{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T08:11:02Z","timestamp":1778227862492,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jtha.2025.09.044","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T01:43:58Z","timestamp":1762307038000},"page":"470-482","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pain diagnostics in people with hemophilia \u2013 pain pressure thresholds and influence of age and joint status"],"prefix":"10.1016","volume":"24","author":[{"given":"Thomas","family":"Hilberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas C.","family":"Strauss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Oldenburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Goldmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natascha","family":"Marquardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1738-4891","authenticated-orcid":false,"given":"Fabian","family":"Tomschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2025.09.044_bib1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.blre.2017.09.004","article-title":"Treatment of musculo-skeletal pain in haemophilia","volume":"32","author":"Rodriguez-Merchan","year":"2018","journal-title":"Blood Rev"},{"key":"10.1016\/j.jtha.2025.09.044_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/hae.13509","article-title":"Gaining insight into the complexity of pain in patients with haemophilia: state-of-the-art review on pain processing","volume":"24","author":"Roussel","year":"2018","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.09.044_bib3","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/hae.13214","article-title":"Self-reported prevalence, description and management of pain in adults with haemophilia: methods, demographics and results from the Pain, Functional Impairment, and Quality of life (P-FiQ) study","volume":"23","author":"Witkop","year":"2017","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.09.044_bib4","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.2147\/PPA.S87659","article-title":"Associations of quality of life, pain, and self-reported arthritis with age, employment, bleed rate, and utilization of hemophilia treatment center and health care provider services: results in adults with hemophilia in the HERO study","volume":"9","author":"Forsyth","year":"2015","journal-title":"Patient Prefer Adherence"},{"key":"10.1016\/j.jtha.2025.09.044_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/hae.14046","article-title":"WFH guidelines for the management of hemophilia, 3rd edition","volume":"26","author":"Srivastava","year":"2020","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.09.044_bib6","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.2147\/PPA.S141389","article-title":"Reliability of patient-reported outcome instruments in US adults with hemophilia: the Pain, Functional Impairment and Quality of life (P-FiQ) study","volume":"11","author":"Kempton","year":"2017","journal-title":"Patient Prefer Adherence"},{"key":"10.1016\/j.jtha.2025.09.044_bib7","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/hae.14544","article-title":"Gaining more insight into ankle pain in haemophilia: a study exploring pain, structural and functional evaluation of the ankle joint","volume":"28","author":"Roussel","year":"2022","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.09.044_bib8","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1365-2516.2006.01312.x","article-title":"Hemophilia joint health score reliability study","volume":"12","author":"Hilliard","year":"2006","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.09.044_bib9","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1046\/j.1365-2516.2001.00540.x","article-title":"Pain status of patients with severe haemophilic arthropathy","volume":"7","author":"Wallny","year":"2001","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.09.044_bib10","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1365-2516.2012.02808.x","article-title":"Pain management in patients with haemophilia: a European survey","volume":"18","author":"Holstein","year":"2012","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.09.044_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.832172","article-title":"The eEgg: evaluation of a new device to measure pain","volume":"13","author":"B\u00f6ing-Me\u00dfing","year":"2022","journal-title":"Front Physiol"},{"key":"10.1016\/j.jtha.2025.09.044_bib12","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1186\/s12891-021-04408-0","article-title":"Pressure pain thresholds in individuals with knee pain: a cross-sectional study","volume":"22","author":"Sylwander","year":"2021","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.jtha.2025.09.044_bib13","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/BF02032098","article-title":"Measurement of pain threshold in patients with rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and healthy controls","volume":"8","author":"Gerecz-Simon","year":"1989","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.jtha.2025.09.044_bib14","article-title":"Optimizing acute pain relief in severe knee Osteoarthritis: the influence of resistance exercise volume and psychosocial factors","volume":"79","author":"S\u00e1nchez-Sabater","year":"2025","journal-title":"Musculoskelet Sci Pract"},{"key":"10.1016\/j.jtha.2025.09.044_bib15","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1080\/09593985.2021.2023929","article-title":"Pain pressure threshold algometry in knee osteoarthritis: intra- and inter-rater reliability","volume":"39","author":"Stausholm","year":"2023","journal-title":"Physiother Theory Pract"},{"key":"10.1016\/j.jtha.2025.09.044_bib16","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/hae.14380","article-title":"Changes in pain profile of patients with haemophilia during 1-year follow-up","volume":"27","author":"Kr\u00fcger","year":"2021","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.09.044_bib17","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1016\/j.pain.2011.04.030","article-title":"Joint pain in people with hemophilia depends on joint status","volume":"152","author":"Hilberg","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.jtha.2025.09.044_bib18","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S1090-3801(03)00082-X","article-title":"Pressure pain thresholds of tender point sites in patients with fibromyalgia and in healthy controls","volume":"8","author":"Maquet","year":"2004","journal-title":"Eur J Pain"},{"key":"10.1016\/j.jtha.2025.09.044_bib19","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.pain.2004.09.012","article-title":"Core outcome measures for chronic pain clinical trials: IMMPACT recommendations","volume":"113","author":"Dworkin","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.jtha.2025.09.044_bib20","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/hae.12289","article-title":"Assessment of pain threshold in haemophilic patients","volume":"20","author":"Teyssler","year":"2014","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.09.044_bib21","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/hae.15011","article-title":"Structural alterations and pain perception at the ankle joint in patients with haemophilia","volume":"30","author":"Schmidt","year":"2024","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.09.044_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/rth2.12690","article-title":"The Hemophilia Joint Health Score version 2.1 validation in adult patients study: a multicenter international study","volume":"6","author":"St-Louis","year":"2022","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.09.044_bib23","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1111\/hae.12197","article-title":"Using the Haemophilia Joint Health Score for assessment of teenagers and young adults: exploring reliability and validity","volume":"19","author":"Fischer","year":"2013","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.09.044_bib24","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ejpain.2004.04.001","article-title":"Deep pain thresholds in the distal limbs of healthy human subjects","volume":"9","author":"Rolke","year":"2005","journal-title":"Eur J Pain"},{"key":"10.1016\/j.jtha.2025.09.044_bib25","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/hae.13472","article-title":"Pain and structural alterations in knee joints in patients with haemophilia","volume":"24","author":"Kr\u00fcger","year":"2018","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.09.044_bib26","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1111\/hae.13016","article-title":"Pain sensitivity in patients with haemophilia following moderate aerobic exercise intervention","volume":"22","author":"Kr\u00fcger","year":"2016","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.09.044_bib27","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.sjpain.2015.05.004","article-title":"Reliability of pressure pain threshold testing in healthy pain free young adults","volume":"9","author":"Waller","year":"2015","journal-title":"Scand J Pain"},{"key":"10.1016\/j.jtha.2025.09.044_bib28","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1515\/sjpain-2018-0017","article-title":"Relative and absolute test-retest reliabilities of pressure pain threshold in patients with knee osteoarthritis","volume":"18","author":"Srimurugan Pratheep","year":"2018","journal-title":"Scand J Pain"},{"key":"10.1016\/j.jtha.2025.09.044_bib29","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00482-002-0162-1","article-title":"Development and evaluation of the multidimensional German pain questionnaire","volume":"16","author":"Nagel","year":"2002","journal-title":"Schmerz"},{"key":"10.1016\/j.jtha.2025.09.044_bib43","series-title":"Statistical Power Analysis for the behavioral sciences","author":"Cohen","year":"1988"},{"key":"10.1016\/j.jtha.2025.09.044_bib30","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3389\/fnagi.2020.00116","article-title":"Age-related changes in pain perception are associated with altered functional connectivity during resting state","volume":"12","author":"Gonz\u00e1lez-Rold\u00e1n","year":"2020","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.jtha.2025.09.044_bib31","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/ejp.1011","article-title":"Age-related changes in pain sensitivity in healthy humans: a systematic review with meta-analysis","volume":"21","author":"El Tumi","year":"2017","journal-title":"Eur J Pain"},{"key":"10.1016\/j.jtha.2025.09.044_bib32","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neubiorev.2017.01.039","article-title":"Age changes in pain perception: a systematic-review and meta-analysis of age effects on pain and tolerance thresholds","volume":"75","author":"Lautenbacher","year":"2017","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.jtha.2025.09.044_bib33","article-title":"Reference values of joint-specific pressure pain thresholds in healthy male individuals: a retrospective study","volume":"29:e70050","author":"Tomschi","year":"2025","journal-title":"Eur J Pain"},{"key":"10.1016\/j.jtha.2025.09.044_bib34","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/hae.14344","article-title":"The effect of age on the pressure pain threshold of asymptomatic ankles and knees in young individuals with haemophilia","volume":"27","author":"Etzweiler","year":"2021","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.09.044_bib35","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/hae.12034","article-title":"Quadriceps strength, inter-extremity difference (IED) and joint status in adult persons with severe haemophilia in different age stages","volume":"19","author":"Brunner","year":"2013","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.09.044_bib36","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/hae.15013","article-title":"Primary prophylaxis implementation and long-term joint outcomes in Swedish haemophilia A patients","volume":"30","author":"Arvanitakis","year":"2024","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2025.09.044_bib37","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.joca.2021.09.011","article-title":"Quantitative sensory testing: identifying pain characteristics in patients with osteoarthritis","volume":"30","author":"Arant","year":"2022","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jtha.2025.09.044_bib38","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.joca.2015.02.163","article-title":"Pain sensitization in people with knee osteoarthritis: a systematic review and meta-analysis","volume":"23","author":"Fingleton","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jtha.2025.09.044_bib39","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/art.39488","article-title":"Association of joint inflammation with pain sensitization in knee osteoarthritis: the multicenter osteoarthritis study","volume":"68","author":"Neogi","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jtha.2025.09.044_bib40","doi-asserted-by":"crossref","first-page":"644","DOI":"10.2519\/jospt.2011.3666","article-title":"Reliability, standard error, and minimum detectable change of clinical pressure pain threshold testing in people with and without acute neck pain","volume":"41","author":"Walton","year":"2011","journal-title":"J Orthop Sports Phys Ther"},{"key":"10.1016\/j.jtha.2025.09.044_bib41","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3233\/BMR-181208","article-title":"Reliability of pressure pain threshold to discriminate individuals with neck and low back pain","volume":"34","author":"Zicarelli","year":"2021","journal-title":"J Back Musculoskelet Rehabil"},{"key":"10.1016\/j.jtha.2025.09.044_bib42","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1002\/ejp.878","article-title":"The effects of total knee replacement and non-surgical treatment on pain sensitization and clinical pain","volume":"20","author":"Skou","year":"2016","journal-title":"Eur J Pain"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625007159?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625007159?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T07:22:07Z","timestamp":1778224927000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783625007159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S1538783625007159"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2025.09.044","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pain diagnostics in people with hemophilia \u2013 pain pressure thresholds and influence of age and joint status","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2025.09.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}]}}