differentiate between sepsis and non-infectious SIRS and predicts mortality in intensive care patients with SIRS","volume":"5","author":"Schrijver","year":"2017","journal-title":"Intensive Care Med Exp"},{"key":"10.1016\/j.jtha.2025.09.006_bib56","article-title":"Assessment of S100A8\/A9 and resistin as predictive biomarkers for mortality in critically ill patients with sepsis","volume":"15","author":"Chen","year":"2025","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jtha.2025.09.006_bib57","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.757041","article-title":"Effects of neutrophil extracellular traps in patients with septic coagulopathy and their interaction with autophagy","volume":"12","author":"Mao","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jtha.2025.09.006_bib58","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1080\/00365513.2019.1703216","article-title":"Calprotectin is superior to procalcitonin as a sepsis marker and predictor of 30-day mortality in intensive care patients","volume":"80","author":"Larsson","year":"2020","journal-title":"Scand J Clin Lab Invest"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625005963?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625005963?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T08:05:14Z","timestamp":1773907514000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783625005963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S1538783625005963"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2025.09.006","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A distinctive immunophenotypic signature in thrombocytopenic septic patients: platelet and neutrophil dysregulations as key contributors to disease severity","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2025.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}